First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
heterogeneous nuclear ribonucleoprotein R, Q family
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP).  Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester...
Glycosyltransferase sugar-binding region containing DXD motif
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...
Alpha and gamma adaptin binding protein p34
Serine/Threonine protein kinases, catalytic domain
Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the...
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...
Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...
Threonyl and Alanyl tRNA synthetase second additional domain
Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]
PQQ-dependent dehydrogenases and related proteins
Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinases 1 and 3
Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase
The ABCA subfamily mediates the transport of a variety of lipid compounds.  Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency
Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...
ABC-type multidrug transport system, ATPase component [Defense mechanisms]
ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]
daunorubicin resistance ABC transporter ATP-binding subunit
ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...
MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...
ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]
ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]
P-loop containing Nucleoside Triphosphate Hydrolases
ATM1 is an ABC transporter that is expressed in the mitochondria.  Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to...
Conjugate Transporter-2 (CT2) Family protein
thiol reductant ABC exporter, CydD subunit
TAP, the Transporter Associated with Antigen Processing
multi drug resistance-associated protein (MRP)
Domain 1 of the ABC subfamily C.  This family is also known as MRP (mulrtidrug resisitance-associated protein).  Some of the MRP members have five additional transmembrane segments in their N-terminas, but the function of these additional...
Domain 2 of the ABC subfamily C.  This family is also known as MRP (mulrtidrug resisitance-associated protein).  Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional...
putative bacteriocin export ABC transporter, lactococcin 972 group
ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]
ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]
The SUR domain 1.  The sulfonylurea receptor SUR is an ATP transporter of the ABCC/MRP family with tandem ATPase binding domains.  Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the...
The SUR domain 2.  The sulfonylurea receptor SUR is an ATP binding cassette (ABC) protein of the ABCC/MRP family.  Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel...
Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protei
Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.  The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...
Type II (General) Secretory Pathway (IISP) Family protein
Possible Fer4-like domain in RNase L inhibitor, RLI
The ATPase domain 1 of RNase L inhibitor.  The ABC ATPase, RNase L inhibitor (RLI), is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids.  RLI s are not transport proteins and thus cluster...
The ATPase domain 2 of RNase L inhibitor.  The ABC ATPase, RNase L inhibitor (RLI), is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. RLI's are not transport proteins and thus cluster...
ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]
ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...
The Eye Pigment Precursor Transporter (EPP) Family protein
ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR).  DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...
The White subfamily represents ABC transporters homologous to the Drosophila white gene, which acts as a dimeric importer for eye pigment precursors.  The eye pigmentation of Drosophila is developed from the synthesis and deposition in the cells of red...
proline-specific peptidases, Bacillus coagulans-type subfamily
Platelet-activating factor acetylhydrolase, isoform II
Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...
Src homology 3 domain of Abl Interactor 1
Src homology 3 domain of Abl Interactor 2
Src homology 3 domain of Abl Interactor proteins
Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
The first LIM domain of actin binding LIM (abLIM) proteins
The second LIM domain on actin binding LIM (abLIM) proteins
The third LIM domain of actin binding LIM (abLIM) proteins
The fourth LIM domain of actin binding LIM (abLIM) proteins
LIM is a small protein-protein interaction domain, containing two zinc fingers
Glycosyltransferase family 6 comprises enzymes responsible for the production of the human ABO blood group antigens
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
BCR (breakpoint cluster region)-related pleckstrin homology (PH) domain
C2 domain in the Active BCR (Breakpoint cluster region) Related protein
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain
GTPase-activator protein for Rho-like GTPases
Broad-Complex, Tramtrack and Bric a brac
Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...
Carbamoyl-phosphate synthase L chain, N-terminal domain
Biotin carboxyl carrier protein [Lipid metabolism]
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase
epoxide hydrolase N-terminal domain-like phosphatase
Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others
Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)
Acyl-CoA dehydrogenases similar to fadE2
Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan
C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 1
Centaurin Pleckstrin homology (PH) domain
Putative GTPase activating protein for Arf
The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
Putative GTP-ase activating proteins for the small GTPase, ARF
The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 3
Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...
Peptidase family M2 Angiotensin converting enzyme (ACE)
G protein-coupled chemokine receptor-like protein
7 transmembrane receptor (rhodopsin family)
Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA)
Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...
Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...
Acyl-CoA thioester hydrolase/BAAT N-terminal region
BAAT / Acyl-CoA thioester hydrolase C terminal
Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis
Lipid-binding START domain of mammalian STARDT14 and related proteins
Lipid-binding START domain of mammalian STARD15 and related proteins
PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...
Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...
Low molecular weight phosphotyrosine protein phosphatase
Histidine phosphatase domain found in histidine acid phosphatases and phytases
Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases
Ly-6 antigen / uPA receptor -like domain
Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]
Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Spectrin repeats, found in several proteins involved in cytoskeletal structure
Transforming growth factor beta type I GS-motif
Succinylglutamate desuccinylase / Aspartoacylase family
Peptidase M14 Aspartoacylase (ASPA) subfamily
Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...
Adenosine deaminase [Nucleotide transport and metabolism]
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III
tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze  the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that...
Centaurin alpha Pleckstrin homology (PH) domain
Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...
Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
Predicted unusual protein kinase [General function prediction only]
Adenylyl- / guanylyl cyclase, catalytic domain
Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]
7 transmembrane receptor (Secretin family)
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...
G-protein-coupled receptor proteolytic site domain
Domains in Na-Ca exchangers and integrin-beta4
Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]
S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase
Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism
Collagen triple helix repeat (20 copies)
Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...
ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group.  They are found in certain hyperthermophilic archaea and in higher eukaryotes.  A functional...
Homo sapiens Nbla03831 and related proteins, metallophosphatase domain
Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and  G protein-coupled receptor kinase 3 (GRK3)
Catalytic domain of the Protein Serine/Threonine Kinase, beta-adrenergic receptor kinase
Extension to Ser/Thr-type protein kinases
Beta adrenergic receptor kinase 1(beta ARK1)(GRK2) pleckstrin homology (PH) domain
Proteasome complex subunit Rpn13 ubiquitin receptor
Ubiquitin C-terminal hydrolase 37 receptor binding site
Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...
Coagulation factor 5/8 C-terminal domain, discoidin domain
Peptidase M14 carboxypeptidase subfamily N/E-like
Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase
DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]
DEDDh 3'-5' exonuclease domain of Interferon Stimulated Gene product of 20 kDa, and similar proteins
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC
Albumin domain, contains five or six internal disulphide bonds
Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...
M14 family of metallocarboxypeptidases and related proteins
Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
Peptidase M14-like domain of ATP/GTP binding protein AGBL-4 and related proteins
Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
Alpha amylase catalytic domain found in glycogen debranching enzymes
Agmatinase-like family includes proclavaminic acid amidinohydrolase
PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille
Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of...
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
FAD/FMN-containing dehydrogenases [Energy production and conversion]
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...
Laminin-type epidermal growth factor-like domain
Laminin-type epidermal growth factor-like domai
Domain found in sea urchin sperm protein, enterokinase, agrin
Angiotensinogen is part of the renin-angiotensin system (RAS), which plays an important role in blood pressure regulation, renal haemodynamics, fluid and electrolyte homeostasis. It is also involved in normal and abnormal growth processes. The growth...
Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
Angiotensin II, type I receptor-associated protein
Angiotensin II, type I receptor-associated protein (AGTRAP)
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT)
4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]
S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...
DNA polymerase III subunits gamma and tau
Src Homology 3 domain of Abelson helper integration site-1 (AHI-1)
PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...
Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]
AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain
Pyrin: a protein-protein interaction domain
tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae...
Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc
The first LIM domain of Ajuba-like proteins
The second LIM domain of Ajuba-like proteins
The third LIM domain of Ajuba-like proteins
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...
Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]
Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...
Adenylate kinase and related kinases [Nucleotide transport and metabolism]
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...
Regulator of G protein signaling (RGS) domain superfamily
Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2
Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2
A-kinase anchor protein 110 kDa (AKAP 110)
Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...
PKA-RI-RII subunit binding domain of A-kinase anchor protein
Pericentrin-AKAP-450 domain of centrosomal targeting protein
Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...
Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]
Catalytic domain of the Protein Serine/Threonine Kinase, Protein Kinase B
Ubiquitin-conjugating enzyme E2, catalytic domain homologues
Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...
7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]
NAD-dependent aldehyde dehydrogenases [Energy production and conversion]
AAK_P5CS_ProBA: Glutamate-5-kinase (G5K) domain of the bifunctional delta 1-pyrroline-5-carboxylate synthetase (P5CS), composed of an N-terminal G5K (ProB) and a C-terminal glutamyl 5- phosphate reductase (G5PR, ProA), the first and second enzyme...
Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19
NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]
10-formyltetrahydrofolate dehydrogenase (FDH), N-terminal hydrolase domain
The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase
10-formyltetrahydrofolate dehydrogenase, ALDH family 1L
Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17
Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like
Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2
NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B
Human aldehyde dehydrogenase family 8 member A1-like
NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1
This family is most closely related to the GT1 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and...
This family is most closely related to the GT1 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown...
Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...
Glycosyltransferase family 28 C-terminal domain
Oligosaccharide biosynthesis protein Alg14 like
This family is most closely related to the GT1 family of glycosyltransferases.  ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)...
Glycosyltransferase [Cell envelope biogenesis, outer membrane]
DPG_synthase is involved in protein N-linked glycosylation
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...
Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
DNA alkylation damage repair protein AlkB
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and...
Regulator of chromosome condensation (RCC1) repeat
Vacuolar sorting protein 9 (VPS9) domain
Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]
Lipocalin / cytosolic fatty-acid binding protein family
BPTI/Kunitz family of serine protease inhibitors
Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria
N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...
N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]
Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs)
Anti-Mullerian hormone, N terminal region
Transforming growth factor-beta (TGF-beta) family
Leucine-rich repeats, typical (most populated) subfamily
Antagonist of mitotic exit network protein 1
AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway
The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
Glycine cleavage T-protein C-terminal barrel domain
Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
Glycosidases [Carbohydrate transport and metabolism]
Peptidase family M54, also called archaemetzincins or archaelysins
APC10 subunit of the anaphase-promoting complex (APC) that mediates substrate ubiquitination
APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
Anaphase-promoting complex subunit 11 RING-H2 finger
Anaphase promoting complex (APC) subunit 2
Anaphase-promoting complex subunit 4 WD40 domain
Anaphase-promoting complex, cyclosome, subunit 4
Canonical RNase A family includes all vertebrate homologues to the bovine pancreatic ribonuclease A (RNase A) that contain the catalytic site, necessary for RNase activity.  In the human genome 8 RNases , refered to as 'canonical' RNases, have been...
The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1...
Domain present in ZO-1 and Unc5-like netrin receptors
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo
Death Domain: a protein-protein interaction domain
Translation initiation factor eIF3 subunit 135
Protein present in Fab1, YOTB, Vac1, and EEA1
GIY-YIG domain of hypothetical proteins from Metazoa
ATPase involved in DNA repair [DNA replication, recombination, and repair]
SAM domain of AIDA1AB-like proteins, repeat 1
SAM domain of AIDA1AB-like proteins, repeat 2
SAM domain of ANKS6 (or SamCystin) subfamily
whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of...
Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in...
Acyloxyacyl-hydrolase like subfamily of the SGNH-hydrolase family. Acyloxyacyl-hydrolase is a leukocyte-secreted enzyme that deacetylates bacterial lipopolysaccharides
CO dehydrogenase flavoprotein C-terminal domain
Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
Molybdopterin-binding domain of aldehyde dehydrogenase
C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1
C-terminal domain of medium Mu1B subunit in epithelial cell-specific clathrin-associated adaptor protein (AP) complex AP-1
C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
C-terminal domain of medium Mu3A subunit in ubiquitously expressed adaptor protein (AP) complex AP-3
C-terminal domain of medium Mu3B subunit in neuron-specific adaptor protein (AP) complex AP-3
C-terminal domain of medium Mu4 subunit in adaptor protein (AP) complex AP-4
Clathrin adaptor complex, small subunit [Intracellular trafficking and secretion]
Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)
Caspase activation and recruitment domain similar to that found in Apoptotic Protease-Activating Factor 1
Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
Adenomatous polyposis coli tumour suppressor protein
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...
Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases
Human Ape2-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases
Copper-binding of amyloid precursor, CuBD
Plasmid replication region DNA-binding N-term
The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 1
The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Phosphoribosyl transferase (PRT)-type I domain
aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are...
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...
DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
Ligand binding domain of the nuclear receptor androgen receptor, ligand activated transcription regulator
Ubiquitin domain of  Raf serine/threonine kinases
SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their...
Mu homology domain (MHD) of adaptor protein (AP) coat protein I (COPI) delta subunit
Domain Homologous to E6-AP Carboxyl Terminus with
ADP-ribosylation factor-1 (Arf1) and ADP-ribosylation factor-5 (Arf5)
The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
Arginase types I and II and arginase-like family
Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to...
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins
The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion 2
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase)
Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing...
Src Homology 3 domain of Rho GTPase-activating protein 12
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins
The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been...
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their...
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their...
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by...
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the...
RhoGAP_ARHGAP22_24_25:  GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins
TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
Oligophrenin Pleckstrin homology (PH) domain
Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
Src Homology 3 domain of Rho GTPase-activating protein 27
Domain with 2 conserved Trp (W) residues
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts...
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins
The phosphoinositide binding Phox Homology domain of PX-RICS
Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
The Phox Homology domain, a phosphoinositide binding module
The phosphoinositide binding Phox Homology domain of Tc10/Cdc42 GTPase-activating protein
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and...
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin...
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases
Src homology 3 domain of Slit-Robo GTPase Activating Protein 4
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
The Bin/Amphiphysin/Rvs (BAR) domain of Rho GTPase activating protein 10-like
Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 3
The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
Src Homology 3 domain of Rho GTPase-activating protein 9 and similar proteins
Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF5 and ARHGEF19
The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
Second C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba, and similar domains
Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
Collybistin pleckstrin homology (PH) domain
Src Homology 3 domain of alpha-Pak Interactive eXchange factor
Cool (cloned out of library)/Pix (PAK-interactive exchange factor) pleckstrin homology (PH) domain
Src Homology 3 domain of beta-Pak Interactive eXchange factor
Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
BRIGHT, ARID (A/T-rich interaction domain) domain
Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence...
RNA binding activity-knot of a chromodomain
Arf-like tumor suppressor gene 1 (ARLTS1 or Arl11)
ADP-ribosylation factor(Arf)/Arf-like (Arl) small GTPases
Arf-like 9 (Arl9) and 10 (Arl10) GTPases
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H...
Arrestin (or S-antigen), N-terminal domain
Arrestin (or S-antigen), C-terminal domain
Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]
Transforming growth factor beta like domain
AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA).  AC catalyzes the hydrolysis of ceramide to sphingosine and...
Linear amide C-N hydrolases, choloylglycine hydrolase family
The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 2
Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 3
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The...
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of...
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins...
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable...
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been...
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha...
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the...
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS...
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor...
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The...
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The...
K homology RNA-binding domain_vigilin_like.  The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has...
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region
C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional...
Domain in SPla and the RYanodine Receptor
Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...
ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...
Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...
The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...
Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...
Gn_AT_II_novel.  This asparagine synthase-related domain is present in eukaryotes but its function has not yet been determined.  The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process
Homoserine dehydrogenase, NAD binding domain
Type I (cytosolic) bacterial L-asparaginase
ASRGL1_like domains, a subfamily of the L-Asparaginase type 2-like enzymes. The wider family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. The proenzymes undergo autoproteolytic cleavage before a threonine to generate alpha...
Argininosuccinate synthase [Amino acid transport and metabolism]
Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...
PIN (PilT N terminus) domain: Superfamily
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...
PHD domain of transcriptional enhancer, Asx
ATPases associated with a variety of cellular activities
ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate
Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
GCN4 central activation domain-like acidic activation domain
AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]
Autophagocytosis associated protein, active-site domain
UV radiation resistance protein and autophagy-related subunit 14
N-terminal region of Chorein, a TM vesicle-mediated sorter
Autophagocytosis associated protein (Atg3), N-terminal domain
Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an...
Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]
Glycosyl hydrolase family 65 central catalytic domain
Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...
Guanylate-binding protein (GBP) family (N-terminal domain)
Telomere-length maintenance and DNA damage repair
Ataxia telangiectasia mutated (ATM), catalytic domain
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...
Cation transport ATPase [Inorganic ion transport and metabolism]
Putative hydrolase of sodium-potassium ATPase alpha subunit
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...
Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
P-type ATPase of unknown pump specificity (type V)
sarco/endoplasmic reticulum calcium-translocating P-type ATPase
Plasma membrane calcium transporter ATPase C terminal
golgi membrane calcium-translocating P-type ATPase
ATP synthase alpha/beta family, beta-barrel domain
F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...
ATP synthase alpha/beta chain, C terminal domain
F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...
F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]
ATP synthase, Delta/Epsilon chain, beta-sandwich domain
Mitochondrial ATP synthase epsilon chain
Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
ATP synthase D chain, mitochondrial (ATP5H)
Mitochondrial ATP synthase coupling factor 6
Mitochondrial F1F0-ATP synthase, subunit f
pentatricopeptide repeat domain (PPR motif)
Vacuolar ATP synthase subunit S1 (ATP6S1)
vacuolar ATP synthase 16 kDa proteolipid subunit
V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...
V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...
Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]
VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p)
ATPase, P-type (transporting), HAD superfamily, subfamily IC
Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide
This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily
Domain in UVSB PI-3 kinase, MEI-41 and ESR-1
ATR (Ataxia telangiectasia and Rad3-related), catalytic domain
C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
ADDz domain of ATRX (alpha-thalassemia/mental retardation, X-linked)
Spinocerebellar ataxia type 10 protein domain
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase
N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
Catalytic domain of AGC family Protein Serine/Threonine Kinases
Mitochondrial domain of unknown function (DUF1713)
Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
Docking domain of Afi1 for Arf3 in vesicle trafficking
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like
Tankyrase binding N-terminal segment of axin
Regulator of G protein signaling (RGS) domain found in the Axin protein
Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
Catalytic domain of the Protein Tyrosine Kinase, Axl
Class I Histocompatibility antigen, domains alpha 1 and 2
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
recombination and DNA strand exchange inhibitor protein
chromosome segregation protein SMC, common bacterial type
Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor
Diaminopimelate decarboxylase [Amino acid transport and metabolism]
Class I major histocompatibility complex (MHC) beta2-microglobulin
Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]
Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
Ciliary basal body-associated, B9 protein
Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
Cellular and retroviral pepsin-like aspartate proteases
BAG domains, present in regulator of Hsp70 proteins
BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the...
Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 1
Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 1, also called Insulin Receptor Tyrosine Kinase Substrate (IRTKS)
Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins
Munc13 (mammalian uncoordinated) homology domain
C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins
Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane...
BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain
The BEN domain is found in diverse animal proteins
Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5) and BAP1
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...
ATP-utilising chromatin assembly and remodelling N-terminal
domain in different transcription and chromosome remodeling factors
Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting...
chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...
Repeats in sea squirt COS41.4, worm R01H10.6, fly CG1126 etc
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...
C-type lectin (CTL)/C-type lectin-like (CTLD) domain
Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins
C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1
Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking
Guanine nucleotide exchange factor for Ras-like small GTPases
Breast carcinoma amplified sequence 2 (BCAS2)
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...
pyruvate dehydrogenase E1 component, alpha subunit
Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module
Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
Signal transduction histidine kinase [Signal transduction mechanisms]
Caspase activation and recruitment domain of B-cell lymphoma 10
Apoptosis regulator proteins, Bcl-2 family
Retinal pigment epithelial membrane protein
This domain is found at the N terminal of the mitochondrial ATPase BSC1. It encodes the import and intramitochondrial sorting for the protein
human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...
