Canada's Michael Smith Genome Sciences Centre offers scientists the opportunity to pursue careers in the field of genomic research. With close ties to the local academic communities and to scientific collaborators around the world, we offer a diverse, rich environment in state of the art genomic research activities. With our offices and labs located in Vancouver, BC, this means living in a city that often ranks at the top of list in best places to live.

HEU and HSA union members

Internal applicants please visit internaljobs.phsa.ca to apply online for internal job postings.

Research Programmer (Web Development)

BC Cancer’s Michael Smith Genome Sciences Centre (GSC) in collaboration with other labs across Canada is developing clinical NGS test for lymphoma. The GSC is seeking a Research Programmer interested in working with a multi-disciplinary clinical and academic team specializing in molecular diagnostics. The incumbent will develop web-based applications and design databases to be used for data analysis and reporting results to clinicians. Applicants must be comfortable doing both backend and front end work, with some knowledge of Linux server maintenance.

Duties/Accountabilities: 

  • Frontend and backend development of secure, interactive web-based applications to allow for status tracking and report dissemination

  • Development of secure databases to be used for tracking sensitive information (i.e. patient information) and analysis results for reports used by clinical staff and physicians

  • Development of interactive tools to allow for interpretation of results from genetic and genomic assays

  • Set-up and maintenance of servers to host applications, databases, and tools described above

  • Quality-assurance and security testing for websites and databases

  • Other related duties as assigned


Qualifications:

    • Graduation from a recognized degree or diploma program in computer programming or an equivalent combination of education, training and experience. 


Core Skills and Abilities: 

  • Familiarity with HTTP, HTML 5, XML, JavaScrpt, PHP

  • Experience with Linux is essential; working knowledge of Windows and Macintosh is an asset.

  • Experience in the development, testing, and maintenance of relational databases

  • Knowledge of security protocols and procedures necessary to protect sensitive information

  • Working knowledge of software testing, documentation, and version control

  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment

  • Demonstrated ability to efficiently organize work assignments and establish priorities

  • Ability to communicate effectively both verbally and in writing

Additional Assets:

  • Three (3) years of recent related experience with a Unix/Javascript stack and systems/network administration

    • Familiarity with frontend JavaScript frameworks (preferable React.js)
  • Some graphic design, UI/UX experience

  • Some knowledge of Python

  • Experience with Agile software practices 

The successful applicant will work in a team environment which includes clinicians, research scientists, technicians, and bioinformaticians.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

To Apply

Please send your resume with cover letter to bcgscjobs@bcgsc.ca

We request that you specify the position you are applying for by identifying the Job Code only (e.g. "RPWD 11-20-2019") in the subject line of your emailed application.

Staff Scientist 2

Job Code: SS2 11-14-2019

The Holt Laboratory at BC Cancer is looking for a qualified candidate to aid in the preclinical and clinical development of novel cancer vaccines and cellular immunotherapies. The candidate will work with local, national and international partners, collaborators and service providers in academia, industry, government and not-for-profit organizations.

The successful candidate will have a PhD or equivalent degree and at least seven years of relevant experience.  Knowledge of and research experience with standard methods and approaches in microbiology, immunology, cell biology, molecular biology, genomics and proteomics; and familiarity with the fields of cancer immunology and immunotherapy are assets.  A strong background in preclinical and clinical research methodology is highly desirable.

The applicant should also demonstrate the ability to work independently, supervise trainees and technical staff, and conceive, initiate, prioritize, organize and manage multiple concurrent projects.  Excellent verbal and written communication skills are a necessity as well as the ability to work in a team environment.  Management experience with large, multi-center projects is an asset. 

This position will begin ASAP.  This is a one-year term appointment subject to annual renewal.  Salary will be commensurate with qualifications and experience.

