Canada's Michael Smith Genome Sciences Centre offers scientists the opportunity to pursue careers in the field of genomic research. With close ties to the local academic communities and to scientific collaborators around the world, we offer a diverse, rich environment in state of the art genomic research activities. With our offices and labs located in Vancouver, B.C., this means living in a city that often ranks at the top of list in best places to live.

HEU and HSA union members

Internal applicants please visit to apply online for internal job postings.

Quality Systems Manager


Reporting to the Head of Quality Systems and Regulatory Affairs, the Quality System (QS) Manager is responsible for the management and operation of the Quality Management System (QMS) of the Conconi Family Immunotherapy Laboratory (CFIL) at the Deeley Research Centre in Victoria, BC. The QS Manager will provide oversight and management of quality activities related to clinical trial execution and GMP driven cell-based manufacturing of clinical drug development. The QS manager will also support the design and development of Quality Control tests, procedures and specifications for preclinical and clinical trial programs. The QS Manager will be accountable for assuring compliance with applicable regulatory requirements and internal QMS requirements, identifying/driving quality system improvement and generation of metrics to drive continuous improvement. 


This position is primarily located in Victoria, BC, and occasional travel to Vancouver will be required.    


  • Responsible for the management, maintenance and monitoring of the existing QMS for the CFIL’s Cancer Immunotherapy Program to assure compliance with GCP, GMP, Health Canada and other applicable regulatory requirements.  
  • Develops and implements quality policies and procedures while ensuring they are carried out under controlled conditions. 
  • Maintains a comprehensive change control and validation program for changes in pipelines, processes, equipment, reagents and consumables.
  • Supports the internal and supplier audit programs, conducts supplier audits and generates audit reports as needed.
  • Participates in supplier evaluation and qualification while being responsible for customer/supplier agreement development and/or annual review.
  • Attends to day-to-day quality issues and alerts appropriate personnel of recurring problems and/or quality deficiencies.
  • Participates in the external accreditation (e.g. FACT) and client assessments. Interacts with the auditors addressing questions.    
  • Drives investigations to closure, facilitating root cause analysis and the development of effective CAPA plans.
  • Supports and provides oversight for the maintenance of the quality control program to ensure conformity of raw material, purchased reagents and material and final products to quality standards.
  • Establishes user requirements for purchase, qualification of QC analytical equipment. Works with internal and external resources to maintain equipment in an optimal state.
  • Supports and oversees the development and management of QC release assays, documentation for in-process and final product release and stability testing programs.
  • Responsible for analyzing and trending QC data, generating stability and other trending reports as necessary.
  • Serves as a subject matter expert for investigation and resolution of out-of-specification (OOS) and out-of-trend (OOT) testing results.
  • Participates and authors analytical sections of regulatory submissions as needed
  • Leads analytical method validation and reviews technology transfer protocols.
  • Maintains, monitors and implements additional environmental and personnel monitoring programs to ensure compliance to regulatory requirements for a multi-product manufacturing facility.
  • Oversees the management of the current document control system ensuring only current and valid documents are used. 
  • Accountable for the preparation of the annual QMS review reports and for ensuring that the performance of the QMS is periodically reviewed by senior management for effectiveness and continuing suitability.
  • Identifies training requirements and provides educational sessions on quality policies, processes and procedures to CFIL staff.
  • Develops positive relationships with various stakeholders including internal and external scientific and clinical collaborators.
  • Recruits, trains and manages QS staff as needed. Performs ongoing competency assessment and performance evaluations, sets goals and provides feedback.



The ideal candidate will possess the following qualifications in terms of education, work experience and competencies.

Educational Requirements

  • A level of education, training, and experience equivalent to PhD in a science related filed, preferably in cell biology, immunology, molecular biology or biochemistry with 3+ years of QC/QA experience or MSc with 6+ years or BSc with 8+ years of QC/QA experience in the GMP regulated biopharmaceutical or pharmaceutical industry supporting gene/cell therapy product manufacturing for clinical and/or commercial use.