Microtubule-binding stalk of dynein motor
Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain
Transport protein particle (TRAPP) component
Chromosome segregation ATPases [Cell division and chromosome partitioning]
Domain containing Gla (gamma-carboxyglutamate) residues
Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]
SAM domain of BICC1 (bicaudal) subfamily
Theoretical model of a pro-apoptotic protein
Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 2
The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 3
Baculoviral inhibition of apoptosis protein repeat domain
Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...
PIN domain of Xeroderma pigmentosum complementation group G (XPG) nuclease, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
H3TH domain of Xeroderma pigmentosum complementation group G (XPG) nuclease, a structure-specific, divalent-metal-ion dependent, 5' nuclease
Src homology 3 domain of Blk Protein Tyrosine Kinase
Src homology 2 (SH2) domain found in B lymphoid kinase (Blk)
Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
Peptidase C1B subfamily (MEROPS database nomenclature)
Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
Biogenesis of lysosome-related organelles complex-1 subunit 2
Oxidoreductase family, NAD-binding Rossmann fold
biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins
Trypsin Inhibitor like cysteine rich domain
Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes
Src homology 2 (SH2) domain found  in Tec protein, Bmx
Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
COMPASS (Complex proteins associated with Set1p) component shg1
Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases
LBP / BPI / CETP family, N-terminal domain
Zn-finger in ubiquitin-hydrolases and other protein
BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous...
BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous...
BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous...
Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex
The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2.   BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region.  In myeloid leukemias
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene...
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be...
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine
Brain and reproductive organ-expressed protein (BRE)
Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...
The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer
Protein-interacting Bro1-like domain of human Brox1 and related proteins
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and...
ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38
biotinidase and vanins (class 4 nitrilases)
Src Homology 3 domain of Bruton's tyrosine kinase
Src homology 2 (SH2) domain found  in Tec protein, Bruton's tyrosine kinase (Btk)
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins
GP4d_helicase is a homohexameric 5'-3' helicases. Helicases couple NTP hydrolysis to the unwinding of nucleic acid duplexes into their component strands
Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...
RPA1_DBD_C: A subfamily of OB folds corresponding to the C-terminal OB fold, the ssDNA-binding domain (DBD)-C, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which...
Myelin gene regulatory factor -C-terminal domain 1
Myelin gene regulatory factor C-terminal domain 2
Eukaryotic protein of unknown function (DUF2003)
Uncharacterized ACR, YggU family COG1872
NADH-ubiquinone reductase complex 1 MLRQ subunit
Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains
Septation ring formation regulator, EzrA
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
Eukaryotic protein of unknown function (DUF866)
Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred...
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...
domain in TBC and LysM domain containing proteins
NAD(P)H-nitrite reductase [Energy production and conversion]
occurring C-terminal to leucine-rich repeats
isoprenoid biosynthesis protein with amidotransferase-like domain
Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1
C2 domain found in the Human chromosome 21 open reading frame 25 (C21orf25) protein
C2 domain found in C2 calcium-dependent domain containing 3 (C2cd3) proteins
C2 domain found in the Human KIAA0528 cDNA clone
Proteins similar to C3, C4 and C5 of vertebrate complement.  The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the...
NTR/C345C domain, complement C3 subfamily
NTR/C345C domain, complement C4 subfamily
NTR/C345C domain, complement C5 subfamily
Uncharacterized protein conserved in bacteria (DUF2336)
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism
fatty oxidation complex, alpha subunit FadB
Mouse protein of unknown function (DUF781)
U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification]
The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3
poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA
Escherichia coli YaeB and related proteins
Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
Peptidase M1 family contains aminopeptidase N and leukotriene A4 hydrolase
Carbonic anhydrase alpha, isozymes I, II, and III and XIII.  Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on...
Carbonic anhydrase [Inorganic ion transport and metabolism]
Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are...
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide
Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...
Carbonic anhydrase alpha, CA isozyme V_like subgroup.  Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...
Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...
Carbonic anhydrase alpha, CA isozyme VII_like subgroup.  Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...
Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a...
Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...
Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at...
Neuronal voltage-dependent calcium channel alpha 2acd
Voltage gated calcium channel subunit beta domain 4Aa N terminal
Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta-1
Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta
Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta4
Cactus-binding C-terminus of cactin protein
p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter...
carbamoyl phosphate synthase small subunit
Carbamoyl-phosphate synthase small chain, CPSase domain
Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
Carbamoyl-phosphate synthetase large chain, oligomerisation domain
Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain
Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]
The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the...
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
putative band 4.1 homologues' binding motif
First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3))
Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3))
Protein kinase C conserved region 2 (CalB)
Calcium binding and coiled-coil domain (CALCOCO1) like
D1 dopamine receptor-interacting protein (calcyon)
Calcium/calmodulin dependent protein kinase II Association
Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...
Flagellar hook-length control protein FliK
LPS binding domain of CAP18 (C terminal)
CG-1 domains are highly conserved domains of about 130 amino-acid residues
Adenylate cyclase associated (CAP) N terminal
Adenylate cyclase associated (CAP) C terminal
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are...
Zn-finger in Ran binding protein and others
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear
MIT (microtubule interacting and transport) domain
Microtubule Interacting and Trafficking molecule domain
Cytoplasmic activation/proliferation-associated protein-1 C term
Proteins similar to Escherichia coli YajQ
Caspase activation and recruitment domain of CARD10-like proteins
Caspase activation and recruitment domain of CARD11-like proteins
Caspase activation and recruitment domain of CARD14-like proteins
Caspase activation and recruitment domain found in Caspase-1 and related proteins
Caspase activation and recruitment domain: a protein-protein interaction domain
Caspase activation and recruitment domain of CARD9-like proteins
Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein
B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily
Coactivator-associated arginine methyltransferase 1 N terminal
Glutathione S-transferase C-terminal-like, alpha helical domain of Cysteinyl-tRNA synthetase from higher eukaryotes
catalytic core domain of cysteinyl tRNA synthetase
Cocaine and amphetamine regulated transcript protein (CART)
GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p
10 TM Acyl Transferase domain found in Cas1p
Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...
Src Homology 3 domain of CASK interacting protein 1
Src Homology 3 domain of CASK interacting protein 2
Caspase, interleukin-1 beta converting enzyme (ICE) homologues
The Death Domain Superfamily of protein-protein interaction domains
Death Effector Domain, repeat 2, of Caspase-10
Death effector domain, repeat 1, of Caspase-10
Caspase activation and recruitment domain of Caspase-2
Death effector domain, repeat 1, of Caspase-8
Caspase 8-associated protein 2 myb-like domain
Caspase activation and recruitment domain of Caspase-9
PDIb family, Calsequestrin subfamily, N-terminal TRX-fold domain
PDIb family, Calsequestrin subfamily, Middle TRX-fold domain
Protein Disulfide Isomerase (PDIb') family, Calsequestrin subfamily, C-terminal TRX-fold domain
Ligand-binding domain of the CaSR calcium-sensing receptor, which is a member of the family C receptors within the G-protein coupled receptor superfamily
7 transmembrane sweet-taste receptor of 3 GCPR
Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein family member 4
Catalase [Inorganic ion transport and metabolism]
Clade 3 of the heme-binding enzyme catalase
CBL proto-oncogene N-terminus, EF hand-like domain
Src homology 2 (SH2) domain found in the Cbl-b TKB domain
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...
Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...
Cobalamin synthesis protein cobW C-terminal domain
Chromo Shadow Domain,  found in association with N-terminal chromo (CHRromatin Organization MOdifier) domain
Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241
C2 domain found in 5' repressor element under dual repression binding protein-1 (Freud-1)
chromosome segregation protein SMC, primarily archaeal type
Eukaryotic and archaeal DNA primase small subunit
Protein of unknown function N-terminal domain (DUF2450)
Protein of unknown function C-terminus (DUF2451)
Predicted coiled-coil domain-containing protein (DUF2360)
Uncharacterized conserved protein H4 (DUF2046)
SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like
Microtubule associated protein (MAP65/ASE1 family)
Coiled-coil domain containing protein (DUF2052)
Alpha helical coiled-coil rod protein (HCR)
Chemokine_CC:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues
Chemokine_CC_DCCL:  subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues
Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity
Small cytokines (intecrine/chemokine), interleukin-8 like
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
C-terminal deadenylase domain of nocturnin and related domains
Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...
TCP-1 (CTT or eukaryotic type II) chaperonin family, beta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL)...
TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins
TCP-1 (CTT or eukaryotic type II) chaperonin family, delta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins
TCP-1 (CTT or eukaryotic type II) chaperonin family, epsilon subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins
TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL)...
TCP-1 (CTT or eukaryotic type II) chaperonin family, eta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL)
TCP-1 (CTT or eukaryotic type II) chaperonin family, theta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins
Fungal domain of unknown function (DUF1712)
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model...
Multi-glycosylated core protein 24 (MGC-24)
Immunoglobulin (Ig)-like domain of semaphorin
First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins
First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins
T-cell surface glycoprotein CD3 zeta chain
C-type lectin-like domain (CTLD) of the type found in human thrombomodulin(TM), Endosialin, C14orf27, and C1qR
Tumor necrosis factor receptor (TNFR) domain
Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
First Src Homology 3 domain (SH3A) of CD2-associated protein
Second Src Homology 3 domain (SH3B) of CD2-associated protein
Third Src Homology 3 domain (SH3C) of CD2-associated protein
GYF domain: contains conserved Gly-Tyr-Phe residues
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
Immunoglobulin (Ig)-like domain of CD3 gamma and delta chains
Immunoglobulin (Ig)-like domain of CD3 epsilon chain
DNA-directed RNA polymerase I subunit RPA34.5
Second immunoglobulin (Ig) domain of CD4
Tumor necrosis factor receptor / nerve growth factor receptor repeats
This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding...
The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor...
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model...
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans...
C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
Class II MHC-associated invariant chain trimerisation domain
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like
Immunoglobulin (Ig) like domain of CD8 alpha chain
Immunoglobulin (Ig) like domain of CD8 beta chain
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans...
Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...
Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides
Anaphase-promoting complex, cyclosome, subunit 3
Anaphase promoting complex subunit 8 / Cdc23
Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to...
Anaphase-promoting complex APC subunit 1
cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
Catalytic domain of Myotonic Dystrophy protein kinase-like Protein Serine/Threonine Kinases
MRCK (myotonic dystrophy-related Cdc42-binding kinase)  pleckstrin homology (PH) domain
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II
Winged-helix domain of essential DNA replication protein Cell division control protein (Cdc6), which mediates DNA binding
RNA pol II accessory factor, Cdc73 family
Zinc-finger domain of monoamine-oxidase A repressor R1
Cell division cycle-associated protein 8
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes-like
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase
Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3
Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5
Cyclin-dependent kinase 5 activator protein
Protein-interacting V-domain of mammalian Alix and related domains
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9
2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]
Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5
Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus
Cyclin-dependent kinase inhibitor 3 (CDKN3)
Degradation arginine-rich protein for mis-folding
The middle winged helix fold of replication licensing factor Cdt1 binds geminin to inhibit binding of the MCM complex to origins of replication and DNA
The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase
Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]
First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase
Uracil-DNA glycosylases (UDG) and related enzymes
polyadenylate binding protein, human types 1, 2, 3, 4 family
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
Centromere protein B dimerisation domain
Kinesin motor domain, CENP-E/KIP2-like subgroup, involved in chromosome movement and/or spindle elongation during mitosis. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are...
Rb-binding domain of kinetochore protein Cenp-F/LEK1
CENP-A-nucleosome distal (CAD) centromere subunit
Histones H3 and H4 [Chromatin structure and dynamics]
CENP-A nucleosome associated complex (NAC) subunit
Transforming acidic coiled-coil-containing protein (TACC)
Phosphoenolpyruvate carboxylase [Energy production and conversion]
Centrosome microtubule-binding domain of Cep57
Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...
Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]
LBP / BPI / CETP family, C-terminal domain
Domain abundant in complement control proteins
Cofilin, Destrin, and related actin depolymerizing factors
Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
cystic fibrosis transmembrane conductor regulator (CFTR)
The CFTR subfamily domain 1.  The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical...
Cystic fibrosis TM conductance regulator (CFTR), regulator domain
The CFTR subfamily domain 2.  The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical...
Glycoprotein hormone beta chain homologues
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...
Chromatin assembly factor 1 p150 subunit
Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]
Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...
ARC105 or Med15 subunit of Mediator complex non-fungal
domain in transcription and CHROMO domain helicases
This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active...
The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...
Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome.  SI-CLP has a glycosyl...
Choline Kinase (ChoK) in eukaryotes. The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK)
Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
C-terminal domain of Fibronectin type III
Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two...
p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta...
Histone-like transcription factor (CBF/NF-Y) and archaeal histone
A domain in the BMP inhibitor chordin and in microbial proteins
von Willebrand factor (vWF) type C domain
Neurotransmitter-gated ion-channel ligand binding domain
Signal recognition particle, alpha subunit, N-terminal
C-terminal duplication domain of Friend of PRMT1
Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the...
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin...
CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin...
CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with...
N-terminal domain of CBF1 interacting co-repressor CIR
CDGSH-type zinc finger. Function unknown
Iron-containing outer mitochondrial membrane protein N-terminus
Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain
Catalytic domain of the Protein Serine/Threonine Kinase, Citron Rho-interacting kinase
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may...
calcium-activated chloride channel protein 1
ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is...
The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...
ClC-3-like chloride channel proteins.  This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has...
ClC-6-like chloride channel proteins. This CD includes ClC-6, ClC-7 and ClC-B, C, D in plants. Proteins in this family are ubiquitous in eukarotes and their functions are unclear. They are expressed in intracellular organelles membranes.  This family...
CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...
Domain in cystathionine beta-synthase and other proteins
C-type lectin-like domain (CTLD) of the type found in the tetranectin (TN), cartilage derived C-type lectin (CLECSF1), and stem cell growth factor (SCGF)
SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed...
C-type lectin-like domain (CTLD) of the type found in CEL-1 from Cucumaria echinata and Echinoidin from Anthocidaris crassispina
GST_N family, Chloride Intracellular Channel (CLIC) subfamily
C-terminal, alpha helical domain of Chloride Intracellular Channel 1
C-terminal, alpha helical domain of Chloride Intracellular Channel 2
C-terminal, alpha helical domain of Chloride Intracellular Channel 3
C-terminal, alpha helical domain of Chloride Intracellular Channel 4
C-terminal, alpha helical domain of Chloride Intracellular Channel 5
C-terminal, alpha helical domain of the Glutathione S-transferase family
C-terminal, alpha helical domain of Chloride Intracellular Channel 6
Nucleotide-sensitive chloride conductance regulator (ICln)
Pre-mRNA cleavage complex II protein Clp1
Predicted GTPase subunit of the pre-mRNA cleavage complex [Translation, ribosomal structure and biogenesis]
Molybdopterin guanine dinucleotide synthesis protein B
C-terminal, D2-small domain, of ClpB protein
Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease
Cleft lip and palate transmembrane protein 1 (CLPTM1)
ATP-dependent protease ATP-binding subunit ClpX
Citrate lyase beta subunit [Carbohydrate transport and metabolism]
CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety
Cytochrome c oxidase biogenesis protein Cmc1 like
Thymidylate kinase [Nucleotide transport and metabolism]
Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
effector domain of the CAP family of transcription factors
universal minicircle sequence binding protein (UMSBP)
M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase
SAM domain of CNK1,2,3-suppressor subfamily
Connector enhancer of kinase suppressor of ras
PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated
Connector enhancer of KSR (Kinase suppressor of ras)  (CNK) pleckstrin homology (PH) domain
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...
Hemolysins and related proteins containing CBS domains [General function prediction only]
Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
Not1 N-terminal domain, CCR4-Not complex component
C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)
Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
Fourth Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
Cytochrome oxidase complex assembly protein 1
Cytochrome c oxidase assembly protein PET191
phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes
Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis
Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different...
von Willebrand factor (vWF) type A domain
COG (conserved oligomeric Golgi) complex component, COG2
C-terminal tandem repeated domain in type 4 procollagen
C-terminal tandem repeated domain in type 4 procollagens
Goodpasture antigen binding protein (GPBP) Pleckstrin homology (PH) domain
Ceramide-binding START domain of mammalian STARD11 and related domains
VWA_collagen alpha(VI) type: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than...
VWA_collagen alpha 3(VI) like: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than...
C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. The COMM Domain is found at the C-terminus of a...
COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins
COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins
COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of proteins
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in...
COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins
COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins
Coatomer (COPI) alpha subunit C-terminus
Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5
Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in COP9 signalosome complex subunit 6
Coenzyme Q-binding protein COQ10p and similar proteins
Coenzyme Q (ubiquinone) biosynthesis protein Coq4
Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain
One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
Coactosin-like members of the ADF homology domain family
Cytochrome c oxidase assembly protein CtaG/Cox11
cytochrome c oxidase assembly protein-like
Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]
Cytochrome c oxidase assembly protein COX16
Cytochrome C oxidase copper chaperone (COX17)
Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
Cytochrome c oxidase subunit Vb.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
Cytochrome c oxidase subunit VIa.   Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
Cytochrome c oxidase subunit VIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
Cytochrome C oxidase chain VIIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
Cytochrome oxidase c subunit VIII.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
Cytochrome C oxidase subunit II, periplasmic domain
Peptidase M14 carboxypeptidase subfamily A/B-like
VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae
Homo sapiens CSTP1 and related proteins, metallophosphatase domain
Predicted aminopeptidases [General function prediction only]
PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions
M28 Zn-Peptidase Plasma glutamate carboxypeptidase
Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]
Cleavage and polyadenylation factor 2 C-terminal
Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]
Zinc finger C-x8-C-x5-C-x3-H type (and similar)
Cysteine-rich domain of carboxypeptidase Z, a member of the carboxypeptidase E family
CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain
Death domain of RIP-associated ICH-1 homologous protein with a death domain
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to...
Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that...
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors
Corticotropin-releasing factor binding protein (CRF-BP)
Insulin-like growth factor binding protein
The LIM domain of Cysteine-Rich Intestinal Protein (CRIP)
The first LIM domain of thymus LIM protein (TLP)
The second LIM domain of thymus LIM protein (TLP)
SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a...
Src homology 2 domain found in cancer-related signaling adaptor protein CRK
N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins
S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100...
First (N-terminal) immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-3 (also known as cell adhesion molecules CADM3, CADM1, and CADM2 respectively)
Transducer of regulated CREB activity, N terminus
Transducer of regulated CREB activity middle domain
Transducer of regulated CREB activity, C terminus
Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]
Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaA-crystallin (HspB4, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers...
Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]
Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers...
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)
NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]
Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...
Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...
Macrophage colony stimulating factor-1 (CSF-1)
Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR) and similar proteins
Catalytic domain of the Protein Tyrosine Kinase, Colony-Stimulating Factor-1 Receptor
Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of polypeptide growth factors called cytokines. It stimulates a wide variety of hematopoietic and nonhematopoietic cell types via binding to members of the cytokine...
Interleukin-6 receptor alpha chain, binding
Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones
Src Homology 3 domain of C-terminal Src kinase
Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]
Neural chondroitin sulphate proteoglycan cytoplasmic domain
The first LIM domain of Cysteine Rich Protein 1 (CRP1)
The second LIM domain of Cysteine Rich Protein (CRP)
The first LIM domain of Cysteine Rich Protein 2 (CRP2)
The first LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)
The second LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)
Hinge domain of cleavage stimulation factor subunit 2
Transcription termination and cleavage factor C-terminal
Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]
D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Chitobiase (also known as di-N-acetylchitobiase) is a lysosomal glycosidase that hydrolyzes the reducing-end N-acetylglucosamine from the chitobiose core of oligosaccharides during the ordered degradation of asparagine-linked glycoproteins in eukaryotes
catalytic domain of ctd-like phosphatases
TFIIF-interacting CTD phosphatases, including NLI-interacting factor [Transcription]
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...
