The personalized approaches in the treatment of head and neck cancer (PATH) study is a longitudinal study of head and neck cancer patients in BC currently recruiting patients. The aims of the project are to determine the molecular correlates of relapse in head and neck cancer and to compare virus-positive (HPV and EBV) and virus-negative cases in terms of genomic and epigenomic features. To achieve this, tumour samples are undergoing short- and long-read whole-genome sequencing (WGS), as well as RNA-sequencing. In particular, long-read WGS will allow us to probe virus-associated structural variation (SV) and methylation and to compare these features to other forms of SV and methylation in virus-negative cases.
The Personalized Approaches in the Treatment of Head and Neck Cancers (PATH) study
Canada’s Michael Smith Genome Sciences Centre respectfully acknowledges that we operate on the traditional, ancestral and unceded territories of the xʷməθkwəy̓əm (Musqueam), Səl̓ílwətaʔ/Selilwitulh (Tsleil-Waututh), and Skwxwú7mesh (Squamish) nations who have cared and nurtured this land for all time. We give thanks, as uninvited guests, to be able to live and work on these lands.
