Advancing Genomics Technologies for Health and Life Sciences

The Michael Smith Genome Sciences Centre (GSC), a provincial program within the Provincial Health Services Authority (PHSA), is a recognized international leader in genomics, bioinformatics, and genome technology innovation. By developing and deploying cutting-edge sequencing and computational platforms, the GSC supports breakthrough research across cancer, rare and infectious diseases, and the broader life sciences. Our work enables earlier diagnosis, novel therapeutic approaches, and transformative applications of genomics to improve human health and environmental resilience—delivering both social and economic impact through science.

Job Reference No. RA_P00400_HSA194508_BiospecCore_2026_01_30

Job Summary

In accordance with the Purpose, Vision, Values and Coast Salish Teachings, and strategic direction of PHSA, safety, including both patient and employee safety, is a priority and a responsibility shared by everyone at PHSA. As such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

Under the direction of the Group Leader of Biospecimen Core or designate, provides input into the development of experimental techniques and process improvements, and under limited supervision performs experiments following established laboratory procedures. Ensures the research objectives in the Biospecimen Core Group are met by coordinating day-to-day laboratory activities.

Duties

Ensures that the day to day activities in the Biospecimen Core Group meet research and operational objectives by performing typical duties such as the following:

1. Provides input into the development of new procedures and experimental techniques at the request of the Group Leader, Biospecimen Core.
2. Designs, tests and implements new processes under direction of the Group Leader and within the GSC Quality Management System.
3. Optimizes methods and reagents for existing experimental and operational procedures to improve efficiency and scalability.
4. Creates and revises Standard Operating Procedure documents for new procedures and corresponding LIMS protocols.
5. Performs established laboratory procedures according to written protocols, such as: receipt of samples
   (including clinical samples); DNA and RNA preparation and QC; blood processing; tissue procurements.
6. Processes patient samples according to established procedures for clinical sequencing diagnostic tests.
7. Provides training and demonstrates new work methods and procedures to GSC technologists and research assistants/associates at affiliated sites and provides sign-off on tissue procurement and processing procedures.
8. Searches scientific literature for relevant reagents, techniques and applications.
9. Provides significant contributions to the preparation and/or presentation of research papers.
10. Performs general laboratory coordination duties such as maintenance of equipment, tracking supplies inventory and placing order for reagents.
11. Liaises with vendors and collaborators on behalf of the department for lab-related procurement tasks, as directed by the Biospecimen Core Group Leader.
12. Performs other related duties as assigned.

Qualifications

Education, Training and Experience

• Graduation with a Bachelor of Science degree in Molecular Biology, Genetics, or Biochemistry.

• Five (5) years of recent, related experience in a research laboratory.

OR

• An equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and Abilities

• Experience with standard molecular biology techniques including DNA and RNA preparation and QC.
• Experience with large-scale and high-throughput genomics technologies.
• Experience with DNA fingerprinting protocols and physical mapping methodologies.
• Demonstrated ability to accept responsibility and work independently.
• Demonstrated ability to exercise initiative and independent judgment in the performance of duties.
• Demonstrated knowledge of related equipment and computer software.
• Previous experience collaborating in the preparation and/or presentation of research.
• Excellent ability to organize work and communicate effectively.
• Demonstrated skills in CPR techniques.

Benefits:

Every PHSA employee enables the best possible patient care for our patients and their families. Whether you are providing direct care, conducting research, or making it possible for others to do their work, you impact the lives of British Columbians today and in the future. That’s why we’re focused on your care too – offering health, wellness, development programs to support you – at work and at home.

• Join one of BC’s largest employers with province-wide programs, services and operations – offering vast opportunities for growth, development, and recognition programs that honour the commitment and contribution of all employees.
• Access to professional development opportunities through our in-house training programs, including +2,000 courses, such as our San’yas Indigenous Cultural Safety Training course, or Core Linx for Leadership roles.
• Enjoy a comprehensive benefits package, which includes statutory benefits - Canada Pension Plan, Employment Insurance and WorkSafe BC plus the PHSA group benefits plan which includes medical & dental extended health, and group life insurance coverage, and psychological health & safety programs and holistic wellness resources.
• Annual statutory holidays (13) with generous vacation entitlement and accruement.
• PHSA is a remote work friendly employer, welcoming flexible work options to support our people (eligibility may vary, depending on position).
• Access to WorkPerks, a premium discount program offering a wide range of local and national discounts on electronics, entertainment, dining, travel, wellness, apparel, and more.

