Alternative expression values of the type: KnownBoundary for comparison: PostTx_vs_PreTx (abs(SI) value > 2)


Distribution of log2 SI values for comparison: PostTx_vs_PreTx and data type: KnownBoundary

Distribution of all splicing index values that meet the SI cutoff (indicated by red dotted lines) for the feature type: KnownBoundary. The total number of features with SI values exceeding the cutoff, as well as the max and min log2 SI observed are noted in the legend. *If you can not see the figure below, click here




Significant alternatively expressed KnownBoundary features

The following table provides a ranked list of alternatively expressed KnownBoundary features for a single pair-wise library comparison. The first column contains the Gene Name (which links to the ALEXA-Seq gene record), the Feature Name, and the name of each library being compared (which links to the feature's coordinates in the UCSC Genome Browser and displays expression data). The 'SI' column reports the Splicing Index calculated for the feature. The 'Gene FC' column reports the Fold-Change calculated for the entire gene to which the feature belongs. The 'Seq FC' column reports the Fold-Change of the feature itself. The 'Reciprocity' column reports the Reciprocity Index (RI) for the feature. The 'Percent Seq DE' column reports the Percent Feature Contribution (PFC) value for the feature. A description of the purpose and calculation of SI, RI and PFC values can be found in our manuscript. Briefly, the SI value is a measure of the degree of change in expression of a feature (e.g. an exon) between two conditions relative to the change in expression at the gene level. The RI value is a measure of the degree to which the change of the feature is reciprocal in direction to that observed for the gene overall. For example, if an exon is up-regulated but the gene overall is down-regulated, this will give a higher RI value. The PFC value is a measure of the degree of differential expression of the feature compared to the entire gene. For example, if a gene is not changed overall between two conditions, but the feature is highly differentially expressed, this will give a higher PFC value. To sort this table by each of the data values, simply click the column header. A bold row indicates that the feature is not currently supported by EST or mRNA sequence alignments. For exon junction features the number of exons skipped by the junction is indicated as 'Sn' where n is the number of exons skipped (e.g. S0 means no exons skipped, S1 means one exon skipped, etc.).


RANKPostTx_vs_PreTx (Gene | Feature | Links)SIGene FCSeq FCReciprocityPercent Seq DE
