Lineage-selective genome-wide repressive histone modification signature unique to myelo/erythroid lineage involved in hematopoietic differentiation.
Researchers in British Columbia have developed an optimized new protocol for extracting COVID-19 viral nucleic acids for PCR testing using generic reagents, including magnetic beads, on an open-deck liquid handling robot.
A mutation in a transcription factor essential for ovary development is commonly used as a diagnostic marker for a type of ovarian cancer, but little is known about how it effects the tumour cell itself. Extensive analysis of how this mutation alters DNA binding has revealed the potential for a novel treatment strategy.
As the COVID-19 pandemic continues, public health authorities around the world are facing a significant challenge: ensuring a large enough supply of reagents to scale-up diagnostic testing. Researchers at Canada's Michael Smith Genome Sciences Centre at BC Cancer (GSC), the University of British Columbia (UBC) and the BC Centre for Disease Control (BCCDC) are working to develop new non-proprietary reagents to support current and future testing in British Columbia.