Applications, accompanied by a detailed curriculum vitae and three letters of reference addressing scholarly, professional and creative work, plus supervisory and administrative service, should be directed to: 

Rob Holt, PhD
Scientific Co-Director, BC Cancer Immunotherapy Program

Distinguished Scientist, Canada's Michael Smith Genome Sciences Centre

Professor of Medical Genetics, University of British Columbia

Professor of Molecular Biology & Biochemistry, Simon Fraser University
Email: rholt@bcgsc.ca

This position will remain open until filled. 

This is a temporary position with a possibility of extension.

Research Assistant 2, Proteomics

Job Code: RA2 07-04-2019

The Research Assistant 2 – Proteomics works under supervision and performs experiments by following established laboratory procedures.

In this role you will: 

  • Prepare samples for proteomic analysis

  • Operating facility instrumentation including off-line HPLC fractionation systems, mass spectrometers, and speed vacs

  • Perform initial data analysis

  • Assist in the development of cutting edge protocols for clinical proteomics

  • Maintain logs of samples analyzed and instrument use

  • Liaise with collaborators to coordinate sample submission and communicating results

  • Collaborate with client lab personnel

  • Maintain a details lab notebook

You hold:

A laboratory technician degree in chemical and biotechnical science with direct work experience in proteomics.

You Have:

  • Theoretical knowledge and practical experience with tandem mass spectrometry

  • Experience with state-of-the-art mass spectrometry instrumentation including Orbitraps

  • Experience with clinical sample preparation for proteomics and nucleic acid analysis

  • Experience with processing cells and tissues for global and targeted proteomics

  • Practical experience with analytical reversed phase chromatography (HPLC and nanoLC), specifically for peptide separation

  • Two (2) years recent related experience in a research laboratory

If this sounds like you, apply now!

About Us

BC Cancer is part of the Provincial Health Services Authority (PHSA). PHSA provides specialized health services to British Columbians, including cancer care, organ transplantation, pediatrics, emergency services, mental health and substance use services. Our values reflect our commitment to excellence and include: Respect people – Be compassionate – Dare to innovate – Cultivate partnerships – Serve with purpose. Learn more about PHSA and our programs: https://jobs.phsa.ca/family-brands

Canada's Michael Smith Genome Science Centre is a leading international centre for genomics and bioinformatics research.   Our mandate is to advance knowledge about cancer and other diseases, to improve human health through disease prevention, diagnosis and therapeutic approaches, and to realize the social and economic benefits of genomic research.  We are a high through-put sequencing facility in Vancouver, Canada having sequenced over 2,402,168,248,871,630 raw bases to date. We have numerous research collaborations both locally and internationally with a primary focus on human cancers.

PHSA hires on the basis of merit and is committed to employment equity. We encourage all qualified persons to apply. We recognize that our ability to provide the best care for our diverse patient populations relies on a rich diversity of skills, knowledge, backgrounds and experiences. We strive to create a safe and welcoming environment where everyone can come to work and be their best, authentic self.

In accordance with Canadian Immigration requirements, this advertisement is first directed to Canadian citizens and permanent residents but international candidates are invited to apply. We encourage applications from all qualified individuals, including Aboriginal peoples, persons with disabilities and members of visible minorities. English is the official language used at PHSA.

PHSA offers a very generous benefit package which includes 4 weeks’ vacation entitlement, extended medical, dental and coverage, life & disability insurance plus professional development opportunities with over 1000 online courses available on our Learning Hub. 

To Apply

Please send your resume with cover letter to bcgscjobs@bcgsc.ca. We request that you specify the position you are applying for by identifying the Job Code only (e.g. "RA2 07-04-2019") in the subject line of your emailed application. Or apply by visiting the following link: https://jobs.phsa.ca/job/vancouver/research-assistant-2-proteomics/909/….