Professional Work Experience

  • Advanced working knowledge and understanding of Canadian and international (e.g. ICH) GMP regulations, procedures and guidelines that govern manufacturing, quality control and quality assurance of biologics/drugs produced for clinical trial investigation.
  • Minimum of 2 years demonstrated track record of management of QA/QC groups with people development and performance management skills.
  • Demonstrable working knowledge in managing and monitoring of QMS.
  • Expert knowledge of Health Canada, FDA and ICH regulatory requirements for cell therapy products.
  • Experience in performing internal and supplier audits. 
  • Experience in deviation investigations, determining root cause, and developing corrective action plans.
  • Experience in process justification, process validation, risk assessment, training and document management.
  • Demonstrable experience of QC analytical methods and in-depth knowledge of US and European Pharmacopeia requirements for biologic product testing and method validation.
  • Sound understanding and demonstrated application of statistical methods/tools.
  • Identifying, writing, evaluating and closing OOS’s and investigations.
  • Experience with the application and validation of analytical techniques in a QC environment, including Compendial testing, Spectrometry, Chromatography, ELISA, PCR, Cell-based potency assays.
  • Direct experience with batch review and release of cell therapy product lots is considered a plus.
  • Skilled use of Word, Excel and other similar programs along with experience with an electronic Quality Management System or Laboratory management System is an asset.
  • The CFIL facility is embedded in a research institution; therefore experience working at the interface between a research environment and a regulated environment would be an asset.


  • Excellent analytical and project management skills
  • Effective written and verbal communication skills
  • Exceptional critical thinking, troubleshooting and problem solving skills
  • Strong organizational skills and ability to manage multiple priorities
  • Self-motivated, detail-oriented and comfortable in a fast-paced research environment with minimal direction and able to adjust workload based upon changing priorities

Canadian citizens and permanent residents will be given priority.

Research Programmer – Microservice Developer

The Michael Smith Genome Science Centre of BC Cancer is looking for an enthusiastic and self-motivated Research Programmer to work on the next generation of our federated genome and health data sharing platform, CanDIG ( The project was originally based on the Global Alliance for Genomics and Health framework and now connects the lead sequencing institutions in Canada. The position is within Dr. Jones group therefore successful candidate will have the opportunity to get insights on Personalized OncoGenomics (POG) program and other precision medicine initiatives. This requires a combination of interest in DNA technology and strong background in software development.


The successful candidate will have an undergraduate degree in computer science or software engineering.

Mandatory Skills and Abilities:

* 3+ years experience in Python programming

* Front and/or back end development experience

* Previous API development projects, Open API or Rest API

* General understanding or previous experience in microservice architecture and development

* Any web framework experience

* Database development knowledge

Bonus to have:

* Previous project on database access restriction or authorization tool knowledge

* RBAC experience

* Experience building rich queries using GraphQL or other data query language

* Experience working with distributed systems

Basic understanding of DNA technology or previous work experience with genetic data is a plus, but not required for the position. The position requires working with a wide variety of researchers, software developers and clinicians, thus excellent communication skills are essential.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Administrative Assistant 2

Role Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position. The Administrative Assistant provides confidential administrative and secretarial support to the designated Senior Leader(s) and assists with the activities of the program/services including workload support and organization-wide activities, relevant human resource actions and subsequent projects and taking direction from other designated personnel as appropriate. The Administrative Assistant follows administrative policies and procedures and works independently with minimal direction to balance priorities and workflow. The Administrative Assistant interacts with senior leaders, managers/directors and administrative support staff across the organization to convey information and professionally represent the interests of the department/senior leader utilizing strong persuasion and communication abilities and the exchange of information. The Administrative Assistant determines courses of action from established alternatives to make decisions that will have a positive impact in the program/service and exercises initiative, judgment and problem-solving skills to complete confidential, time-sensitive work. Judgments affect the accuracy and acceptability of further processes or services in the organization.

