Canada's Michael Smith Genome Sciences Centre offers scientists, researchers and others the opportunity to pursue careers at the forefront of genome science and precision medicine. With close ties to local and national clinical and academic communities—and to scientific collaborators around the world—we offer a rich and diverse research environment. With offices and laboratories located in Vancouver, British Columbia, we work in a city that consistently ranks as one of the best places in the world to live.

Come work with us!

HEU and HSA union members
Internal applicants please visit internaljobs.phsa.ca to apply online for internal job postings.

COVID-19

All jobs at the GSC are based in Vancouver, British Columbia, Canada. With current COVID-19 conditions and restrictions, for positions with work that can be conducted remotely, some employees and positions will be required to work remotely. Flexible work options may be extended for some positions in the future. Regardless, employees in most roles must be able to work onsite at the GSC, offsite (from home or remotely) or some combination of these.

Postdoctoral Fellow, Gastrointestinal Cancers

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics, and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets, and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole-genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC, but it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers, and clinicians. We look for people who share our core values—science, timeliness, and respect—to join us in our mission to provide genomics, bioinformatics, and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position may require working remotely.  This restriction would be re-evaluated upon re-contracting*


Role Summary

A Post-doctoral position is available immediately for a highly motivated recent PhD or MD/PhD graduate to join a dynamic translational research group, headed by Dr. Isabella Tai, Associate Professor in the Division of Gastroenterology, University of British Columbia and Senior Scientist at Canada's Michael Smith Genome Sciences Centre at BC Cancer.

Current projects in the laboratory revolve around improving our understanding of the mechanisms involved in the development of chemotherapy resistance and metastasis in gastrointestinal cancers (colorectal, gastric, liver and biliary cancers). The goal is to develop either novel therapeutic targets for GI cancer treatment or novel screening tools for diagnosis. We continue to use the latest genomics (including single cell sequencing), proteomics and bioinformatic approaches to identify potential targets or markers for this purpose. Learn more about research projects in the Tai lab here.

Eligibility

Interested individuals with a recent PhD or MD/PhD and strong publication records and excellent academic credentials are encouraged to apply.  Experience in molecular biology, cell biology, tissue culture and animal tumor models, is preferable.  Experience in bioinformatics is an asset.

Duration

Three years (possibility of extension).

To Apply

Please submit a cover letter, curriculum vitae, and the names of three referees willing to provide letters of reference. The cover letter should include a brief description of your previous research experience, long-term career goals and an indication of the desired length of postdoctoral position.

Please email your application to bcgscjobs@bcgsc.ca

Quality Assurance Specialist

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics, and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets, and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole-genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC, but it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers, and clinicians. We look for people who share our core values—science, timeliness, and respect—to join us in our mission to provide genomics, bioinformatics, and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position may require working remotely.  This restriction would be re-evaluated upon re-contracting*


Role Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient and employees safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

Reporting to the Head of Quality and Regulatory Affairs or designate, the Quality Assurance Specialist ensures that the manufacturing and delivery of clinical products and diagnostic data at BC Cancer immunotherapy program and the GSC meets applicable quality and regulatory standards to facilitate the provision of quality clinical trial products and accurate, actionable sequencing reports to clinical sites, physicians and other scientific collaborators. The Quality Assurance Specialist applies scientific, clinical and technical knowledge to bring a comprehensive quality perspective to the manufacturing and high throughput production sites, assisting with developing manufacturing protocols and delivering training material to manufacturing and production staff , creating and deploying quality procedures, defining and producing reports and supporting efficient change request processes. The Quality Assurance Specialist provides feedback and advice to BC Cancer immunotherapy manufacturing and high throughput sequencing sites to promote continuous improvements in product manufacturing and data quality.  The Quality Assurance Specialist assists with budget development by monitoring expenditures in relation to performance outcomes.

