Journal
Neuro-oncology, 2020
Authors
Wongthida, Phonphimon, Schuelke, Matthew R, Driscoll, Christopher B, Kottke, Timothy, Thompson, Jill M, Tonne, Jason, Stone, Cathy, Huff, Amanda L, Wetmore, Cynthia, Davies, James A, Parker, Alan L, Evgin, Laura, Vile, Richard G
Diffuse midline glioma, formerly DIPG (diffuse intrinsic pontine glioma), is the deadliest pediatric brainstem tumor with median survival of less than one year. Here, we investigated (i) whether direct delivery of adenovirus-expressing cluster of differentiation (CD)40 ligand (Ad-CD40L) to brainstem tumors would induce immune-mediated tumor clearance and (ii) if so, whether therapy would be associated with a manageable toxicity due to immune-mediated inflammation in the brainstem.
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Title
Ad-CD40L mobilizes CD4 T cells for the treatment of brainstem tumors.
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