Alternative expression values of the type: KnownBoundary for comparison: PostTx_vs_PreTx (abs(SI) value > 2)


Distribution of log2 SI values for comparison: PostTx_vs_PreTx and data type: KnownBoundary

Distribution of all splicing index values that meet the SI cutoff (indicated by red dotted lines) for the feature type: KnownBoundary. The total number of features with SI values exceeding the cutoff, as well as the max and min log2 SI observed are noted in the legend. *If you can not see the figure below, click here




Significant alternatively expressed KnownBoundary features

The following table provides a ranked list of alternatively expressed KnownBoundary features for a single pair-wise library comparison. The first column contains the Gene Name (which links to the ALEXA-Seq gene record), the Feature Name, and the name of each library being compared (which links to the feature's coordinates in the UCSC Genome Browser and displays expression data). The 'SI' column reports the Splicing Index calculated for the feature. The 'Gene FC' column reports the Fold-Change calculated for the entire gene to which the feature belongs. The 'Seq FC' column reports the Fold-Change of the feature itself. The 'Reciprocity' column reports the Reciprocity Index (RI) for the feature. The 'Percent Seq DE' column reports the Percent Feature Contribution (PFC) value for the feature. A description of the purpose and calculation of SI, RI and PFC values can be found in our manuscript. Briefly, the SI value is a measure of the degree of change in expression of a feature (e.g. an exon) between two conditions relative to the change in expression at the gene level. The RI value is a measure of the degree to which the change of the feature is reciprocal in direction to that observed for the gene overall. For example, if an exon is up-regulated but the gene overall is down-regulated, this will give a higher RI value. The PFC value is a measure of the degree of differential expression of the feature compared to the entire gene. For example, if a gene is not changed overall between two conditions, but the feature is highly differentially expressed, this will give a higher PFC value. To sort this table by each of the data values, simply click the column header. A bold row indicates that the feature is not currently supported by EST or mRNA sequence alignments. For exon junction features the number of exons skipped by the junction is indicated as 'Sn' where n is the number of exons skipped (e.g. S0 means no exons skipped, S1 means one exon skipped, etc.).


RANKPostTx_vs_PreTx (Gene | Feature | Links)SIGene FCSeq FCReciprocityPercent Seq DE
