Canada’s Michael Smith Genome Sciences Centre (GSC)
Today’s Research. Tomorrow’s Medicine.
The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.
Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.
Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.
By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values — science, timeliness, respect — to join us on our mission to use genome science for the betterment of health and society.
Job Reference No: PCD_E00375_2021_08_11
Reporting to the Bioinformatics Group Leader the Process Development Coordinator (PDC) will support the development, testing and validation of clinical bioinformatics processes at the Genome Sciences Centre (GSC)—a large scale, high throughput biologics facility. The PDC will develop new Clinical procedures and bioinformatic workflows, monitor and review performance within the clinical production process, and where applicable, improve existing analyses.
Scope and complexity
The PDC monitors existing processes and recommends and/or develops new processes in support of the clinical sequencing objectives at the GSC. The PDC designs and performs informatic experiments to validate either existing methods or novel methods providing new functionality. The successful candidate will strive to streamline existing functionality, and maximize output quality and efficiency while balancing costs. Monitoring of results and comparison to outlined standards will be performed.
The PDC collaborates closely with key stakeholders for the clinical process including the clinical director, bioinformatics groups and quality assurance group.
Oversees the development and testing of clinical bioinformatics production processes by:
- Designing and performing experiments pertaining to the generation of clinically relevant results. This includes, but is not limited to, the development and testing of new analyses, protocol optimization, Quality Assurance and Quality Control, testing of prototypes and related activities. The PDC continually monitors performance of protocols within the production process and identifies areas for improvement. All activities will yield documented recommendations and implementation plans.
- Troubleshooting existing clinical computational processes where necessary. Makes recommendations and adjustments and reports problems.
- Training designated members of the clinical bioinformatics group in new or optimized analysis workflows. Writes or revises protocols accordingly.
- Performing technical functions related to the Bioinformatics groups of the GSC.
- Other related duties as necessary.
- Graduation from a recognized Bachelor’s program in an appropriate discipline such as Computer Science, Bioinformatics, Genetics, Molecular Biology or Biochemistry (PhD) preferred).
- Five (5) years of recent related experience in a research and or clinical laboratory including supervisory experience
An equivalent combination of education, training and experience acceptable to the GSC Group Leaders.
Skills and knowledge
- Proven expertise with Python and/or other similar high level languages.
- Demonstrated ability in R or other similar statistical programming languages and in statistical analysis.
- Functional knowledge of distributed version control systems, such as Git.
- Demonstrated experience with next generation/ third generation sequencing technology with an in-depth understanding of standards and guidelines for validating clinical bioinformatics analysis pipelines using these technologies.
- Excellent verbal and written communication skills.
- Comfortable working in a Linux environment, including experience with shell scripting and common command-line tools.
- Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
- Experience liaising with multiple stakeholders to support consensus goals.
- Demonstrated ability to efficiently organize work assignments and establish priorities to meet set milestones.
- Demonstrated ability to write technical documents including validations and procedure manuals
- Excellent analytical skills
- Demonstrated ability to accept responsibility and work independently.
- Experience with bioinformatic workflow managers eg Nextflow would be considered an asset.
Please submit a detailed cover letter and resume to firstname.lastname@example.org, using Process Development Coordinator-Clinical_PCD_E00375_2021_08_11 in the subject line of your email.
This posting will remain online until filled.
We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.
We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.
All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.
Due to COVID-19 restrictions, the position would require working remotely on a temporary basis. This restriction would be re-evaluated upon re-contracting