Canada's Michael Smith Genome Sciences Centre offers scientists, researchers and others the opportunity to pursue careers at the forefront of genome science and precision medicine. With close ties to local and national clinical and academic communities—and to scientific collaborators around the world—we offer a rich and diverse research environment. With offices and laboratories located in Vancouver, British Columbia, we work in a city that consistently ranks as one of the best places in the world to live. Come work with us!

HEU and HSA union members
Internal applicants please visit internaljobs.phsa.ca to apply online for internal job postings.

Computational Biologist, Database Developer HSA Req# 095325

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC. But it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers and clinicians. We look for people who share our core values—science, timeliness and respect—to join us in our mission to provide genomics, bioinformatics and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity is essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.


Job Title

Computational Biologist, Database Developer
HSA Req# 095325

Role Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority, patient safety is a priority and a responsibility shared by everyone at PHSA. As such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

The Computational Biologist will participate in the analysis of sequencing data by developing, refining and adapting bioinformatics tools for a high-throughput processing pipeline. They will also participate in the development and maintenance of our production databases, which provide tracking of all of the laboratory and bioinformatics analysis pipelines at the GSC. Packaging and distribution of developed tools and analysis results to the scientific community and contribution to preparation of scientific publications are expected. 

Key Responsibilities

  • Develops and maintains the core sequence analysis pipelines at the GSC, including but not limited to:
    • QC of sequencing data
    • Alignment of sequenced reads
    • Formatting and manipulation of alignment files for use by downstream pipelines (e.g., merging, reheadering)
    • Dissemination of data to collaborators
    • New analyses pipelines as required
  • Develops and maintains GSC laboratory, quality and analysis databases, including:
    • Routine database integrity checks and database maintenance
    • Development of views and interfaces for data entry
    • Development of reports for internal users and collaborators
    • Investigation of new frameworks and designing new schemas and tables
  • Communicates with stakeholders in the lab, on analysis teams, and with external collaborators to understand and document requirements for development and to respond to questions about collaborator data and data quality
  • Works with upstream and lab teams generating data to be housed in the database, with downstream users of the databases to meet requirements and responds to internal requests for query and API support
  • Maintains and develops ETL pipelines between GSC production databases
  • Manages the storage and compression of over 5 Pb of internally generated sequencing data as well as the download and storage of external data
  • Works closely with the GSC Systems team and Quality Assurance team to establish and carry out best practices for data security and ensure compliance with IS27001 certification and other data use agreements
  • Tests and validates new data analysis software for analyses such as alignment, duplicate marking and merging
  • Participates in code walk-throughs and reviews of solutions
  • Designs and builds database solutions taking performance into consideration
  • Coordinates production problem resolution for assigned applications, including working with other technical teams
  • Evaluates third-party software and incorporate new systems into legacy systems
  • Produces thorough but concise written documentation of database tables, applications, validations, SOPs, and other processes and procedures as required
  • Performs other related duties as required

Qualifications

Education, training and experience:

  • Graduation from a recognized Bachelor of Science Program in Computer Science or equivalent with significant computer science components 
  • Two (2) years of recent related experience or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders

Skills and abilities:

  • Demonstrated expertise in database programming and database design
  • Demonstrated ability in Python
  • Experience designing and/or maintaining a relational database including knowledge of SQL or PostgreSQL, and with ORMs
  • Experience with REST API development
  • Experience with front-end web development (AngularJS, React)
  • Functional knowledge of distributed version control systems, such as GIT
  • Experience developing software as part of a team, familiarity with Agile development and ticketing systems
  • Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools
  • Excellent verbal and written communication skills
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment
  • Demonstrated ability to efficiently organize work assignments and establish priorities
  • Previous experience in a bioinformatic setting, though not required, would be considered an asset

To Apply

HSA union position
Internal applicants please visit internaljobs.phsa.ca to apply online for internal job postings.
External applicants please email a cover letter and resume to bcgscjobs@bcgsc.ca.

