With more than 35 peer-reviewed scientific publications, findings from the POG program are influencing precision oncology approaches around the world.
POG peer-reviewed publications
Pleasance E, Titmuss E, Williamson L et al. Pan-cancer analysis of advanced patient tumors reveals interactions between therapy and genomic landscapes. Nature Cancer. 2020.
Lavoie JM, Mitchell T, Lee SE et al. Patient selection for a developmental therapeutics program using whole genome and Transcriptome analysis. Investigational New Drugs. 2020.
Wong D, Shen Y, Levine AB et al. The pivotal role of sampling recurrent tumors in the precision care of patients with tumors of the central nervous system. Cold Spring Harbor Molecular Case Studies. 2019.
Williamson LM, Steel M, Grewal JK et al. Genomic characterization of a well-differentiated grade 3 pancreatic neuroendocrine tumor. Cold Spring Harbor Molecular Case Studies. 2019.
Thibodeau ML, Zhao EY, Reisle C et al. Base excision repair deficiency signatures implicate germline and somatic MUTYH aberrations in pancreatic ductal adenocarcinoma and breast cancer oncogenesis. Cold Spring Harbor Molecular Case Studies. 2019.
Majounie E, Wee K, Williamson LM et al. Fluorouracil sensitivity in a head and neck squamous cell carcinoma with a somatic DPYD structural variant. Cold Spring Harbor Molecular Case Studies. 2019.
Karasinska J, Topham JT, Kalloger SE et al. Altered gene expression along the glycolysis-cholesterol synthesis axis is associated with outcome in pancreatic cancer. Clinical Cancer Research. 2019.
Feng X, Pleasance E, Zhao EY, et al. Therapeutic implication of genomic landscape of adult metastatic sarcoma. JCO Precision Oncology. 2019.
Jones MR, Williamson LM, Topham JT, et al. NRG1 gene fusions are recurrent, clinically actionable gene rearrangements in KRAS wild-type pancreatic ductal adenocarcinoma. Clinical Cancer Research. 2019.
Grewal JK, Tessier-Cloutier B, Jones M, et al. Application of a neural network whole transcriptome-based pan-cancer method for diagnosis of primary and metastatic cancers. JAMA Network Open. 2019.
Tsang ES, Shen Y, Chooback N, et al. Clinical outcomes after whole-genome sequencing in patients with metastatic non-small-cell lung cancer. Cold Spring Harbor Molecular Case Studies. 2019.
Ko JJ, Grewal JK, Ng T, et al. Whole-genome and transcriptome profiling of a metastatic thyroid-like follicular renal cell carcinoma. Cold Spring Harbor Molecular Case Studies. 2018.
Wong HL, Zhao EY, Jones MR, et al. Temporal dynamics of genomic alterations in a BRCA1 germline-mutated pancreatic cancer with low genomic instability burden but exceptional response to Fluorouracil, Oxaliplatin, Leucovorin, and Irinotecan. JCO Precision Oncology. 2018.
Newton Y, Rassekh RS, Deyell RJ, et al. Comparative RNA-sequencing analysis benefits a pediatric patient with relapsed cancer. JCO Precision Oncology. 2018.
Chahal M, Pleasance E, Grewal J, et al. Personalized oncogenomic analysis of metastatic adenoid cystic carcinoma: using whole-genome sequencing to inform clinical decision making. Cold Spring Harbor Molecular Case Studies. 2018.
Ronsley R, Rassekh SR, Shen Y, et al. Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma. Cold Spring Harbor Molecular Case Studies. 2018.
Owen DR, Wong HL, Bonakdar M, et al. Molecular characterization of ERBB2-amplified colorectal cancer identifies potential mechanisms of resistance to targeted therapies: a report of two instructive cases. Cold Spring Harbor Molecular Case Studies. 2018.
Thibodeau ML, Bonakdar M, Zhao E, et al. Whole genome and whole transcriptome genomic profiling of a metastatic eccrine porocarcinoma. NPJ Precision Oncology.
Zhao EY, Shen Y, Pleasance E, et al. Homologous recombination deficiency and platinum-based therapy outcomes in advanced breast cancer. Clinical Cancer Research. 2017.
Jones MR, Lim H, Shen Y, et al. Successful targeting of the NRG1 pathway indicates novel treatment strategy for metastatic cancer. Annals in Oncology. 2017.
Wong HL, Yang KC, Shen Y, et al. Molecular characterization of metastatic pancreatic neuroendocrine tumours (PNETs) using whole genome and transcriptome sequencing. Cold Spring Harbor Molecular Case Studies. 2018.
Grewal JK, Eirew P, Jones M, et al. Detection and genomic characterization of a mammary-like adenocarcinoma. Cold Spring Harbor Molecular Case Studies. 2017.