1 TIMD4 | E10_Da | (PostTx) | (PreTx)1.08-5.75-2.71N/A36.31
2 PTRF | E1_Da | (PostTx) | (PreTx)1.02-5.21-2.57N/A36.36
3 C1S | E6_Ad | (PostTx) | (PreTx)-1.16-4.47-9.99N/A60.58
4 VAMP1 | E4_Ab | (PostTx) | (PreTx)1.094.389.30N/A60.18
5 ANTXR1 | E23_Ab | (PostTx) | (PreTx)-1.27-4.03-9.72N/A62.01
6 C17orf87 | E8_Da | (PostTx) | (PreTx)-1.44-3.75-10.21N/A63.72
7 AQP1 | E5_Dd | (PostTx) | (PreTx)-1.59-3.66-11.05N/A64.93
8 SLC12A8 | E14_Da | (PostTx) | (PreTx)-1.11-3.57-7.70N/A61.62
9 EPHB1 | E11_Da | (PostTx) | (PreTx)1.093.477.39N/A61.64
10 SH3PXD2A | E17_Da | (PostTx) | (PreTx)-1.12-3.07-6.66N/A62.84
11 FOSL2 | E5_Da | (PostTx) | (PreTx)-1.13-2.92-6.38N/A63.36
12 RAPH1 | E4_Da | (PostTx) | (PreTx)-1.04-2.82-5.78N/A62.89
13 NPHP3 | E1_Ac | (PostTx) | (PreTx)1.252.606.19N/A65.63
14 NPHP3 | E45_Da | (PostTx) | (PreTx)1.392.606.81N/A66.75
15 APLNR | E1_Ac | (PostTx) | (PreTx)-1.37-2.60-6.69N/A66.58
16 MXRA7 | E5_Da | (PostTx) | (PreTx)-1.59-2.57-7.70N/A68.41
17 CCDC14 | E2_Ac | (PostTx) | (PreTx)1.172.515.65N/A65.26
18 RPS27A | E6_Da | (PostTx) | (PreTx)1.012.475.00N/A63.99
19 CD40 | E4_Db | (PostTx) | (PreTx)1.212.465.68N/A65.84
20 SELPLG | E2_Db | (PostTx) | (PreTx)-1.10-2.44-5.25N/A65.02
21 ZC3H12D | E8_Ab | (PostTx) | (PreTx)1.202.445.60N/A65.92
22 LAIR1 | E11_Db | (PostTx) | (PreTx)-1.67-2.44-7.76N/A69.71
23 CTLA4 | E4_Da | (PostTx) | (PreTx)1.102.415.18N/A65.14
24 NCR3 | E2_Da | (PostTx) | (PreTx)-1.22-2.39-5.55N/A66.34
25 NCR3 | E1_Ab | (PostTx) | (PreTx)-1.66-2.39-7.55N/A69.92
26 CREBZF | E1_Ab | (PostTx) | (PreTx)1.482.346.52N/A68.79
27 MPP1 | E3_Da | (PostTx) | (PreTx)-1.08-2.32-4.89N/A65.37
28 CD9 | E2_Ab | (PostTx) | (PreTx)-1.03-2.23-4.55N/A65.42
29 PH-4 | E6_Da | (PostTx) | (PreTx)1.292.215.41N/A68.00
30 C22orf9 | E11_Da | (PostTx) | (PreTx)-1.05-2.15-4.45N/A66.11
31 KCNN4 | E1_Ab | (PostTx) | (PreTx)1.152.014.45N/A68.20
32 MS4A1 | E2_Ab | (PostTx) | (PreTx)1.672.006.39N/A72.76
33 C10orf54 | E2_Ab | (PostTx) | (PreTx)-2.38-1.95-10.19N/A77.64
34 AGXT2L2 | E5_Da | (PostTx) | (PreTx)1.841.946.96N/A74.47
35 SLC2A11 | E5_Ab | (PostTx) | (PreTx)1.041.913.93N/A67.89
36 NRIP1 | E4_Da | (PostTx) | (PreTx)-1.63-1.87-5.79N/A73.64
37 PLEKHG2 | E20_Da | (PostTx) | (PreTx)1.461.865.12N/A72.41
38 GLIPR2 | E8_Da | (PostTx) | (PreTx)-1.57-1.84-5.48N/A73.54
39 ZNF117 | E4_Db | (PostTx) | (PreTx)2.011.837.39N/A76.77
40 SEPT8 | E10_Ac | (PostTx) | (PreTx)-1.01-1.82-3.68N/A68.47
41 SPSB3 | E6_Ab | (PostTx) | (PreTx)1.581.785.32N/A74.40
42 RAB24 | E4_Ab | (PostTx) | (PreTx)1.651.765.52N/A75.14
43 SETDB2 | E7_Ab | (PostTx) | (PreTx)1.011.753.54N/A69.26
44 FANCL | E1_Ac | (PostTx) | (PreTx)1.541.745.06N/A74.45