Eukaryotic domain of unknown function (DUF1716)
CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...
Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase
Cathepsin_D2, pepsin family of proteinases
Cathepsin E, non-lysosomal aspartic protease
Cathepsin propeptide inhibitor domain (I29)
Peptidase C1A subfamily (MEROPS database nomenclature)
tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]
Mouse development and cellular proliferation protein Cullin-7
APC10-like DOC1 domain of CUL7, subunit of the SCF-ROC1-like E3 ubiquitin ligase complex that mediates substrate ubiquitination
Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]
Domain in DAP-5, eIF4G, MA-3 and other proteins
cyclophilin_CeCYP16-like: cyclophilin-type peptidylprolyl cis- trans isomerase) (PPIase) domain similar to Caenorhabditis elegans cyclophilin 16. C. elegans CeCYP-16, compared to the archetypal cyclophilin Human cyclophilin A has, a reduced...
Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain
HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...
Chemokine_CX3C:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteines
Chemokine_CXC:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues
CpG binding protein zinc finger C terminal domain
The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain
Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold
Vertebrate cytochrome b(561), CYB561 gene product
Vertebrate cytochrome b(561), CYBASC3 gene product
Eukaryotic cytochrome b(561), including the CYB561D2 gene product
Cytochrome b5-like Heme/Steroid binding domain
Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a...
p23_like domain found in NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR) and similar proteins.  NCB5OR is widely expressed in human organs and tissues and is localized in the ER (endoplasmic reticulum). It appears to play a critical role in maintaining...
Ferric reductase like transmembrane component
NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX...
Vertebrate cytochrome b(561), CYBRD1 gene product
Cytochrome c, mono- and diheme variants [Energy production and conversion]
Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...
Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]
Cytohesin Pleckstrin homology (PH) domain
RAS GTPase-activating protein (GAP) CG5898 Pleckstrin homology (PH) domain
C2 domain present in Ras GTPase activating protein (GAP) family
The DAB2IP family of Ras GTPase-activating proteins includes DAB2IP, nGAP, and Syn GAP. Disabled 2 interactive protein, (DAB2IP
Cadherin-like repeat domain of alpha dystroglycan
Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is 'interfacial activation,' the process of...
Mitochondrial ribosomal death-associated protein 3
Death domain found in death-associated protein kinase 1
Catalytic domain of the Protein Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( DAPP1)/B lymphocyte adaptor molecule of 32 kDa (Bam32)-like proteins
AspRS_cyto_N: N-terminal, anticodon recognition domain of the type found in Saccharomyces cerevisiae and human cytoplasmic aspartyl-tRNA synthetase (AspRS). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop
Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...
EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...
Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...
DOMON-like domain of copper-dependent monooxygenases and related proteins
Copper type II ascorbate-dependent monooxygenase, N-terminal domain
Copper type II ascorbate-dependent monooxygenase, C-terminal domain
ADF homology domain of drebrin and actin-binding protein 1 (abp1)
Dysbindin (Dystrobrevin binding protein 1)
Src homology 3 domain of eumetazoan Actin-binding protein 1
Dbr1 RNA lariat debranching enzyme, N-terminal metallophosphatase domain
Lariat debranching enzyme, C-terminal domain
Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...
2-oxoacid dehydrogenases acyltransferase (catalytic domain)
First immunoglobulin (Ig)-like domain in neogenin and similar proteins
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1
TRF2-binding region of apollo and similar proteins
mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical...
Scavenger mRNA decapping enzyme (DcpS) N-terminal
Scavenger mRNA decapping enzyme C-term binding
TATA element modulatory factor 1 DNA binding
Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...
Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping...
Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs
xylulose reductase-like, classical (c) SDRs
Mono-functional DNA-alkylating methyl methanesulfonate N-term
DNA damage inducible protein 1 ubiquitin-like domain
Oligosaccharyltransferase 48 kDa subunit beta
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2
Macrophage migration inhibitory factor (MIF)
DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif
KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...
Caspase activation and recruitment domain found in RIG-I, second repeat
ERCC4-like helicases [DNA replication, recombination, and repair]
helical domain inserted in SF2-type helicase domain in Hef-, MDA5- and FancM-like proteins
Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
The Delta4-sphingolipid Fatty Acid Desaturase (Delta4-sphingolipid-FADS)-like CD includes the integral-membrane enzymes, dihydroceramide Delta-4 desaturase, involved in the synthesis of sphingosine
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
Domain always found upstream of DENN domain, found in a variety of signalling proteins
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
domain involved in Ras-like GTPase signaling
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed...
C-terminal domain of DENR and related proteins
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also known as DEPDC1B, is a DEP containing protein of unknown function
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain...
DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown
2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family
Intermediate filament head (DNA binding) region
CIDE_N domain of ICAD. The CIDE_N  (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD (DFF45). These proteins are...
DNA Fragmentation factor 45kDa, C terminal domain
CIDE_N domain of CAD nuclease. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are...
Second harmonin_N_like domain (repeat 2) of the long isoform of whirlin, and related domains
First harmonin_N_like domain (repeat 1) of the long isoform of whirlin, and related domains
C-type lectin-like domain (CTLD) of the type found in DGCR2, an integral membrane protein deleted in DiGeorge Syndrome (DGS)
DiGeorge syndrome critical region 6 (DGCR6) protein
Diacylglycerol kinase catalytic domain (presumed)
Diacylglycerol kinase accessory domain (presumed)
SAM domain of diacylglycerol kinase delta
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
Phorbol esters/diacylglycerol binding domain (C1 domain)
Ubiquitin-like domain of Diacylgylcerol kinase (DAGK)
Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS)
Predicted dehydrogenases and related proteins [General function prediction only]
Oxidoreductase family, C-terminal alpha/beta domain
Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5
Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein
Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...
human dehydrogenase/reductase (SDR family) member 1 (DHRS1) -like, classical (c) SDRs
Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]
human dehydrogenase/reductase SDR family member (DHRS)-12/FLJ13639-like, classical (c)-like SDRs
retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs
Short-chain dehydrogenases of various substrate specificities [General function prediction only]
human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
Porcine peroxisomal carbonyl reductase like, classical (c) SDR
11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module
HrpA-like helicases [DNA replication, recombination, and repair]
insert domain of MDA5 helicase and similar proteins
S1_DHX8_helicase: The  N-terminal S1 domain of human ATP-dependent RNA helicase DHX8, a DEAH (Asp-Glu-Ala-His) box polypeptide.  The DEAH-box RNA helicases are thought to play key roles in pre-mRNA splicing and DHX8 facilitates nuclear export of spliced...
Second Mitochondria-derived Activator of Caspases
PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named...
RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...
Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
Domain in the central regions of transcription elongation factor S-II (and elsewhere)
Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
This domain is the catalytic domain of ribonuclease II
Pseudouridine synthase, human dyskerin like
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a...
C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
Polyubiquitination (PEST) N-terminal domain of MAGUK
Src Homology 3 domain of Disks Large homolog 1
Src Homology 3 domain of Disks Large homolog 2
Src Homology 3 domain of Disks Large homolog 3
Src Homology 3 domain of Disks Large homolog 4
Plant protein of unknown function (DUF827)
Src homology 3 domain of Disks Large homolog 5
Homeobox protein distal-less-like N terminal
DNA methyltransferase 1-associated protein 1 (DMAP1)
Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a...
Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane...
Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
Hydrolytic ATP binding site of dynein motor region D1
Dynein heavy chain and region D6 of dynein motor
P-loop containing dynein motor region D3
P-loop containing dynein motor region D4
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s
C-terminal substrate binding domain of DnaJ and HSP40
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
Protein Disulfide Isomerase (PDIa) family, redox active TRX domains
TRX domain, DnaJ domain containing protein family
Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex
C2 domain of PTEN tumour-suppressor protein
Catalytic domain, repeat 1, of Deoxyribonuclease II alpha and similar proteins
Catalytic domain, repeat 2, of Deoxyribonuclease II alpha and similar proteins
Catalytic domain, repeat 1, of Deoxyribonuclease II beta and similar proteins
Catalytic domain, repeat 2, of Deoxyribonuclease II beta and similar proteins
Dynamin_like protein family includes dynamins and Mx proteins
First N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
Second N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
Third N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
Fourth N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
First C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
Cytosine specific DNA methyltransferase replication foci domain
BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG...
BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG...
Site-specific DNA methylase [DNA replication, recombination, and repair]
The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis.  In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in...
ADDz domain of DNA (cytosine-5) methyltransferases (C5-MTases) 3 a (Dnmt3a)
ADDz domain of DNA (cytosine-5) methyltransferases (C5-MTases) 3 b (Dnmt3b)
ADDz domain of DNA (cytosine-5) methyltransferases (C5-MTases) 3 like (Dnmt3l)
Aminopeptidase I zinc metalloprotease (M18)
Nucleotidyltransferase (NT) domain of family X DNA Polymerases
C2 domain first repeat present in Rabphilin and Double C2 domain
C2 domain second repeat present in Rabphilin and Double C2 domain
Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11
Src Homology 3 domain of Class A Dedicator of Cytokinesis protein 2
Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 2
Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 5
Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 6
Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 7
Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
Downstream of tyrosine kinase  (DOK) Phosphotyrosine-binding domain
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is...
UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is...
UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]
renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics
diphthamide biosynthesis enzyme Dph1/Dph2 domain
DPM1_like represents putative enzymes similar to eukaryotic DPM1
Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)
Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)
Dipeptidyl peptidase IV (DPP IV) N-terminal region
Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]
Dppa2/4 conserved region in higher vertebrates
Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]
Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...
Developmentally Regulated GTP-binding protein (DRG)
TGS_DRG_C:   DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it...
Seventh immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)
Eight immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM)
Vacuolar protein sorting-associated protein 26
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
Domain found at the C-terminus of deltex-like
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...
Dual oxidase and related animal heme peroxidases
Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...
Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...
N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by...
Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins.  Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway...
Segment polarity protein dishevelled (Dsh) C terminal
Cytoplasmic dynein 1 intermediate chain 2
p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD...
E2F/DP family winged-helix DNA-binding domain
RNA polymerase II transcription elongation factor
catalytic core domain of discriminating glutamyl-tRNA synthetase
Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved...
Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
Evolutionarily conserved signalling intermediate in Toll pathway
Epithelial cell transforming 2 (ECT2) pleckstrin homology (PH) domain
PA_EDEM3_like: protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar...
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators
Elongation Factor 1-alpha (EF1-alpha) protein family
EF1_alpha_II: this family represents the domain II of elongation factor 1-alpha (EF-1a) that is found in archaea and all eukaryotic lineages. EF-1A is very abundant in the cytosol, where it is involved in the GTP-dependent binding of aminoacyl-tRNAs to...
Domain III of EF-1. Eukaryotic elongation factor 1 (EF-1) is responsible for the GTP-dependent binding of aminoacyl-tRNAs to ribosomes. EF-1 is composed of four subunits: the alpha chain, which binds GTP and aminoacyl-tRNAs, the gamma chain that probably...
Glutathione S-transferase C-terminal-like, alpha helical domain of eukaryotic translation Elongation Factor 1 beta
Elongation factor 1 beta (EF1B) guanine nucleotide exchange domain. EF1B catalyzes the exchange of GDP bound to the G-protein, EF1A, for GTP, an important step in the elongation cycle of the protein biosynthesis. EF1A binds to and delivers the aminoacyl...
Eukaryotic elongation factor 1 beta central acidic region
Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 3
GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily
Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins
Elongation factor 1 gamma, conserved domain
Elongation Factor 2 (EF2) in archaea and eukarya
EF2_snRNP_like_II: this subfamily represents domain II of elongation factor (EF) EF-2 found eukaryotes and archaea and, the C-terminal portion of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast...
This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP
eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart...
SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome
selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...
Domain present in phytochromes and cGMP-specific phosphodiesterases
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases
Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding proteins
C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Embryonal Fyn-associated Substrate
Snu114p, a spliceosome protein, is a GTPase
Loc2 eEF2_C_snRNP, cd01514/C terminal domain:eEF2_C_snRNP: This family includes C-terminal portion of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart Snu114p.  This domain is...
EF-2_domain IV_snRNP domain is a part of 116kD U5-specific protein of the U5 small nucleoprotein (snRNP) particle, essential component of the spliceosome. The protein is structurally closely related to the eukaryotic translational elongation factor EF2
eEF2_C_snRNP: This family includes a C-terminal portion of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart Snu114p.  This domain is homologous to the C-terminal domain of the...
Low-density lipoprotein receptor repeat class B
Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase
Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
Prolyl 4-hydroxylase alpha subunit homologues
N-terminal C2 in EEIG1 and EHBP1 proteins
Eps15 homology domain (EHD), C-terminal domain
Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
multifunctional fatty acid oxidation complex subunit alpha
S1_eIF1AD_like: eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found...
S1_IF1A: Translation initiation factor IF1A, also referred to as eIF1A in eukaryotes and aIF1A in archaea, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. IF1A is essential for translation...
Eukaryotic translation initiation factor eIF2A
The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...
Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2
Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...
eIF-2B gamma subunit, C-terminal Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is...
The N-terminal domain of epsilon subunit of the eIF-2B is a subfamily of glycosyltransferase 2
eIF-2B epsilon subunit, central Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is...
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon
N-terminal domain of eIF2D and related proteins
C-terminal domain of eIF2D and related proteins
Translation initiation factor 2, alpha subunit (eIF-2alpha) [Translation, ribosomal structure and biogenesis]
S1_IF2_alpha: The alpha subunit of translation Initiation Factor 2, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Eukaryotic and archaeal Initiation Factor 2 (e- and aIF2, respectively)...
Eukaryotic translation initiation factor 2 alpha subunit
eukaryotic translation initiation factor 2 gamma subunit
Gamma subunit of initiation factor 2 (eIF2 gamma)
eIF2_gamma_II: this subfamily represents the domain II of the gamma subunit of eukaryotic translation initiation factor 2 (eIF2-gamma) found in Eukaryota and Archaea. eIF2 is a G protein that delivers the methionyl initiator tRNA to the small ribosomal...
Initiation factor eIF2 gamma, C terminal
Eukaryotic translation initiation factor 3 subunit 8 N-terminus
Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF3f
Eukaryotic translation initiation factor 3 subunit G
Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h
Translation initiation factor eIF3 subunit
RNA polymerase I-associated factor PAF67
Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
C-terminal W2 domain of eukaryotic translation initiation factor 5
eukaryotic translation initiation factor 5A
S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential...
Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
aeIF5B_II: This family represents the domain II of archeal and eukaryotic aeIF5B. aeIF5B is a homologue of prokaryotic Initiation Factor 2 (IF2).  Disruption of the eIF5B gene (FUN12) in yeast causes a severe slow-growth phenotype, associated with a...
Ribosome anti-association factor IF6 binds the large ribosomal subunit and prevents the two subunits from associating during translation initiation. IF6 comprises a family of translation factors that includes both eukaryotic (eIF6) and archeal (aIF6)...
Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]
Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators
Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators
Transcription elongation factor Elf1 like
Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p)
Engrailed homeobox C-terminal signature domain
Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins.  The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the...
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions
TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...
Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...
Type I phosphodiesterase / nucleotide pyrophosphatase
T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA...
HIF-1 alpha C terminal transactivation domain
Transglutaminase family, C-terminal ig like domain
Ligand Binding Domain of Ephrin type-A Receptor 1
Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases
SAM domain of EPH-A1 subfamily of tyrosine kinase receptors
Ligand Binding Domain of Ephrin Receptors
Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A10
SAM domain of EPH-A10 subfamily of tyrosine kinase receptors
Ligand Binding Domain of Ephrin type-A Receptor 2
Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2
SAM domain of EPH-A2 family of tyrosine kinase receptors
Ligand Binding Domain of Ephrin type-A Receptor 3
Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
SAM domain of EPH-A3 subfamily of tyrosine kinase receptors
Ligand Binding Domain of Ephrin type-A Receptor 4
SAM domain of EPH-A4 subfamily of tyrosine kinase receptors
Ligand Binding Domain of Ephrin type-A Receptor 5
SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
Ligand Binding Domain of Ephrin type-A Receptor 6
Ligand Binding Domain of Ephrin type-A Receptor 7
SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
Ligand Binding Domain of Ephrin type-A Receptor 8
SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
Ligand Binding Domain of Ephrin type-B receptors
Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
SAM domain of EPH-B1 subfamily of tyrosine kinase receptors
Ligand Binding Domain of Ephrin type-B Receptor 2
SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
Ligand Binding Domain of Ephrin type-B Receptor 3
SAM domain of EPH-B3 subfamily of tyrosine kinase receptors
Ligand Binding Domain of Ephrin type-B Receptor 4
SAM domain of EPH-B4 subfamily of tyrosine kinase receptors
Ligand Binding Domain of Ephrin type-B Receptor 6
SAM domain of EPH-B6 subfamily of tyrosine kinase receptors
Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]
The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...
Glutathione S-transferase C-terminal-like, alpha helical domain of bifunctional Glutamyl-Prolyl-tRNA synthetase
catalytic core domain of glutaminyl-tRNA synthetase
tRNA synthetases class I (E and Q), anti-codon binding domain
WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates...
Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...
ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...
TATA element modulatory factor 1 TATA binding
Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
Epidermal growth factor receptor kinase substrate (EPS8) Phosphotyrosine-binding (PTB) domain
Animal heme peroxidases and related proteins
Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases
GTPase [General function prediction only]
E. coli Ras-like protein (Era) is a multifunctional GTPase
Ral (Ras-like) family containing highly homologous RalA and RalB
Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
Catalytic domain of the Protein Tyrosine Kinase, HER2
Transmembrane domain of ErbB3, a Protein Tyrosine Kinase
Pseudokinase domain of the Protein Tyrosine Kinase, HER3
Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
Catalytic domain of the Protein Tyrosine Kinase, HER4
RIM-binding protein of the cytomatrix active zone
epidermal growth factor-like protein (EGF-like protein)
Sterile alpha motif (SAM)/Pointed domain of ERG transcription factor
Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)
DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
Glucosidase II beta subunit-like protein
The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...
Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]
A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...
M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1
The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
RNase domain (also known as the kinase extension nuclease domain) of Ire1
Endoplasmic Reticulum Oxidoreductin 1 (ERO1)
Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b
Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'
PDIa family, endoplasmic reticulum protein 29 (ERp29) subfamily
PDIa family, endoplasmic reticulum protein 44 (ERp44) subfamily
PDIb family, ERp44 subfamily, first redox inactive TRX-like domain b
PDIb' family, ERp44 subfamily, second redox inactive TRX-like domain b'
heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains
heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of human T-cell leukemia virus type 1 (HTLV-1), and related domains
heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including Ebola virus and human immunodeficiency virus type 1 (HIV-1)
heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of the human endogenous retrovirus ENVV1, and related domains
DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
Oestrogen-type nuclear receptor final C-terminal
DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)
DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
The ligand binding domain of estrogen receptor-related nuclear receptors
DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
C2 domain first and third repeat in Synaptotagmin-like proteins
C2 domain second repeat present in Synaptotagmin-like proteins
C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]
electron transfer flavoprotein subunit alpha
The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...
Electron transfer flavoprotein FAD-binding domain
Dehydrogenases (flavoproteins) [Energy production and conversion]
Ferredoxin-like protein [Energy production and conversion]
Zn-dependent hydrolases, including glyoxylases [General function prediction only]
Ethanolamine kinase (ETNK) in eukaryotes. ETNK is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...
