Alternative expression values of the type: KnownBoundary for comparison: PostTx_vs_PreTx (abs(SI) value > 2)


Distribution of log2 SI values for comparison: PostTx_vs_PreTx and data type: KnownBoundary

Distribution of all splicing index values that meet the SI cutoff (indicated by red dotted lines) for the feature type: KnownBoundary. The total number of features with SI values exceeding the cutoff, as well as the max and min log2 SI observed are noted in the legend. *If you can not see the figure below, click here




Significant alternatively expressed KnownBoundary features

The following table provides a ranked list of alternatively expressed KnownBoundary features for a single pair-wise library comparison. The first column contains the Gene Name (which links to the ALEXA-Seq gene record), the Feature Name, and the name of each library being compared (which links to the feature's coordinates in the UCSC Genome Browser and displays expression data). The 'SI' column reports the Splicing Index calculated for the feature. The 'Gene FC' column reports the Fold-Change calculated for the entire gene to which the feature belongs. The 'Seq FC' column reports the Fold-Change of the feature itself. The 'Reciprocity' column reports the Reciprocity Index (RI) for the feature. The 'Percent Seq DE' column reports the Percent Feature Contribution (PFC) value for the feature. A description of the purpose and calculation of SI, RI and PFC values can be found in our manuscript. Briefly, the SI value is a measure of the degree of change in expression of a feature (e.g. an exon) between two conditions relative to the change in expression at the gene level. The RI value is a measure of the degree to which the change of the feature is reciprocal in direction to that observed for the gene overall. For example, if an exon is up-regulated but the gene overall is down-regulated, this will give a higher RI value. The PFC value is a measure of the degree of differential expression of the feature compared to the entire gene. For example, if a gene is not changed overall between two conditions, but the feature is highly differentially expressed, this will give a higher PFC value. To sort this table by each of the data values, simply click the column header. A bold row indicates that the feature is not currently supported by EST or mRNA sequence alignments. For exon junction features the number of exons skipped by the junction is indicated as 'Sn' where n is the number of exons skipped (e.g. S0 means no exons skipped, S1 means one exon skipped, etc.).


RANKPostTx_vs_PreTx (Gene | Feature | Links)SIGene FCSeq FCReciprocityPercent Seq DE