1 MICAL1 | E8_Da | (PostTx) | (PreTx)2.881.6412.08N/A83.37
2 BCL2L12 | E1_Ab | (PostTx) | (PreTx)-2.831.23-5.77-1.2789.39
3 MBP | E15_Da | (PostTx) | (PreTx)2.721.117.33N/A94.85
4 OGFR | E2_Da | (PostTx) | (PreTx)2.69-1.046.23-1.0497.93
5 WDR33 | E7_Ab | (PostTx) | (PreTx)2.591.046.23N/A98.13
6 PPM1A | E5_Db | (PostTx) | (PreTx)2.491.176.57N/A92.28
7 BTF3L4 | E6_Da | (PostTx) | (PreTx)-2.481.22-4.57-1.3088.36
8 NCDN | E1_Da | (PostTx) | (PreTx)2.391.306.81N/A88.11
9 C10orf54 | E2_Ab | (PostTx) | (PreTx)-2.38-1.95-10.19N/A77.64
10 ANKRD41 | E5_Da | (PostTx) | (PreTx)2.311.376.77N/A85.87
11 RASSF4 | E3_Ab | (PostTx) | (PreTx)2.301.246.12N/A89.28
12 BCL2L1 | E2_Ab | (PostTx) | (PreTx)2.26-1.044.57-1.0697.22
13 RPL31 | E2_Da | (PostTx) | (PreTx)-2.211.52-3.04-2.2272.50
14 PAQR3 | E8_Da | (PostTx) | (PreTx)-2.211.22-3.78-1.3586.94
15 MAN1B1 | E13_Da | (PostTx) | (PreTx)-2.191.44-3.18-1.9276.05
16 INTS6 | E1_Da | (PostTx) | (PreTx)2.181.125.05N/A93.63
17 NNT | E23_Da | (PostTx) | (PreTx)2.15-1.094.07-1.1394.28
18 DYNLT1 | E3_Da | (PostTx) | (PreTx)2.091.737.39N/A78.48
19 C7orf27 | E5_Da | (PostTx) | (PreTx)2.081.205.06N/A89.82
20 USP48 | E11_Da | (PostTx) | (PreTx)2.071.044.37N/A97.32
21 DPY19L3 | E3_Ab | (PostTx) | (PreTx)2.071.245.21N/A88.38
22 UBAP2 | E30_Dd | (PostTx) | (PreTx)2.071.255.25N/A88.01
23 TDRKH | E5_Da | (PostTx) | (PreTx)-2.06-1.09-4.57N/A94.49
24 NDRG3 | E5_Da | (PostTx) | (PreTx)-2.06-1.57-6.54N/A80.69
25 RASGRP2 | E4_Ae | (PostTx) | (PreTx)2.051.405.78N/A83.93
26 ZNF117 | E4_Db | (PostTx) | (PreTx)2.011.837.39N/A76.77
27 ILI8BP | E2_Ae | (PostTx) | (PreTx)1.99-1.123.55-1.1991.85
28 TMSL3 | E1_Ab | (PostTx) | (PreTx)-1.941.50-2.56-2.5070.02
29 AC135457.2 | E1_Da | (PostTx) | (PreTx)1.931.224.66N/A88.38
30 RAB2B | E4_Ab | (PostTx) | (PreTx)-1.921.19-3.18-1.3686.90
31 MICAL1 | E8_Ab | (PostTx) | (PreTx)1.891.646.11N/A78.45
32 TP53RK | E1_Ab | (PostTx) | (PreTx)1.88-1.143.22-1.2589.84
33 AGXT2L2 | E5_Da | (PostTx) | (PreTx)1.841.946.96N/A74.47
34 ANKMY1 | E9_Da | (PostTx) | (PreTx)1.841.515.39N/A80.44
35 CAMSAP1 | E19_Da | (PostTx) | (PreTx)1.831.154.07N/A91.15
36 FGFR1OP | E13_Da | (PostTx) | (PreTx)1.821.435.06N/A81.95
37 SPTY2D1 | E3_Da | (PostTx) | (PreTx)1.81-1.322.66-1.8077.80
38 POMT1 | E8_Da | (PostTx) | (PreTx)1.801.635.65N/A78.07
39 QKI | E7_Ad | (PostTx) | (PreTx)-1.80-1.62-5.63N/A78.12
40 GBA2 | E14_Ab | (PostTx) | (PreTx)1.791.525.25N/A79.76
41 CCDC86 | E1_Db | (PostTx) | (PreTx)-1.78-1.01-3.47N/A99.04
42 MRPL12 | E1_Ab | (PostTx) | (PreTx)1.761.083.66N/A94.24
43 AP006216.9 | E20_Ab | (PostTx) | (PreTx)1.711.083.54N/A94.18