Job Type: 

Regular Full-Time, 7.5 hrs. per day

Onsite

Salary Range: 

Grid 10 - $36.69/hour for the 1st year - $45.81/ hour for the 6th year

The starting salary for this position would be determined with consideration of the successful candidate’s relevant education and experience, and would be in alignment with the provincial compensation reference plan and grant fund availability.

Higher salary offers above the midpoint range require additional review and approval.

Apply:

As this is a union position, you will also have to apply either as an internal or external applicant through http://www.phsa.ca/careers using the posting reference 194508.

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No. RA_P00400_HSA194508_BiospecCore_2026_01_30 in the subject line of your email.

While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Important!

COVID-19 vaccines protect against infection from severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) that causes COVID-19. 

The COVID-19 vaccine has been added to the list of high-priority immunizations recommended for health-care workers. Health care workers should ensure they are up-to-date on all routine immunizations. 

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

 

Advancing Genomics Technologies for Health and Life Sciences

The Michael Smith Genome Sciences Centre (GSC), a provincial program within the Provincial Health Services Authority (PHSA), is a recognized international leader in genomics, bioinformatics, and genome technology innovation. By developing and deploying cutting-edge sequencing and computational platforms, the GSC supports breakthrough research across cancer, rare and infectious diseases, and the broader life sciences. Our work enables earlier diagnosis, novel therapeutic approaches, and transformative applications of genomics to improve human health and environmental resilience—delivering both social and economic impact through science.

Job Reference No. CB_P01060_HSA194507_CCG_2026_01_30

Job Summary

In accordance with the Purpose, Vision, Values and Coast Salish Teachings, and strategic direction of PHSA, safety, including both patient and employee safety, is a priority and a responsibility shared by everyone at PHSA. As such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

The Computational Biologist performs bioinformatics analyses and contributes to software development related to the operation of a large-scale clinical sequencing facility.

Duties

1. Contributes to the design, development, implementation, validation, running, and maintenance of clinical bioinformatics pipelines and related databases.
2. Contributes to incorporation of third-party software into clinical bioinformatics pipelines, including:
   1. identifying candidate software to consider
   2. comparing software candidates to aid in selection.
   3. determining optimal parameters for the chosen software
   4. developing interfaces to integrate the chosen software and
   5. validating integration of the chosen software
3. Participates in the development of novel software solutions, as directed by the Assistant Bioinformatics Coordinator or Clinical Bioinformatics Coordinator.
4. Participates in peer code review.
5. Contributes to writing and updating official procedures and other documentation related to clinical bioinformatics pipelines.
6. Verifies results produced by clinical bioinformatics pipelines.
7. Performs exploratory analyses to identify potential root causes of issues encountered during production processing, and implements corrective actions as directed by the Assistant Bioinformatics Coordinator or Clinical Bioinformatics Coordinator.
8. Performs bioinformatics analyses to answer questions from the Clinical Director, Clinical Bioinformatics Coordinator, or Assistant Bioinformatics Coordinator.
9. Presents implementation plans, analysis results, and validation results internally and externally, in oral presentations and written documentation.
10. Contributes to the development of research papers by providing materials, methods, and/or analyzed data.
11. Participates in the training of others through orientation, informal instruction, and sharing of job information.
12. Performs other related duties as required.

Qualifications

Education, Training and Experience

• Graduation from a recognized Bachelor of Applied Science or Bachelor of Science Program in either Biological Sciences or Computer Science.
• Two (2) year’s of recent related experience or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and Abilities

• Demonstrated skill with Python or other similar high level languages
• Functional knowledge of distributed version control systems, such as Git.
• Demonstrated ability in R or other similar statistical programming languages.
• Familiarity with relational databases, such as PostgreSQL, and with ORMs
• Ability to program and run analyses in a production environment.t
• Excellent verbal and written communication skills
• Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools.
• Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
• Demonstrated ability to efficiently organize work assignments to complete required tasks on time.
• Familiarity with next-generation sequencing, cancer genetics, principles of clinical testing, experimental design, statistical hypothesis testing, and/or machine learning would be considered an asset.
• Ability to use related equipment.
• Demonstrated skills in CPR techniques.

Benefits:

Every PHSA employee enables the best possible patient care for our patients and their families. Whether you are providing direct care, conducting research, or making it possible for others to do their work, you impact the lives of British Columbians today and in the future. That’s why we’re focused on your care too – offering health, wellness, development programs to support you – at work and at home.