For more information on this opportunity please contact Amirah Matiets, Talent Acquisition Representative at (604) 875-7258 or email Amirah.matiets@phsa.ca

Posting #: PHSA-RA2

  • Status: Regular (permanent) Full-Time (37.5 hour per week)
  • Salary: $46,213 to $60,655 per year
  • Hours: Monday to Friday 0830-1630
  • Location: Genome Sciences Centre - 675 West 10th Avenue, Vancouver BC V5Z 1L3

Assistant Bioinformatics Coordinator, Software Development

Job Code: ABCSD HSA Req 86652

The Assistant Bioinformatics Coordinator provides supervisory and technical support to the Bioinformatics group of the Genome Sequence Centre (GSC). Ensures that the day-to-day activities of a large scale, high throughput facility meet research, data analysis throughput and software development objectives.

Duties:

1.  Assists the Bioinformatics Coordinator in the day to day activities of the Bioinformatics group by performing duties such as providing input on quantity and quality of work, making recommendations for improvements, workflow and procedures. 

2.  Coordinates projects of the Bioinformatics group by performing duties such as chairing project-specific meetings and provides project status reports to the Bioinformatics Coordinator, with suggestions towards any required improvement of project management, task allocation and overall process.

3.  Develops and implements assays to monitor project progress and measure project accomplishments to ensure that appropriate project focus is maintained and to provide feedback to staff. 

4.  Provides supervisory support to the Bioinformatics group by performing duties such as:

          a.  Orientating new staff.

          b.   Providing input to the Bioinformatics Coordinator on training requirements and performing group specific training.

          c.   Providing input to the Bioinformatics Coordinator on the establishment of clear definitions of responsibility for employees. 

         d.   Assigning workload assignments and establishing work schedules.

         e.   Reviewing and establishing work priorities and adjusting work schedules to ensure priorities are met.

         f.    Completing performance reviews and addressing performance issues in conjunction with the Bioinformatics Coordinator.

5. Participates in the recruitment of staff through methods such as interviewing internal and external applicants and forwards hiring recommendations.

6.  Participates in the development and implementation of quality improvement programs to ensure services are provided in the most efficient and effective way by performing duties such as:

          a.   Monitoring quality and quantity of service and information provided by the bioinformatics group and identifying areas for change and/or improvement.

          b.   Generating test metrics to evaluate progress of research programs.

          c. Writing and updating Standard operating procedures pertaining to tasks and pipelines run by the group.

          d. Coordinating and writing technical validation documents for new and improved pipelines and processes.

7.  Assesses practical needs for identified research direction of the GSC in conjunction with the Bioinformatics Coordinator and Bioinformatics Group Leader.

8.  Participates in a variety of meetings by performing duties such as providing and/or receiving information and contributing to decision making.

9.  Participates, in conjunction with the Bioinformatics Coordinator, in determining the computer infrastructure necessary for successful completion of projects and ensured viability of research programs by performing duties such as providing input and recommendations regarding purchasing decisions related to hardware, software and related items for the Bioinformatics platform.

10. Interprets statistical analyses and makes recommendations for review including preparing reports on statistical findings for publication and presentation in HTML format or as advised.

11. Conducts feasibility studies for computerization by performing duties such as determining user requirements, examining and identifying problems with existing systems and recommending modifications to and/or new systems; provides details of estimated implementation costs including associated staffing requirements.

12. Performs technical functions related to the bioinformatic  department of the GSC.

13. Performs other related duties as required.

Qualifications

 Education, Training and Experience

  • Graduation from a recognized Bachelor’s program in a related discipline such as Biochemistry, Genetics, Computer Science, Electrical Engineering or Physics.  A minimum of four (4) years of recent related experience including experience in computer programming and quantitative data analysis, handling biological sequence and/or mapping data, database development and data storage schemas or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders. 

Skills and Abilities

  • Experience with computer operating systems such as Linux, MacOS.

  • Demonstrated ability to work with software languages, frameworks and databases such as Python, C, C++, Javascript, React.js, Perl , R, Postgres, MySQL, Hadoop.

  • Demonstrated ability to accept responsibility and work independently.

