The overall objectives of our lab are directed at understanding the role of epigenetics in cancer and to investigate the therapeutic potential of interventions directed at epigenetic processes. We approach this from an epigenomic perspective by combining innovative molecular biology and computational techniques with genome wide detection platforms.

The Hirst Lab publishes epigenomic data at the Canadian Epigenetics, Environment and Health Research Consortium (CEEHRC).

 More information about the Hirst lab is available here.




Sinéad Aherne

Projects Manager

Rachelle Cao, MSc

Research Assistant

Annaïck Carles

Computational Biologist

Michelle Moska

Lab Manager

Raisa Shabbir

Research Assistant

Edmund Su

Computational Biologist

Sherry Wang

Projects Team Leader


Gloria Li

Graduate Student

Alireza Lorzadeh

M&I PhD Candidate

Linda Wang

M&I PhD Student

Jasper Wong

Graduate Student

Alice Zhu

GSAT PhD Candidate

Selected Publications

Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia.

Nature communications, 2019
Kusakabe, Manabu, Sun, Ann Chong, Tyshchenko, Kateryna, Wong, Rachel, Nanda, Aastha, Shanna, Claire, Gusscott, Samuel, Chavez, Elizabeth A, Lorzadeh, Alireza, Zhu, Alice, Hill, Ainsleigh, Hung, Stacy, Brown, Scott, Babaian, Artem, Wang, Xuehai, Holt, Robert A, Steidl, Christian, Karsan, Aly, Humphries, R Keith, Eaves, Connie J, Hirst, Martin, Weng, Andrew P

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy.

Nature, 2017
Lan, Xiaoyang, Jörg, David J, Cavalli, Florence M G, Richards, Laura M, Nguyen, Long V, Vanner, Robert J, Guilhamon, Paul, Lee, Lilian, Kushida, Michelle M, Pellacani, Davide, Park, Nicole I, Coutinho, Fiona J, Whetstone, Heather, Selvadurai, Hayden J, Che, Clare, Luu, Betty, Carles, Annaick, Moksa, Michelle, Rastegar, Naghmeh, Head, Renee, Dolma, Sonam, Prinos, Panagiotis, Cusimano, Michael D, Das, Sunit, Bernstein, Mark, Arrowsmith, Cheryl H, Mungall, Andrew J, Moore, Richard A, Ma, Yussanne, Gallo, Marco, Lupien, Mathieu, Pugh, Trevor J, Taylor, Michael D, Hirst, Martin, Eaves, Connie J, Simons, Benjamin D, Dirks, Peter B


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