Sterile alpha motif (SAM)/Pointed domain of ETS-1
Sterile alpha motif (SAM)/Pointed domain of ETS-2
PEA3 subfamily ETS-domain transcription factor N terminal domain
Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein
Ellis van Creveld protein 2 like protein
Ectropic viral integration site 2A protein (EVI2A)
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
DEDDy 3'-5' exonuclease domain of Drosophila Egalitarian (Egl) and similar proteins
DEDDy 3'-5' exonuclease domain of WRN and similar proteins
DEDDy 3'-5' exonuclease domain of Caenorhabditis elegans mut-7 and similar proteins
PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
Defects in morphology protein 1, mitochondrial precursor
Sec8 exocyst complex component specific domain
Exocyst complex 84-kDa subunit Pleckstrin Homology (PH) domain
Exosome complex exonuclease RRP4 N-terminal region
S1_CSL4: CSL4, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. ScCSL4 protein is a subunit of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation...
DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain) [Translation, ribosomal structure and biogenesis]
S1_Rrp4: Rrp4 S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Rrp4 protein is a subunit of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation in...
S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain
S1_Rrp40: Rrp40 S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Rrp4 protein is a subunit of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation...
archaeal exosome-like complex exonuclease 1
exosome complex RNA-binding protein Rrp42
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces...
Interferon-alpha/beta receptor, fibronectin type III
Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]
Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]
Death Effector Domain found in Fas-Associated via Death Domain
Fas-associated Death Domain protein-protein interaction domain
The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...
The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...
UAS family, FAS-associated factor 1 (FAF1) subfamily
2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]
Fas apoptotic inhibitory molecule (FAIM1)
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
Eukaryotic protein of unknown function (DUF842)
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active...
Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]
Eukaryotic protein of unknown function (DUF846)
N-terminal domain of NEFA-interacting nuclear protein NIP30
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl
C-terminal putative kinase domain of FAM20A
C-terminal putative kinase domain of FAM20B xylose kinase
C-terminal putative kinase domain of FAM20C (also known as Dentin Matrix Protein 4, DMP4)
Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
Pancreatitis induced protein 49 C terminal
N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83A
N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83B
N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83C
N-terminal phospholipase D-like domain of the protein, Family with sequence similarity 83D
Catalytic domain of phospholipase D superfamily proteins
N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83F
N-terminal phospholipase D-like domain of the uncharacterized protein Family with sequence similarity 83G
N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83H
The Bin/Amphiphysin/Rvs (BAR) domain of Family with sequence similarity 92 (FAM92)
This model contains proteins with the VRR-NUC domain
Fanconi anemia ID complex proteins FANCI and FANCD2
Fanconi anemia complementation group E protein, C-terminal domain
insert domain of FANCM helicase and similar proteins
ERCC4-type nuclease [DNA replication, recombination, and repair]
fatty acyl CoA reductases (FARs), extended (e) SDRs
C-terminal domain of fatty acyl CoA reductases
Chondrocyte-derived ezrin-like domain containing protein (CDEP) Pleckstrin homology (PH) domain
Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...
Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...
Death domain of FAS or TNF receptor superfamily member 6
polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...
Dehydratase domain in polyketide synthase (PKS) enzymes
beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
This domain is found in various eukaryotic species, particularly in apicomplexans
Mitochondrial and peroxisomal fission factor Mff
GST_N family, Metaxin subfamily, Metaxin-like proteins
C-terminal, alpha helical domain of Metaxin and related proteins
Fibrillarin-like rRNA methylase [Translation, ribosomal structure and biogenesis]
The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
The third LIM domain of Zyxin-like family
Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1
Putative zinc finger in N-recognin (UBR box)
Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]
C-terminal GTPase-like domain of F-Box Only Protein 4
Immunoglobulin (IG)-like domain of of FcalphaRI
Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
PIN domain of rRNA-processing protein, Fcf1 (Utp24, YDR339C), and other eukaryotic homologs
This domain contains 8 conserved cysteine residues
von Willebrand factor (vWF) type D domain
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 1 (FCH domain only 1 or FCHo1, also known as KIAA0290) and similar proteins
mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 2 (FCH domain only 2 or FCHo2) and similar proteins
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH and double SH3 domains 1 (FCHSD1)
First Src Homology 3 domain of FCH and double SH3 domains proteins
Second Src Homology 3 domain of FCH and double SH3 domains protein 1
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH and double SH3 domains 2 (FCHSD2)
Second Src Homology 3 domain of FCH and double SH3 domains protein 2
Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...
NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]
Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...
Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...
PIN domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
H3TH domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease: Eukaryotic homologs
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
Catalytic domain of the Protein Tyrosine Kinase, Fer
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
FGD (faciogenital dysplasia protein) pleckstrin homology (PH) domain
Acidic and basic fibroblast growth factor family
First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1)
Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup
Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
Catalytic domain of Src kinase-like Protein Tyrosine Kinases
FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...
The first LIM domain of Four and a half LIM domains protein 1
The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
The third LIM domain of Four and a half LIM domains protein (FHL)
The fourth LIM domain of Four and a half LIM domains protein 3 (FHL3)
The first LIM domain of Four and a half LIM domains protein 3 (FHL3)
The second LIM domain of Four and a half LIM domains protein 3 (FHL3)
The first LIM domain of Four and a half LIM domains protein (FHL)
The second LIM domain of Four and a half LIM domains protein 5 (FHL5)
The fourth LIM domain of Four and a half LIM domains protein (FHL)
Acidic fibroblast growth factor binding (FIBP)
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain
Mitochondria Fission Protein Fis1, cytosolic domain
Inositol phospholipid synthesis and fat-storage-inducing TM
C-terminal kinase domain of Drosophila Four-jointed (Fj), mouse Fjx1, and related proteins
FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]
Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]
Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...
This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...
Vesicle coat protein involved in Golgi to plasma membrane transport
Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...
First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins
Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors
First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3)
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
Src Homology 3 domain of Formin Binding Protein 17
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 1-Like
Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
Src Homology 3 domain of Formin Binding Protein 1-Like
Protein prenyltransferase alpha subunit repeat
PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...
M28 Zn-peptidase prostate-specific membrane antigen
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...
Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]
Mur ligase family, glutamate ligase domain
Folate-sensitive fragile site protein Fra10Ac1
Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins
DOMON domain of stromal cell-derived receptor 2 (ferric chelate reductase 1) and related proteins
Eukaryotic cytochrome b(561), including the FRRS1 gene product
Fibroblast growth factor receptor substrate 2 (FRS2/SNT1) Phosphotyrosine-binding domain
Cysteine-rich domain of the secreted frizzled-related protein 3 (SFRP3, alias FRZB), a Wnt antagonist
NTR domain, Secreted frizzled-related protein (Sfrp) 3-like subfamily
Gonadotropin hormone receptor transmembrane region
Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
23S rRNA methylase [Translation, ribosomal structure and biogenesis]
Peptidase S8 family domain in Protein convertases
Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]
Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease
Helically extended Src Homology 3 domain of Adhesion and Degranulation-promoting Adaptor Protein
Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
Src homology 2 (SH2) domain found in Fyn isoform a like proteins
Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
Src homology 2 (SH2) domain found in Fyn
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 1 (Fz1) receptor
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 10 (Fz10) receptor
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 2 (Fz2) receptor
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 3 (Fz3) receptor
Cysteine-rich Wnt-binding domain of the frizzled 4 (Fz4) receptor
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 5 (Fz5) receptor.proteins
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 7 (Fz7) receptor
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 8 (Fz8) receptor
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 9 (Fz9) receptor
Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many...
PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an...
Membrane-associated phospholipid phosphatase [Lipid metabolism]
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...
Glucose-6-phosphate dehydrogenase, NAD binding domain
This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two...
Gab (Grb2-associated binder) pleckstrin homology (PH) domain
Ubiquitin domain of GABA-receptor-associated protein
Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain
Growth arrest and DNA-damage-inducible proteins-interacting protein 1
Galanin message associated peptide (GMAP)
UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs
Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...
This family includes the closely related glycosyl hydrolase family 31 (GH31) isozymes, neutral alpha-glucosidase C (GANC) and the alpha subunit of heterodimeric neutral alpha-glucosidase AB (GANAB). Initially distinguished on the basis of differences in...
Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Rab5-activating protein 6 (RAP6) is an endosomal protein with a role in the regulation of receptor-mediated endocytosis. RAP6 contains a Vps9 domain, which is involved in the activation of Rab5, and a Ras GAP domain (RGD). Rab5 is a small GTPase required...
GlyRS_RNA binding domain.  This short RNA-binding domain is found at the  N-terminus of GlyRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix-turn-helix structure , which is similar to other RNA-binding...
Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...
GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...
Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis
Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
Src homology 3 domain of Growth Arrest Specific protein 7
N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme)
Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes
Alpha amylase, C-terminal all-beta domain
Guanine nucleotide exchange factor in Golgi transport N-terminal
GC-rich sequence DNA-binding factor-like protein
GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...
GTP cyclohydrolase I feedback regulatory protein (GFRP)
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars
Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...
Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...
C-terminal, alpha helical domain of Ganglioside-induced differentiation-associated protein 1
GST_N family, Ganglioside-induced differentiation-associated protein 1 (GDAP1) subfamily
C-terminal, alpha helical domain of Ganglioside-induced differentiation-associated protein 1-like 1
Macro domain, GDAP2_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...
Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE1 and similar proteins
Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE4 and similar proteins
Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE3 and similar proteins
Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]
Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE6 and similar proteins
Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE2 and similar proteins
Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
Survival motor neuron (SMN) interacting protein 1 (SIP1)
PIN domain of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
H3TH domain of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis
mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...
EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...
mtEFG2_C: C-terminus of mitochondrial Elongation factor G2 (mtEFG2)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...
mtEF-G2 domain IV. This subfamily is a part the of mitochondrial transcriptional elongation factor, mtEF-G2. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory...
EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...
Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]
Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...
SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...
Type 1 glutamine amidotransferase (GATase1) domain found in gamma-Glutamyl Hydrolase
Gamma-glutamyltransferase [Amino acid transport and metabolism]
CTLH/CRA C-terminal to LisH motif domain
Alpha-helical domain of GINS complex protein Psf1
Alpha-helical domain of GINS complex protein Psf2 (partner of Sld5 2)
Alpha-helical domain of GINS complex protein Psf3 (partner of Sld5 3)
Alpha-helical domain of GINS complex protein Sld5
G protein-coupled receptor kinase-interacting protein 1 C term
Gap junction channel protein cysteine-rich domain
Metazoan glycerol kinase 1 and 3-like proteins
Glycerol kinase [Energy production and conversion]
metazoan glycerol kinase 5-like proteins
Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase
Glycosyl hydrolases family 2, sugar binding domain
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1
SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich...
SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian...
Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione
This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases
This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins
Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily
TRX domain, PICOT (for PKC-interacting cousin of TRX) subfamily
Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily
GT8_like_1 represents a subfamily of GT8 with unknown function
Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]
NAD(P) binding domain of glutamate dehydrogenase, subgroup 1
Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
Putative glycerate kinase [Carbohydrate transport and metabolism]
The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha.  In a variety of cell lines, NP60 has been shown to localize to the...
3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]
GM2 activator protein (GM2-AP) is a non-enzymatic lysosomal protein that acts as cofactor in the sequential degradation of gangliosides. GM2A is an essential cofactor for beta-hexosaminidase A (Hex A) in the enzymatic hydrolysis of GM2 ganglioside to GM3
The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2  and several proteins of...
GDP-mannose 4,6 dehydratase, extended (e) SDRs
ADF-homology domain of glia maturation factor beta and related proteins
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras...
N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]
N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins
IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...
Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase
The C-terminal domain of GMP synthetase. It contains two subdomains
Alpha subunit of G proteins (guanine nucleotide binding)
Neuroendocrine-specific golgi protein P55 (NESP55)
Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues
Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]
A circularly permuted subfamily of the Ras GTPases
A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
ribosome biogenesis GTP-binding protein YlqF
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily
PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...
PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...
Snare region anchored in the vesicle membrane C-terminus
Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4...
Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
glycerol-3-phosphate dehydrogenase, anaerobic, B subunit
MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea
Molybdopterin biosynthesis enzyme [Coenzyme metabolism]
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...
Myelin proteolipid protein (PLP or lipophilin)
Conserved hypothetical ATP binding protein
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
polycystic kidney disease I (PKD) domain
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the...
Abscisic acid G-protein coupled receptor
Ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor
LGN motif, putative GEFs specific for G-alpha GTPases
domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins
N-terminal Src homology 3 domain of GRB2-related adaptor protein
Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
C-terminal Src homology 3 domain of GRB2-related adaptor protein
N-terminal Src homology 3 domain of GRB2-related adaptor protein 2
C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...
Eukaryotic homologues of bacterial periplasmic substrate binding proteins
Type 1 periplasmic binding fold superfamily
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta1 receptor of an orphan glutamate receptor family
Bacterial extracellular solute-binding proteins, family 3
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta2 receptor of an orphan glutamate receptor family
First harmonin_N_like domain (repeat 1) of L-delphilin, and related domains
Second harmonin_N_like domain (repeat 2) of L-delphilin, and related domains
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR5-7 subunits of Kainate receptor
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
N-methyl D-aspartate receptor 2B3 C-terminus
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR3 subunit of NMDA receptor family
Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 1 (GRK1)
Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1
Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 4 (GRK4)
Catalytic domain of G protein-coupled Receptor Kinase 4-like Protein Serine/Threonine Kinases
Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 5 (GRK5)
Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 7 (GRK7)
Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7
Ligand binding domain of the group I metabotropic glutamate receptor
Homer-binding domain of metabotropic glutamate receptor
Ligand binding domain of the group II metabotropic glutamate receptor
Ligand-binding domain of the group III metabotropic glutamate receptor
GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding
Histone-binding protein RBBP4 or subunit C of CAF1 complex
Glutaredoxin (GRX) family, GRX-like domain containing protein subfamily
Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
eRF3_II: domain II of the eukaryotic class II release factor (eRF3). In eukaryotes, translation termination is mediated by two interacting release factors, eRF1 and eRF3, which act as class I and II factors, respectively. eRF1 functions as an omnipotent...
This family represents eEF1alpha-like C-terminal region of eRF3 homologous to the domain III of EF-Tu. eRF3 is a GTPase, which enhances the termination efficiency by stimulating the eRF1 activity in a GTP-dependent manner. The C-terminal region is...
C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
DsbA family, Glutathione (GSH) S-transferase Kappa (GSTK) subfamily
C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
C-terminal, alpha helical domain of Class Pi Glutathione S-transferases
C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
Precursor of TFIIA alpha and beta subunits and similar proteins
Transcription factor IIA, alpha/beta subunit
Gamma subunit of transcription initiation factor IIA, N-terminal helical domain
Transcription initiation factor IIA, gamma subunit [Transcription]
Gamma subunit of transcription initiation factor IIA, C-terminal domain
C-terminal general transcription factor TFIIE alpha
TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
Transcription initiation factor IIF, alpha subunit, N-terminal region of RAP74. Subunit of transcription initiation complex involved in initiation, elongation and promoter escape.Tetramer of 2 alpha and 2 beta TFIIF subunits interacts directly with RNA...
Transcription initiation factor IIF, beta subunit
Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins...
Transcription factor TFIIH complex subunit Tfb5
Transcription factor IIIC subunit delta N-term
Putative zinc-finger of transcription factor IIIC complex
RNA polymerase III transcription factor (TF)IIIC subunit
GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
Domain II of the GP-1 family of GTPase. This group includes proteins similar to GTPBP1 and GTPBP2. GTPB1 is structurally, related to elongation factor 1 alpha, a key component of protein biosynthesis machinery. Immunohistochemical analyses on mouse...
Domain III of the GP-1 family of GTPase. This group includes proteins similar to GTPBP1 and GTPBP2. GTPB1 is structurally, related to elongation factor 1 alpha, a key component of protein biosynthesis machinery. Immunohistochemical analyses on mouse...
Catalytic cysteine-containing C-terminus of GTPase, MnmE
GTPases [General function prediction only]
Ligand-binding domain of the membrane guanylyl cyclase C
Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
LepA also known as Elongation Factor 4 (EF4)
lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...
lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...
Glycosyl hydrolases family 2, TIM barrel domain
GT8_like_2 represents a subfamily of GT8 with unknown function
Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
Glycogen synthase, which is most closely related to the GT1 family of glycosyltransferases, catalyzes the transfer of a glucose molecule from UDP-glucose to a terminal branch of a glycogen molecule, a rate-limit step of glycogen biosynthesis. GSY2, the...
Macro domain, Macro_H2A_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]
Protein tyrosine phosphatase-like protein, PTPLA
Pyrimidine (PYR) binding domain of POX and related proteins
Thiamine pyrophosphate enzyme, central domain
Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module
fatty acid oxidation complex, alpha subunit, mitochondrial
Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL)
Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP)
HisRS_RNA binding domain.  This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding...
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...
Hyaluronan synthases catalyze polymerization of hyaluronan
Histone acetyl transferase HAT1 N-terminus
domain in Ataxins and HMG containing proteins
eRF3_II_like: domain similar to domain II of the eukaryotic class II release factor (eRF3). In eukaryotes, translation termination is mediated by two interacting release factors, eRF1 and eRF3, which act as class I and II factors, respectively. eRF1...
HBS1_C: this family represents the C-terminal domain of Hsp70 subfamily B suppressor 1 (HBS1) which is homologous to the domain III of EF-1alpha. This group contains proteins similar to yeast Hbs1, a G protein known to be important for efficient growth...
Src homology 2 (SH2) domain found in HCK
Src homology 3 domain of Hematopoietic lineage cell-specific protein 1
Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]
Histone deacetylase class IV also known as histone deacetylase 11
Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]
The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids.  The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation.  Most PWWP-domain proteins...
The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1
Lens epithelium-derived growth factor (LEDGF)
U3 small nucleolar RNA-associated protein 10
APC10-like DOC1 domain of HECTD3, a HECT E3 ubiquitin ligase protein that mediates substrate ubiquitination
C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]
Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or...
APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain protein
Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the...
Glycosyl hydrolase family 20, catalytic domain
Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...
Repulsive guidance molecule (RGM) N-terminus
Repulsive guidance molecule (RGM) C-terminus
VHS domain family, Hrs and Vps27p subfamily
Hepatocyte growth factor-regulated tyrosine kinase substrate
Hypoxia induced protein conserved region
Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...
Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core
Holliday junction recognition protein-associated repeat
Holliday junction regulator protein family C-terminal repeat
KRAB (Kruppel-associated box) domain -A box
Class II histocompatibility antigen, alpha domain
Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
Class II histocompatibility antigen, beta domain
Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain
Type 1 glutamine amidotransferase (GATase1)-like domain
Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]
Biotin/lipoate A/B protein ligase family
Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]
Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...
HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone...
High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I...
Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]
3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain
Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...
Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...
SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...
Hepatocyte nuclear factor 1 (HNF-1), N terminus
Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus
DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are...
Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]
N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS)
C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS)
insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs
C-terminal, alpha helical domain of Class Sigma Glutathione S-transferases
Glycosyl hydrolase family 79, N-terminal domain
Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...
The phosphoinositide binding Phox Homology domain of HS1BP3
Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]
human estrogenic 17beta-hydroxysteroid dehydrogenase type 1 (type 1 17beta-HSD)-like, classical (c) SDRs
17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs
17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
retinal dehydrogenase-like, classical (c) SDR
The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...
HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit
3-keto steroid reductase, classical (c) SDRs
beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs
human 3beta-HSD (hydroxysteroid dehydrogenase) and HSD3B1(delta 5-delta 4-isomerase)-like, extended (e) SDRs
human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs
Vertebrate heat shock transcription factor
Src homology 2 domain found in hematopoietic SH2 (HSH2) protein
Nucleotide-binding domain of HSPA12A and similar proteins
Nucleotide-binding domain of HSPA12B and similar proteins
Nucleotide-binding domain of human HSPA13 and similar proteins
Nucleotide-binding domain of human HSPA14 and similar proteins
Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
Nucleotide-binding domain of human HSPA5 and similar proteins
Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins
Alpha crystallin domain (ACD) found in mammalian small (s)heat shock protein (Hsp)-27 (also denoted HspB1 in human) and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally...
Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB2/heat shock 27kDa protein 2 and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally...
Alpha crystallin domain (ACD) found in mammalian HspB3, also known as heat-shock protein 27-like protein (HSPL27, 17-kDa) and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are...
Alpha-crystallin domain found in alphaA-crystallin (HspB4), alphaB-crystallin (HspB5), and the small heat shock protein (sHsp) HspB6, also known as Hsp20. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress
Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB7, also known as cardiovascular small heat shock protein (cvHsp), and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect...
Alpha-crystallin domain (ACD) found in mammalian 21.6 KDa small heat shock protein (sHsp) HspB8, also denoted as Hsp22 in humans, and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and...
Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB9 and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers...
GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...
Chaperonin 10 Kd subunit (cpn10 or GroES)
Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
Third immunoglobulin (Ig)-like domain found in Perlecan and similar proteins
Vomeronasal organ pheromone receptor family, V1R
Insulin growth factor-binding protein homologues
Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
Kazal-type serine protease inhibitor domain
Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]
Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash.  The SGNH-family of hydrolases is a diverse family of...
catalytic core domain of isoleucyl-tRNA synthetases
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases
Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]
The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
Islet cell autoantigen ICA69, C-terminal domain
Intercellular adhesion molecule (ICAM), N-terminal domain
Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
Isoprenylcysteine carboxyl methyltransferase (ICMT) family
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
isocitrate dehydrogenase, NAD-dependent, mitochondrial type
Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...
Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits
Gluconate kinase [Carbohydrate transport and metabolism]
Gamma interferon inducible lysosomal thiol reductase (GILT)
Interferon-induced 35 kDa protein (IFP 35) N-terminus
Caspase activation and recruitment domain found in MDA5, first repeat
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...
Intraflagellar transport complex B protein 46 C terminal
Catalytic domain of the Protein Tyrosine Kinase, Insulin-like Growth Factor-1 Receptor
R3H domain of Smubp-2_like proteins.  Smubp-2_like proteins also contain a helicase_like and an AN1-like Zinc finger domain and have been shown to bind single-stranded DNA. The name of the R3H domain comes from the characteristic spacing of the most...
Immunoglobulin (Ig)-like domain of titin and similar proteins
polyubiquitin binding domain of NEMO and related proteins
Orthopoxvirus interleukin 18 binding protein
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1)
Interleukin-4 receptor alpha chain, N-terminal
domain in DSRM or ZnF_C2H2 domain containing proteins
Serine/threonine phosphatases, family 2C, catalytic domain
Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]
Ribosomal protein S4 and related proteins [Translation, ribosomal structure and biogenesis]
S4/Hsp/ tRNA synthetase RNA-binding domain
The Brix domain is found in a number of eukaryotic proteins
IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...
Chromosome passenger complex (CPC) protein INCENP N terminal
Inner centromere protein, ARK binding region
Inhibitor of growth proteins N-terminal histone-binding
Type I inositol polyphosphate 5-phosphatase I
Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate...
Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins
Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Inositol polyphosphate-5-phosphatase E and related proteins
Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins
Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
SAM domain of Ship2 lipid phosphatase proteins
IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and...
IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP
Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
IQGAP1 is a homodimeric protein that is widely expressed among vertebrate cell types from early embryogenesis. Mammalian IQGAP1 protein is the best characterized member of the IQGAP family, and contains several protein-interacting domains. Human IQGAP1...
IQGAP2 is a member of the IQGAP family that contains a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeat, a single WW domain, four IQ motifs which mediate interactions with calmodulin, and a Ras-GTPase-activating protein (GAP)...
RasGAP: Ras-GTPase Activating Domain.  RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin.  Although the Rho (Ras...
Death domain of Interleukin 1 Receptor Associated Kinase-1
Death domain of Interleukin 1 Receptor Associated Kinase-2
Death domain of Interleukin 1 Receptor Associated Kinase-M
Death domain of Interleukin-1 Receptor-Associated Kinase 4
Interferon regulatory factor 2-binding protein zinc finger
Uncharacterized protein involved in propionate catabolism [General function prediction only]
p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
Insulin receptor substrate (IRS) Phosphotyrosine-binding domain(PTB)
Motif in Iroquois-class homeodomain proteins (only). Unknown function
NifU homolog involved in Fe-S cluster formation [Energy production and conversion]
ISG15 ubiquitin-like protein, first repeat of 2
The first LIM domain of Isl, a member of LHX protein family
The second LIM domain of Isl, a member of LHX protein family
CDP-ME synthetase is involved in mevalonate-independent isoprenoid production
Regulator of Vps4 activity in the MVB pathway
C2 domain present in E3 ubiquitin ligase
Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta...
Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain
Integrin beta subunits (N-terminal portion of extracellular region)
Inter-alpha-trypsin inhibitor heavy chain C-terminus
vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...
marine proteobacterial sortase target protein
Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase
NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...
Inositol 1, 3, 4-trisphosphate 5/6-kinase
Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
Second Src homology 3 domain (or SH3B) of Intersectin-1
Third Src homology 3 domain (or SH3C) of Intersectin-1
Fourth Src homology 3 domain (or SH3D) of Intersectin-1
Fifth Src homology 3 domain (or SH3E) of Intersectin-1
First Src homology 3 domain (or SH3A) of Intersectin-1
First Src homology 3 domain (or SH3A) of Intersectin-2
Second Src homology 3 domain (or SH3B) of Intersectin-2
Third Src homology 3 domain (or SH3C) of Intersectin-2
Fourth Src homology 3 domain (or SH3D) of Intersectin-2
Fifth Src homology 3 domain (or SH3E) of Intersectin-2
Involucrin of squamous epithelia N-terminus
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS)
Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney,  using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers
Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinases, Janus kinases 2 and 3
Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases 2 and 3
Src homology 2 (SH2) domain in the Janus kinase 3 (Jak3) proteins
Small domain found in the jumonji family of transcription factors
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
A domain family that is part of the cupin metalloenzyme superfamily
C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2
Jumping translocation breakpoint protein (JTB)
First Src homology 3 domain of the RhoGEF kinase, Kalirin
Second Src homology 3 domain of the RhoGEF kinase, Kalirin
LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop
Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...
PCAF (P300/CBP-associated factor) N-terminal domain
Histone acetyltransferase (MYST family) [Chromatin structure and dynamics]
BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in...
Zinc finger, ZZ type. Zinc finger present in potassium channel modulatory factor (PCMF) 1  and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Human potassium channel...
Potassium channel Kv1.4 tandem inactivation domain
Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
Inward rectifier potassium channel N-terminal
Calcium-activated BK potassium channel alpha subunit
Calcium-activated potassium channel, beta subunit
Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta subunits, the two subunits...
Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 2 (VEGFR-2)
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2
3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR
Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1...
Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose.  KHK can also phosphorylate several other furanose sugars.  It is found in higher eukaryotes...
Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]
RNA pol II promoter Fmp27 protein domain
Hereditary spastic paraplegia protein strumpellin
Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
N-terminal LabA-like domain of limkain b1 and similar proteins
The first LOTUS domain on Limkain b1(LKAP)
The second LOTUS domain on Limkain b1(LKAP)
The third LOTUS domain on Limkain b1(LKAP)
The fourth LOTUS domain on Limkain b1(LKAP)
The fifth LOTUS domain on Limkain b1(LKAP)
The sixth LOTUS domain on Limkain b1(LKAP)
The seventh LOTUS domain on Limkain b1(LKAP)
The eighth LOTUS domain on Limkain b1(LKAP)
KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...
Predicted integral membrane metal-binding protein (DUF2296)
Src Homology 3 domain of Mixed Lineage Kinase 4
Kinesin motor domain, BimC/Eg5 spindle pole proteins, participate in spindle assembly and chromosome segregation during cell division. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are...
Kinesin motor domain. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. In...
Kinesin motor domain, KIF1_like proteins. KIF1A (Unc104) transports synaptic vesicles to the nerve terminal, KIF1B has been implicated in transport of mitochondria. Both proteins are expressed in neurons. This catalytic (head) domain has ATPase activity...
Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes
Kinesin motor domain, KLP2-like subgroup. Members of this subgroup seem to play a role in mitosis and meiosis. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are microtubule-dependent...
The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
Kinesin motor domain, kinesins II or KIF3_like proteins. Subgroup of kinesins, which form heterotrimers composed of 2 kinesins and one non-motor accessory subunit. Kinesins II play important roles in ciliary transport, and have been implicated in...
Kinesin motor domain, KIP3-like subgroup. The yeast kinesin KIP3 plays a role in positioning the mitotic spindle. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are microtubule-dependent...
Kinesin motor domain, KIF23-like subgroup. Members of this group may play a role in mitosis. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are microtubule-dependent molecular motors that play...
Kinesin motor domain, KIF4-like subfamily. Members of this group seem to perform a variety of functions, and have been implicated in neuronal organelle transport and chromosome segregation during mitosis. This catalytic (head) domain has ATPase activity...
Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]
Kinesin motor domain, KIF22/Kid-like subgroup. Members of this group might play a role in regulating chromosomal movement along microtubules in mitosis. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases
Gammaherpesvirus protein of unknown function (DUF848)
Kinesin motor domain, KIF2-like group. KIF2 is a protein expressed in neurons, which has been associated with axonal transport and neuron development
Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup. Members of this group have been associated with organelle transport. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are...
Kinesin motor domain, KIF9-like subgroup
Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins. Ncd is a spindle motor protein necessary for chromosome segregation in meiosis. KIFC2/KIFC3-like kinesins have been implicated in motility of the Golgi apparatus as well as dentritic...
Domain of Kin17 curved DNA-binding protein
Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2)
Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein (also known as Neph2)
Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2) and similar proteins
Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
Catalytic domain of the Protein Tyrosine Kinase, Kit
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]
Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many...
Cysteine-rich motif following a subset of SET domains
Guanine nucleotide exchange factor for Ras-like GTPases
Karyopherin (importin) alpha [Intracellular trafficking and secretion]
Karyopherin (importin) beta [Intracellular trafficking and secretion]
Bacterial protein of unknown function (DUF883)
SAM like domain present in kinase suppressor RAS 1
Sixth immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
Fourth immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]
Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]
C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...
Bacterial protein of unknown function (DUF948)
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer)
Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]
Mitogen-activated protein kinase kinase 1 interacting
eukaryotic Lanthionine synthetase C-like protein. This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1 and LANCL2 (testes-specific adriamycin...
Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...
La RNA-binding domain of La-related protein 1
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
La RNA-binding domain proteins similar to La-related proteins 1 and 2
La RNA-binding domain of La-related protein 4
La RNA-binding domain of La-related protein 5
La RNA-binding domain of La-related protein 6
La RNA-binding domain of La-related protein 7
catalytic core domain of leucyl-tRNA synthetases
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases
The LIM domain of LIM and SH3 Protein (LASP)
The Nebulin repeat is present also in Las1
C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1
Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 1
Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin
Src homology 3 domain of Lck Protein Tyrosine Kinase
Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
The first LIM domain of ZASP/Cypher family
The second LIM domain of Enigma-like family
The third LIM domain of ZASP/Cypher family
lactate/malate dehydrogenase, alpha/beta C-terminal domain
Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)
Glutamine synthetase [Amino acid transport and metabolism]
Lipoma HMGIC fusion partner-like protein
The first LIM domain of Lhx1 (also known as Lim1) and Lhx5
The second LIM domain of Lhx1 (also known as Lim1) and Lhx5
The second LIM domain of Lhx2 and Lhx9 family
The second LIM domain of Lhx3-Lhx4 family
Adenylation domain of eukaryotic DNA Ligase I
The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase I is a DNA-binding module that is part of the catalytic core unit
Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase III is a DNA-binding module that is part of the catalytic core unit
The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
The Lim domain of Epithelial Protein Lost in Neoplasm (Eplin)
a LIM domain subfamily on a group of proteins with unknown function
The second LIM domain of LIMK1 (LIM domain Kinase 1)
The first LIM domain of LIMK1 (LIM domain Kinase 1)
The second LIM domain of LIMK2 (LIM domain Kinase 2)
The first LIM domain of LIMK2 (LIM domain Kinase 2)
Pancreatic lipase-like enzymes.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is 'interfacial activation,' the...
PLAT/ LH2 domain present in lipoprotein lipase (LPL).  LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the...
ERGIC-53 and ERGL type 1 transmembrane proteins, N-terminal lectin domain
VIP36 and VIPL type 1 transmembrane proteins, lectin domain
The first LIM domain of Testin-like family
The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
The first LIM domain of LMO2 (LIM domain only protein 2)
The second LIM domain of LMO2 (LIM domain only protein 2)
The first LIM domain of LMO4 (LIM domain only protein 4)
The second LIM domain of LMO4 (LIM domain only protein 4)
Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2
The second LIM domain of Lmx1a and Lmx1b
Nuclear pore complex interacting protein (NPIP)
Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with encoding genes sharing substantial sequence similarity. Their family subunits may be grouped into five subfamilies, A-E. Uteroglobin (subfamily A), which is identical...
Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]
Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...
DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
Found in ATP-dependent protease La (LON)
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2)  domain.  It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and...
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins
This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the...
The fourth LIM domain of the Paxillin-like protein family
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking,  are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor
Subgroup of the immunoglobulin (Ig) superfamily
Guanylate kinase [Nucleotide transport and metabolism]
Low-density lipoprotein receptor domain class A
Leucine-rich repeat containing protein 8
Double stranded RNA binding protein (DUF2051)
Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
Squalene cyclase (SQCY) domain subgroup 1
Peptidase M1 family contains leukotriene A4 hydrolase
MD-1 and MD-2 are cofactors required for LPS signaling through cell surface receptors. MD-2 and its binding partner, Toll-like receptor 4 (TLR4), are essential for the innate immune responses of mammalian cells to bacterial lipopolysaccharide (LPS)
Goose Egg White Lysozyme domain. Eukaryotic 'goose-type' lysozymes (GEWL). These enzymes catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc).  Members include tunicate, Japanese...
Src homology 3 domain of Lyn Protein Tyrosine Kinase
Src homology 2 (SH2) domain found in Lyn
Catalytic domain of the Protein Tyrosine Kinase, Lyn
Lysine Motif is a small domain involved in binding peptidoglycan
FOG: LysM repeat [Cell envelope biogenesis, outer membrane]
Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]
Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...
Domain always found downstream of DENN domain, found in a variety of signalling proteins
RING-type zinc-finger, LisH dimerisation motif
Melanoma associated antigen family N terminal
Herpesvirus transcription activation factor (transactivator)
Mago nashi proteins, integral members of the exon junction complex
Nuclear protein with HMG-like acidic region [General function prediction only]
Death domain similar to that found in Mucosa-associated lymphoid tissue-lymphoma-translocation gene 1
N-terminal catalytic domain of Golgi alpha-mannosidase II and similar proteins
N-terminal catalytic domain of Golgi alpha-mannosidase IIx, and similar proteins
N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins
N-terminal catalytic domain of mammalian core-specific lysosomal alpha 1,6-mannosidase and similar proteins
Glycosyl hydrolases family 38 C-terminal domain
Alpha-mannosidase [Carbohydrate transport and metabolism]
N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins
Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily
Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]
Glycoside hydrolase family 99, an endo-alpha-1,2-mannosidase
Glycoside hydrolase families 71, 99, and related domains
Tau and MAP protein, tubulin-binding repeat
Catalytic domain of the dual-specificity Protein Kinase, MAP/ERK Kinase 1
Catalytic domain of the dual-specificity Protein Kinases, MAP kinase kinases 3 and 6
Catalytic domain of the dual-specificity Protein Kinase, MAP kinase kinase 4
Catalytic domain of the dual-specificity Protein Kinase, MAP kinase kinase 5
PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5...
Catalytic domain of the dual-specificity Protein Kinase, MAP kinase kinase 7
Catalytic domain of the Protein Serine/Threonine Kinase, MAP/ERK kinase kinase 1
Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
Catalytic domain of Protein Tyrosine Kinases
Catalytic domain of the Protein Serine/Threonine Kinase, Apoptosis signal-regulating kinase
Catalytic domain of the Protein Serine/Threonine Kinase, Yeast Sps1/Ste20-related kinase 4
The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3)...
Catalytic domain of the Protein Serine/Threonine Kinase, MAP/ERK kinase kinase 2
Catalytic domain of the Protein Serine/Threonine Kinase, MAP/ERK kinase kinase 3
Catalytic domain of the Protein Serine/Threonine Kinase, MAP/ERK kinase kinase 4
Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase-like Protein Serine/Threonine Kinases
Catalytic domain of the Protein Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5
Herpesvirus latent membrane protein 1 (LMP1)
Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase
Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 and 6
Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
Src homology 3 domain of JNK-interacting protein 1
Src homology 3 domain of JNK-interacting protein 2
JNK-interacting protein (JIP) Phosphotyrosine-binding (PTB) domain
Procyclic acidic repetitive protein (PARP)
Stress-activated map kinase interacting protein 1 (SIN1)
Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
Tripartite ATP-independent periplasmic transporters, DctQ component
Glutathione S-transferase C-terminal-like, alpha helical domain of Methionyl-tRNA synthetase from higher eukaryotes
catalytic core domain of methioninyl-tRNA synthetases
Anticodon-binding domain of methionyl tRNA synthetases
MetRS_RNA binding domain. This short RNA-binding domain is found at the C-terminus of MetRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is repeated in Drosophila MetRS. This domain consists of a helix-turn-helix structure, which is...
Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase
dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs
Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments
Trimeric coiled-coil oligomerisation domain of matrilin
Caspase activation and recruitment domain (CARD) found in IPS-1
MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding...
C-terminal domain of methyl-CpG binding protein 2 and 3
MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to...
Peptidase S8 family domain in SKI-1-like proteins
Sterol regulatory element-binding protein (SREBP) Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50A), regulates intramembrane proteolysis (RIP) of SREBP and is part of a signal transduction mechanism involved in sterol and lipid...
Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...
malonyl CoA-acyl carrier protein transacylase
PDZ domain of MCC-2 bdg protein for Usher syndrome
Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
Dbs (DBL's big sister) pleckstrin homology (PH) domain
Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
Nuclear protein export factor [Intracellular trafficking and secretion / Cell division and chromosome partitioning]
Predicted ATPase involved in replication control, Cdc46/Mcm family [DNA replication, recombination, and repair]
N-terminal region of micro-spherule protein
C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
N-terminal domain of multiple copies T cell malignancies 1 and related proteins
Cytoplasmic and cytosolic Malate dehydrogenases
Glyoxysomal and mitochondrial malate dehydrogenases
PTN/MK heparin-binding protein family, N-terminal domain
VWA_Midasin: Midasin is a member of the AAA ATPase family. The proteins of this family are unified by their common archetectural organization that is based upon a conserved ATPase domain. The AAA domain of midasin contains six tandem AAA protomers. The...