  • Demonstrated ability to work effectively with others in a team environment.

  • Demonstrated ability to supervise staff and schedule work.

  • Excellent organizational, leadership interpersonal and communication skills.

  • Physical ability to perform the duties of the job.

To Apply

External Applicants

Please send your resume with cover letter to bcgscjobs@bcgsc.ca.

Internal Applicants

Internal (HEU and HSA union members) applicants please visit internaljobs.phsa.ca to apply online for internal job postings.

Manager, Employee Relations, GSC

Job Code: MER 08-23-2019

Manager, Employee Relations (ER) is a key member of the Management and Administration Group (MAG) core for the BC Cancer Genome Sciences Centre (GSC), providing leadership and guidance in the establishment and operation of employee resources, services, and systems for the GSC. Leads in the provision of employee services, working collaboratively with BC Cancer/PHSA Human Resources to support organizational initiatives and projects, aligning those with the policies, standards, and objectives of PHSA and the GSC.

The Manager, ER leads and oversees the ER management of various projects, teams and programs, supporting all staff and personnel, and works in consultation with the Director, BC Cancer Research Office of Research Administration, PHSA HR, and appropriate partner institutions, such as UBC and SFU. In addition, this role is responsible for establishing, monitoring and reporting on ER initiatives with the GSC, such as performance management, hiring and termination processes, onboarding processes, organizational structure, timekeeping, team dynamics and leader/manager professional development. 

The Manager ER builds the strength of the administrative core; develops ER processes and standards for the Centre; develops, promotes and maintains effective relationships; and ensures consistency and standardization of policy, practices and service delivery within the GSC in conjunction with PHSA.

Collaborates with other Managers and Directors within the administrative core to ensure an integrated and seamless service delivery model. Must demonstrate exceptional ability to support the expertise and commitment of the Centre to the highest professional standards.

JOB RESPONSIBILITIES: 

  • Manages the day-to-day operations of the ER functions for the Centre, assesses and monitors staffing requirements and recommendations. 

  • Supervises GSC ER Coordinator(s) and other staff as appropriate

  • Coordinates priorities with the Director and assists team members to define shared and individual goals, meet target dates and ensure alignment of team goals with GSC needs. 

  • Responds to changing GSC and program needs by methods such as conducting continuous assessments of the activities, facilitating feedback within and across programs and responding to changing demands. Participates as a member of the administrative core, providing key leadership, expert advice and counsel throughout the GSC on a wide variety of human resource matters. 

  • Recruits, hires, and supervises staff orientations by working with GSC leaders and teams to identify vacancies, interview applicants, and contribute to hiring decisions in collaboration with the appropriate manager and/or Director; investigate work and staff issues; and clarify roles, in collaboration with appropriate internal stakeholders, peers, and the HR teams at collaborating institutions (ex. UBC) as appropriate

  • Provides leadership to staff through collaborative coaching, guiding and modelling key behaviours and strategies, encouraging dialogue and providing guidance and advice to facilitate resolutions to work issues. 

  • Coordinates and monitors requests for vacation, leaves of absences and sick time, and establishes processes for these with the leadership team. 

  • Fosters team spirit, trust and mutual respect.

  • Manages employee recognition programs as appropriate.

  • Provides guidance, technical advice and supports effective human resource practices and processes in a variety of areas. Ensures consistency and standardization of policy, practice and contract interpretation, adherence to industry best practices, and compliance with collective agreements, arbitration decisions and legislation changes to minimize and mitigate organizational risk. 

    JOB QUALIFICATIONS: 

  • A level of education, training and experience equivalent to a Bachelor’s Degree in Human Resources or a related discipline supplemented by seven (7) to ten (10) years of progressively more senior experience in an academic health sciences environment

  • Solid understanding of research and grant based programs and administration

  • Aptitude for detailed work

  • Preference will be given to candidates with or pursuing a Chartered Professionals in Human Resources designation.