1 SELM | E3_Ac | (PostTx) | (PreTx)-1.27-1.00-2.41N/A99.59
2 AC145132.2 | E6_Da | (PostTx) | (PreTx)1.251.012.40N/A99.17
3 CCDC86 | E1_Db | (PostTx) | (PreTx)-1.78-1.01-3.47N/A99.04
4 NFYC | E4_Ab | (PostTx) | (PreTx)1.391.012.66N/A98.59
5 WDR33 | E7_Ab | (PostTx) | (PreTx)2.591.046.23N/A98.13
6 OGFR | E2_Da | (PostTx) | (PreTx)2.69-1.046.23-1.0497.93
7 HMGB1 | E8_Dd | (PostTx) | (PreTx)-1.09-1.02-2.16N/A97.83
8 SLC35B2 | E4_Ab | (PostTx) | (PreTx)1.401.032.70N/A97.33
9 USP48 | E11_Da | (PostTx) | (PreTx)2.071.044.37N/A97.32
10 BCL2L1 | E2_Ab | (PostTx) | (PreTx)2.26-1.044.57-1.0697.22
11 KIAA1826 | E2_Ac | (PostTx) | (PreTx)1.591.033.11N/A97.09
12 STX5 | E2_Ab | (PostTx) | (PreTx)-1.431.03-2.61-1.0796.82
13 RBM12 | E2_Ab | (PostTx) | (PreTx)1.16-1.032.17-1.0796.77
14 BTN3A2 | E1_Ab | (PostTx) | (PreTx)-1.131.03-2.14-1.0796.67
15 RBM4 | E4_Da | (PostTx) | (PreTx)-1.40-1.04-2.74N/A96.15
16 PRKCBP1 | E25_Db | (PostTx) | (PreTx)-1.54-1.05-3.06N/A95.66
17 BCOR | E17_Da | (PostTx) | (PreTx)-1.45-1.06-2.89N/A95.17
18 LYPLAL1 | E3_Ab | (PostTx) | (PreTx)-1.26-1.05-2.52N/A95.07
19 MBP | E15_Da | (PostTx) | (PreTx)2.721.117.33N/A94.85
20 TDRKH | E5_Da | (PostTx) | (PreTx)-2.06-1.09-4.57N/A94.49
21 NNT | E23_Da | (PostTx) | (PreTx)2.15-1.094.07-1.1394.28
22 MRPL12 | E1_Ab | (PostTx) | (PreTx)1.761.083.66N/A94.24
23 AP006216.9 | E20_Ab | (PostTx) | (PreTx)1.711.083.54N/A94.18
24 SCAP | E12_Db | (PostTx) | (PreTx)1.31-1.062.34-1.1493.80
25 INTS6 | E1_Da | (PostTx) | (PreTx)2.181.125.05N/A93.63
26 VPRBP | E17_Ab | (PostTx) | (PreTx)-1.39-1.07-2.82N/A93.60
27 PPM1A | E5_Db | (PostTx) | (PreTx)2.491.176.57N/A92.28
28 OAS1 | E6_Ab | (PostTx) | (PreTx)1.631.113.45N/A92.15
29 ILI8BP | E2_Ae | (PostTx) | (PreTx)1.99-1.123.55-1.1991.85
30 LY9 | E2_Ab | (PostTx) | (PreTx)-1.121.07-2.04-1.2091.73
31 CAMSAP1 | E19_Da | (PostTx) | (PreTx)1.831.154.07N/A91.15
32 SMARCC2 | E28_Da | (PostTx) | (PreTx)1.041.092.24N/A90.67
33 CLN5 | E4_Ab | (PostTx) | (PreTx)1.46-1.102.51-1.2390.61
34 NFX1 | E2_Ab | (PostTx) | (PreTx)1.21-1.092.13-1.2490.19
35 TP53RK | E1_Ab | (PostTx) | (PreTx)1.88-1.143.22-1.2589.84
36 C7orf27 | E5_Da | (PostTx) | (PreTx)2.081.205.06N/A89.82
37 NCF4 | E8_Da | (PostTx) | (PreTx)1.601.153.49N/A89.69
38 MAP3K7IP3 | E8_Ab | (PostTx) | (PreTx)1.48-1.112.51-1.2689.64
39 BCL2L12 | E1_Ab | (PostTx) | (PreTx)-2.831.23-5.77-1.2789.39
40 NIF3L1 | E8_Ab | (PostTx) | (PreTx)1.311.132.81N/A89.31
41 RASSF4 | E3_Ab | (PostTx) | (PreTx)2.301.246.12N/A89.28
42 TRIM26 | E1_Ab | (PostTx) | (PreTx)-1.65-1.17-3.68N/A89.23
43 KYNU | E18_Da | (PostTx) | (PreTx)1.36-1.112.30-1.3088.56