Key Accountabilities

  • Provides administrative support that respects confidentiality and ensures that administrative matters are organized and dealt with in a professional manner.
  • Prepares documents including presentations, spreadsheets, correspondence, meeting minutes, and reports in an accurate and timely manner. Utilizes a variety of software applications to ensure professional standards are maintained, relevant and current data is used and end product is appropriately and professionally formatted. Compiles information into structured reports.
  • Maintains a consistently updated and accurate appointment schedule for the senior leader and others as required. Coordinates meetings ensuring well-defined and timely agendas, identification of and notification to interested parties, compilation of background information and supporting materials and preparation of packages/summary documents to assist in decision making and meeting facilitation. Makes catering, travel and accommodation arrangements. Attends meetings and in-services as required.
  • Designs and maintains filing and distribution systems for a variety of records and files including confidential information, such as personnel files, payroll files, financial information and other sensitive documents relating to the management of the Department using methods that can be easily accessible to assigned staff.
  • Assists in budget development ensuring information is current and accurately compiled, monitors expenditures, ensures invoices are authorized to predetermined amounts and analyzes and reports variances for multiple departments/programs. Completes purchase requisitions/online purchasing and forwards for processing and ensures invoices are authorized for payment and submitted for payment.
  • Completes and submits timekeeping records, vacation entitlements, and responds to related queries from departments such as Finance, Payroll and Human Resources.
  • Provides work direction and guidance to support staff as needed to ensure administrative needs of the area are met.
  • Participates in the development and maintenance of administrative and clinical policies and helps to ensure all staff are aware of and adhere to policies and procedures.


A level of education, training and experience equivalent to graduation from a recognized post-secondary administrative assistant/secretarial program, additional course work in advanced word processing, spreadsheet, and database applications, and four (4) years’ progressive experience supporting senior level management. Demonstrated ability to work both independently and collaboratively, resolve administrative issues/problems,
prioritize workload, and to be flexible to meet and adapt to changes in organizational priorities. Demonstrated ability to use Microsoft Office applications, including word processing, spreadsheet and presentation software, at an advanced level. Demonstrated organizational skills and ability to prioritize workload and work under time
pressures to meet deadlines. Demonstrated ability to communicate effectively both verbally and in writing, including the ability to respond professionally, courteously, and in a clear manner. Demonstrated interpersonal and time management skills. Demonstrated ability to record and transcribe minutes of meetings. Ability to type 60 w.p.m.

To Apply

Please send your resume with cover letter to

Research Programmer (Web Development)

BC Cancer’s Michael Smith Genome Sciences Centre (GSC) in collaboration with other labs across Canada is developing clinical NGS test for lymphoma. The GSC is seeking a Research Programmer interested in working with a multi-disciplinary clinical and academic team specializing in molecular diagnostics. The incumbent will develop web-based applications and design databases to be used for data analysis and reporting results to clinicians. Applicants must be comfortable doing both backend and front end work, with some knowledge of Linux server maintenance.


  • Frontend and backend development of secure, interactive web-based applications to allow for status tracking and report dissemination

  • Development of secure databases to be used for tracking sensitive information (i.e. patient information) and analysis results for reports used by clinical staff and physicians

  • Development of interactive tools to allow for interpretation of results from genetic and genomic assays

  • Set-up and maintenance of servers to host applications, databases, and tools described above

  • Quality-assurance and security testing for websites and databases

  • Other related duties as assigned


    • Graduation from a recognized degree or diploma program in computer programming or an equivalent combination of education, training and experience. 

Core Skills and Abilities: 

  • Familiarity with HTTP, HTML 5, XML, JavaScrpt, PHP

  • Experience with Linux is essential; working knowledge of Windows and Macintosh is an asset.