NAD(P) binding domain of malic enzyme (ME), subgroup 1
Mediator of RNA polymerase II transcription subunit 1
Transcription factor subunit Med10 of Mediator complex
Transcription mediator complex subunit Med12
Eukaryotic Mediator 12 catenin-binding domain
Mediator of RNA pol II transcription subunit 19
TATA-binding related factor (TRF) of subunit 20 of Mediator complex
Surfeit locus protein 5 subunit 22 of Mediator complex
Mediator complex subunit 25 von Willebrand factor type A
Mediator complex subunit 25 PTOV activation and synapsin 2
Vitamin-D-receptor interacting Mediator subunit 4
Mediator of RNA polymerase II transcription complex subunit 8
RNA polymerase II transcription mediator complex subunit 9
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I...
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers.  Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/...
RPA1_DBD_B: A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which...
Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility
Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as...
Meprin family, Alpha subunit, MATH domain
Meprin family, Beta subunit, MATH domain
Catalytic Domain of Axl-like Protein Tyrosine Kinases
Chaperone for wingless signalling and trafficking of LDL receptor
The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present...
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present...
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present...
Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides
Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...
Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides
6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]
The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase
Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
Src Homology 3 domain of Melanoma Inhibitory Activity 3 protein
Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has...
The LIM domain of Mical (molecule interacting with CasL) like family
The LIM domain of Mical (molecule interacting with CasL)
This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
Thyroid hormone-inducible hepatic protein Spot 14
Myb-Like Dna-Binding Domain of MTA3 and related proteins
Peptidase M3 mitochondrial intermediate peptidase (MIP)
Zn-dependent oligopeptidases [Amino acid transport and metabolism]
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear
Di-glucose binding within endoplasmic reticulum
Myelodysplasia-myeloid leukemia factor 1-interacting protein
MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to...
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to...
Myelin-associated oligodendrocytic basic protein (MOBP)
The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate...
NER and RNAPII transcription protein n terminal
CDK-activating kinase assembly factor MAT1
Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]
molybdenum cofactor biosynthesis protein A
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...
ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...
Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein...
Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases
Alkyladenine DNA glycosylase catalyzes the first step in base excision repair
U3 small nucleolar ribonucleoprotein component [Translation, ribosomal structure and biogenesis]
Mov34/MPN/PAD-1 family: Histone H2A deubiquitinase
Src Homology 3 domain of Membrane Protein, Palmitoylated 1 (or MAGUK p55 subfamily member 1)
domain in receptor targeting proteins Lin-2 and Lin-7
Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
Src Homology 3 domain of Membrane Protein, Palmitoylated 3 (or MAGUK p55 subfamily member 3)
Src Homology 3 domain of Membrane Protein, Palmitoylated 4 (or MAGUK p55 subfamily member 4)
Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)
Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)
human MPPE1 and related proteins, metallophosphatase domain
Homo sapiens 239FB and related proteins, metallophosphatase domain
Outspread Pleckstrin homology (PH) domain
Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]
Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain
Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain
Immunoglobulin (Ig)-like domain of Protein zero (P0)
Myelin-PO cytoplasmic C-term p65 binding region
Immunoglobulin (Ig)-like domain of Protein zero (P0) and similar proteins
Immunoglobulin (Ig)-like domain of epithelial V-like antigen 1 (EVA)
Mre11 nuclease, N-terminal metallophosphatase domain
rRNA methylases [Translation, ribosomal structure and biogenesis]
RNA 2'-O ribose methyltransferase substrate binding
Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...
Ribosomal protein L10 family, L10 subfamily
Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...
Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...
Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...
Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...
Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...
Ribosomal Proteins L2, RNA binding domain
Ribosomal Proteins L2, C-terminal domain
Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...
Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...
Mitochondrial 28S ribosomal protein S30 (PDCD9)
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes
TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...
Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane
Mitochondrial ribosomal protein L46 (MRP L46) is a component of the large subunit (39S) of the mammalian mitochondrial ribosome and a member of the Nudix hydrolase superfamily. MRPs are thought to be involved in the maintenance of the mitochondrial DNA
Mitochondrial 39-S ribosomal protein L47 (MRP-L47)
Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...
Mitochondrial large subunit ribosomal protein (Img2)
S12-like family, 30S ribosomal protein S12 subfamily
Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome
Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...
ribosomal protein S5, bacterial/organelle type
Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family
Ribosomal protein L10 family, P0-like protein subfamily
Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]
MutS2 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...
DNA-binding domain of DNA mismatch repair MUTS family
MutS5 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...
The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS.   The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been...
Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)
Zinc-finger of mitochondrial splicing suppressor 51
The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
Catalytic domain of Mammalian Ste20-like protein kinase 3-like Protein Serine/Threonine Kinases
Catalytic domain of the Protein Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4
Human Misato shows similarity with Tubulin/FtsZ family of GTPases and is localized to the the outer membrane of mitochondria. It has a role in mitochondrial fusion and in mitochondrial distribution and morphology. Mutations in its Drosophila homolog
BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH...
Methionyl-tRNA formyltransferase, N-terminal hydrolase domain
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase
NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]
NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...
This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell
mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...
Translation initiation factor 3 (IF-3) [Translation, ribosomal structure and biogenesis]
Translation initiation factor IF-3, N-terminal domain
Translation initiation factor IF-3, C-terminal domain
Protein tyrosine phosphatase, catalytic domain motif
tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA
Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family [Signal transduction mechanisms / Cell division and chromosome partitioning / Chromatin structure and dynamics / DNA replication, recombination, and repair / Intracellular...
TOR (Target of rapamycin), catalytic domain
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...
B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy)
Vitamin B12 dependent methionine synthase, activation domain
Protein chain release factor B [Translation, ribosomal structure and biogenesis]
Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred...
Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
GST_N family, Metaxin subfamily, Metaxin 1-like proteins
C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins
GST_N family, Metaxin subfamily, Metaxin 2
C-terminal, alpha helical domain of Metaxin 2
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
C-terminal cystine knot-like domain (CTCK)
Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA).  MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase...
Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase
Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily
methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...
A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...
C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
Death domain of Myeloid Differentation primary response protein MyD88
Basic domain in HLH proteins of MYOD family
Myosin motor domain, type II myosins. Myosin II mediates cortical contraction in cell motility, and is the motor in smooth and skeletal muscle. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins...
Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
Myosin motor domain. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport
Myosin motor domain, type XV myosins. In vertebrates, myosin XV appears to be expressed in sensory tissue and play a role in hearing. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are...
Myosin motor domain, type XVIII myosins. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and...
Myosin motor domain, type I myosins. Myosin I generates movement at the leading edge in cell motility, and class I myosins have been implicated in phagocytosis and vesicle transport. Myosin I, an unconventional myosin, does not form dimers. This...
Src homology 3 domain of Myosins Ie, If, and similar proteins
Catalytic domain of the Protein Serine/Threonine Kinase, Class IIIA myosin
Myosin motor domain, type III myosins. Myosin III has been shown to play a role in  the vision process in insects and in hearing in mammals. Myosin III, an unconventional myosin, does not form dimers. This catalytic (head) domain has ATPase activity and...
Catalytic domain of the Protein Serine/Threonine Kinase, Class IIIB myosin
Myosin motor domain, type V myosins. Myosins V transport a variety of intracellular cargo processively along actin filaments, such as membraneous organelles and mRNA. This catalytic (head) domain has ATPase activity and belongs to the larger group of...
Myosin motor domain, type VI myosins. Myosin VI is a monomeric myosin, which moves towards the minus-end of actin filaments, in contrast to most other myosins. It has been implicated in endocytosis, secretion, and cell migration. This catalytic (head)...
Myosin motor domain, type VII myosins. Myosins in this group have been associated with functions in sensory systems such as vision and hearing. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins...
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a...
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a...
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
C-temrinal immunoglobulin (Ig)-like domain of myomesin and M-protein
C-terminal immunoglobulin (Ig)-like domain of M-protein (also known as myomesin-2)
C-terminal immunoglobulin (Ig)-like domain of myotilin
Mitotic-spindle organizing gamma-tubulin ring associated
Acetyltransferases [General function prediction only]
N-acetyltransferase B complex (NatB) non catalytic subunit
Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
PA_hNAALADL2_like: Protease-associated domain containing proteins like human N-acetylated alpha-linked acidic dipeptidase-like 2 protein (hNAALADL2). This group contains various PA domain-containing proteins similar to hNAALADL2. The function of...
SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In...
Transcription factor homologous to NACalpha-BTF3 [Transcription]
Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases)
NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...
Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to...
Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]
AAK_NAGS-Urea: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the urea cycle found in animals. Ureogenic NAGS is a mitochondrial enzyme catalyzing the formation of NAG from acetylcoenzyme A and L-glutamate
DUF619 domain of various N-acetylglutamate Synthases (NAGS) of the urea (U) cycle of humans and fish
pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general
C-terminal SAF domain of sialic acid synthetase
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...
Iron only hydrogenase large subunit, C-terminal domain
Aspartyl/asparaginyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]
AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...
EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...
The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves...
Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears...
First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1
Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)
Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)
First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan
non-SMC mitotic condensation complex subunit 1, N-term
non-SMC mitotic condensation complex subunit 1
Nuclear condensing complex subunits, C-term domain
Condensin II non structural maintenance of chromosomes subunit
Middle domain of eukaryotic initiation factor 4G (eIF4G)
The phosphoinositide binding Phox Homology domain of the p47phox subunit of NADPH oxidase
First or N-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1
Second or C-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1
NADPH oxidase subunit p47Phox, C terminal domain
N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
A PB1 domain is present in p67 proteins which forms a signaling complex with p40, a crucial step for activation of  NADPH oxidase during phagocytosis. PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in...
C-terminal (or second) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
The phosphoinositide binding Phox Homology domain of the p40phox subunit of NADPH oxidase
Src Homology 3 domain of the p40phox subunit of NADPH oxidase
The PB1 domain is essential part of the p40 adaptor protein which plays an important role in activating phagocyte NADPH oxidase during phagocytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in...
Second Src Homology 3 domain of Nck1 adaptor protein
Third Src Homology 3 domain of Nck1 adaptor protein
Src homology 2 (SH2) domain found in Nck
First Src Homology 3 domain of Nck1 adaptor protein
First Src Homology 3 domain of Nck2 adaptor protein
Second Src Homology 3 domain of Nck2 adaptor protein
Third Src Homology 3 domain of Nck2 adaptor protein
Src homology 3 domain of SH3 protein interacting with Nck, 90 kDa (SPIN90)
M28 Zn-Peptidase Nicalin, Nicastrin-like protein
M28 Zn-Peptidase Nicastrin, a main component of gamma-secretase complex
Protein involved in chromosome segregation, interacts with SMC proteins [Cell division and chromosome partitioning]
NUDE protein, C-terminal conserved region
Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via...
NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a...
NADH ubiquinone oxidoreductase subunit NDUFA12
NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs
Complex I intermediate-associated protein 30 (CIA30)
Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially characterized nuclear protein, which is homologous to E3-3 from rat and known to be alternatively spliced. Its function is unknown. This family is part of the...
ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)
NADH-ubiquinone oxidoreductase B12 subunit family
NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)
NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)
NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)
NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...
Respiratory-chain NADH dehydrogenase, 49 Kd subunit
NADH (or F420H2) dehydrogenase, subunit C
NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
Respiratory-chain NADH dehydrogenase 24 Kd subunit
TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily
C-terminal Src Homology 3 domain of Nebulin
C-terminal Src Homology 3 domain of Nebulette and LIM-nebulette (or Lasp2)
First immunoglobulin (Ig) domain of nectin-1 (also known as poliovirus receptor related protein 1, or as CD111) and similar proteins
Second immunoglobulin (Ig) domain of nectin-1 (also known as poliovirus receptor related protein 1, or as CD111) and similar proteins
First immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3) and similar proteins
Second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3), nectin-4 (poliovirus receptor related protein 4) and similar proteins
C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9
Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9
C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9
N-terminal domain of metazoan Nei-like glycosylase 1 (NEIL1)
N-terminal domain of metazoan Nei-like glycosylase 2 (NEIL2)
N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases
N-terminal domain of metazoan Nei-like glycosylase 3 (NEIL3)
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 1
F0F1-type ATP synthase, subunit b [Energy production and conversion]
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 11
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 2
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 3
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 4
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 5
Catalytic domain of the Protein Serine/Threonine Kinases, Never In Mitosis gene A-related kinase 6 and 7
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 8
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 9
Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...
Neurofibromin is the product of the neurofibromatosis type 1 gene (NF1) and shares a region of similarity with catalytic domain of the mammalian p120RasGAP protein and an extended similarity with the Saccharomyces cerevisiae RasGAP proteins Ira1 and Ira2
Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
N-terminal sub-domain of the Rel homology domain (RHD)
CTF/NF-I family transcription modulation region
Vertebrate interleukin-3 regulated transcription factor
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to...
Death domain of the Nuclear Factor-KappaB1 precursor protein p105
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor kappa B2 (NF-kappa B2)
Death domain of the Nuclear Factor-KappaB2 precursor protein p100
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...
R3H domain of the X1 box binding protein (NF-X1) and related proteins. Human NF-X1 is a transcription factor that regulates the expression of class II major histocompatibility complex (MHC) genes. The Drosophila homolog shuttle craft (STC) has been shown...
Src homology 3 domain of the Rho guanine nucleotide exchange factor, ephexin-1 (also called NGEF or ARHGEF27)
Death domain of p75 Neurotophin Receptor
PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
domain present in PNGases and other hypothetical proteins
PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins
Protein involved in ribosomal biogenesis, contains PUA domain [Translation, ribosomal structure and biogenesis]
HEAT repeat associated with sister chromatid cohesion
The phosphoinositide binding Phox Homology domain of the Imidazoline Receptor Antisera-Selected
Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes
Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases)
R3H domain of the NF-kappaB-repression factor (NRF). NRF is a nuclear inhibitor of NF-kappaB proteins that can silence the IFNbeta promoter via binding to a negative regulatory element (NRE). Beside R3H NRF also contains a G-patch domain. The name of the...
cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...
Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin
Pyrin death domain found in NALP proteins
Caspase activation and recruitment domain found in Human ASC, NALP1, and similar proteins
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also...
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also...
TRX domain, TRX and NDP-kinase (NDPK) fusion protein family
NDP kinase domain of thioredoxin domain-containing proteins  (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which...
NmrA (a transcriptional regulator), HSCARG (an NADPH sensor), and triphenylmethane reductase (TMR) like proteins, atypical (a) SDRs
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR...
NAD/NADP transhydrogenase beta subunit [Energy production and conversion]
PIN domain of eukaryotic ribosome assembly factor Nob1 and archaeal UPF0129 protein Ta0041-like homologs
Protein involved in the nuclear export of pre-ribosomes [Translation, ribosomal structure and biogenesis / Intracellular trafficking and secretion]
Caspase activation and recruitment domain similar to that found in NOD1
Caspase activation and recruitment domain of NOD2, repeat 1
Caspase activation and recruitment domain of NOD2, repeat 2
Nucleolar RNA-binding protein, Nop10p family
Protein implicated in ribosomal biogenesis, Nop56p homolog [Translation, ribosomal structure and biogenesis]
Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...
The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an
DYC-1 (DYB-1 binding and Capon related) Phosphotyrosine-binding (PTB) domain
Src homology 3 domain of Nitric Oxide Synthase TRaffic INducer
The PB1 domain is present in the p51 protein, a homolog of the p67 protein.  p51 plays an  important role in NADPH oxidase activation during phagosytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical...
C-terminal Src Homology 3 domain of NADPH oxidase activator 1
First or N-terminal Src homology 3 domain of Nox Organizing protein 1
Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1
The phosphoinositide binding Phox Homology domain of Nox Organizing protein 1
Sterol-sensing domain of SREBP cleavage-activation
Niemann-Pick type C2 (Npc2) is a lysosomal protein in which a mutation in the gene causes a rare form of Niemann-Pick type C disease, an autosomal recessive lipid storage disorder characterized by accumulation of low-density lipoprotein-derived...
Neural proliferation differentiation control-1 protein (NPDC1)
Src Homology 3 domain of Nephrocystin (or Nephrocystin-1)
Eighth immunoglobulin-like domain of nephrin
Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...
N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL)
NPL4 family, putative zinc binding region
Mov34/MPN/PAD-1 family: nuclear protein localization-4 (Npl4) domain
Ligand-binding domain of type A natriuretic peptide receptor
Ligand-binding domain of type B natriuretic peptide receptor
Ligand-binding domain of type C natriuretic peptide receptor
Nitrogen Permease regulator of amino acid transport activity 3
Pancreatic Hormone domain, a regulator of pancreatic and gastrointestinal functions
The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain
DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers
The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily
The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
DNA-binding domain of Farnesoid X receptor (FXR) family is composed of two C4-type zinc fingers
The ligand binding domain of Farnesoid X receptor:a member of the nuclear receptor superfamily of ligand-activated transcription factors
The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
DNA-binding domain of pregnane X receptor (PXRs) is composed of two C4-type zinc fingers
The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
The ligand binding domain of the orphan nuclear receptors TR4 and TR2
DNA-binding domain of Tailless (TLX) is composed of two C4-type zinc fingers
The ligand binding domain of Tailless-like proteins,  orphan nuclear receptors
DNA-binding domain of the photoreceptor cell-specific nuclear receptor (PNR) is composed of two C4-type zinc fingers
DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers
Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
Ligand binding domain of the mineralocorticoid receptor, a member of the nuclear receptor superfamily
DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
The ligand binding domain of  Nurr1, a member of conserved family of nuclear receptors
The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
The ligand binding domain of the liver receptor homolog-1, a member of  nuclear receptor superfamily
DNA-binding domain of Germ cell nuclear factor (GCNF) F1 is composed of two C4-type zinc fingers
The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule)
Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule)
NLS-binding and DNA-binding and dimerisation domains of Nrf1
Nrf1 activator activation site binding domain
Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
Immunoglobulin (Ig)-like domain in neuregulins (NRGs)
Catalytic domain of Class III myosin-like Protein Serine/Threonine Kinases
pre-ribosomal protein NSA2 (Nop seven-associated 2)
The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS).  When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as...
human NSDHL (NAD(P)H steroid dehydrogenase-like protein)-like, extended (e) SDRs
Cell division protein 48 (CDC48), N-terminal domain
Cell division protein 48 (CDC48) N-terminal domain
Cell division protein 48 (CDC48), domain 2
Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47
Nse1 non-SMC component of SMC5-6 complex
Coiled-coil domain-containing protein 55 (DUF2040)
tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]
Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HAD superfamily (subfamily IG) hydrolase, 5'-nucleotidase
5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]
CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain
Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A
Fifth domain (immunoglobulin-like) of Trk receptor TrkB
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...
Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]
p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I)...
p23_NUDCD1: p23-like NUD (nuclear distribution) C-like domain found in human NUD (nuclear distribution) C domain-containing protein 1, NUDCD1 (also known as CML66), and similar proteins. NUDCD1/CML66 is a broadly immunogenic tumor associated antigen
p23-like NUD (nuclear distribution) C-like found in human NUDC domain-containing protein 2 (NUDCD2) and similar proteins.  Little is known about the function of the proteins in this subgroup
p23-like NUD (nuclear distribution) C-like domain found in human NUDC domain-containing protein 3 (NUDCD3) and similar proteins.   Little is known about the function of the proteins in this subgroup
MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...
Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...
NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]
NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...
NADH pyrophosphatase-like rudimentary NUDIX domain
ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+
Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...
Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...
ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P.  Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also...
Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)
Nucleoporin subcomplex protein binding to Pom34
Undecaprenyl pyrophosphate synthase [Lipid metabolism]
Tryparedoxin (TryX)-like family, TryX and nucleoredoxin (NRX) subfamily
PDIb' family, NRX subgroup, redox inactive TRX-like domain b'
Tryparedoxin (TryX)-like family, Rod-derived cone viability factor (RdCVF) subfamily
RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner
3-oxoacyl-(acyl carrier protein) synthase III
Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...
Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
2'-5' oligoadenylate synthetase-like protein, repeat 1 of 2
hOBFC1_like: A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which...
Src homology 3 domain of Obscurin and similar proteins
otoconin_90: Phospholipase A2-like domains present in otoconin-90 and otoconin-95, mammal proteins that are principal matrix proteins of calcitic otoconia. Interactions involving otoconin-90 may trigger or constitute key events in otoconia formation. The...
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...
Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]
Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...
Ovarian carcinoma immunoreactive antigen (OCIA)
Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB10, also known as sperm outer dense fiber protein (ODFP), and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell...
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]
Oxoglutarate and iron-dependent oxygenase degradation C-term
Opioid growth factor receptor (OGFr) conserved region
8-oxoguanine DNA glycosylase, N-terminal domain
TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...
Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]
The Bin/Amphiphysin/Rvs (BAR) domain of Oligophrenin-1
BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC...
Origin recognition complex (ORC) subunit 3 N-terminus
Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]
Origin recognition complex subunit 6 (ORC6)
Middle domain of the origin recognition complex subunit 6
Oxysterol binding protein (OSBP) Pleckstrin homology (PH) domain
putative bacillithiol system oxidoreductase, YpdA family
Src Homology 3 domain of metazoan osteoclast stimulating factor 1
Osteopetrosis-associated transmembrane protein 1 precursor
Insulin-resistance promoting peptide in skeletal muscle
Preprotein translocase subunit YidC [Intracellular trafficking and secretion]
Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]
Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...
Catalytic domain of the Protein Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
Oxidative-stress-responsive kinase 1 C terminal
Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
PDIa family, C-terminal TRX domain (a') subfamily
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...
Poly-adenylate binding protein, unique domain
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1)
Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
Protein-arginine deiminase (PAD) N-terminal domain
Protein-arginine deiminase (PAD) middle domain
SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases
PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate...
ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, phenylalanine hydroxylases (PAH)
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
Catalytic domain of the Protein Serine/Threonine Kinase, Group I p21-activated kinase
Catalytic domain of the Protein Serine/Threonine Kinase, Group II p21-activated kinase
Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 6
C-terminal immunoglobulin (Ig)-like domain of palladin
DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain
Poly(A) polymerase predicted RNA binding domain
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor
Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...
The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions...
amino-terminal ubiquitin-like of parkin protein
Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1
R3H domain of Poly(A)-specific ribonuclease (PARN). PARN is a poly(A)-specific 3' exonuclease from the RNase D family that, in Xenopus, deadenylates a specific class of maternal mRNAs which results in their translational repression. The name of the R3H...
WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins,  which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a...
Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component...
Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...
Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)
WGR domain of poly(ADP-ribose) polymerases
WGR domain of poly(ADP-ribose) polymerase 3 and similar proteins
ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell
ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding
Plant protein of unknown function (DUF869)
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2
Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2
PEP-CTERM family integral membrane protein
Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...
SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases
CID (CTD-Interacting Domain) domain family
Invertebrate innate immunity transcript family
Phosphorylated CTD interacting factor 1 WW domain
Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...
C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
proliferating cell nuclear antigen (pcna)
Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea.  These polymerase processivity factors play a role in DNA replication and repair.  PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the...
Peptidase domain in the S8 and S53 families
type VII secretion-associated serine protease mycosin
Peptidase S8 family domain in ProteinaseK-like proteins
Lipid-binding START domain of mammalian STARD2 and related proteins
Casein kinase substrate phosphoprotein PP28
Phosducin (Phd)-like family, Phd subfamily
S1_Rrp5_repeat_hs1_sc1: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats...
S1_Rrp5_repeat_hs2_sc2: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats...
Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]
S1_Rrp5_repeat_hs3: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats in...
S1_Rrp5_repeat_hs4: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats in...
S1_Rrp5_repeat_hs5: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats in...
S1_Rrp5_repeat_hs6_sc5: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats...
S1_Rrp5_repeat_hs7: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats in...
S1_Rrp5_repeat_hs8_sc7: Rrp5 Homo sapiens S1 repeat 8 (hs8) and Saccharomyces cerevisiae S1 repeat 7 (sc7)-like domains. Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits.  Rrp5 has two distinct...
S1_Rrp5_repeat_hs10: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats in...
S1_Rrp5_repeat_hs11_sc8: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats...
S1_Rrp5_repeat_hs12_sc9: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats...
S1_Rrp5_repeat_hs13: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits.  Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats in...
S1_Rrp5_repeat_hs14: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats in...
Programmed cell death protein 2, C-terminal putative domain
Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
Protein-interacting Bro1-like domain of mammalian Alix and related domains
Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily
Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein
Putative intracellular protease/amidase [General function prediction only]
FOG: GAF domain [Signal transduction mechanisms]
Metal dependent phosphohydrolases with conserved 'HD' motif
Retinal cGMP phosphodiesterase, gamma subunit
Platelet-derived growth factor, N terminal region
Frst immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)
Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR) alpha
Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha
branched-chain alpha-keto acid dehydrogenase subunit E2
PDIb family, ERp57 subfamily, first redox inactive TRX-like domain b
PDIb' family, ERp72 and ERp57 subfamily, second redox inactive TRX-like domain b'
PDIb family, ERp72 subfamily, first redox inactive TRX-like domain b
PDIb family, PDIR subfamily, N-terminal TRX-like b domain
P5 family, C-terminal redox inactive TRX-like domain
This family represents the LIM domain of CLP36
The LIM domain of Mystique, a subfamily of ALP LIM domain proteins
This family represents the LIM domain of ALP, actinin-associated LIM protein
The first LIM domain of the Enigma Homolog (ENH) family
The third LIM domain of the Enigma Homolog (ENH) family
3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
Isoprenoid Biosynthesis enzymes, Class 1
Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...
Domains similar to the N-terminal protein-binding module of harmonin
Domain present in PSD-95, Dlg, and ZO-1/2
Death Effector Domain of Astrocyte phosphoprotein PEA-15
Predicted RNA-binding proteins [General function prediction only]
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides
Xaa-Pro aminopeptidase [Amino acid transport and metabolism]
Peroxisome biogenesis factor 1, N-terminal
ATPase family associated with various cellular activities (AAA)
Peroxisomal biogenesis factor 11 (PEX11)
Src Homology 3 domain of eumetazoan Peroxisomal biogenesis factor 13
Peroxisomal membrane anchor protein (Pex14p) conserved region
phosphoribosylformylglycinamidine synthase, single chain form
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP
Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase
Predicted prefoldin, molecular chaperone implicated in de novo protein folding [Posttranslational modification, protein turnover, chaperones]
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent...
Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the...
Pepsin A, aspartic protease produced in gastric mucosa of mammals
Gastricsins, asparate proteases produced in gastric mucosa
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones]
Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes...
Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...
Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...
Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction
The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...
This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...
PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into...
Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...
Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
Catalytic domain, repeat 1, of eukaryotic PhosphatidylGlycerophosphate Synthases
Catalytic domain, repeat 2, of eukaryotic phosphatidylglycerophosphate synthases
Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein).  Individual proteins of this band 7 domain family may...
MYM-type Zinc finger with FCS sequence motif
SAM domain of Ph (polyhomeotic) proteins of Polycomb group
Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]
Phosphoserine phosphatase [Amino acid transport and metabolism]
Male germ-cell putative homeodomain transcription factor
SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...
SCP_HrTT-1: SCP-like extracellular protein domain in HrTT-1, a tail-tip epidermis marker in ascidians. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins
Trappin protein transglutaminase binding domain
Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain)
Phosphoinositide 4-kinase (PI4K), Type III, alpha isoform, catalytic domain
Phosphoinositide 4-kinase (PI4K), Type III, beta isoform, catalytic domain
The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
Death Domain of p53-induced protein with a death domain
GPI-GlcNAc transferase complex, PIG-H component
Phosphatidylinositol-glycan biosynthesis class S protein
Gpi16 subunit, GPI transamidase component
This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa
C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain)
Phosphoinositide 3-kinase (PI3K), class II, alpha isoform, catalytic domain
The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
Phosphoinositide 3-kinase (PI3K), class II, beta isoform, catalytic domain
The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases
Phosphoinositide 3-kinase (PI3K), class II, gamma isoform, catalytic domain
The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases
C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)
Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain)
Phosphoinositide 3-kinase family, accessory domain (PIK domain)
Phosphoinositide 3-kinase (PI3K), class III, catalytic domain
C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
Phosphoinositide 3-kinase (PI3K) class I, accessory domain
Phosphoinositide 3-kinase (PI3K), class IA, alpha isoform, catalytic domain
Phosphoinositide 3-kinase (PI3K), class IA, beta isoform, catalytic domain
C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
Phosphoinositide 3-kinase (PI3K), class IA, delta isoform, catalytic domain
C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
Phosphoinositide 3-kinase (PI3K), class IB, gamma isoform, catalytic domain
C-terminal Src homology 2 (cSH2) domain found in p85
N-terminal Src homology 2 (nSH2) domain found in p85
Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region...
Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
Phosphoinositide 3-kinase gamma adapter protein p101 subunit
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol...
TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this...
Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment  includes type II...
Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]
Lipid-binding SRPBCC domain of mammalian PITPNA, -B, and related proteins (Class I PITPs)
Lipid-binding SRPBCC domain of mammalian PITPNC1,and related proteins (Class IIB PITPs)
Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
PAZ domain,  Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the...
Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of...
present in yeast cell wall integrity and stress response component proteins
Repeats in polycystic kidney disease 1 (PKD1) and other proteins
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological...
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...
Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...
Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
C2 domain in Protein kinase C-like (PKN) proteins
Catalytic domain of the Protein Serine/Threonine Kinase, Protein Kinase N
First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N3
PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes
Group XII secretory phospholipase A2 precursor (PLA2G12)
PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes
PLA2_bee_venom_like: A sub-family of  Phospholipase A2, similar to bee venom PLA2. PLA2 is a super-family of secretory and cytosolic enzymes
PLA2_group_III_like: A sub-family of  Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes
Cytoplasmic phospholipase A2, catalytic subunit
Patatin-like phospholipase domain containing protein 9
Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity.  It's members may be involved in the conversion of phosphatidylcholine to fatty acids and...
Phospholipase C (PLC) pleckstrin homology (PH) domain
Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta
Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta4
Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
Src homology 3 domain of Phospholipase C (PLC) gamma 1
Phosphatidylinositol-specific phospholipase C, Y domain
Src homology 3 domain of Phospholipase C (PLC) gamma 2
Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta
Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1
Catalytic domain of metazoan phosphoinositide-specific phospholipase C-zeta
The phosphoinositide binding Phox Homology domain of Phospholipase D1
Phospholipase D (PLD) pleckstrin homology (PH) domain
Catalytic domain, repeat 1, of vertebrate phospholipase D1
Catalytic domain, repeat 2, of vertebrate phospholipase D1
The phosphoinositide binding Phox Homology domain of Phospholipase D2
Catalytic domain, repeat 1, of vertebrate phospholipase D2
Catalytic domain, repeat 2, of vertebrate phospholipase D2
Putative catalytic domain, repeat 1, of vertebrate phospholipase PLD3
Putative catalytic domain, repeat 2, of vertebrate phospholipase PLD3
Putative catalytic domain, repeat 1, of vertebrate phospholipase PLD4
Putative catalytic domain, repeat 2, of vertebrate phospholipase PLD4
Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
Catalytic domain of vertebrate phospholipase D6 and similar proteins
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 1-like proteins.  Pleckstrin 1 plays a role in cell spreading and reorganization of actin cytoskeleton in platelets and leukocytes. Its activity is highly regulated by phosphorylation
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 2-like proteins.  Pleckstrin 2 is found in a wide variety of cell types, which suggest a more general role in signaling than pleckstrin 1. Pleckstrin-like proteins contain a central...
Phafin2  Pleckstrin Homology (PH) domain
Clg (common-site lymphoma/leukemia guanine nucleotide exchange factor) pleckstrin homology (PH) domain
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both...
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a...
The Sema domain, a protein interacting module, of Plexin A1
The Sema domain, a protein interacting module, of Plexin A2
The Sema domain, a protein interacting module, of Plexin A3
domain found in Plexins, Semaphorins and Integrins
The Sema domain, a protein interacting module, of semaphorins and plexins
The Sema domain, a protein interacting module, of Plexin A4
The Sema domain, a protein interacting module, of Plexin B1
The Sema domain, a protein interacting module, of Plexin B2
The Sema domain, a protein interacting module, of Plexin B3
The Sema domain, a protein interacting module, of Plexin C1
The Sema domain, a protein interacting module, of Plexin D1
M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily
Predicted Zn-dependent peptidases [General function prediction only]
MutL_Trans_hPMS1_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM1 (hPSM1) and yeast MLH2. hPSM1 and yMLH2 are members of the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is...
MutL_Trans_hPMS2_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM2 (hPSM2). hPSM2 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...
PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of...
purine nucleoside phosphorylase I, inosine and guanosine-specific
Patatin-like phospholipase domain containing protein 1
Patatin-like phospholipase domain containing protein 2
Patatin-like phospholipase domain containing protein 3
Patatin-like phospholipase domain containing protein 4
Patatin-like phospholipase domain containing protein 5
Patatin-like phospholipase domain containing protein 6 and protein 7
Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]
Patatin-like phospholipase domain containing protein 8
Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region
Polyribonucleotide nucleotidyltransferase, RNA binding domain
Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...
Ribosomal protein S1-like RNA-binding domain
GDP-fucose protein O-fucosyltransferase and related proteins
DNA polymerase alpha subunit p180 N terminal
inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase
DNA polymerase type-B alpha subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) alpha is almost exclusively...
DNA polymerase alpha subunit B N-terminal
DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase delta, a family-B DNA polymerase
DNA polymerase type-B delta subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. Presently, no direct data is available regarding...
C4-type zinc-finger of DNA polymerase delta
PolD2 (DNA polymerase delta, subunit 2), C-terminal domain
Hemimethylated DNA-binding protein YccV like
DNA polymerase family B, exonuclease domain
DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase epsilon, a family-B DNA polymerase
DNA polymerase type-B epsilon subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) epsilon has been proposed...
DNA polymerase elongation subunit (family B) [DNA replication, recombination, and repair]
Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication
Pol gammaA is a family A polymerase that is responsible for DNA replication and repair in mitochondria
C-terminal domain of mitochondrial DNA polymerase gamma B subunit, which is required for processivity. Polymerase gamma replicates and repairs mitochondrial DNA. The c-terminal domain of its B subunit is strikingly similar to the anticodon-binding domain...
Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]
DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation
DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]
Largest subunit of RNA polymerase (RNAP), C-terminal domain
Largest subunit (Rpa1) of Eukaryotic RNA polymerase I (RNAP I), C-terminal domain
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...
AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
AC19 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
A49-like RNA polymerase I associated factor
Largest subunit (Rpb1) of Eukaryotic RNA polymerase II (RNAP II), C-terminal domain
RPB3 subunit of Eukaryotic RNA polymerase II
DNA-directed RNA polymerase II subunit family protein
DNA-directed RNA polymerase II subunit 7
RNAP_II_Rpb7_N: Rpb7, N-terminal ribonucleoprotein (RNP) domain. Rpb7 is a subunit of eukaryotic RNA polymerase (RNAP) II that is homologous to Rpc25 of RNAP III, RpoE of archaeal RNAP, and Rpa43 of eukaryotic RNAP I. Rpb7 heterodimerizes with Rpb4 and...
S1_RNAPII_Rpb7: Eukaryotic RNA polymerase II (RNAPII) Rpb7 subunit C-terminal S1 domain. RNAPII is composed of 12 subunits (Rpb1-12). Rpb4 and Rpb7 form a heterodimer that associate with the RNAPII core. Rpb7 is a homolog of the Rpc25 of RNA polymerase...
DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]
RPB11 subunit of Eukaryotic RNA polymerase II
Largest subunit (Rpc1) of Eukaryotic RNA polymerase III (RNAP III), C-terminal domain
RNA polymerase III subunit RPC82 helix-turn-helix domain
DNA-directed RNA polymerase III subunit Rpc31
DNA-directed RNA polymerase, subunit E' [Transcription]
RNAP_III_Rpc25_N: Rpc25, N-terminal ribonucleoprotein (RNP) domain. Rpc25 is a subunit of eukaryotic RNA polymerase (RNAP) III and is homologous to Rpa43 of eukaryotic RNAP I, Rpb7 of eukaryotic RNAP II, and RpoE of archaeal RNAP. Rpc25 has two domains
Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
Ribonucleases P/MRP protein subunit POP1
A domain found in a protein subunit of human RNase MRP and RNase P ribonucleoprotein complexes and archaeal proteins
Rpp20 subunit of nuclear RNase MRP and P
hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats...
hPOT1_OB1_like: A subfamily of OB folds similar to the first OB fold (OB1) of human protection of telomeres 1 protein (hPOT1), the single OB fold of the N-terminal domain of Schizosaccharomyces pombe POT1 (SpPOT1), and the first OB fold of the N-terminal...
Found in Pit-Oct-Unc transcription factors
POU domain, class 2, associating factor 1
Pou domain - N-terminal to homeobox domain
Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers
DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
The ligand binding domain of peroxisome proliferator-activated receptors
Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...
DNA / pantothenate metabolism flavoprotein
Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
Protein phosphatase 2A homologues, catalytic domain
SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
SAM domain of liprin-beta1,2 proteins repeat 1
SAM domain of liprin-beta proteins repeat 3
SAM domain of liprin-beta1,2 proteins repeat 2
cyclophilin_ABH_like: Cyclophilin  A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which...
peptidyl-prolyl cis-trans isomerase B (rotamase B)
cyclophilin_SpCYP2_like: cyclophilin 2-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to Schizosaccharomyces pombe cyp-2. These proteins bind their respective SNW chromatin binding protein in autologous systems, in a CsA independent...
cyclophilin_RING: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal...
Cyclophilin_PPIL3_like. Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a
cyclophilin_RRM: cyclophilin-type peptidylprolyl cis- trans isomerase domain occuring with a C-terminal RNA recognition motif domain (RRM). This subfamily of the cyclophilin domain family contains a number of eukaryotic cyclophilins having the RRM domain...
Protein serine/threonine phosphatase 2C, C-terminal domain
PP1, PPKL (PP1 and kelch-like) enzymes,  and related proteins, metallophosphatase domain
Src Homology 3 domain of Apoptosis Stimulating of p53 protein 1
Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
Phosphatase-1 catalytic subunit binding region
eIF2-alpha phosphatase phosphorylation constitutive repressor
Phostensin PP1-binding and SH3-binding region
SAM domain of SAM_Neurabin-like subfamily
PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
Phosphotyrosyl phosphatase activator (PTPA) is also known as protein phosphatase 2A (PP2A) phosphatase activator. PTPA is an essential, well conserved protein that stimulates the tyrosyl phosphatase activity of PP2A. It also reactivates the serine...
Protein phosphatase 2A regulatory B subunit (B56 family)
Component of IIS longevity pathway SMK-1
cyclophilin_WD40: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain
PA_hPAP21_like: Protease-associated domain containing proteins like the human secreted glycoprotein hPAP21 (human protease-associated domain-containing protein, 21kDa). This group contains various PA domain-containing proteins similar to hPAP21. Complex...
Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily
Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]
Peroxiredoxin (PRX) family, PRX5-like subfamily
Peroxiredoxin (PRX) family, 1-cys PRX subfamily
Prolyl oligopeptidase, N-terminal beta-propeller domain
Protease II [Amino acid transport and metabolism]
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF...