• Join one of BC’s largest employers with province-wide programs, services and operations – offering vast opportunities for growth, development, and recognition programs that honour the commitment and contribution of all employees.
• Access to professional development opportunities through our in-house training programs, including +2,000 courses, such as our San’yas Indigenous Cultural Safety Training course, or Core Linx for Leadership roles.
• Enjoy a comprehensive benefits package, which includes statutory benefits - Canada Pension Plan, Employment Insurance and WorkSafe BC plus the PHSA group benefits plan which includes medical & dental extended health, and group life insurance coverage, and psychological health & safety programs and holistic wellness resources.
• Annual statutory holidays (13) with generous vacation entitlement and accruement.
• PHSA is a remote work friendly employer, welcoming flexible work options to support our people (eligibility may vary, depending on position).
• Access to WorkPerks, a premium discount program offering a wide range of local and national discounts on electronics, entertainment, dining, travel, wellness, apparel, and more.

Job Type: 

Temporary Full-Time, 7.5 hrs. per day

Hybrid

Salary Range: 

Grid 9 - $37.89/hour for the 1st year - $47.20/ hour for the 6th year

The starting salary for this position would be determined with consideration of the successful candidate’s relevant education and experience, and would be in alignment with the provincial compensation reference plan and grant fund availability.

Higher salary offers above the midpoint range require additional review and approval.

Apply:

As this is a union position, you will also have to apply either as an internal or external applicant through http://www.phsa.ca/careers using the posting reference 194507.

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No. CB_P01060_HSA194507_CCG_2026_01_30 in the subject line of your email.

While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Important!

COVID-19 vaccines protect against infection from severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) that causes COVID-19. 

The COVID-19 vaccine has been added to the list of high-priority immunizations recommended for health-care workers. Health care workers should ensure they are up-to-date on all routine immunizations. 

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

 

Advancing Genomics Technologies for Health and Life Sciences

The Michael Smith Genome Sciences Centre (GSC), a provincial program within the Provincial Health Services Authority (PHSA), is a recognized international leader in genomics, bioinformatics, and genome technology innovation. By developing and deploying cutting-edge sequencing and computational platforms, the GSC supports breakthrough research across cancer, rare and infectious diseases, and the broader life sciences. Our work enables earlier diagnosis, novel therapeutic approaches, and transformative applications of genomics to improve human health and environmental resilience—delivering both social and economic impact through science.

Job Reference No. CB_P01066_HSA194506_SoftDev_2026_01_30

Job Summary

In accordance with the Purpose, Vision, Values and Coast Salish Teachings, and strategic direction of PHSA, safety, including both patient and employee safety, is a priority and a responsibility shared by everyone at PHSA. As such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

The Computational Biologist participates in developing, improving and maintaining bioinformatics tools for high-throughput processing pipelines. The Computational Biologist specifies, implements, tests and maintains bioinformatics computer applications and systems, and participates in the code walk-throughs and design and review of bioinformatics software solutions. The Computational Biologist will also assist in the packaging and distribution of developed tools and analysis results to the scientific community, and will contribute to the preparation of scientific publications.

Duties

1. Codes in Python and specifies, implements, tests, and maintains bioinformatics pipelines and applications as assigned.
2. Assists with devising or modifying systems to solve complex problems associated with high throughput pipelines, considering computer equipment capacity and limitations, operating time and form of desired results.
3. Participates in code walk-throughs and reviews of the coded solutions to PEP8 standards.
4. Participates in the design and build of database and software solutions taking performance into consideration.
5. Coordinates production problem resolution for assigned applications, including working with other technical teams.
6. Evaluates third-party software and incorporates new systems into legacy systems.
7. Produces written documentation of algorithms, validations, SOPs, and other processes related to pipeline updates and procedures as required.
8. Presents results of bioinformatics software testing internally and externally.
9. Performs literature searches, testing and validation of new data analysis software related to bioinformatics pipelines.
10. Performs other related duties as required.

Qualifications

Education, Training and Experience

• Graduation from a recognized Bachelor of Applied Science or Bachelor of Science Program in either Computer Science, Biological Sciences, or equivalent program.
• Two (2) years of recent related experience in a bioinformatic setting or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and Abilities

• Demonstrated expertise with Python or other similar high level languages for application in data analysis.
• Demonstrated ability to program and run analysis in a high throughput bioinformatics production environment.
• Functional knowledge of distributed version control systems, such as GIT.
• Functional knowledge of Agile development and ticketing systems.
• Demonstrated ability to work with bioinformatics workflow managers (e.g. Nextflow).
• Excellent verbal and written communication skills.
• Demonstrated ability to work in an Unix environment, including experience with shell scripting and common command-line tools.
• Demonstrated ability to develop software as part of a team.
• Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
• Demonstrated ability to efficiently organize work assignments and establish priorities.