  • Experience in the development, testing, and maintenance of relational databases

  • Knowledge of security protocols and procedures necessary to protect sensitive information

  • Working knowledge of software testing, documentation, and version control

  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment

  • Demonstrated ability to efficiently organize work assignments and establish priorities

  • Ability to communicate effectively both verbally and in writing

Additional Assets:

  • Three (3) years of recent related experience with a Unix/Javascript stack and systems/network administration

    • Familiarity with frontend JavaScript frameworks (preferable React.js)
  • Some graphic design, UI/UX experience

  • Some knowledge of Python

  • Experience with Agile software practices 

The successful applicant will work in a team environment which includes clinicians, research scientists, technicians, and bioinformaticians.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

To Apply

Please send your resume with cover letter to

Staff Scientist 2

Job Code: SS2 11-14-2019

The Holt Laboratory at BC Cancer is looking for a qualified candidate to aid in the preclinical and clinical development of novel cancer vaccines and cellular immunotherapies. The candidate will work with local, national and international partners, collaborators and service providers in academia, industry, government and not-for-profit organizations.

The successful candidate will have a PhD or equivalent degree and at least seven years of relevant experience.  Knowledge of and research experience with standard methods and approaches in microbiology, immunology, cell biology, molecular biology, genomics and proteomics; and familiarity with the fields of cancer immunology and immunotherapy are assets.  A strong background in preclinical and clinical research methodology is highly desirable.

The applicant should also demonstrate the ability to work independently, supervise trainees and technical staff, and conceive, initiate, prioritize, organize and manage multiple concurrent projects.  Excellent verbal and written communication skills are a necessity as well as the ability to work in a team environment.  Management experience with large, multi-center projects is an asset. 

This position will begin ASAP.  This is a one-year term appointment subject to annual renewal.  Salary will be commensurate with qualifications and experience.

Applications, accompanied by a detailed curriculum vitae and three letters of reference addressing scholarly, professional and creative work, plus supervisory and administrative service, should be directed to: 

Rob Holt, PhD
Scientific Co-Director, BC Cancer Immunotherapy Program

Distinguished Scientist, Canada's Michael Smith Genome Sciences Centre

Professor of Medical Genetics, University of British Columbia

Professor of Molecular Biology & Biochemistry, Simon Fraser University

This position will remain open until filled. 

This is a temporary position with a possibility of extension.

Research Assistant 2, Proteomics

Job Code: RA2 07-04-2019

The Research Assistant 2 – Proteomics works under supervision and performs experiments by following established laboratory procedures.

In this role you will: 

  • Prepare samples for proteomic analysis

  • Operating facility instrumentation including off-line HPLC fractionation systems, mass spectrometers, and speed vacs

  • Perform initial data analysis

  • Assist in the development of cutting edge protocols for clinical proteomics

  • Maintain logs of samples analyzed and instrument use

  • Liaise with collaborators to coordinate sample submission and communicating results

  • Collaborate with client lab personnel

  • Maintain a details lab notebook

You hold:

A laboratory technician degree in chemical and biotechnical science with direct work experience in proteomics.

You Have:

  • Theoretical knowledge and practical experience with tandem mass spectrometry

  • Experience with state-of-the-art mass spectrometry instrumentation including Orbitraps

  • Experience with clinical sample preparation for proteomics and nucleic acid analysis

  • Experience with processing cells and tissues for global and targeted proteomics

  • Practical experience with analytical reversed phase chromatography (HPLC and nanoLC), specifically for peptide separation

  • Two (2) years recent related experience in a research laboratory

If this sounds like you, apply now!

About Us

BC Cancer is part of the Provincial Health Services Authority (PHSA). PHSA provides specialized health services to British Columbians, including cancer care, organ transplantation, pediatrics, emergency services, mental health and substance use services. Our values reflect our commitment to excellence and include: Respect people – Be compassionate – Dare to innovate – Cultivate partnerships – Serve with purpose. Learn more about PHSA and our programs:

Canada's Michael Smith Genome Science Centre is a leading international centre for genomics and bioinformatics research.   Our mandate is to advance knowledge about cancer and other diseases, to improve human health through disease prevention, diagnosis and therapeutic approaches, and to realize the social and economic benefits of genomic research.  We are a high through-put sequencing facility in Vancouver, Canada having sequenced over 2,402,168,248,871,630 raw bases to date. We have numerous research collaborations both locally and internationally with a primary focus on human cancers.

