Journal
BMC genomics, 2018
Authors
Xue, Zhuyi, Warren, René L, Gibb, Ewan A, MacMillan, Daniel, Wong, Johnathan, Chiu, Readman, Hammond, S Austin, Yang, Chen, Nip, Ka Ming, Ennis, Catherine A, Hahn, Abigail, Reynolds, Sheila, Birol, Inanc
Alternative polyadenylation (APA) results in messenger RNA molecules with different 3' untranslated regions (3' UTRs), affecting the molecules' stability, localization, and translation. APA is pervasive and implicated in cancer. Earlier reports on APA focused on 3' UTR length modifications and commonly characterized APA events as 3' UTR shortening or lengthening. However, such characterization oversimplifies the processing of 3' ends of transcripts and fails to adequately describe the various scenarios we observe.
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Title
Recurrent tumor-specific regulation of alternative polyadenylation of cancer-related genes.
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