Research Associate - Bioinformatics

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC. But it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers and clinicians. We look for people who share our core values—science, timeliness and respect—to join us in our mission to provide genomics, bioinformatics and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity is essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.


Role Summary

The GSC is currently looking for a senior bioinformatician to develop approaches to analyzing and sharing “big data”. This role is instrumental in the development of the CFI-funded cyberinfrastructure project, CanDIG—a state-of-the-art data sharing platform contributing to the development of an international effort to facilitate information exchange as part of the Global Alliance for Genomics & Health (GA4GH). CanDIG also supports large-scale provincial and national data sharing projects, including BC Cancer’s Personalized OncoGenomics program, the Terry Fox Research Institute (TFRI) PROFYLE project and the TFRI-led Marathon of Hope Cancer Centres Network—a major federal initiative to accelerate the adoption of precision medicine for cancer in Canada.

Based at the BC Cancer Research Institute in Vancouver, the successful incumbent will help to devise, develop and implement data sharing methods between our partner sites for cancer genome and transcriptome data. They will also research how these data can be used within Canada to improve precision medicine as it applies to the delivery of healthcare for cancer, ultimately generating a "big data" analytics platform from which further insights into the biology of cancer will be realized.  

Key Responsibilities

  • Conduct research and supervise projects 
  • Develop and use new and novel methods for the analysis of cancer genome sequence
  • Interact closely with principal investigators and clinicians about the biology and clinical history of research subjects
  • Evaluate sequence variants using software prediction tools, and apply guidelines for the interpretation of sequence variants in the context of precision medicine
  • Manage and track of next generation DNA and RNA sequence data
  • Develop innovative ways to annotate and discover relationships between cancer genes and clinical outcomes
  • Present findings at local, national and international scientific meetings
  • Write scientific manuscripts related to research findings
  • Develop research grant applications
  • Contribute to required quarterly and annual reports for research projects
  • Work with principal investigators to ensure that all scientific milestones are achieved
  • Develop computer code according to professional and industry standards
  • Perform other related duties as required

Qualifications

Education and Experience:

  • PhD in a life sciences or quantitative discipline
  • A minimum of 2 years demonstrated experience in bioinformatics, focused on genome sequence data processing and analysis

Skills and Abilities:

  • Expertise in bioinformatics, emphasizing genome sequence analysis and gene annotation
  • Knowledge of scientific tools, technologies and online resources as pertaining to cancer genomics
  • Python, Javascript and SQL programming experience
  • Previous API development projects using Open API or Rest API is a plus
  • Experience with high-performance computing
  • Experience in a supervisory role is an asset

To Apply

email cover letter and resume to: bcgscjobs@bcgsc.ca

Projects Manager

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC. But it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers and clinicians. We look for people who share our core values—science, timeliness and respect—to join us in our mission to provide genomics, bioinformatics and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity is essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.


Role Summary

The Genome Sciences Centre is seeking a Projects Manager. This role is for a Manager of research projects, grants and platforms in a research environment.

Reporting to the Head Project Management or Projects Team Leader and working closely with the Principal Investigators and Project Leaders, you will play a key role in managing research projects and grants within the context of a research culture with established policies and procedures, vision and values. The major focus of this position is to work with the Principal Investigators and Project leaders to establish the objectives, milestones, and budgets for various research projects and grants, and monitor and facilitate progress against these objectives and milestones. Projects will involve personalized oncogenomics, immunotherapy, collaborative services management, or other cancer genomics research.

Key Responsibilities

  • establishing budgets for research projects, grants, collaborations and core activities
  • assisting with preparing grants, progress reports, statement of work documents, compliance documents, sample status or analysis reports
  • monitoring budgets and expenditures
  • establishing, monitoring, and coordinating project progress, milestones, deadlines and objectives, which may include, meeting coordination and follow-up, coordination of case reviews
  • maintain accurate information on sample status, including sample and associated metadata acquisition, processing, stakeholder reporting
  • recommending strategies for improving projects management methods
  • liaising with grant/core funding agencies
  • interacting directly with research collaborators or clinical study teamsas required

Excellent written and verbal communication skills and proactive interactions with collaborators are a must to perform successfully in this position. Active participation in laboratory meetings and seminars relevant to the project activities is highly encouraged.