45 SUPT7L | E2_Ab | (PostTx) | (PreTx)1.591.745.26N/A74.93
46 DYNLT1 | E3_Da | (PostTx) | (PreTx)2.091.737.39N/A78.48
47 DYNLT1 | E3_Dc | (PostTx) | (PreTx)1.551.735.06N/A74.74
48 C7orf43 | E13_Db | (PostTx) | (PreTx)1.031.703.47N/A70.15
49 TMEM102 | E1_Da | (PostTx) | (PreTx)-1.53-1.70-4.91N/A75.04
50 ORMDL1 | E3_Ab | (PostTx) | (PreTx)1.461.694.66N/A74.59
51 AC106788.3 | E6_Ab | (PostTx) | (PreTx)1.461.674.57N/A74.85
52 MICAL1 | E8_Ab | (PostTx) | (PreTx)1.891.646.11N/A78.45
53 MICAL1 | E8_Da | (PostTx) | (PreTx)2.881.6412.08N/A83.37
54 PLEKHA1 | E15_Db | (PostTx) | (PreTx)-1.03-1.63-3.34N/A71.05
55 POMT1 | E8_Da | (PostTx) | (PreTx)1.801.635.65N/A78.07
56 QKI | E7_Dc | (PostTx) | (PreTx)-1.04-1.62-3.34N/A71.34
57 QKI | E7_Ad | (PostTx) | (PreTx)-1.80-1.62-5.63N/A78.12
58 TBL1X | E20_Db | (PostTx) | (PreTx)-1.09-1.62-3.44N/A71.90
59 BCAS3 | E16_Da | (PostTx) | (PreTx)-1.07-1.60-3.34N/A72.08
60 UCRC | E2_Da | (PostTx) | (PreTx)1.251.593.77N/A74.12
61 ZNF675 | E4_Db | (PostTx) | (PreTx)1.021.583.20N/A71.77
62 SRRM2 | E16_Ab | (PostTx) | (PreTx)1.491.584.45N/A76.52
63 NDRG3 | E5_Da | (PostTx) | (PreTx)-2.06-1.57-6.54N/A80.69
64 IFRD1 | E2_Ab | (PostTx) | (PreTx)1.521.574.49N/A77.02
65 DAAM1 | E21_Ab | (PostTx) | (PreTx)1.531.544.46N/A77.46
66 STARD3NL | E10_Da | (PostTx) | (PreTx)1.081.543.26N/A73.26
67 TIAL1 | E10_Da | (PostTx) | (PreTx)1.471.534.23N/A77.35
68 RPL31 | E2_Da | (PostTx) | (PreTx)-2.211.52-3.04-2.2272.50
69 RPL31 | E2_Dc | (PostTx) | (PreTx)1.321.523.82N/A76.07
70 GBA2 | E14_Ab | (PostTx) | (PreTx)1.791.525.25N/A79.76
71 PRPF38B | E1_Ac | (PostTx) | (PreTx)1.181.513.43N/A74.90
72 TNFRSF14 | E2_Ab | (PostTx) | (PreTx)1.111.513.26N/A74.25
73 ANKMY1 | E9_Da | (PostTx) | (PreTx)1.841.515.39N/A80.44
74 ATP6V1C1 | E13_Da | (PostTx) | (PreTx)-1.25-1.50-3.56N/A75.86
75 TMSL3 | E1_Ab | (PostTx) | (PreTx)-1.941.50-2.56-2.5070.02
76 LSR | E1_Da | (PostTx) | (PreTx)1.161.473.29N/A75.42
77 MRS2L | E11_Da | (PostTx) | (PreTx)1.011.472.97N/A73.82
78 KLHL6 | E5_Dc | (PostTx) | (PreTx)1.011.472.95N/A73.72
79 MAN1B1 | E13_Da | (PostTx) | (PreTx)-2.191.44-3.18-1.9276.05
80 MECP2 | E5_Da | (PostTx) | (PreTx)-1.35-1.44-3.65N/A78.13
81 FGFR1OP | E13_Da | (PostTx) | (PreTx)1.821.435.06N/A81.95
82 PLEKHB2 | E1_Ab | (PostTx) | (PreTx)-1.02-1.41-2.85N/A75.34
83 ARPC5 | E1_Ac | (PostTx) | (PreTx)1.021.412.85N/A75.47
84 TLK1 | E24_Da | (PostTx) | (PreTx)-1.03-1.40-2.86N/A75.58
85 PNRC1 | E1_Da | (PostTx) | (PreTx)1.70-1.402.32-2.3571.26
86 MAP3K2 | E17_Db | (PostTx) | (PreTx)-1.19-1.40-3.21N/A77.49
87 RASGRP2 | E4_Ae | (PostTx) | (PreTx)2.051.405.78N/A83.93