Benefits:

Every PHSA employee enables the best possible patient care for our patients and their families. Whether you are providing direct care, conducting research, or making it possible for others to do their work, you impact the lives of British Columbians today and in the future. That’s why we’re focused on your care too – offering health, wellness, development programs to support you – at work and at home.

• Join one of BC’s largest employers with province-wide programs, services and operations – offering vast opportunities for growth, development, and recognition programs that honour the commitment and contribution of all employees.
• Access to professional development opportunities through our in-house training programs, including +2,000 courses, such as our San’yas Indigenous Cultural Safety Training course, or Core Linx for Leadership roles.
• Enjoy a comprehensive benefits package, which includes statutory benefits - Canada Pension Plan, Employment Insurance and WorkSafe BC plus the PHSA group benefits plan which includes medical & dental extended health, and group life insurance coverage, and psychological health & safety programs and holistic wellness resources.
• Annual statutory holidays (13) with generous vacation entitlement and accruement.
• PHSA is a remote work friendly employer, welcoming flexible work options to support our people (eligibility may vary, depending on position).
• Access to WorkPerks, a premium discount program offering a wide range of local and national discounts on electronics, entertainment, dining, travel, wellness, apparel, and more.

Job Type: 

Temporary Full-Time, 7.5 hrs. per day

Hybrid

Salary Range: 

Grid 9 - $37.89/hour for the 1st year - $47.20/ hour for the 6th year

The starting salary for this position would be determined with consideration of the successful candidate’s relevant education and experience, and would be in alignment with the provincial compensation reference plan and grant fund availability.

Higher salary offers above the midpoint range require additional review and approval.

Apply:

As this is a union position, you will also have to apply either as an internal or external applicant through http://www.phsa.ca/careers using the posting reference 194506.

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No. CB_P01066_HSA194506_SoftDev_2026_01_30 in the subject line of your email.

While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Important!

COVID-19 vaccines protect against infection from severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) that causes COVID-19. 

The COVID-19 vaccine has been added to the list of high-priority immunizations recommended for health-care workers. Health care workers should ensure they are up-to-date on all routine immunizations. 

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

 

Advancing Genomics Technologies for Health and Life Sciences

The Michael Smith Genome Sciences Centre (GSC), a provincial program within the Provincial Health Services Authority (PHSA), is a recognized international leader in genomics, bioinformatics, and genome technology innovation. By developing and deploying cutting-edge sequencing and computational platforms, the GSC supports breakthrough research across cancer, rare and infectious diseases, and the broader life sciences. Our work enables earlier diagnosis, novel therapeutic approaches, and transformative applications of genomics to improve human health and environmental resilience—delivering both social and economic impact through science.

Job Reference No. PDF_01553_Jones Lab_ctDNA MRD_2026_01_30

Background

The Personalized Approaches in the Treatment of Head and Neck Cancer (PATH) study aims to use longitudinal plasma cell‑free DNA sequencing to develop a minimally invasive method for detecting minimal residual disease (MRD) and recurrence in head and neck squamous cell carcinoma (HNSCC). Approximately 35 % of patients with HNSCC recur and die despite aggressive treatment. There are currently no validated biomarkers to monitor treatment response or detect residual disease. The proposed pilot will collect serial blood draws from 30–50 patients per year and perform whole‑genome sequencing (WGS) on Illumina and Oxford Nanopore Technology (ONT) platforms. It will integrate genomic, epigenomic and fragmentomic features (SNVs, copy‑number variants, methylation marks, fragment size, end‑motifs, nucleosomal positioning, viral integration) to sensitively detect low tumour fractions. The project’s third aim is to explore bioinformatics tools to develop a genome‑wide multimodal MRD analysis pipeline, analyze baseline plasma samples, and retrospectively analyze longitudinal samples to detect tumour burden. This position will be central to achieving those aims.