Qualifications

While equivalencies will be considered, ideally you bring a degree in Science (preferably Genetics, Biochemistry, Microbiology or Computer Science) plus 5 years' recent related experience in project management and/or research development management.

Certification as a Project Management professional will help you make the short list, as will experience in academic scientific research or the biotech or software industry. Proficiency with MS Word, Excel and Project is essential and you should have excellent organizational, analytical and verbal and written communication skills.

 Successful candidate(s) will be offered positions through Provincial Health Services Authority at level Research Project Coordinator, which is equivalent to that described above.

To Apply

email: bcgscjobs@bcgsc.ca

Postdoctoral Fellow – Integrative Genomic Analysis of Lymphoid Cancers

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC. But it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers and clinicians. We look for people who share our core values—science, timeliness and respect—to join us in our mission to provide genomics, bioinformatics and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity is essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.


Postdoctoral Fellow
Job code: LYMPHOMA-PDF
Lab/group: Ryan Morin Lab  

Role Summary
The Morin and Scott laboratories are seeking a Postdoctoral Fellow to take a leadership role in an ongoing effort to resolve the molecular aetiology of aggressive lymphoid cancers using genomic techniques. This individual will work closely with a team of bioinformaticians, biostatisticians and clinician-scientists in a highly productive and stimulating research environment at a world-class research facility in Vancouver, Canada.

The successful applicant will apply cutting-edge bioinformatic techniques to analyze hundreds of terabytes of high-throughput sequencing data produced from clinical cancer samples, namely RNA-seq (bulk/single cell), whole exome, whole genome, and circulating tumour DNA sequencing data. This position demands a strong background in bioinformatics, computational biology or data science. Detailed knowledge of cancer biology (particularly non-Hodgkin lymphomas) would be an asset.

Familiarity with algorithms for inferring clonal structure of tumours and network/pathway deregulation from sequence data is also desirable. Experience with machine learning, statistical modelling, survival analysis, and data visualization are all desirable. Characteristics of the ideal candidate include strong verbal and written communication skills, attention to detail, creativity, and the ability to remain organized in a fast-paced and dynamic environment. The successful candidate will thrive in our highly collaborative setting while also being able to drive projects independently.

Diversity is an integral part of Canadian history, culture, and identity. In the Morin laboratory, we strive to maintain an equitable and inclusive culture where all forms of diversity are seen as added value in the unifying goal of reducing the impact of cancer.

The successful candidate will report to Drs. ​Ryan Morin​ and David Scott and will be affiliated with Canada’s Michael Smith Genome Sciences Centre at BC Cancer.

Key Responsibilities :
Duties will include some combination of the following:

  • Deploy pipelines to detect somatic alterations such as CNAs, SNVs, indels and structural alterations/fusion transcripts
  • Perform clustering analyses on mutational and/or gene expression features to identify novel subgroupings
  • Develop machine learning models for the accurate identification of somatic mutations in heterogeneous and/or noisy tumour samples (e.g. FFPE, unpaired, ctDNA)
  • Identify cis-regulatory mutations using copy number, SV, and non-coding mutations
  • Quantify mutational signatures de novo or using reference signatures for simple somatic mutations and SVs
  • Model the effect of coding and non-coding mutations, respectively, on protein and RNA structure and function
  • Resolve clonal substructure and track tumour evolution using tissue biopsies and ctDNA
  • Identify gene expression or splicing features associated with clinical or genetic variables
  • Create bespoke visualizations of high-dimensional genomic datasets
  • Design and execute experiments and disseminate results through conference presentations and publications
  • Contribute to the writing of grant applications and training of junior lab members

Qualifications
Suitable candidates should possess a PhD degree in bioinformatics, computer science, or molecular biology and must be competent in at least one programming language such as Python or R.

To apply
Applicants are requested to send a cover letter and CV to rdmorin@sfu.ca with LYMPHOMA-PDF in the subject line

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