  • Solid understanding of human resource practices, related legislation and applicable collective agreements. Demonstrated ability to supervise and lead staff. 

  • Ability to establish courses of action for self and others that are results oriented. 

  • Excellent communication skills including the ability to facilitate, negotiate, and persuade others. 

  • Ability to respond to the needs of stakeholders supported by an acute awareness of the impact of actions. 

  • Ability to create and execute strategic human resource plans. 

  • Excellent organizational skills including the ability to prioritize workload to meet deadlines. 

  • Ability to deal effectively with all levels of staff. 

  • Ability to use related equipment including institutional information systems, word processing, spreadsheet, database and internet tools. 

  • Sensitivity to working with marginalized populations, such as people with substance use disorders.

  • Physical ability to perform the duties of the position.

To Apply

Please send your resume with cover letter to bcgscjobs@bcgsc.ca

We request that you specify the position you are applying for by identifying the Job Code only (e.g. "MER 08-23-2019") in the subject line of your emailed application.

Post-doctoral Fellow in the proteomic discovery of immunotherapy

Job Code: PdFP 09-26-2019

The Genome Sciences Centre within the BC Cancer Research Centre, in Vancouver, British Columbia, Canada has an opening for a post-doctoral fellow in the laboratory of Dr. Gregg Morin to work on a project involving the discovery and development of pediatric cancer surfaceome immunotherapeutic targets.

The scientist will join an ongoing collaboration with Drs. John Maris (CHOP) and Poul Sorensen (Molecular Oncology, BC Cancer) to study surface protein expression in high-risk pediatric cancers by analyzing patient derived xenograft (PDX) samples. The fellow will perform laboratory research to design and interpret experiments using proteomic, molecular, biochemical, and genomic tools to thoroughly and robustly quantify changes in surface protein expression. Specifically, the candidate will develop and perform global proteomic techniques in conjunction with a variety of surface enrichment techniques to identify and evaluate specific molecular vulnerabilities in childhood cancers that would be useful for immunotherapeutic targeting. The desirable candidate should have experience in protein biochemistry, proteomic sample preparation, liquid chromatography, and/or mass spectrometry. Experience with mammalian tissue culture, enzymatic assays, recombinant protein purification, molecular biology, and mass-spectrometry based proteomics will be beneficial to the candidate.

The successful scientist will join the laboratory of Dr. Gregg Morin in Canada’s Michael Smith Genome Sciences Centre at BC Cancer. In collaboration with the laboratories of Dr. John Maris and Dr. Poul Sorensen, and the Genome Sciences Centre, the team has access to exceptional tools for next generation sequencing, bioinformatics, and advanced proteomics.

The Genome Sciences Centre provides a stimulating working environment and is located at the British Columbia Cancer Research Centre in Vancouver, one of the world’s most livable and attractive cities. 

Additional information can be obtained at Careers, www.bcgsc.ca

To Apply

Applicants should send a cover letter, curriculum vitae, and names of three referees by email to bcgscjobs@bcgsc.ca, and reference “Post-doctoral Fellow, Immunotherapy – G Morin Lab” and your family name in the subject line.

Research Associate, Precision Genomics for Cancer

Job Code: RAPGFC 09-27-2019

The Genome Sciences Centre is seeking a temporary full time Research Associate to work on cancer genomics projects to develop clinical assays for (1) Lymphoid cancers and (2) cancer monitoring and detection using blood samples (aka liquid biopsy). The successful applicant will work in a team to develop high-throughput, clinically accredited pipelines to aid in identifying pathogenic alterations in cancer. This project involves the development of new assays for cancer patients with the goal of individualized patient management.