44 GTPBP4 | E19_Ab | (PostTx) | (PreTx)-1.39-1.16-3.03N/A88.41
45 AC135457.2 | E1_Da | (PostTx) | (PreTx)1.931.224.66N/A88.38
46 DPY19L3 | E3_Ab | (PostTx) | (PreTx)2.071.245.21N/A88.38
47 BTF3L4 | E6_Da | (PostTx) | (PreTx)-2.481.22-4.57-1.3088.36
48 NCDN | E1_Da | (PostTx) | (PreTx)2.391.306.81N/A88.11
49 UBAP2 | E30_Dd | (PostTx) | (PreTx)2.071.255.25N/A88.01
50 AFF2 | E24_Db | (PostTx) | (PreTx)1.491.183.30N/A87.94
51 AC093620.6 | E32_Da | (PostTx) | (PreTx)1.65-1.152.73-1.3287.79
52 ODF2 | E7_Da | (PostTx) | (PreTx)1.691.213.89N/A87.76
53 TM9SF4 | E6_Ab | (PostTx) | (PreTx)-1.52-1.19-3.41N/A87.58
54 MFSD5 | E3_Ab | (PostTx) | (PreTx)1.19-1.112.06-1.3487.40
55 ZMYM2 | E4_Ab | (PostTx) | (PreTx)1.331.182.96N/A86.98
56 PAQR3 | E8_Da | (PostTx) | (PreTx)-2.211.22-3.78-1.3586.94
57 RAB2B | E4_Ab | (PostTx) | (PreTx)-1.921.19-3.18-1.3686.90
58 CRTC1 | E15_Ab | (PostTx) | (PreTx)1.281.182.86N/A86.65
59 PPM1B | E2_Da | (PostTx) | (PreTx)-1.01-1.14-2.30N/A86.42
60 C6orf61 | E12_Ab | (PostTx) | (PreTx)1.591.233.72N/A86.24
61 HNRNPC | E3_Ab | (PostTx) | (PreTx)1.29-1.132.16-1.3886.17
62 ANKRD41 | E5_Da | (PostTx) | (PreTx)2.311.376.77N/A85.87
63 SHMT1 | E16_Da | (PostTx) | (PreTx)-1.33-1.20-3.03N/A85.74
64 FBRS | E7_Ab | (PostTx) | (PreTx)1.271.192.88N/A85.58
65 DNAJC14 | E2_Da | (PostTx) | (PreTx)-1.30-1.21-2.97N/A85.22
66 UNG | E2_Ab | (PostTx) | (PreTx)-1.24-1.20-2.84N/A85.00
67 RASGRP2 | E4_Ae | (PostTx) | (PreTx)2.051.405.78N/A83.93
68 FLAD1 | E1_Da | (PostTx) | (PreTx)1.631.314.07N/A83.82
69 ITGA4 | E1_Ac | (PostTx) | (PreTx)-1.66-1.33-4.19N/A83.47
70 MICAL1 | E8_Da | (PostTx) | (PreTx)2.881.6412.08N/A83.37
71 LZIC | E9_Db | (PostTx) | (PreTx)-1.24-1.25-2.95N/A82.84
72 CLIP1 | E11_Da | (PostTx) | (PreTx)-1.28-1.27-3.08N/A82.54
73 ZNF419 | E10_Ad | (PostTx) | (PreTx)1.361.303.33N/A82.30
74 HMGB1L15 | E1_Da | (PostTx) | (PreTx)-1.561.21-2.43-1.5582.26
75 SEC16A | E19_Ab | (PostTx) | (PreTx)1.44-1.202.27-1.5682.00
76 FGFR1OP | E13_Da | (PostTx) | (PreTx)1.821.435.06N/A81.95
77 HRB | E15_Db | (PostTx) | (PreTx)-1.30-1.30-3.19N/A81.74
78 RNF103 | E8_Da | (PostTx) | (PreTx)-1.29-1.32-3.23N/A80.70
79 NDRG3 | E5_Da | (PostTx) | (PreTx)-2.06-1.57-6.54N/A80.69
80 NDEL1 | E1_Ab | (PostTx) | (PreTx)-1.41-1.36-3.61N/A80.64
81 ANKMY1 | E9_Da | (PostTx) | (PreTx)1.841.515.39N/A80.44
82 KIAA0652 | E18_Da | (PostTx) | (PreTx)-1.08-1.28-2.71N/A80.07
83 DYNC1I2 | E2_Ad | (PostTx) | (PreTx)-1.02-1.26-2.56N/A80.06
84 CDCA4 | E2_Da | (PostTx) | (PreTx)1.231.333.11N/A79.96
85 GBA2 | E14_Ab | (PostTx) | (PreTx)1.791.525.25N/A79.76
86 MATR3 | E7_Ab | (PostTx) | (PreTx)-1.15-1.31-2.91N/A79.64
87 RBMX2 | E1_Ab | (PostTx) | (PreTx)-1.02-1.28-2.61N/A79.27