Responsibilities

• Explore, design, and implement an analysis pipeline to sensitively detect low tumour fractions from plasma ctDNA using data from Illumina short‑read and ONT long‑read WGS. This includes integrating whole genomic alterations (SNVs, indels, copy‑number variants), epigenetic marks, fragmentomics (fragment length, end‑motifs, nucleosome positioning) and viral integration patterns.
• Adapt and evaluate existing tools and develop novel algorithms as required to improve MRD sensitivity and specificity.
• Perform longitudinal analyses of serial plasma samples from patients with and without recurrence, tracking ctDNA tumour fraction over time and correlating ctDNA trends with clinical events and imaging.
• Incorporate tumour‑informed analysis by leveraging matched tumour and normal WGS data from the PATH study; build HNSCC‑specific methylation classification models.
• Identify and characterize genomic features of HPV/EBV‑positive cancers, including viral integration and methylation patterns.
• Generate comprehensive reports, visualizations and manuscripts for internal review, conference presentations and peer‑reviewed publications.

Qualifications

• Ph.D. in Bioinformatics, Computational Biology, Genomics, Computer Science or a related discipline.
• Expertise in next‑generation sequencing data analysis; familiarity with both short‑read (Illumina) and long‑read (ONT) platforms; experience with variant calling, copy‑number analysis, methylation analysis, fragmentomics and viral integration analysis.
• Strong programming skills (Python, R, C/C++ or similar), proficiency with workflow management (Snakemake, Nextflow, CWL), version control (Git), and high‑performance computing.
• Knowledge of cancer genomics, liquid biopsy technologies, epigenetics and MRD; experience with tumour‑informed analysis or minimal residual disease detection is highly desirable.
• Experience developing or customizing bioinformatics tools and demonstrated ability to analyze complex genomic datasets.
• Excellent communication and interpersonal skills to collaborate with a multidisciplinary team.
• Proven publication record in cancer genomics or related fields and commitment to open‑science principles.

High‑level Summary of the Role

The post‑doctoral fellow will lead the development of an integrated analysis pipeline for detecting minimal residual disease in head and neck cancer patients by analyzing longitudinal plasma ctDNA. Using whole‑genome sequencing from both Illumina and Oxford Nanopore platforms, the fellow will combine genomic mutations, copy‑number alterations, methylation signatures, fragmentomics and viral integration data to sensitively track tumour burden over time. They will adapt and create bioinformatics methods, apply tumour‑informed analyses using matched tumour and normal WGS, and analyze baseline and follow‑up blood samples to identify early ctDNA signals before clinical standard of care recurrence. The fellow will collaborate within the GSC and PATH project to produce reports and manuscripts, and help scale the pipeline for future studies to impact cancer patient care.

Benefits:

Every PHSA employee enables the best possible patient care for our patients and their families. Whether you are providing direct care, conducting research, or making it possible for others to do their work, you impact the lives of British Columbians today and in the future. That’s why we’re focused on your care too – offering health, wellness, development programs to support you – at work and at home.

• Join one of BC’s largest employers with province-wide programs, services and operations – offering vast opportunities for growth, development, and recognition programs that honour the commitment and contribution of all employees.
• Access to professional development opportunities through our in-house training programs, including +2,000 courses, such as our San’yas Indigenous Cultural Safety Training course, or Core Linx for Leadership roles.
• Enjoy a comprehensive benefits package, which includes statutory benefits - Canada Pension Plan, Employment Insurance and WorkSafe BC plus the PHSA group benefits plan which includes medical & dental extended health, and group life insurance coverage, and psychological health & safety programs and holistic wellness resources.
• Annual statutory holidays (13) with generous vacation entitlement and accruement.
• PHSA is a remote work friendly employer, welcoming flexible work options to support our people (eligibility may vary, depending on position).
• Access to WorkPerks, a premium discount program offering a wide range of local and national discounts on electronics, entertainment, dining, travel, wellness, apparel, and more.

Job Type: 

Temporary Full-Time, 7.5 hrs. per day

Hybrid

Salary Range: 

$50,000 - $70,000 p.a.

The starting salary for this position would be determined with consideration of the successful candidate’s relevant education and experience, and would be in alignment with the provincial compensation reference plan and grant fund availability.

Higher salary offers above the midpoint range require additional review and approval.

Apply:

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No. PDF_01553_Jones Lab_ctDNA MRD_2026_01_30 in the subject line of your email.

While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Important!

COVID-19 vaccines protect against infection from severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) that causes COVID-19. 

The COVID-19 vaccine has been added to the list of high-priority immunizations recommended for health-care workers. Health care workers should ensure they are up-to-date on all routine immunizations. 