Duties/Accountabilities: 

  • Design, documentation, and analysis of experiments to test new assays and new methods
  • Summary and presentation of experimental findings to stakeholders
  • Modification and development of bioinformatic pipelines to analyze genomic data yielding clinical grade variant and expression data
  • Assist in choosing and modifying gene targets and samples for assay development
  • Analysis of NGS data to investigate clonality, somatic hypermutation, microsattelite instability and intergenic translocations
  • Development and assessment of bioinformatic tools for RNA-Seq expression analysis and variant calling
  • Development and assessment of bioinformatic tools for determining the clinical significance of detected variants
  • Statistical analysis to determine analytical sensitivity and specificity of obtained results
  • Development of software pipelines for analyzing next-generation sequencing data
  • Support of research staff by providing analysis and software tools
  • Contributions to the writing of research publications

Qualifications:

  • PhD in Bioinformatics, Microbiology, Biochemistry or a related field
  • Two (2) years of recent related experience or an equivalent combination of education, training and relevant experience
  • A Master’s degree in a relevant field would be considered 

Skills and Abilities: 

  • Knowledge of RNA-Seq and other genomic data analysis, including expression analysis, structural variant detection, and variant-calling.
  • Experience working in a Unix environment, including experience with shell scripting and common command-line tools
  • Expertise in one or more scripting language(s) (e.g. Python)
  • Experience working with next-generation sequencing data and tools (i.e. tools for alignment and variant-calling)
  • Expertise in statistical analysis using modern computational tools.  Experience with any relevant tools will be considered, but R and Python are preferred
  • Experience writing reports of results in accurate and concise language; expertise in scientific/technical writing is required
  • Experience with methods in high-dimensional data analysis for bioinformatics such as clustering, machine learning and data mining would be assets
  • Experience with software testing and cluster computing would be assets
  • Familiarity with cancer genetics would be an asset, as would a history of publications in relevant fields.

The successful candidate will also have:

  • Excellent verbal and written communication skills
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
  • Demonstrated ability to efficiently organize work assignments and establish priorities. 

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

To Apply

Please send your resume with cover letter to bcgscjobs@bcgsc.ca

We request that you specify the position you are applying for by identifying the Job Code only (e.g. "RAPGFC 09-27-2019") in the subject line of your emailed application.

Research Associate

Job Code: RA 10-07-2019

The Research Associate provides laboratory support for our antimicrobial peptide discovery research arm at the Genome Sciences Centre. The successful applicant will work in the laboratory to test the therapeutic candidacy of novel compounds while also working independently in a cross-disciplinary environment and participating as a project team member on specific genome research projects, including to help develop laboratory protocols.

Key Accountabilities 

  • Collaborate with the Principal Investigator, other Lab Personnel and Staff members to develop and test laboratory protocols and assays in conjunction with our antimicrobial peptide research

  • Set up the laboratory and instruments

  • Conduct literature reviews and provide input and recommendations to managers

  • Prepare documentation in accordance with prescribed standards (eg. Protocols, SOPs, research proposals)

  • Participate in lab meetings and present work for review by others

  • Contribute to the preparation and/or presentation of research manuscripts

  • May provide day-to-day work direction to others

Qualifications

  • Ph.D. in Microbiology, Molecular Biology, Biochemistry or a related field
  • Molecular biology and microbiology laboratory skills are essential for this position

  • Experience in microbial and eukaryotic cell culture techniques, cell imaging, peptide biochemistry, nucleic acid extraction, and preparation of DNA/RNA sequencing libraries

  • Demonstrated effective communication skills

  • Experience in bioinformatics (eg. knowledge of Python, R, PERL, unix, version control), and prior experience with analyzing next-generation sequencing data (DNA, RNA) will be considered assets 

The successful applicant will be part of a team of research scientists working in a dynamic environment with the overarching goal of developing bioinformatics pipelines and laboratory protocols to mine ‘omics data and test hypotheses in the laboratory. You will be contributing to advancing science and genome research locally and worldwide.

To Apply

Please send your resume with cover letter to bcgscjobs@bcgsc.ca

We request that you specify the position you are applying for by identifying the Job Code only (e.g. "RA 10-07-2019") in the subject line of your emailed application.

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