Key Responsibilities

  • Implements, evaluates and maintains the Quality Management processes and procedures for the BC Cancer’s immunotherapy clinical trial program and GSC’s clinical and production operations under the supervision of the Head of Quality and Regulatory Affairs or a designate. The Quality Assurance Specialist exercises initiative and independent judgment in the performance of these duties.
  • Reviews clinical trial product manufacturing batch records, patient sample information and data collected during product and data delivery to ensure that all manufacturing and production steps are correctly executed, appropriate clinical labels are applied, confidential information is appropriately classified and de-identified by applying both clinical and technical perspectives and using quality standards to guide decision-making.  Makes any required changes in the release processes to consistently promote a high level of product quality to facilitate the provision of quality product and data delivery.
  • Reviews change requests submitted by the manufacturing and production staff for quality assurance to promote accuracy and completeness of requested change information and facilitates timely and efficient completion of approved changes by the quality systems group.
  • Defines, creates and provides regular reports on quality activities and provides the reports to enable continuous quality improvement in the areas of product and data quality non-conformance reporting and follows-up on CAPAs and change requests.  Consults directly with manufacturing and production group leaders, project managers and other senior level staff to promote the application and integration of findings into quality improvement efforts.
  • Works collaboratively with the manufacturing, team, laboratory operations and project management team to develop, revise, deploy and deliver training and education to staff at all levels on quality systems, GMP, DAP and ISO standards and to define and develop summary reports and identify opportunities to improve quality system processes.
  • Participates in system testing and other quality assurance processes to facilitate system upgrades and improvements, providing clinical product and data quality perspectives.
  • Leads small projects that involve manufacturing and production staff at GSC and BC Cancer immunotherapy program, applying basic project management methods, using a quality improvement model and reporting to the Head of Quality and Regulatory Affairs and other Group Leaders as required on project status.
  • Assesses the effectiveness of QMS and identifies key opportunities for improvement in accordance with GMP/GLP and other applicable quality/regulatory standards and guidelines.
  • Reviews and edits validation protocols to ensure alignment with GMP and GLP practices in order to ensure regular compliance for equipment, analytics methods, and production process in support of manufacturing operations.
  • Supports the preparation of regulatory submissions such as clinical trial applications and amendments as required through the gathering of data and information, completing forms, reviewing and providing guidance to those writing submissions. 
  • Participates in the development of appropriate quality control program to ensure conformity of raw material, purchased reagents and material, and final products to quality standards.
  • Conducts root-cause investigations associated with deviations, non-conformances, and failures through interviews, process review and root cause analysis, summarizes findings, and recommends follow-up and or/corrective actions. Performs quarterly and annual CAPA reviews.
  • Hires, trains, and supervises staff as needed by establishing employee responsibilities, workload assignments and schedules. Completes staff performance reviews.
  • Assess Quality service level requirements and participates in developing essential services plans on behalf of management in preparation for job action.
  • Applies risk assessment methodologies to evaluate new process, process change implementations and new suppliers and vendors. Performs annual risk assessments and maintains a risk catalogue.
  • Frequently travels to other immunotherapy manufacturing worksites as needed to release clinical products for patient management
  • Other related duties as necessary.

Qualifications

A level of education and experience equivalent to a Bachelor’s degree in a scientific field (eg Biology, Engineering, Nursing) and a minimum of 3 years of experience combining direct QA/QC experience in the GMP compliant pharmaceutical/biotech environment executing risk assessments, quality control assays, process improvements and non-conformance investigations.

Skills required include strong verbal and written communication skills, excellent interpersonal skills, attention to detail and accuracy in work, strong computer skills, including familiarity with MS Office products and use of the Internet.  A strong working knowledge with equipment qualification, test methods and other processes related to GMP/GLP practices.  Experience with data quality assurance work is preferred, as is familiarity with reporting software products.  Excellent organizational and time management skills and clear, concise writing and proof-reading skills. Ability to interact constructively and efficiently in a cross functional team environment. Capacity to independently manage multiple priorities in a fast-pace manufacturing environment. Flexibility and a commitment to self-directed learning are also important skills, combined with the ability to remain calm under pressure.  An appreciation and respect for the sensitive and confidential nature of the data is also critical. Knowledge of clinical trials in Canada, cell therapy, genomics, immunology and/or immunotherapy would be considered a plus.

Please email your cover letter and resume to bcgscjobs@bcgsc.ca

Research Programmer

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics, and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets, and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole-genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC, but it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers, and clinicians. We look for people who share our core values—science, timeliness, and respect—to join us in our mission to provide genomics, bioinformatics, and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely.  This restriction would be re-evaluated upon re-contracting*


Role Summary

The Karsan lab team at Canada’s Michael Smith Genome Sciences Centre (GSC) is seeking a research programmer to join a Genome British Columbia software automation project. The team will be working with the Karsan lab, which is responsible for developing high-throughput, clinically accredited pipelines to analyse sequenced data from genomic assays for individualized patient management of cancer. We seek candidates with strong Python software and programming skills to automate and improve existing pipelines and potentially incorporate third-party software into the system.