44 PNRC1 | E1_Da | (PostTx) | (PreTx)1.70-1.402.32-2.3571.26
45 ODF2 | E7_Da | (PostTx) | (PreTx)1.691.213.89N/A87.76
46 MS4A1 | E2_Ab | (PostTx) | (PreTx)1.672.006.39N/A72.76
47 LAIR1 | E11_Db | (PostTx) | (PreTx)-1.67-2.44-7.76N/A69.71
48 NCR3 | E1_Ab | (PostTx) | (PreTx)-1.66-2.39-7.55N/A69.92
49 ITGA4 | E1_Ac | (PostTx) | (PreTx)-1.66-1.33-4.19N/A83.47
50 TRIM26 | E1_Ab | (PostTx) | (PreTx)-1.65-1.17-3.68N/A89.23
51 AC093620.6 | E32_Da | (PostTx) | (PreTx)1.65-1.152.73-1.3287.79
52 RAB24 | E4_Ab | (PostTx) | (PreTx)1.651.765.52N/A75.14
53 OAS1 | E6_Ab | (PostTx) | (PreTx)1.631.113.45N/A92.15
54 FLAD1 | E1_Da | (PostTx) | (PreTx)1.631.314.07N/A83.82
55 NRIP1 | E4_Da | (PostTx) | (PreTx)-1.63-1.87-5.79N/A73.64
56 NCF4 | E8_Da | (PostTx) | (PreTx)1.601.153.49N/A89.69
57 AQP1 | E5_Dd | (PostTx) | (PreTx)-1.59-3.66-11.05N/A64.93
58 SUPT7L | E2_Ab | (PostTx) | (PreTx)1.591.745.26N/A74.93
59 C6orf61 | E12_Ab | (PostTx) | (PreTx)1.591.233.72N/A86.24
60 KIAA1826 | E2_Ac | (PostTx) | (PreTx)1.591.033.11N/A97.09
61 MXRA7 | E5_Da | (PostTx) | (PreTx)-1.59-2.57-7.70N/A68.41
62 SPSB3 | E6_Ab | (PostTx) | (PreTx)1.581.785.32N/A74.40
63 GLIPR2 | E8_Da | (PostTx) | (PreTx)-1.57-1.84-5.48N/A73.54
64 HMGB1L15 | E1_Da | (PostTx) | (PreTx)-1.561.21-2.43-1.5582.26
65 DYNLT1 | E3_Dc | (PostTx) | (PreTx)1.551.735.06N/A74.74
66 PRKCBP1 | E25_Db | (PostTx) | (PreTx)-1.54-1.05-3.06N/A95.66
67 FANCL | E1_Ac | (PostTx) | (PreTx)1.541.745.06N/A74.45
68 TMEM102 | E1_Da | (PostTx) | (PreTx)-1.53-1.70-4.91N/A75.04
69 DAAM1 | E21_Ab | (PostTx) | (PreTx)1.531.544.46N/A77.46
70 IFRD1 | E2_Ab | (PostTx) | (PreTx)1.521.574.49N/A77.02
71 TM9SF4 | E6_Ab | (PostTx) | (PreTx)-1.52-1.19-3.41N/A87.58
72 SRRM2 | E16_Ab | (PostTx) | (PreTx)1.491.584.45N/A76.52
73 AFF2 | E24_Db | (PostTx) | (PreTx)1.491.183.30N/A87.94
74 MAP3K7IP3 | E8_Ab | (PostTx) | (PreTx)1.48-1.112.51-1.2689.64
75 CREBZF | E1_Ab | (PostTx) | (PreTx)1.482.346.52N/A68.79
76 TIAL1 | E10_Da | (PostTx) | (PreTx)1.471.534.23N/A77.35
77 ORMDL1 | E3_Ab | (PostTx) | (PreTx)1.461.694.66N/A74.59
78 CLN5 | E4_Ab | (PostTx) | (PreTx)1.46-1.102.51-1.2390.61
79 PLEKHG2 | E20_Da | (PostTx) | (PreTx)1.461.865.12N/A72.41
80 AC106788.3 | E6_Ab | (PostTx) | (PreTx)1.461.674.57N/A74.85
81 BCOR | E17_Da | (PostTx) | (PreTx)-1.45-1.06-2.89N/A95.17
82 C17orf87 | E8_Da | (PostTx) | (PreTx)-1.44-3.75-10.21N/A63.72
83 SEC16A | E19_Ab | (PostTx) | (PreTx)1.44-1.202.27-1.5682.00
84 STX5 | E2_Ab | (PostTx) | (PreTx)-1.431.03-2.61-1.0796.82
85 NDEL1 | E1_Ab | (PostTx) | (PreTx)-1.41-1.36-3.61N/A80.64
86 RBM4 | E4_Da | (PostTx) | (PreTx)-1.40-1.04-2.74N/A96.15
87 SLC35B2 | E4_Ab | (PostTx) | (PreTx)1.401.032.70N/A97.33