Chooback N, Shen Y, Jones M, et al. Carcinoma ex pleomorphic adenoma: case report and options for systemic therapy. Current Oncology. 2017.
Chow-White P, Ha D, Laskin J, et al. Knowledge, attitudes, and values among physicians working with clinical genomics: a survey of medical oncologists. Human Resources for Health. 2017.
Thibodeau ML, Reisle C, Zhao E, et al. Genomic profiling of pelvic genital type leiomyosarcoma in a woman with a germline CHEK2:c.1100delC mutation and a concomitant diagnosis of metastatic invasive ductal breast carcinoma. Cold Spring Harbor Molecular Case Studies. 2017.
Weymann D, Laskin J, Roscoe R, et al. The cost and cost-trajectory of whole-genome analysis guiding treatment of patients with advanced cancer. Molecular Genetetics and Genomic Medicine. 2017.
Sheffield BS, Tessier-Cloutier B, Li-Chang H, et al. Personalized oncogenomics in the management of gastrointestinal carcinomas-early experiences from a pilot study. Current Oncology. 2016.
Laskin J, Ha D, Chan T, et al. Clinicians identify high need to increase their genomic literacy to applied cancer genomics. Annals of Oncology. 2016.
Sheffield BS, Fulton R, Kalloger SE, et al. Investigation of PD-L1 biomarker testing methods for PD-1 axis inhibition in non-squamous non-small cell lung cancer. Journal of Histochemistry and Cytochemistry. 2016.
Alassiri AH, Ali RH, Shen Y, et al. ETV6-NTRK3 is expressed in a subset of ALK-negative inflammatory myofibroblastic tumors. The American Journal of Surgical Pathology. 2016.
Jones, MR, Schrader KA, Shen Y, et al. Response to angiotensin blockade with irbesartan in a patient with metastatic colorectal cancer. Annals of Oncology. 2016.
Parker JD, Shen Y, Pleasance E, et al. Molecular etiology of an indolent lymphoproliferative disorder determined by whole-genome sequencing. Cold Spring Harbor Molecular Case Studies. 2016.
Laskin J, Jones S, Aparicio S, et al. Lessons learned from the application of whole-genome analysis to the treatment of patients with advanced cancers. Cold Spring Harbor Molecular Case Studies. 2015.
Bose, P, Pleasance ED, Jones M, et al. Integrative genomic analysis of ghost cell odontogenic carcinoma. Oral Oncology. 2015.
Sheffield BS, Tinker AV, Shen Y, et al. Personalized oncogenomics: clinical experience with malignant peritoneal mesothelioma using whole genome sequencing. PLoS One. 2015.
Jamshidi F, Pleasance E, Li Y, et al. Diagnostic value of next-generation sequencing in an unusual sphenoid tumor. Oncologist. 2014.
Jones SJ, Laskin J, Li YY, et al. Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors. Genome Biology. 2010.
POG-associated peer-reviewed publications
Chan-Seng-Yue M, Kim JC, Wilson GW et al. Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution. Nature Genetics. 2020.
Vaske OM, Bjork I, Salama SR et al. Comparative tumor RNA sequencing analysis for difficult-to-treat pediatric and young adult patients with cancer. JAMA Network Open. 2019.
Pandoh PK, Corbett RD, McDonald H et al. A high-throughput protocol for isolating cell-free circulating tumor DNA from peripheral blood. BioTechniques. 2019.
Haile S, Corbett RD, Bilobram S et al. Evaluation of protocols for rRNA depletion-based RNA sequencing of nanogram inputs of mammalian total RNA. PLoS One. 2019.
Haile S, Corbett RD, Bilobram S et al. Sources of erroneous sequences and artifact chimeric reads in next generation sequencing of genomic DNA from formalin-fixed paraffin-embedded samples. Nucleic Acids Research. 2019.
Haile S, Pandoh PK, McDonald H et al. Automated high throughput nucleic acid purification from formalin-fixed paraffin-embedded tissue samples for next generation sequence analysis. PLoS One. 2017.
Peer-reviewed publications citing POG
Belli V et al. Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models. Journal of Experimental and Clinical Cancer Research. 2019.
Pantziarka P, Meheus L. Omics-driven drug repurposing as a source of innovative therapies in rare cancers. Expert Opinions on Orphan Drugs. 2018.
Pantziarka P, Bouche G, André N. “Hard” drug repurposing for precision oncology: the missing link? Frontiers in Pharmacology. 2018.
Berger MF, Mardis ER. The emerging clinical relevance of genomics in cancer medicine. Nature Reviews in Clinical Oncology. 2018.