88 RASGRP2 | E4_Ad | (PostTx) | (PreTx)1.341.403.55N/A79.03
89 DYNLT1 | E3_Da | (PostTx) | (PreTx)2.091.737.39N/A78.48
90 MICAL1 | E8_Ab | (PostTx) | (PreTx)1.891.646.11N/A78.45
91 MECP2 | E5_Da | (PostTx) | (PreTx)-1.35-1.44-3.65N/A78.13
92 QKI | E7_Ad | (PostTx) | (PreTx)-1.80-1.62-5.63N/A78.12
93 POMT1 | E8_Da | (PostTx) | (PreTx)1.801.635.65N/A78.07
94 SPTY2D1 | E3_Da | (PostTx) | (PreTx)1.81-1.322.66-1.8077.80
95 C10orf54 | E2_Ab | (PostTx) | (PreTx)-2.38-1.95-10.19N/A77.64
96 MAP3K2 | E17_Db | (PostTx) | (PreTx)-1.19-1.40-3.21N/A77.49
97 DAAM1 | E21_Ab | (PostTx) | (PreTx)1.531.544.46N/A77.46
98 TIAL1 | E10_Da | (PostTx) | (PreTx)1.471.534.23N/A77.35
99 PEX3 | E8_Da | (PostTx) | (PreTx)1.011.342.70N/A77.22
100 IFRD1 | E2_Ab | (PostTx) | (PreTx)1.521.574.49N/A77.02
101 ANKRD11 | E10_Ac | (PostTx) | (PreTx)-1.03-1.36-2.78N/A76.86
102 ZNF117 | E4_Db | (PostTx) | (PreTx)2.011.837.39N/A76.77
103 SRRM2 | E16_Ab | (PostTx) | (PreTx)1.491.584.45N/A76.52
104 HMGA1 | E1_Ab | (PostTx) | (PreTx)-1.321.24-2.00-1.9176.21
105 RPL31 | E2_Dc | (PostTx) | (PreTx)1.321.523.82N/A76.07
106 MAN1B1 | E13_Da | (PostTx) | (PreTx)-2.191.44-3.18-1.9276.05
107 ATP6V1C1 | E13_Da | (PostTx) | (PreTx)-1.25-1.50-3.56N/A75.86
108 TLK1 | E24_Da | (PostTx) | (PreTx)-1.03-1.40-2.86N/A75.58
109 ARPC5 | E1_Ac | (PostTx) | (PreTx)1.021.412.85N/A75.47
110 LSR | E1_Da | (PostTx) | (PreTx)1.161.473.29N/A75.42
111 PLEKHB2 | E1_Ab | (PostTx) | (PreTx)-1.02-1.41-2.85N/A75.34
112 RAB24 | E4_Ab | (PostTx) | (PreTx)1.651.765.52N/A75.14
113 TMEM102 | E1_Da | (PostTx) | (PreTx)-1.53-1.70-4.91N/A75.04
114 SUPT7L | E2_Ab | (PostTx) | (PreTx)1.591.745.26N/A74.93
115 PRPF38B | E1_Ac | (PostTx) | (PreTx)1.181.513.43N/A74.90
116 AC106788.3 | E6_Ab | (PostTx) | (PreTx)1.461.674.57N/A74.85
117 DYNLT1 | E3_Dc | (PostTx) | (PreTx)1.551.735.06N/A74.74
118 ORMDL1 | E3_Ab | (PostTx) | (PreTx)1.461.694.66N/A74.59
119 AGXT2L2 | E5_Da | (PostTx) | (PreTx)1.841.946.96N/A74.47
120 FANCL | E1_Ac | (PostTx) | (PreTx)1.541.745.06N/A74.45
121 SPSB3 | E6_Ab | (PostTx) | (PreTx)1.581.785.32N/A74.40
122 TNFRSF14 | E2_Ab | (PostTx) | (PreTx)1.111.513.26N/A74.25
123 UCRC | E2_Da | (PostTx) | (PreTx)1.251.593.77N/A74.12
124 MRS2L | E11_Da | (PostTx) | (PreTx)1.011.472.97N/A73.82
125 KLHL6 | E5_Dc | (PostTx) | (PreTx)1.011.472.95N/A73.72
126 NRIP1 | E4_Da | (PostTx) | (PreTx)-1.63-1.87-5.79N/A73.64
127 GLIPR2 | E8_Da | (PostTx) | (PreTx)-1.57-1.84-5.48N/A73.54
128 STARD3NL | E10_Da | (PostTx) | (PreTx)1.081.543.26N/A73.26
129 MS4A1 | E2_Ab | (PostTx) | (PreTx)1.672.006.39N/A72.76
130 RPL31 | E2_Da | (PostTx) | (PreTx)-2.211.52-3.04-2.2272.50