The role is ideally suited for a creative individual with a strong interest in software development and testing, data analysis, and automation within a high throughput academic setting.

Key responsibilities

  • Design, plan, and implement automated bioinformatics pipelines to meet the objectives of the project
  • Work with other project team members to develop and test code, and implement software
  • Evaluate third-party software and incorporate new systems into legacy systems
  • Produce thorough but concise written documentation of algorithms, validations, SOPs, and other processes and procedures as required

Qualifications

Education, training and experience

  • Graduation from a recognized Bachelor of Science Program in Computer Science. A Master’s degree in a relevant field would be a strong asset. 
  • Two (2) years of recent related experience or an equivalent combination of education, training, and experience acceptable to the project lead.

Core Skills and Abilities 

  • Expertise with Python 3.X and able to provide links to code samples via GitHub or another open repository
  • Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools
  • Familiarity with molecular and cellular biology
  • Excellent verbal and written communication skills.
  • Demonstrated ability to efficiently organize work assignments and establish priorities.
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.

Additional Assets

  • Familiarity in statistical analysis using modern computational tools.  Experience with any relevant tools will be considered, but R and Python are preferred
  • Familiarity with the development, testing, and maintenance of relational databases
  • Familiarity in next-generation sequencing
  • Experience with software testing
  • Experience with Agile software practices
  • Functional knowledge of distributed version control systems, such as SVN or GIT

Please email your cover letter and resume to bcgscjobs@bcgsc.ca

Please note that this position will remain posted until filled.

Assistant Bioinformatics Coordinator

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC. But it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers and clinicians. We look for people who share our core values—science, timeliness and respect—to join us in our mission to provide genomics, bioinformatics and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity is essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely.  This restriction would be re-evaluated upon re-contracting.


Role Summary

Job Code: ABC HSA Req #097093

The Assistant Bioinformatics Coordinator (ABC) of the data sharing applications team provides supervisory and technical support to the Bioinformatics group of the Canada’s Michael Smith Genome Sciences Centre (GSC) at BC Cancer. The ABC ensures that the day-to-day activities of a large scale, high throughput facility meet research, data analysis throughput and software development objectives.  We seek candidates with strong coding experience in Python and/or Javascript, demonstrated expertise in development and management of large databases and web applications.  The successful candidate will be responsible for the ongoing design as well as managing the implementation and maintenance of several large-scale full-stack development projects. These projects include several large-scale databases, which house genomic and clinical data from over ten thousand patients. They will be involved in several high-profile national data sharing efforts in which databases play a central role. Previous experience with Hadoop or other high-performance data solutions such as graph databases is highly desired

Key Responsibilities

  • Assists the Bioinformatics Group Leader in the day to day activities of the Bioinformatics group by performing duties such as providing input on quantity and quality of work, making recommendations for improvements, workflow and procedures.
  • Coordinates projects of the Bioinformatics group by performing duties such as chairing project-specific meetings and provides project status reports to the Bioinformatics Group Leader, with suggestions towards any required improvement of project management, task allocation and overall process.
  • Develops and implements assays to monitor project progress and measure project accomplishments to ensure that appropriate project focus is maintained and to provide feedback to staff.
  • Provides supervisory support to the Bioinformatics group by performing duties such as:
    • Orientating new staff.
    • Providing input to the Bioinformatics Group Leader on training requirements.
    • Providing input to the Production Coordinator on the establishment of clear definitions of responsibility for employees.
    • Assigning workload assignments and establishing work schedules.
    • Reviewing and establishing work priorities and adjusting work schedules to ensure priorities are met.
    • Completing performance reviews and addressing performance issues in conjunction with the Bioinformatics Group Leader.
  • Participates in the recruitment of staff through methods such as interviewing internal and external applicants and forwards hiring recommendations.
  • Participates in the development and implementation of quality improvement programs to ensure services are provided in the most efficient and effective way by performing duties such as:
    • Monitoring quality and quantity of service and information provided by the bioinformatics group and identifying areas for change and/or improvement.
    • Generating test metrics to evaluate progress of research programs.
  • Participates in a variety of meetings by performing duties such as providing and/or receiving information and contributing to decision making.
  • Participates, in conjunction with the Bioinformatics Group Leader, in determining the computer infrastructure necessary for successful completion of projects and ensured viability of research programs by performing duties such as providing input and recommendations regarding purchasing decisions related to hardware, software and related items for the Bioinformatics platform.
  • Interprets statistical analyses and makes recommendations for review including preparing reports on statistical findings for publication and presentation.
  • Conducts feasibility studies for computerization by performing duties such as determining user requirements, examining and identifying problems with existing systems and recommending modifications to and/or new systems; provides details of estimated implementation costs including associated staffing requirements.
  • Performs technical functions related to the bioinformatic functions of the GSC.
  • Performs other related duties as required.