PHSA hires on the basis of merit and is committed to employment equity. We encourage all qualified persons to apply. We recognize that our ability to provide the best care for our diverse patient populations relies on a rich diversity of skills, knowledge, backgrounds and experiences. We strive to create a safe and welcoming environment where everyone can come to work and be their best, authentic self.

In accordance with Canadian Immigration requirements, this advertisement is first directed to Canadian citizens and permanent residents but international candidates are invited to apply. We encourage applications from all qualified individuals, including Aboriginal peoples, persons with disabilities and members of visible minorities. English is the official language used at PHSA.

PHSA offers a very generous benefit package which includes 4 weeks’ vacation entitlement, extended medical, dental and coverage, life & disability insurance plus professional development opportunities with over 1000 online courses available on our Learning Hub. 

To Apply

Please send your resume with cover letter to We request that you specify the position you are applying for by identifying the Job Code only (e.g. "RA2 07-04-2019") in the subject line of your emailed application. Or apply by visiting the following link:….

For more information on this opportunity please contact Amirah Matiets, Talent Acquisition Representative at (604) 875-7258 or email

Posting #: PHSA-RA2

  • Status: Regular (permanent) Full-Time (37.5 hour per week)
  • Salary: $46,213 to $60,655 per year
  • Hours: Monday to Friday 0830-1630
  • Location: Genome Sciences Centre - 675 West 10th Avenue, Vancouver BC V5Z 1L3

Assistant Bioinformatics Coordinator, Software Development

Job Code: ABCSD HSA Req 86652

The Assistant Bioinformatics Coordinator provides supervisory and technical support to the Bioinformatics group of the Genome Sequence Centre (GSC). Ensures that the day-to-day activities of a large scale, high throughput facility meet research, data analysis throughput and software development objectives.


1.  Assists the Bioinformatics Coordinator in the day to day activities of the Bioinformatics group by performing duties such as providing input on quantity and quality of work, making recommendations for improvements, workflow and procedures. 

2.  Coordinates projects of the Bioinformatics group by performing duties such as chairing project-specific meetings and provides project status reports to the Bioinformatics Coordinator, with suggestions towards any required improvement of project management, task allocation and overall process.

3.  Develops and implements assays to monitor project progress and measure project accomplishments to ensure that appropriate project focus is maintained and to provide feedback to staff. 

4.  Provides supervisory support to the Bioinformatics group by performing duties such as:

          a.  Orientating new staff.

          b.   Providing input to the Bioinformatics Coordinator on training requirements and performing group specific training.

          c.   Providing input to the Bioinformatics Coordinator on the establishment of clear definitions of responsibility for employees. 

         d.   Assigning workload assignments and establishing work schedules.

         e.   Reviewing and establishing work priorities and adjusting work schedules to ensure priorities are met.

         f.    Completing performance reviews and addressing performance issues in conjunction with the Bioinformatics Coordinator.

5. Participates in the recruitment of staff through methods such as interviewing internal and external applicants and forwards hiring recommendations.

6.  Participates in the development and implementation of quality improvement programs to ensure services are provided in the most efficient and effective way by performing duties such as:

          a.   Monitoring quality and quantity of service and information provided by the bioinformatics group and identifying areas for change and/or improvement.

          b.   Generating test metrics to evaluate progress of research programs.

          c. Writing and updating Standard operating procedures pertaining to tasks and pipelines run by the group.

          d. Coordinating and writing technical validation documents for new and improved pipelines and processes.

7.  Assesses practical needs for identified research direction of the GSC in conjunction with the Bioinformatics Coordinator and Bioinformatics Group Leader.

8.  Participates in a variety of meetings by performing duties such as providing and/or receiving information and contributing to decision making.

9.  Participates, in conjunction with the Bioinformatics Coordinator, in determining the computer infrastructure necessary for successful completion of projects and ensured viability of research programs by performing duties such as providing input and recommendations regarding purchasing decisions related to hardware, software and related items for the Bioinformatics platform.

10. Interprets statistical analyses and makes recommendations for review including preparing reports on statistical findings for publication and presentation in HTML format or as advised.