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

 

About the GSC

Advancing Genomics Technologies for Health and Life Sciences

The Michael Smith Genome Sciences Centre (GSC), a provincial program within the Provincial Health Services Authority (PHSA), is a recognized international leader in genomics, bioinformatics, and genome technology innovation. By developing and deploying cutting-edge sequencing and computational platforms, the GSC supports breakthrough research across cancer, rare and infectious diseases, and the broader life sciences. Our work enables earlier diagnosis, novel therapeutic approaches, and transformative applications of genomics to improve human health and environmental resilience—delivering both social and economic impact through science.

Job Reference: RPM1_R00023_194043_Seq_Clinical Validations_2026_01_21

Summary

The Research Development Coordinator leads and co-ordinates all aspects of the clinical laboratory validation and implementation projects undertaken by the department. The role ensures the deliverables are completed on time and on budget, as identified in the project plan. The Research Development Coordinator identifies and tracks metrics as they relate to the project deliverables. The role provides consultation, guidance and support to designated research project staff, contractors and stakeholders.

This role involves laboratory bench work as well as co-ordination.

Key Accountabilities

• Performs laboratory experiments aimed at implementation of clinical testing utilizing liquid handling robots.
• Establishes detailed research project charter, plans and objectives to outline timelines and project deliverables.
• Executes project plan according to project methodologies, ensures successful and coordinated completion of project components, consults with stakeholders as needed and oversees project implementation.
• Tracks research project progress according to project plan and identified metrics. Monitors and reports on the status of projects and major barriers encountered. Makes recommendations to Principal Investigator or Leader regarding projects scope and related changes required to facilitate a successful outcome.
• Implements or contributes to the implementation of effective processes to assess project risks, identify risk mitigation strategies and monitor risk throughout the project lifecycle.
• Participates in the development and monitoring of research project budgets within the context of operations demands and environmental and resource constraints and uses best practice methods to thoroughly monitor and adhere to allocated budgets.
• Provides leadership by giving advice or guidance in situations that require interpretation and judgment.
• Oversees QA documentation and transfer of processes to production.

Qualifications

• A level of education, training, and experience equivalent to a Master’s Degree in Molecular Biology, or relevant life sciences discipline with a minimum of five (5) year’s recent, related experience in project management and laboratory work.
• On the job experience with next generation sequencing technologies and laboratory automation.
• Experience or working knowledge of quality improvement methodology and change management is key to the success of this role.
• Excellent communication skills to function within a complex interdisciplinary environment including ability to communicate with the physician community.
• Computer literacy with word-processing, spreadsheet, presentation, project

Benefits:

Every PHSA employee enables the best possible patient care for our patients and their families. Whether you are providing direct care, conducting research, or making it possible for others to do their work, you impact the lives of British Columbians today and in the future. That’s why we’re focused on your care too – offering health, wellness, development programs to support you – at work and at home.

• Join one of BC’s largest employers with province-wide programs, services and operations – offering vast opportunities for growth, development, and recognition programs that honour the commitment and contribution of all employees.
• Access to professional development opportunities through our in-house training programs, including +2,000 courses, such as our San’yas Indigenous Cultural Safety Training course, or Core Linx for Leadership roles.
• Enjoy a comprehensive benefits package, which includes statutory benefits - Canada Pension Plan, Employment Insurance and WorkSafe BC plus the PHSA group benefits plan which includes medical & dental extended health, and group life insurance coverage, and psychological health & safety programs and holistic wellness resources.
• Annual statutory holidays (13) with generous vacation entitlement and accruement.
• PHSA is a remote work friendly employer, welcoming flexible work options to support our people (eligibility may vary, depending on position).
• Access to WorkPerks, a premium discount program offering a wide range of local and national discounts on electronics, entertainment, dining, travel, wellness, apparel, and more.

Job Type: 

Temporary Full-Time, 7.5 hrs. per day

Hybrid

Salary Range: 

$88,990 – $127,923 p.a.

The starting salary for this position would be determined with consideration of the successful candidate’s relevant education and experience, and would be in alignment with the provincial compensation reference plan. 

Higher salary offers above the midpoint range require additional review and approval.

Apply:

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No. RPM1_R00023_194043_Seq_Clinical Validations_2026_01_21 in the subject line of your email.

While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Important!

COVID-19 vaccines protect against infection from severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) that causes COVID-19. 

The COVID-19 vaccine has been added to the list of high-priority immunizations recommended for health-care workers. Health care workers should ensure they are up-to-date on all routine immunizations. 

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Reference No. PDF_01553_Tai Lab_2024_11_26

Summary

The Post-doctoral Fellow in the Tai Lab will work on a research project that seeks to define the functional role of a protein normally associated with immune cells in colorectal cancer cells.