88 VPRBP | E17_Ab | (PostTx) | (PreTx)-1.39-1.07-2.82N/A93.60
89 GTPBP4 | E19_Ab | (PostTx) | (PreTx)-1.39-1.16-3.03N/A88.41
90 NFYC | E4_Ab | (PostTx) | (PreTx)1.391.012.66N/A98.59
91 NPHP3 | E45_Da | (PostTx) | (PreTx)1.392.606.81N/A66.75
92 APLNR | E1_Ac | (PostTx) | (PreTx)-1.37-2.60-6.69N/A66.58
93 ZNF419 | E10_Ad | (PostTx) | (PreTx)1.361.303.33N/A82.30
94 KYNU | E18_Da | (PostTx) | (PreTx)1.36-1.112.30-1.3088.56
95 MECP2 | E5_Da | (PostTx) | (PreTx)-1.35-1.44-3.65N/A78.13
96 RASGRP2 | E4_Ad | (PostTx) | (PreTx)1.341.403.55N/A79.03
97 SHMT1 | E16_Da | (PostTx) | (PreTx)-1.33-1.20-3.03N/A85.74
98 ZMYM2 | E4_Ab | (PostTx) | (PreTx)1.331.182.96N/A86.98
99 RPL31 | E2_Dc | (PostTx) | (PreTx)1.321.523.82N/A76.07
100 HMGA1 | E1_Ab | (PostTx) | (PreTx)-1.321.24-2.00-1.9176.21
101 NIF3L1 | E8_Ab | (PostTx) | (PreTx)1.311.132.81N/A89.31
102 SCAP | E12_Db | (PostTx) | (PreTx)1.31-1.062.34-1.1493.80
103 DNAJC14 | E2_Da | (PostTx) | (PreTx)-1.30-1.21-2.97N/A85.22
104 HRB | E15_Db | (PostTx) | (PreTx)-1.30-1.30-3.19N/A81.74
105 PH-4 | E6_Da | (PostTx) | (PreTx)1.292.215.41N/A68.00
106 HNRNPC | E3_Ab | (PostTx) | (PreTx)1.29-1.132.16-1.3886.17
107 RNF103 | E8_Da | (PostTx) | (PreTx)-1.29-1.32-3.23N/A80.70
108 CRTC1 | E15_Ab | (PostTx) | (PreTx)1.281.182.86N/A86.65
109 CLIP1 | E11_Da | (PostTx) | (PreTx)-1.28-1.27-3.08N/A82.54
110 ANTXR1 | E23_Ab | (PostTx) | (PreTx)-1.27-4.03-9.72N/A62.01
111 FBRS | E7_Ab | (PostTx) | (PreTx)1.271.192.88N/A85.58
112 SELM | E3_Ac | (PostTx) | (PreTx)-1.27-1.00-2.41N/A99.59
113 LYPLAL1 | E3_Ab | (PostTx) | (PreTx)-1.26-1.05-2.52N/A95.07
114 NPHP3 | E1_Ac | (PostTx) | (PreTx)1.252.606.19N/A65.63
115 AC145132.2 | E6_Da | (PostTx) | (PreTx)1.251.012.40N/A99.17
116 ATP6V1C1 | E13_Da | (PostTx) | (PreTx)-1.25-1.50-3.56N/A75.86
117 UCRC | E2_Da | (PostTx) | (PreTx)1.251.593.77N/A74.12
118 UNG | E2_Ab | (PostTx) | (PreTx)-1.24-1.20-2.84N/A85.00
119 LZIC | E9_Db | (PostTx) | (PreTx)-1.24-1.25-2.95N/A82.84
120 CDCA4 | E2_Da | (PostTx) | (PreTx)1.231.333.11N/A79.96
121 NCR3 | E2_Da | (PostTx) | (PreTx)-1.22-2.39-5.55N/A66.34
122 NFX1 | E2_Ab | (PostTx) | (PreTx)1.21-1.092.13-1.2490.19
123 CD40 | E4_Db | (PostTx) | (PreTx)1.212.465.68N/A65.84
124 ZC3H12D | E8_Ab | (PostTx) | (PreTx)1.202.445.60N/A65.92
125 MAP3K2 | E17_Db | (PostTx) | (PreTx)-1.19-1.40-3.21N/A77.49
126 MFSD5 | E3_Ab | (PostTx) | (PreTx)1.19-1.112.06-1.3487.40
127 PRPF38B | E1_Ac | (PostTx) | (PreTx)1.181.513.43N/A74.90
128 CCDC14 | E2_Ac | (PostTx) | (PreTx)1.172.515.65N/A65.26
129 C1S | E6_Ad | (PostTx) | (PreTx)-1.16-4.47-9.99N/A60.58
130 LSR | E1_Da | (PostTx) | (PreTx)1.161.473.29N/A75.42
