The Gorski Lab shows that chloroquine induces the secretion of autophagy-related proteins, some of which are partitioned and packaged into distinct small vesicle populations.
Identification of four molecular subgroups of pancreatic neuroendocrine neoplasms (PNENs) with potential implications on patient stratification and treatment.
LRRK2 is a highly studied gene in Parkinson’s disease, where increased activity is thought to play a causative role. Now, new research has established that decreased LRRK2 expression can be involved in the development of lung adenocarcinoma.
In a new study published in Breast Cancer Research and Treatment, led by GSC Distinguished Scientist Dr. Sharon Gorski, researchers revealed that three key autophagy molecules—ATG4B, LC3B and GABARAP—may be useful together to determine prognosis for breast cancer patients.