88 RASGRP2 | E4_Ad | (PostTx) | (PreTx)1.341.403.55N/A79.03
89 ANKRD41 | E5_Da | (PostTx) | (PreTx)2.311.376.77N/A85.87
90 NDEL1 | E1_Ab | (PostTx) | (PreTx)-1.41-1.36-3.61N/A80.64
91 ANKRD11 | E10_Ac | (PostTx) | (PreTx)-1.03-1.36-2.78N/A76.86
92 PEX3 | E8_Da | (PostTx) | (PreTx)1.011.342.70N/A77.22
93 CDCA4 | E2_Da | (PostTx) | (PreTx)1.231.333.11N/A79.96
94 ITGA4 | E1_Ac | (PostTx) | (PreTx)-1.66-1.33-4.19N/A83.47
95 RNF103 | E8_Da | (PostTx) | (PreTx)-1.29-1.32-3.23N/A80.70
96 SPTY2D1 | E3_Da | (PostTx) | (PreTx)1.81-1.322.66-1.8077.80
97 MATR3 | E7_Ab | (PostTx) | (PreTx)-1.15-1.31-2.91N/A79.64
98 FLAD1 | E1_Da | (PostTx) | (PreTx)1.631.314.07N/A83.82
99 ZNF419 | E10_Ad | (PostTx) | (PreTx)1.361.303.33N/A82.30
100 HRB | E15_Db | (PostTx) | (PreTx)-1.30-1.30-3.19N/A81.74
101 NCDN | E1_Da | (PostTx) | (PreTx)2.391.306.81N/A88.11
102 RBMX2 | E1_Ab | (PostTx) | (PreTx)-1.02-1.28-2.61N/A79.27
103 KIAA0652 | E18_Da | (PostTx) | (PreTx)-1.08-1.28-2.71N/A80.07
104 CLIP1 | E11_Da | (PostTx) | (PreTx)-1.28-1.27-3.08N/A82.54
105 DYNC1I2 | E2_Ad | (PostTx) | (PreTx)-1.02-1.26-2.56N/A80.06
106 UBAP2 | E30_Dd | (PostTx) | (PreTx)2.071.255.25N/A88.01
107 LZIC | E9_Db | (PostTx) | (PreTx)-1.24-1.25-2.95N/A82.84
108 RASSF4 | E3_Ab | (PostTx) | (PreTx)2.301.246.12N/A89.28
109 HMGA1 | E1_Ab | (PostTx) | (PreTx)-1.321.24-2.00-1.9176.21
110 DPY19L3 | E3_Ab | (PostTx) | (PreTx)2.071.245.21N/A88.38
111 C6orf61 | E12_Ab | (PostTx) | (PreTx)1.591.233.72N/A86.24
112 BCL2L12 | E1_Ab | (PostTx) | (PreTx)-2.831.23-5.77-1.2789.39
113 AC135457.2 | E1_Da | (PostTx) | (PreTx)1.931.224.66N/A88.38
114 BTF3L4 | E6_Da | (PostTx) | (PreTx)-2.481.22-4.57-1.3088.36
115 PAQR3 | E8_Da | (PostTx) | (PreTx)-2.211.22-3.78-1.3586.94
116 HMGB1L15 | E1_Da | (PostTx) | (PreTx)-1.561.21-2.43-1.5582.26
117 ODF2 | E7_Da | (PostTx) | (PreTx)1.691.213.89N/A87.76
118 DNAJC14 | E2_Da | (PostTx) | (PreTx)-1.30-1.21-2.97N/A85.22
119 SHMT1 | E16_Da | (PostTx) | (PreTx)-1.33-1.20-3.03N/A85.74
120 UNG | E2_Ab | (PostTx) | (PreTx)-1.24-1.20-2.84N/A85.00
121 C7orf27 | E5_Da | (PostTx) | (PreTx)2.081.205.06N/A89.82
122 SEC16A | E19_Ab | (PostTx) | (PreTx)1.44-1.202.27-1.5682.00
123 FBRS | E7_Ab | (PostTx) | (PreTx)1.271.192.88N/A85.58
124 RAB2B | E4_Ab | (PostTx) | (PreTx)-1.921.19-3.18-1.3686.90
125 TM9SF4 | E6_Ab | (PostTx) | (PreTx)-1.52-1.19-3.41N/A87.58
126 AFF2 | E24_Db | (PostTx) | (PreTx)1.491.183.30N/A87.94
127 ZMYM2 | E4_Ab | (PostTx) | (PreTx)1.331.182.96N/A86.98
128 CRTC1 | E15_Ab | (PostTx) | (PreTx)1.281.182.86N/A86.65
129 PPM1A | E5_Db | (PostTx) | (PreTx)2.491.176.57N/A92.28
130 TRIM26 | E1_Ab | (PostTx) | (PreTx)-1.65-1.17-3.68N/A89.23
