Developing and deploying genomics technologies in support of cancer and life sciences research.

Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying cutting-edge genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science. 

Our Technology Platform

The GSC is available to support your research. We guide experimental design, facilitate the processing of complex biological samples and provide numerous sequencing and bioinformatic services with the aim of making genomics accessible to the international scientific community. Explore our technology platforms and services, and if you have questions or would like to collaborate please fill out our contact form or speak directly with one of our platform leaders.

The GSC is ISO27001 certified for information security management.

Our Scientific Research

The 13 faculty members at the GSC have a diverse range of expertise in genomics, bioinformatics, proteomics, epigenomics, immunogenetics, cancer biology, computer science and software development. Together, we apply our knowledge to advance the global understanding of cancer and other diseases with an ultimate aim toward improving human health through disease prevention, the development of novel diagnostic strategies and by uncovering new therapeutic approaches, all the while helping the world to realize the social and economic benefits of genome research.

Our Clinical Programs

The GSC is unique in that it fosters close collaborations between scientists and clinicians, allowing for an unencumbered focus on direct translational research. Through the Personalized OncoGenomics (POG) program, the GSC deploys whole genome and transcriptome sequencing to inform therapeutic and management strategies for late-stage cancer patients in real time. The GSC is also certified by the College of American Pathologists (CAP) and the Diagnostic Accreditation Program (DAP) to perform clinical genomic panel testing.


Please feel free to speak with one of our Platform Leaders directly:

Directors & Platform Leaders


Jul 02, 2020

New sequence simulator helps leverage power of long-read transcriptome sequencing

Long-read sequencing technologies are increasingly being employed by researchers to gain important insights into the transcriptomes of cells, revealing a need for computational tools designed for long-read RNA sequencing analysis. To facilitate software development, researchers have now created a sequence simulator designed to produce simulated long-read transcriptome data, providing a cost-effective means to help develop, refine and benchmark novel tools for data analysis.

May 22, 2020

How B.C. scientists are addressing the COVID-19 testing challenge

As the COVID-19 pandemic continues, public health authorities around the world are facing a significant challenge: ensuring a large enough supply of reagents to scale-up diagnostic testing. Researchers at Canada's Michael Smith Genome Sciences Centre at BC Cancer (GSC), the University of British Columbia (UBC) and the BC Centre for Disease Control (BCCDC) are working to develop new non-proprietary reagents to support current and future testing in British Columbia.


TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate

Cell, 2020
Leandro Venturutti, Matt Teater, Andrew Zhai, Amy Chadburn, Leena Babiker, Daleum Kim, Wendy Béguelin, Tak C Lee, Youngjun Kim, Christopher R Chin, William T Yewdell, Brian Raught, Jude M Phillip, Yanwen Jiang, Louis M Staudt, Michael R Green, Jayanta Chaudhuri, Olivier Elemento, Pedro Farinha, Andrew P Weng, Michael D Nissen, Christian Steidl, Ryan D Morin, David W Scott, Gilbert G Privé, Ari M Melnick

Genetic and evolutionary patterns of treatment resistance in relapsed B-cell lymphoma

Blood Advances, 2020
Christopher K Rushton, Sarah E Arthur, Miguel Alcaide, Matthew Cheung, Aixiang Jiang, Krysta M Coyle, Kirstie L S Cleary, Nicole Thomas, Laura K Hilton, Neil Michaud, Scott Daigle, Jordan Davidson, Kevin Bushell, Stephen Yu, Ryan N Rys, Michael Jain, Lois Shepherd, Marco A Marra, John Kuruvilla, Michael Crump, Koren Mann, Sarit Assouline, Joseph M Connors, Christian Steidl, Mark S Cragg, David W Scott, Nathalie A Johnson, Ryan D Morin
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