131 RBM12 | E2_Ab | (PostTx) | (PreTx)1.16-1.032.17-1.0796.77
132 KCNN4 | E1_Ab | (PostTx) | (PreTx)1.152.014.45N/A68.20
133 MATR3 | E7_Ab | (PostTx) | (PreTx)-1.15-1.31-2.91N/A79.64
134 BTN3A2 | E1_Ab | (PostTx) | (PreTx)-1.131.03-2.14-1.0796.67
135 FOSL2 | E5_Da | (PostTx) | (PreTx)-1.13-2.92-6.38N/A63.36
136 SH3PXD2A | E17_Da | (PostTx) | (PreTx)-1.12-3.07-6.66N/A62.84
137 LY9 | E2_Ab | (PostTx) | (PreTx)-1.121.07-2.04-1.2091.73
138 TNFRSF14 | E2_Ab | (PostTx) | (PreTx)1.111.513.26N/A74.25
139 SLC12A8 | E14_Da | (PostTx) | (PreTx)-1.11-3.57-7.70N/A61.62
140 SELPLG | E2_Db | (PostTx) | (PreTx)-1.10-2.44-5.25N/A65.02
141 CTLA4 | E4_Da | (PostTx) | (PreTx)1.102.415.18N/A65.14
142 EPHB1 | E11_Da | (PostTx) | (PreTx)1.093.477.39N/A61.64
143 HMGB1 | E8_Dd | (PostTx) | (PreTx)-1.09-1.02-2.16N/A97.83
144 VAMP1 | E4_Ab | (PostTx) | (PreTx)1.094.389.30N/A60.18
145 TBL1X | E20_Db | (PostTx) | (PreTx)-1.09-1.62-3.44N/A71.90
146 TIMD4 | E10_Da | (PostTx) | (PreTx)1.08-5.75-2.71N/A36.31
147 STARD3NL | E10_Da | (PostTx) | (PreTx)1.081.543.26N/A73.26
148 KIAA0652 | E18_Da | (PostTx) | (PreTx)-1.08-1.28-2.71N/A80.07
149 MPP1 | E3_Da | (PostTx) | (PreTx)-1.08-2.32-4.89N/A65.37
150 BCAS3 | E16_Da | (PostTx) | (PreTx)-1.07-1.60-3.34N/A72.08
151 C22orf9 | E11_Da | (PostTx) | (PreTx)-1.05-2.15-4.45N/A66.11
152 SMARCC2 | E28_Da | (PostTx) | (PreTx)1.041.092.24N/A90.67
153 SLC2A11 | E5_Ab | (PostTx) | (PreTx)1.041.913.93N/A67.89
154 QKI | E7_Dc | (PostTx) | (PreTx)-1.04-1.62-3.34N/A71.34
155 RAPH1 | E4_Da | (PostTx) | (PreTx)-1.04-2.82-5.78N/A62.89
156 ANKRD11 | E10_Ac | (PostTx) | (PreTx)-1.03-1.36-2.78N/A76.86
157 PLEKHA1 | E15_Db | (PostTx) | (PreTx)-1.03-1.63-3.34N/A71.05
158 C7orf43 | E13_Db | (PostTx) | (PreTx)1.031.703.47N/A70.15
159 CD9 | E2_Ab | (PostTx) | (PreTx)-1.03-2.23-4.55N/A65.42
160 TLK1 | E24_Da | (PostTx) | (PreTx)-1.03-1.40-2.86N/A75.58
161 PTRF | E1_Da | (PostTx) | (PreTx)1.02-5.21-2.57N/A36.36
162 RBMX2 | E1_Ab | (PostTx) | (PreTx)-1.02-1.28-2.61N/A79.27
163 ARPC5 | E1_Ac | (PostTx) | (PreTx)1.021.412.85N/A75.47
164 ZNF675 | E4_Db | (PostTx) | (PreTx)1.021.583.20N/A71.77
165 DYNC1I2 | E2_Ad | (PostTx) | (PreTx)-1.02-1.26-2.56N/A80.06
166 PLEKHB2 | E1_Ab | (PostTx) | (PreTx)-1.02-1.41-2.85N/A75.34
167 RPS27A | E6_Da | (PostTx) | (PreTx)1.012.475.00N/A63.99
168 SETDB2 | E7_Ab | (PostTx) | (PreTx)1.011.753.54N/A69.26
169 SEPT8 | E10_Ac | (PostTx) | (PreTx)-1.01-1.82-3.68N/A68.47
170 MRS2L | E11_Da | (PostTx) | (PreTx)1.011.472.97N/A73.82
171 PPM1B | E2_Da | (PostTx) | (PreTx)-1.01-1.14-2.30N/A86.42
172 PEX3 | E8_Da | (PostTx) | (PreTx)1.011.342.70N/A77.22
173 KLHL6 | E5_Dc | (PostTx) | (PreTx)1.011.472.95N/A73.72