131 GTPBP4 | E19_Ab | (PostTx) | (PreTx)-1.39-1.16-3.03N/A88.41
132 NCF4 | E8_Da | (PostTx) | (PreTx)1.601.153.49N/A89.69
133 AC093620.6 | E32_Da | (PostTx) | (PreTx)1.65-1.152.73-1.3287.79
134 CAMSAP1 | E19_Da | (PostTx) | (PreTx)1.831.154.07N/A91.15
135 TP53RK | E1_Ab | (PostTx) | (PreTx)1.88-1.143.22-1.2589.84
136 PPM1B | E2_Da | (PostTx) | (PreTx)-1.01-1.14-2.30N/A86.42
137 NIF3L1 | E8_Ab | (PostTx) | (PreTx)1.311.132.81N/A89.31
138 HNRNPC | E3_Ab | (PostTx) | (PreTx)1.29-1.132.16-1.3886.17
139 ILI8BP | E2_Ae | (PostTx) | (PreTx)1.99-1.123.55-1.1991.85
140 INTS6 | E1_Da | (PostTx) | (PreTx)2.181.125.05N/A93.63
141 MBP | E15_Da | (PostTx) | (PreTx)2.721.117.33N/A94.85
142 KYNU | E18_Da | (PostTx) | (PreTx)1.36-1.112.30-1.3088.56
143 MAP3K7IP3 | E8_Ab | (PostTx) | (PreTx)1.48-1.112.51-1.2689.64
144 OAS1 | E6_Ab | (PostTx) | (PreTx)1.631.113.45N/A92.15
145 MFSD5 | E3_Ab | (PostTx) | (PreTx)1.19-1.112.06-1.3487.40
146 CLN5 | E4_Ab | (PostTx) | (PreTx)1.46-1.102.51-1.2390.61
147 TDRKH | E5_Da | (PostTx) | (PreTx)-2.06-1.09-4.57N/A94.49
148 NNT | E23_Da | (PostTx) | (PreTx)2.15-1.094.07-1.1394.28
149 SMARCC2 | E28_Da | (PostTx) | (PreTx)1.041.092.24N/A90.67
150 NFX1 | E2_Ab | (PostTx) | (PreTx)1.21-1.092.13-1.2490.19
151 MRPL12 | E1_Ab | (PostTx) | (PreTx)1.761.083.66N/A94.24
152 AP006216.9 | E20_Ab | (PostTx) | (PreTx)1.711.083.54N/A94.18
153 VPRBP | E17_Ab | (PostTx) | (PreTx)-1.39-1.07-2.82N/A93.60
154 LY9 | E2_Ab | (PostTx) | (PreTx)-1.121.07-2.04-1.2091.73
155 SCAP | E12_Db | (PostTx) | (PreTx)1.31-1.062.34-1.1493.80
156 BCOR | E17_Da | (PostTx) | (PreTx)-1.45-1.06-2.89N/A95.17
157 PRKCBP1 | E25_Db | (PostTx) | (PreTx)-1.54-1.05-3.06N/A95.66
158 LYPLAL1 | E3_Ab | (PostTx) | (PreTx)-1.26-1.05-2.52N/A95.07
159 BCL2L1 | E2_Ab | (PostTx) | (PreTx)2.26-1.044.57-1.0697.22
160 USP48 | E11_Da | (PostTx) | (PreTx)2.071.044.37N/A97.32
161 RBM4 | E4_Da | (PostTx) | (PreTx)-1.40-1.04-2.74N/A96.15
162 OGFR | E2_Da | (PostTx) | (PreTx)2.69-1.046.23-1.0497.93
163 WDR33 | E7_Ab | (PostTx) | (PreTx)2.591.046.23N/A98.13
164 KIAA1826 | E2_Ac | (PostTx) | (PreTx)1.591.033.11N/A97.09
165 STX5 | E2_Ab | (PostTx) | (PreTx)-1.431.03-2.61-1.0796.82
166 SLC35B2 | E4_Ab | (PostTx) | (PreTx)1.401.032.70N/A97.33
167 BTN3A2 | E1_Ab | (PostTx) | (PreTx)-1.131.03-2.14-1.0796.67
168 RBM12 | E2_Ab | (PostTx) | (PreTx)1.16-1.032.17-1.0796.77
169 HMGB1 | E8_Dd | (PostTx) | (PreTx)-1.09-1.02-2.16N/A97.83
170 NFYC | E4_Ab | (PostTx) | (PreTx)1.391.012.66N/A98.59
171 CCDC86 | E1_Db | (PostTx) | (PreTx)-1.78-1.01-3.47N/A99.04
172 AC145132.2 | E6_Da | (PostTx) | (PreTx)1.251.012.40N/A99.17
173 SELM | E3_Ac | (PostTx) | (PreTx)-1.27-1.00-2.41N/A99.59