Qualifications

Education, Training and Experience

  • Graduation from a recognized Bachelor of Science Program in Computer Science or equivalent with significant computer science components. 
  • A minimum of four (4) years of recent related experience including experience in computer programming and quantitative data analysis, handling biological sequence and/or mapping data, database development and database schemas or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and Abilities

  • Experience with computer operating systems such as Linux, UNIX.
  • Demonstrated ability to develop with software such as Python, Postgres, and Javascript (NodeJS)
  • Experience with REST API development
  • Familiarity with non-relational databases such as Hadoop or graph databases
  • Demonstrated ability to accept responsibility and work independently.
  • Demonstrated ability to work effectively with others in a team environment.
  • Demonstrated ability to supervise staff and schedule work.
  • Excellent organizational, leadership interpersonal and communication skills.
  • Physical ability to perform the duties of the job.

To Apply

email cover letter and resume to bcgscjobs@bcgsc.ca

Computational Biologist, Analysis

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC. But it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers and clinicians. We look for people who share our core values—science, timeliness and respect—to join us in our mission to provide genomics, bioinformatics and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity is essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely.  This restriction would be re-evaluated upon re-contracting.


Role Summary

Job Code: CBA HSA Req# 96500

The Genome Sciences Centre is seeking a temporary full-time Computational Biologist to join our analysis team in a state of the art, high throughput genomics facility. The successful applicant will participate in the analysis of sequencing data by developing, refining and adapting bioinformatics tools for high-throughput processing pipelines. We seek candidates with strong coding experience in Python or other high-level object-oriented languages (e.g. C/C++, Java etc). Experience with statistical analysis and handling of biological data are also desirable. The role is ideally suited for a creative individual with a strong interest in software development and data analysis within an academic setting. Packaging and distribution of developed tools and analysis results to the scientific community and contribution to preparation of scientific publications are expected.

Key Responsibilities

  • Develops and maintains core analysis pipelines at the GSC, such as: 
    • Somatic and single sample variant calling on whole genomes, exomes and transcriptomes (eg SNVs, indels, CNVs, LOH)
    • De novo assembly of short read sequences and identification of putative structural variants.
    • Gene and transcript expression quantification and differential expression
    • Microbial classification and detection
    • New analyses pipelines as required
    • Performs statistical and population analysis of large cohorts of biological data.
    • Responds to analysis requests from the scientific community by running core pipelines, additional statistical analyses, suggesting analyses where appropriate, preparing presentations of results to collaborators and responding to collaborator questions on results.
  • Prepares data visualization for publication or oral presentations.
  • Presents results of analysis or software testing internally and externally
  • Performs literature searches, testing and validation of new data analysis software.
  • Performs other related duties as required.                

Qualifications

Education, Training and Experience 

  • Graduation from a recognized Bachelor of Science Program in Computer Science or equivalent with a significant genomics, statistical and computer science components.
  • Two years of recent related experience or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders. 

Skills and Abilities 

  • Proven expertise with Python and or other similar high level languages
  • Demonstrated ability in R or other similar statistical programming languages and in statistical analysis
  • Ability to program and run analysis in a production environment
  • Functional knowledge of distributed version control systems, such as GIT
  • Excellent verbal and written communication skills.
  • Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
  • Demonstrated ability to efficiently organize work assignments and establish priorities.
  • Previous experience in a bioinformatic setting, though not required, would be considered an asset

To Apply

email cover letter and resume to bcgscjobs@bcgsc.ca

Research Associate - Bioinformatics

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC. But it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers and clinicians. We look for people who share our core values—science, timeliness and respect—to join us in our mission to provide genomics, bioinformatics and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity is essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely.  This restriction would be re-evaluated upon re-contracting*


Role Summary

The GSC is currently looking for a senior bioinformatician to develop approaches to analyzing and sharing “big data”. This role is instrumental in the development of the CFI-funded cyberinfrastructure project, CanDIG—a state-of-the-art data sharing platform contributing to the development of an international effort to facilitate information exchange as part of the Global Alliance for Genomics & Health (GA4GH). CanDIG also supports large-scale provincial and national data sharing projects, including BC Cancer’s Personalized OncoGenomics program, the Terry Fox Research Institute (TFRI) PROFYLE project and the TFRI-led Marathon of Hope Cancer Centres Network—a major federal initiative to accelerate the adoption of precision medicine for cancer in Canada.