Advanced colorectal cancer (CRC) is a significant clinical problem. These patients have a survival rate less than 20% and the majority of tumors do not respond to conventional therapies. The programmed cell death 1 (PD-1) immune checkpoint is normally associated with the immune system but is also intrinsically expressed by some CRC tumours. CRC patients with high expression levels of PD-1 have inferior survival rates and their tumors have higher mutation and microsatellite instability levels. PD-1 high CRC tumors also over-express proteins associated with an aggressive phenotype favoring tumor survival. The goal of this project is to evaluate the role of tumor cell-intrinsic PD-1 in CRC and understand its impact on current therapeutic strategies in CRC.

The aims of the project are to:

• Characterize the signaling networks of cell-intrinsic PD-1 and define how the protein regulates cancer cell survival and resistance to chemotherapy
• Define the molecular interaction of cell-intrinsic PD-1 with immune cells and/or stemcells in the tumor stroma.

Duties and Responsibilities 

As a Post-doctoral Fellow on the PD-1-CRC project, project, you will report to Dr. Isabella Tai. Your typical duties will include the following:

1. Designing cell libraries for high-throughput screening experiments.
2. Performing Western Blots to validate cell signaling networks
3. Performing immuno-precipitation of binding partners to PD-1
4. Characterizing and validating novel discoveries stemming from gene screening studies including scRNA sequencing.
5. Participating in the analysis of global proteomic assays
6. Reporting research methods and results in meetings.
7. Contributing to the scientific advancement of the PD-1-CRC project by developing new research directions related to PD-1 activity in CRC tumors.
8. Contributing to scientific publications, patents, and funding proposals as needed.

Qualifications

The Postdoctoral Fellow should possess a PhD degree and recent experience in immunology, genomics, cancer biology, cell biology or a related discipline.

Experience in recombinant DNA technologies and viral gene delivery vectors, mammalian cell culture (including primary T cell culture), flow cytometry/FACS, and cell-based assays (such as ELISPOT) is desired. Familiarity with 2^nd and 3^rd generation DNA sequencing platforms (including spatial single-cell sequencing platforms) and bioinformatics analysis will be an asset.

A strong publication record and a track record of success in objective-based research projects are highly desirable. Due to the translational nature of this research project, an interest or aptitude for developing novel technologies, therapeutic strategies and/or commercialization would be a valuable asset.

Benefits:

Every PHSA employee enables the best possible patient care for our patients and their families. Whether you are providing direct care, conducting research, or making it possible for others to do their work, you impact the lives of British Columbians today and in the future. That’s why we’re focused on your care too – offering health, wellness, development programs to support you – at work and at home.

• Join one of BC’s largest employers with province-wide programs, services and operations – offering vast opportunities for growth, development, and recognition programs that honour the commitment and contribution of all employees.
• Access to professional development opportunities through our in-house training programs, including +2,000 courses, such as our San’yas Indigenous Cultural Safety Training course, or Core Linx for Leadership roles.
• Enjoy a comprehensive benefits package, which includes statutory benefits - Canada Pension Plan, Employment Insurance and WorkSafe BC plus the BC Cancer group benefits plan which includes medical & dental extended health, and group life insurance coverage, and psychological health & safety programs and holistic wellness resources.
• Annual statutory holidays (13) with generous vacation entitlement and accruement.
• PHSA is a remote work friendly employer, welcoming flexible work options to support our people (eligibility may vary, depending on position).
• Access to WorkPerks, a premium discount program offering a wide range of local and national discounts on electronics, entertainment, dining, travel, wellness, apparel, and more.

Job Type: 

Temporary Full-Time, 7.5 hrs. per day

Salary Range: 

$45,000 - 55,000 p.a.

The starting salary for this position would be determined with consideration of the successful candidate’s relevant education and experience, and would be in alignment with the provincial compensation reference plan. 

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using PDF_01553_Tai Lab_2024_11_26 in the subject line of your email.

While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Important!

COVID-19 vaccines protect against infection from severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) that causes COVID-19. 

The COVID-19 vaccine has been added to the list of high-priority immunizations recommended for health-care workers. Health care workers should ensure they are up-to-date on all routine immunizations. 

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

Advancing Genomics Technologies for Health and Life Sciences

The Michael Smith Genome Sciences Centre (GSC), a provincial program within the Provincial Health Services Authority (PHSA), is a recognized international leader in genomics, bioinformatics, and genome technology innovation. By developing and deploying cutting-edge sequencing and computational platforms, the GSC supports breakthrough research across cancer, rare and infectious diseases, and the broader life sciences. Our work enables earlier diagnosis, novel therapeutic approaches, and transformative applications of genomics to improve human health and environmental resilience—delivering both social and economic impact through science.