11. Conducts feasibility studies for computerization by performing duties such as determining user requirements, examining and identifying problems with existing systems and recommending modifications to and/or new systems; provides details of estimated implementation costs including associated staffing requirements.

12. Performs technical functions related to the bioinformatic  department of the GSC.

13. Performs other related duties as required.


 Education, Training and Experience

  • Graduation from a recognized Bachelor’s program in a related discipline such as Biochemistry, Genetics, Computer Science, Electrical Engineering or Physics.  A minimum of four (4) years of recent related experience including experience in computer programming and quantitative data analysis, handling biological sequence and/or mapping data, database development and data storage schemas or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders. 

Skills and Abilities

  • Experience with computer operating systems such as Linux, MacOS.

  • Demonstrated ability to work with software languages, frameworks and databases such as Python, C, C++, Javascript, React.js, Perl , R, Postgres, MySQL, Hadoop.

  • Demonstrated ability to accept responsibility and work independently.

  • Demonstrated ability to work effectively with others in a team environment.

  • Demonstrated ability to supervise staff and schedule work.

  • Excellent organizational, leadership interpersonal and communication skills.

  • Physical ability to perform the duties of the job.

To Apply

External Applicants

Please send your resume with cover letter to

Internal Applicants

Internal (HEU and HSA union members) applicants please visit to apply online for internal job postings.

Research Associate, Precision Genomics for Cancer

Job Code: RAPGFC 09-27-2019

The Genome Sciences Centre is seeking a temporary full time Research Associate to work on cancer genomics projects to develop clinical assays for (1) Lymphoid cancers and (2) cancer monitoring and detection using blood samples (aka liquid biopsy). The successful applicant will work in a team to develop high-throughput, clinically accredited pipelines to aid in identifying pathogenic alterations in cancer. This project involves the development of new assays for cancer patients with the goal of individualized patient management.


  • Design, documentation, and analysis of experiments to test new assays and new methods
  • Summary and presentation of experimental findings to stakeholders
  • Modification and development of bioinformatic pipelines to analyze genomic data yielding clinical grade variant and expression data
  • Assist in choosing and modifying gene targets and samples for assay development
  • Analysis of NGS data to investigate clonality, somatic hypermutation, microsattelite instability and intergenic translocations
  • Development and assessment of bioinformatic tools for RNA-Seq expression analysis and variant calling
  • Development and assessment of bioinformatic tools for determining the clinical significance of detected variants
  • Statistical analysis to determine analytical sensitivity and specificity of obtained results
  • Development of software pipelines for analyzing next-generation sequencing data
  • Support of research staff by providing analysis and software tools
  • Contributions to the writing of research publications


  • PhD in Bioinformatics, Microbiology, Biochemistry or a related field
  • Two (2) years of recent related experience or an equivalent combination of education, training and relevant experience
  • A Master’s degree in a relevant field would be considered 

Skills and Abilities: 

  • Knowledge of RNA-Seq and other genomic data analysis, including expression analysis, structural variant detection, and variant-calling.
  • Experience working in a Unix environment, including experience with shell scripting and common command-line tools
  • Expertise in one or more scripting language(s) (e.g. Python)
  • Experience working with next-generation sequencing data and tools (i.e. tools for alignment and variant-calling)
  • Expertise in statistical analysis using modern computational tools.  Experience with any relevant tools will be considered, but R and Python are preferred
  • Experience writing reports of results in accurate and concise language; expertise in scientific/technical writing is required
  • Experience with methods in high-dimensional data analysis for bioinformatics such as clustering, machine learning and data mining would be assets
  • Experience with software testing and cluster computing would be assets
  • Familiarity with cancer genetics would be an asset, as would a history of publications in relevant fields.

The successful candidate will also have:

  • Excellent verbal and written communication skills
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
  • Demonstrated ability to efficiently organize work assignments and establish priorities. 

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

To Apply

Please send your resume with cover letter to

We request that you specify the position you are applying for by identifying the Job Code only (e.g. "RAPGFC 09-27-2019") in the subject line of your emailed application.

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