131 PLEKHG2 | E20_Da | (PostTx) | (PreTx)1.461.865.12N/A72.41
132 BCAS3 | E16_Da | (PostTx) | (PreTx)-1.07-1.60-3.34N/A72.08
133 TBL1X | E20_Db | (PostTx) | (PreTx)-1.09-1.62-3.44N/A71.90
134 ZNF675 | E4_Db | (PostTx) | (PreTx)1.021.583.20N/A71.77
135 QKI | E7_Dc | (PostTx) | (PreTx)-1.04-1.62-3.34N/A71.34
136 PNRC1 | E1_Da | (PostTx) | (PreTx)1.70-1.402.32-2.3571.26
137 PLEKHA1 | E15_Db | (PostTx) | (PreTx)-1.03-1.63-3.34N/A71.05
138 C7orf43 | E13_Db | (PostTx) | (PreTx)1.031.703.47N/A70.15
139 TMSL3 | E1_Ab | (PostTx) | (PreTx)-1.941.50-2.56-2.5070.02
140 NCR3 | E1_Ab | (PostTx) | (PreTx)-1.66-2.39-7.55N/A69.92
141 LAIR1 | E11_Db | (PostTx) | (PreTx)-1.67-2.44-7.76N/A69.71
142 SETDB2 | E7_Ab | (PostTx) | (PreTx)1.011.753.54N/A69.26
143 CREBZF | E1_Ab | (PostTx) | (PreTx)1.482.346.52N/A68.79
144 SEPT8 | E10_Ac | (PostTx) | (PreTx)-1.01-1.82-3.68N/A68.47
145 MXRA7 | E5_Da | (PostTx) | (PreTx)-1.59-2.57-7.70N/A68.41
146 KCNN4 | E1_Ab | (PostTx) | (PreTx)1.152.014.45N/A68.20
147 PH-4 | E6_Da | (PostTx) | (PreTx)1.292.215.41N/A68.00
148 SLC2A11 | E5_Ab | (PostTx) | (PreTx)1.041.913.93N/A67.89
149 NPHP3 | E45_Da | (PostTx) | (PreTx)1.392.606.81N/A66.75
150 APLNR | E1_Ac | (PostTx) | (PreTx)-1.37-2.60-6.69N/A66.58
151 NCR3 | E2_Da | (PostTx) | (PreTx)-1.22-2.39-5.55N/A66.34
152 C22orf9 | E11_Da | (PostTx) | (PreTx)-1.05-2.15-4.45N/A66.11
153 ZC3H12D | E8_Ab | (PostTx) | (PreTx)1.202.445.60N/A65.92
154 CD40 | E4_Db | (PostTx) | (PreTx)1.212.465.68N/A65.84
155 NPHP3 | E1_Ac | (PostTx) | (PreTx)1.252.606.19N/A65.63
156 CD9 | E2_Ab | (PostTx) | (PreTx)-1.03-2.23-4.55N/A65.42
157 MPP1 | E3_Da | (PostTx) | (PreTx)-1.08-2.32-4.89N/A65.37
158 CCDC14 | E2_Ac | (PostTx) | (PreTx)1.172.515.65N/A65.26
159 CTLA4 | E4_Da | (PostTx) | (PreTx)1.102.415.18N/A65.14
160 SELPLG | E2_Db | (PostTx) | (PreTx)-1.10-2.44-5.25N/A65.02
161 AQP1 | E5_Dd | (PostTx) | (PreTx)-1.59-3.66-11.05N/A64.93
162 RPS27A | E6_Da | (PostTx) | (PreTx)1.012.475.00N/A63.99
163 C17orf87 | E8_Da | (PostTx) | (PreTx)-1.44-3.75-10.21N/A63.72
164 FOSL2 | E5_Da | (PostTx) | (PreTx)-1.13-2.92-6.38N/A63.36
165 RAPH1 | E4_Da | (PostTx) | (PreTx)-1.04-2.82-5.78N/A62.89
166 SH3PXD2A | E17_Da | (PostTx) | (PreTx)-1.12-3.07-6.66N/A62.84
167 ANTXR1 | E23_Ab | (PostTx) | (PreTx)-1.27-4.03-9.72N/A62.01
168 EPHB1 | E11_Da | (PostTx) | (PreTx)1.093.477.39N/A61.64
169 SLC12A8 | E14_Da | (PostTx) | (PreTx)-1.11-3.57-7.70N/A61.62
170 C1S | E6_Ad | (PostTx) | (PreTx)-1.16-4.47-9.99N/A60.58
171 VAMP1 | E4_Ab | (PostTx) | (PreTx)1.094.389.30N/A60.18
172 PTRF | E1_Da | (PostTx) | (PreTx)1.02-5.21-2.57N/A36.36
173 TIMD4 | E10_Da | (PostTx) | (PreTx)1.08-5.75-2.71N/A36.31