Job Reference No: RP_R00008_CCGI_2026_01_14

Summary

Canada’s Michael Smith Genome Sciences Centre (GSC) of the BC Cancer Research Institute is a state-of-the-art, large scale, high throughput, clinically accredited genomics and bioinformatics facility in one of the most beautiful, diverse and eclectic cities in the world.

As a Research Programmer within the Centre for Clinical Genomics Informatics team at the GSC, you will be responsible for technical support for clinical programs through development, testing and validation of clinical bioinformatics processes. The Research Programmer will report to the Process Development Coordinator and is anchored within a team of exceptional computational scientists and programmers, who collaborate directly on the development and maintenance of robust, cost efficient, and competitive clinical genomics pipelines. By working within the GSCs bioinformatics facility, you will collaborate with clinical and research computational biologists and programmers across bioinformatics groups, clinical lab staff and the quality assurance group to deliver clinical diagnostic genomic testing for patients in BC.

This is an opportunity to work with highly motivated colleagues in a science-oriented, creative and dynamic environment. We offer a competitive salary, excellent benefits and significant career development opportunities. 

So, what are you waiting for? Apply now!  

Please note that we are recruiting for two (2) candidates for this role.

Duties and Responsibilities:

• Works with team members to identify and implement pipeline improvements to optimize existing clinical pipelines.
• Works with stakeholders to design, plan and implement testing and development of new clinical bioinformatics software.
• Development and maintenance of clinical genomic databases.
• Delivery of clear and concise documentation.
• Actively participate in a team-oriented approach to improve efficiency and productivity.

Qualifications

• Graduation from a recognized Bachelor’s program in an appropriate discipline such as Computer Science, Bioinformatics, Genetics, Molecular Biology or Biochemistry, and three years of recent, related experience in a research and or clinical laboratory.
• Proven expertise with Python, R, and/or other similar high-level languages.
• Functional knowledge of distributed version control systems, such as Git.
• Demonstrated experience with analysis of next generation sequencing data with an understanding of standards and guidelines for validating clinical bioinformatics analysis pipelines using these technologies.
• Comfortable working in a Linux environment, including experience with shell scripting and common command-line tools.
• Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
• Demonstrated ability to efficiently organize work assignments and establish priorities to meet set milestones.
• Demonstrated ability to write technical documents including validations and procedure manuals.
• Experience with bioinformatic workflow managers and database development would be considered an asset.

Benefits:

Every PHSA employee enables the best possible patient care for our patients and their families. Whether you are providing direct care, conducting research, or making it possible for others to do their work, you impact the lives of British Columbians today and in the future. That’s why we’re focused on your care too – offering health, wellness, development programs to support you – at work and at home.

• Join one of BC’s largest employers with province-wide programs, services and operations – offering vast opportunities for growth, development, and recognition programs that honour the commitment and contribution of all employees.
• Access to professional development opportunities through our in-house training programs, including +2,000 courses, such as our San’yas Indigenous Cultural Safety Training course, or Core Linx for Leadership roles.
• Enjoy a comprehensive benefits package, which includes statutory benefits - Canada Pension Plan, Employment Insurance and WorkSafe BC plus the BC Cancer group benefits plan which includes medical & dental extended health, and group life insurance coverage, and psychological health & safety programs and holistic wellness resources.
• Annual statutory holidays (13) with generous vacation entitlement and accruement.
• PHSA is a remote work friendly employer, welcoming flexible work options to support our people (eligibility may vary, depending on position).
• Access to WorkPerks, a premium discount program offering a wide range of local and national discounts on electronics, entertainment, dining, travel, wellness, apparel, and more.

Job Type: 

Temporary Full-Time, 7.5 hrs. per day

Hybrid

Salary Range: 

$67,861 - $97,550 p.a.

The starting salary for this position would be determined with consideration of the successful candidate’s relevant education and experience, and would be in alignment with the provincial compensation reference plan. 

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No: RP_R00008_CCGI_2026_01_14 in the subject line of your email.

While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Important!

COVID-19 vaccines protect against infection from severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) that causes COVID-19. 

The COVID-19 vaccine has been added to the list of high-priority immunizations recommended for health-care workers. Health care workers should ensure they are up-to-date on all routine immunizations. 

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.