Based at the BC Cancer Research Institute in Vancouver, the successful incumbent will help to devise, develop and implement data sharing methods between our partner sites for cancer genome and transcriptome data. They will also research how these data can be used within Canada to improve precision medicine as it applies to the delivery of healthcare for cancer, ultimately generating a "big data" analytics platform from which further insights into the biology of cancer will be realized.  

Key Responsibilities

  • Conduct research and supervise projects 
  • Develop and use new and novel methods for the analysis of cancer genome sequence
  • Interact closely with principal investigators and clinicians about the biology and clinical history of research subjects
  • Evaluate sequence variants using software prediction tools, and apply guidelines for the interpretation of sequence variants in the context of precision medicine
  • Manage and track of next generation DNA and RNA sequence data
  • Develop innovative ways to annotate and discover relationships between cancer genes and clinical outcomes
  • Present findings at local, national and international scientific meetings
  • Write scientific manuscripts related to research findings
  • Develop research grant applications
  • Contribute to required quarterly and annual reports for research projects
  • Work with principal investigators to ensure that all scientific milestones are achieved
  • Develop computer code according to professional and industry standards
  • Perform other related duties as required

Qualifications

Education and Experience:

  • PhD in a life sciences or quantitative discipline
  • A minimum of 2 years demonstrated experience in bioinformatics, focused on genome sequence data processing and analysis

Skills and Abilities:

  • Expertise in bioinformatics, emphasizing genome sequence analysis and gene annotation
  • Knowledge of scientific tools, technologies and online resources as pertaining to cancer genomics
  • Python, Javascript and SQL programming experience
  • Previous API development projects using Open API or Rest API is a plus
  • Experience with high-performance computing
  • Experience in a supervisory role is an asset

To Apply

email cover letter and resume to: bcgscjobs@bcgsc.ca

Projects Manager

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC. But it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers and clinicians. We look for people who share our core values—science, timeliness and respect—to join us in our mission to provide genomics, bioinformatics and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity is essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely.  This restriction would be re-evaluated upon re-contracting*


Role Summary

The Genome Sciences Centre is seeking a Projects Manager. This role is for a Manager of research projects, grants and platforms in a research environment.

Reporting to the Head Project Management or Projects Team Leader and working closely with the Principal Investigators and Project Leaders, you will play a key role in managing research projects and grants within the context of a research culture with established policies and procedures, vision and values. The major focus of this position is to work with the Principal Investigators and Project leaders to establish the objectives, milestones, and budgets for various research projects and grants, and monitor and facilitate progress against these objectives and milestones. Projects will involve personalized oncogenomics, immunotherapy, collaborative services management, or other cancer genomics research.

Key Responsibilities

  • establishing budgets for research projects, grants, collaborations and core activities
  • assisting with preparing grants, progress reports, statement of work documents, compliance documents, sample status or analysis reports
  • monitoring budgets and expenditures
  • establishing, monitoring, and coordinating project progress, milestones, deadlines and objectives, which may include, meeting coordination and follow-up, coordination of case reviews
  • maintain accurate information on sample status, including sample and associated metadata acquisition, processing, stakeholder reporting
  • recommending strategies for improving projects management methods
  • liaising with grant/core funding agencies
  • interacting directly with research collaborators or clinical study teamsas required

Excellent written and verbal communication skills and proactive interactions with collaborators are a must to perform successfully in this position. Active participation in laboratory meetings and seminars relevant to the project activities is highly encouraged.

Qualifications

While equivalencies will be considered, ideally you bring a degree in Science (preferably Genetics, Biochemistry, Microbiology or Computer Science) plus 5 years' recent related experience in project management and/or research development management.

Certification as a Project Management professional will help you make the short list, as will experience in academic scientific research or the biotech or software industry. Proficiency with MS Word, Excel and Project is essential and you should have excellent organizational, analytical and verbal and written communication skills.

 Successful candidate(s) will be offered positions through Provincial Health Services Authority at level Research Project Coordinator, which is equivalent to that described above.

To Apply

email: bcgscjobs@bcgsc.ca

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