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF...
C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)
The PET domain of overexpressed breast tumor protein (OEBT)
The second LIM domain of Testin-like family
AE_Prim_S: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. Primases are DNA-dependent RNA polymerases which synthesis the short RNA primers required for DNA replication. In addition to its...
AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...
Eukaryotic core primase: Large subunit, PriL
N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit
5'-AMP-activated protein kinase beta subunit, interation domain
cAMP-dependent protein kinase catalytic subunit
Catalytic domain of the Protein Serine/Threonine Kinase, cAMP-dependent protein kinase
Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
Dimerization/Docking domain of the Type II alpha Regulatory subunit of cAMP-dependent protein kinase
Dimerization/Docking domain of the Type II beta Regulatory subunit of cAMP-dependent protein kinase
C2 domain in Protein Kinase C (PKC) alpha and gamma
Catalytic domain of the Protein Serine/Threonine Kinase, Classical Protein Kinase C
Catalytic domain of the Protein Serine/Threonine Kinase, Novel Protein Kinase C delta
C2 domain in Protein Kinase C (PKC) epsilon
Catalytic domain of the Protein Serine/Threonine Kinase, Novel Protein Kinase C epsilon
Catalytic domain of the Protein Serine/Threonine Kinase, Novel Protein Kinase C eta
PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3  proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific...
Catalytic domain of the Protein Serine/Threonine Kinase, Atypical Protein Kinase C
Catalytic domain of the Protein Serine/Threonine Kinase, Novel Protein Kinase C theta
Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
DNA-dependent protein kinase (DNA-PK), catalytic domain
Catalytic domain of the Protein Serine/Threonine Kinase, cGMP-dependent protein kinase
Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I beta
Catalytic domain of PRKX-like Protein Serine/Threonine Kinases
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones
Src homology 3 domain of Protein arginine N-methyltransferase 2
Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Eukaryotic YBL036c-like proteins
Splicing Factor Motif, present in Prp18 and Pr04
U5 snRNP spliceosome subunit [RNA processing and modification]
RNA recognition motif of the spliceosomal PrP8
Mpr1p, Pad1p N-terminal (MPN) domains without isopeptidase activity found in splicing factor Prp8
Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
N-terminal domain of ribose phosphate pyrophosphokinase
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion]
Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...
Presenilin enhancer-2 subunit of gamma secretase
The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...
proteasome_alpha_type_1. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on...
proteasome_alpha_type_2. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on...
proteasome_alpha_type_3. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on...
proteasome_alpha_type_4. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on...
proteasome_alpha_type_5. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on...
proteasome_alpha_type_6. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on...
proteasome endopeptidase complex, archaeal, alpha subunit
proteasome_alpha_type_7. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on...
20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
proteasome beta type-1 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...
proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...
proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...
proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...
proteasome beta type-3 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...
proteasome beta type-4 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...
proteasome beta type-6 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...
26 proteosome regulatory subunit 4-like protein
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
26S protease regulatory subunit 6B-like protein
26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of...
26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]
Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in 19S proteasomal subunits Rpn7 and Rpn8
Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 2
The Eukaryotic (Putative) Sterol Transporter (EST) Family
7TM receptor with intracellular HD hydrolase
Domain of unknown function, E. rectale Gene description (DUF3878)
Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...
C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
p23 binds heat shock protein (Hsp)90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis
alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins
13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity
Animal prostaglandin endoperoxide synthase and related bacterial proteins
Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
Src homology 3 domain of Brk (Breast tumor kinase) Protein Tyrosine Kinase (PTK), also called PTK6
Src homology 2 domain found in protein-tyrosine kinase-6 (PTK6) which is also known as breast tumor kinase (Brk)
Catalytic domain of the Protein Tyrosine Kinases, Srm and Brk
Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4
Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
Protein tyrosine phosphatase, catalytic domain
N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
Protein-interacting, N-terminal, Bro1-like domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
Second immunoglobulin (Ig)-like domain of  the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon...
Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...
Peptidyl-tRNA hydrolase, type 2 (PTH2). Peptidyl-tRNA hydrolase (PTH) activity releases tRNA from the premature translation termination product peptidyl-tRNA, therefore allowing the tRNA and peptide to be reused in protein synthesis. PTH2 is present in...
Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported  to encode such activity, Pth present in...
6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...
poly-U binding splicing factor, half-pint family
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria
Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]
Pseudouridine synthase, Saccharomyces cerevisiae Pus3 like
Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi)
Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA
First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
Third immunoglobulin (Ig)-like domain of peroxidasin
Fourth immunoglobulin (Ig)-like domain of peroxidasin
Animal heme peroxidase domain of peroxidasin and related proteins
The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
The first LIM domain of the paxillin like protein family
This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...
Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1
Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
dihydropteridine reductase (DHPR), classical (c) SDRs
Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...
PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily
Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]
Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)
Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25
C2 domain found in Rab11-family interacting proteins (FIP) class I
Rab-related GTPase family includes Rab5 and Rab22
Rab GTPase family 1 includes the yeast homolog Ypt1
Rab GTPase families 18 (Rab18) and 32 (Rab32)
Rab GTPase family 33 includes Rab33A and Rab33B
Rab GTPase families 34 (Rab34) and 36 (Rab36)
Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
Rab3 GTPase-activating protein catalytic subunit
SOCS (suppressors of cytokine signaling) box of Rab40-like proteins. Rab40 is part of the Rab family of small GTP-binding proteins that form the largest family within the Ras superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as...
Rab GTPase family 40 (Rab40) contains Rab40a, Rab40b and Rab40c
Rab geranylgeranyl transferase alpha-subunit, insert domain
Geranylgeranyltransferase type II (GGTase-II)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-IIs are a subgroup of the protein prenyltransferase family of lipid-modifying...
Nucleotide exchange factor for Rab-like small GTPases (RabGEF), Mss4 type
Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin...
Conserved region of Rad21 / Rec8 like protein
The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associated with membrane-spanning domains.  The conserved ATP-binding motifs common to Rad50 and the ABC transporter family include the Walker A and...
transcription termination factor NusA, C-terminal duplication
DNA repair and recombination protein RadA
Recombination-activating protein 1 zinc-finger domain
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1...
Ubiquitin domain of  RalGDS-like factor (RLF) and related proteins
Ras-related nuclear proteins (Ran)/TC4 family of small GTPases
Rap1 family GTPase consists of Rap1a and Rap1b isoforms
Rap2 family GTPase consists of Rap2a, Rap2b, and Rap2c
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by...
Apbb1ip (Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein) pleckstrin homology (PH) domain
Rapsyn N-terminal myristoylation and linker region
DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
Arginyl tRNA synthetase N terminal domain
catalytic core domain of arginyl-tRNA synthetases
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
Src Homology 3 domain of Ras GTPase-Activating Protein 1
C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
C2 domain present in RAS p21 protein activator 1 (RasA1)
p120GAP is a negative regulator of Ras that stimulates hydrolysis of bound GTP to GDP. Once the Ras regulator p120GAP, a member of the GAP protein family, is recruited to the membrane, it is transiently immobilized to interact with Ras-GTP. The down...
C2 domain first repeat present in RasA2 and RasA3
C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
RASA2 (or GAP1(m)) is a member of the GAP1 family of Ras GTPase-activating proteins that includes GAP1_IP4BP (or RASA3), CAPRI, and RASAL. In vitro, RASA2 has been shown to bind inositol 1,3,4,5-tetrakisphosphate (IP4), the water soluble inositol head...
RASA3 (or GAP1_IP4BP) is a member of the GAP1 family and has been shown to specifically bind 1,3,4,5-tetrakisphosphate (IP4). Thus, RASA3 may function as an IP4 receptor. The members of GAP1 family are characterized by a conserved domain structure...
C2 domain first repeat present in RasA1 and RasA4
C2 domain second repeat present in RasA1 and RasA4
Ras GTPase activating-like 4 protein (RASAL4), also known as Ca2+ -promoted Ras inactivator (CAPRI), is a member of the GAP1 family. Members of the GAP1 family are characterized by a conserved domain structure comprising N-terminal tandem C2 domains, a...
RAS_GTPase activating protein (GAP)_CG9209 pleckstrin homology (PH) domain
Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)
Ras-related protein on chromosome 22 (RRP22) family
Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families
Ubiquitin-like domain of RASSF1 tumour supproessor protein
Tumour-suppressor protein CtIP N-terminal domain
DNA repair protein endonuclease SAE2/CtIP C-terminus
Calcitonin gene-related peptide regulator C terminal
Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known...
Component of SCF ubiquitin ligase and anaphase-promoting complex [Posttranslational modification, protein turnover, chaperones / Cell division and chromosome partitioning]
RNA 3' phosphate cyclase domain (class I) This subfamily of cyclase-like proteins are encoded in eukaryotic genomes. They lack a conserved catalytic histidine residue required for cyclase activity, so probably do not function as cyclases. They are...
retinol dehydrogenases (retinol-DHs), classical (c) SDRs
Superfamily II DNA helicase [DNA replication, recombination, and repair]
C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)
N-terminal sub-domain of the Rel homology domain (RHD) of c-Rel
N-terminal sub-domain of the Rel homology domain (RHD) of RelA
N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein
Tumour necrosis factor receptor superfamily member 19
Additional N-terminal subrepeat of reelin
Tandem repeat subunit of reelin and related proteins
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
Renin stimulates production of angiotensin and thus affects blood pressure
Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production...
DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins
DEDDh 3'-5' exonuclease domain of RNA exonuclease 4, XPMC2, Interferon Stimulated Gene product of 20 kDa, and similar proteins
ATPase involved in DNA replication [DNA replication, recombination, and repair]
Replication factor RFC1 C terminal domain
Regulator of G protein signaling (RGS) domain found in the RGS1 protein
Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain
Regulator of G protein signaling (RGS) domain found in the RGS11 protein
Regulator of G protein signaling (RGS) domain found in the RGS12 protein
Regulator of G protein signaling (RGS) domain found in the RGS13 protein
Regulator of G protein signaling (RGS) domain found in the RGS14 protein
Regulator of G protein signaling (RGS) domain found in the RGS16 protein
Regulator of G protein signaling (RGS) domain found in the RZ protein
Regulator of G protein signaling (RGS) domain found in the RGS18 protein
Regulator of G protein signaling (RGS) domain found in the RGS2 protein
Regulator of G protein signaling (RGS) domain found in the RGS21 protein
Regulator of G protein signaling domain RGS_RGS22_2
Regulator of G protein signaling domain RGS_RGS22_3
Regulator of G protein signaling domain RGS_RGS22_4
C2 domain of the Regulator Of G-Protein Signaling (RGS) family
Regulator of G protein signaling (RGS) domain found in the RGS3 protein
Regulator of G protein signaling (RGS) domain found in the RGS4 protein
Regulator of G protein signaling (RGS) domain found in the RGS5 protein
Regulator of G protein signaling (RGS) domain found in the RGS6 protein
Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins
Regulator of G protein signaling (RGS) domain found in the RGS8 protein
Regulator of G protein signaling (RGS) domain found in the RGS9 protein
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2
Ras Homolog Enriched in Brain (RheB) is a small GTPase
Amino terminal of the G-protein receptor rhodopsin
Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
RhoBTB protein is an atypical member of the Rho family of small GTPases
Ras homology family 4 (Rho4) of small guanosine triphosphatases (GTPases)-like
Ras homolog family, member G (RhoG) of small guanosine triphosphatases (GTPases)
Ras homology family (Rho) of small guanosine triphosphatases (GTPases)
Mitochondrial Rho family 1 (Miro1), N-terminal
Mitochondrial Rho family 2 (Miro2), C-terminal
Wnt-1 responsive Cdc42 homolog (Wrch-1) is a Rho family GTPase similar to Cdc42
Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rhophilin-1
Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rhophilin-2
Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-2
Guanine nucleotide exchange factor synembryn
Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
Src homology 3 domains of Rab3-interacting molecules (RIMs) binding proteins
C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
Src homology 2 (SH2) domain found in Ras and Rab interactor 1 (RIN1)-like proteins
Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
Src homology 2 (SH2) domain found in Ras and Rab interactor 3 (RIN3)-like proteins
Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]
Death Domain of Receptor-Interacting Protein 1
Caspase activation and recruitment domain of Receptor Interacting Protein 2
Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)
Uncharacterized ACR, YagE family COG1723
RNase A family, or Pancreatic RNases family
Eukaryotic RNase H is longer and more complex than their prokaryotic counterparts  and unlike prokaryote, RNase H are essential in higher eukaryote
Mammalian RNase HII is functional when it forms a complex with two other accessory protein
Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids
Ribonuclease H2-C is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids
RNase domain (also known as the kinase extension nuclease domain) of RNase L
Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...
PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3...
PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo...
PNGase/UBA or UBX (PUB) domain of the RNF31 (or HOIP) protein
Adenylation domain of GTP-dependent mRNA capping enzymes
Leucine rich repeat, ribonuclease inhibitor type
First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
Catalytic domain of the Protein Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase
Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
Rok (Rho- associated kinase) pleckstrin homology (PH) domain
Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
Reactive mitochondrial oxygen species modulator 1
Cysteine-rich domain of tyrosine kinase-like orphan receptor 1
Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1
Cysteine-rich domain of tyrosine kinase-like orphan receptor 2
DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
Catalytic domain of the Protein Tyrosine Kinase, C-ros
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...
RPA1N: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be involved in all...
RPA1_DBD_A: A subfamily of OB folds corresponding to the second OB fold, the ssDNA-binding domain (DBD)-A, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which...
Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit [DNA replication, recombination, and repair]
RPA2_DBD_D: A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears...
RPA3: A subfamily of OB folds similar to human RPA3 (also called RPA14). RPA3 is the smallest subunit of Replication protein A (RPA). RPA is a nuclear ssDNA binding protein (SSB) which appears to be involved in all aspects of DNA metabolism including...
RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily
Ribosomal protein L20A (L18A) [Translation, ribosomal structure and biogenesis]
Ribosomal protein L19e, eukaryotic.  L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an...
Ribosomal protein L23, N-terminal domain
Ribosomal_L32_L32e: L32 is a protein from the large subunit that contains a surface-exposed globular domain and a finger-like projection that extends into the RNA core to stabilize the tertiary structure. L32 does not appear to play a role in forming the...
60S ribosomal protein L4 C-terminal domain
Ribosomal protein L7, which is found in archaea and eukaryotes but not in prokaryotes, binds domain II of the 23S rRNA as well as the 5S rRNA and is one of five ribosomal proteins that mediate the interactions 5S rRNA makes with the ribosome.  The...
Ribosomal protein L10 family, P0 and L10e subfamily
Ribosomal protein P1. This subfamily represents the eukaryotic large ribosomal protein P1. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P1 is located in the L12 stalk, with proteins...
Ribosomal protein P2. This subfamily represents the eukaryotic large ribosomal protein P2. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P2 is located in the L12 stalk, with proteins...
Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]
ribosomal protein S5(archaeal type)/S2(eukaryote cytosolic type)
S12-like family, 40S ribosomal protein S23 subfamily
S1_S28E: S28E, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. S28E protein is a component of the 30S ribosomal subunit. S28E is highly conserved among archaea and eukaryotes. S28E may...
K homology RNA-binding (KH) domain of the eukaryotic 40S small ribosomal subunit protein S3. S3  is part of the head region of the 40S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...
N-terminal catalytic domain of the Protein Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
N-terminal catalytic domain of the Protein Serine/Threonine Kinase, Mitogen and stress-activated kinase 2
N-terminal catalytic domain of the Protein Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
Catalytic domain of the Protein Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear
Catalytic domain of the Protein Serine/Threonine Kinases, RPK118 and similar proteins
The phosphoinositide binding Phox Homology domain of RPK118-like proteins
Eukaryotic/archaeal ribosomal protein S8e and similar proteins
Ribosomal protein S4/S9 N-terminal domain
Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]
Pseudouridine synthases similar to Saccharomyces cerevisiae RIB2
16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]
Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B
Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D
Ribosome receptor lysine/proline rich region
Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain
RNA polymerase I specific transcription initiation factor RRN3
Ribosomal RNA-processing protein 7 (RRP7)
Ribosome biogenesis regulatory protein (RRS1)
RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine residue is found in...
Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]
Short conserved domain in transcriptional regulators
Rho effector or protein kinase C-related kinase homology region 1 homologues
RT_LTR: Reverse transcriptases (RTs) from retrotransposons and retroviruses which have long terminal repeats (LTRs) in their DNA copies but not in their RNA template. RT catalyzes DNA replication from an RNA template, and is responsible for the...
Src homology 3 domain of RUN and SH3 domain-containing protein 1
Src homology 3 domain of RUN and SH3 domain-containing protein 2
Nuclear/hormone receptor activator site AF-1
DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
Pseudokinase domain of Ryk (Receptor related to tyrosine kinase)
S-100A10: A subgroup of the S-100A10 domain found in proteins similar to S100A10. S100A10 is a member of the S100 family of EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which this S-100A10 group belongs, contains...
S-100A11: S-100A11 domain found in proteins similar to S100A11. S100A11 is a member of the S-100 domain family within EF-hand Ca2+-binding proteins superfamily. Note that the S-100 hierarchy, to which this S-100A11 group belongs, contains only S-100...
Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs
S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy
S-100A6: S-100A6 domain found in proteins similar to S100A6. S100A6 is a member of the S100 domain family within EF-hand Ca2+-binding proteins superfamily. Note that the S-100 hierarchy, to which this S-100A6 group belongs, contains only S-100 EF-hand...
S-100B: S-100B domain found in proteins similar to S100B. S100B is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which...
S-100Z: S-100Z domain found in proteins similar to S100Z. S100Z is a member of the S100 domain family within the EF-hand Ca2+-binding proteins superfamily. Note that the S-100 hierarchy, to which this S-100Z group belongs, contains only S-100 EF-hand...
Higher Eukarytoes and Prokaryotes Nucleotide-binding domain
Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to...
SAM domain of Atherin/Atherin-like subfamily
SAM domain of Samd7,11 subfamily of Polycomb group
SAM domain of sphingomyelin synthase related subfamily
Src homology 3 domain of SAM And SH3 Domain Containing Proteins
Sin3 binding region of histone deacetylase complex subunit SAP30
Sar1 is an essential component of COPII vesicle coats
SAM domain ot SARM1-like proteins, repeat 1
Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...
Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
Src homology 3 domain of Sam And SH3 Domain Containing Protein 3
N-terminal domain of SATB1 and similar proteins
Set binding factor Pleckstrin Homology (PH) domain
Protein of unknown function (DUF3550/UPF0682)
The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...
Neuroendocrine protein 7B2 precursor (Secretogranin V)
Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]
SAM domain of Scm proteins of Polycomb group
SCO (an acronym for Synthesis of Cytochrome c Oxidase) family
Dipeptidase [Amino acid transport and metabolism]
Plasmodium ookinete surface protein Pvs28
Succinate dehydrogenase [ubiquinone] flavoprotein subunit
2Fe-2S iron-sulfur cluster binding domain
Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit
SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Eukaryotic SQRs reduce high potential quinones such as ubiquinone. SQR is also called succinate dehydrogenase or Complex II, and is part of the citric...
3beta-hydroxysteroid dehydrogenase (3b-HSD)-like, subgroup1, extended (e) SDRs
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia
Signal peptidase I [Intracellular trafficking and secretion]
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
Vesicle coat trafficking protein Sec16 mid-region
Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes...
C-terminal Actin depolymerization factor-homology domain of Sec23
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes...
SecE/Sec61-gamma subunits of protein translocation complex
Domain of unknown function in Sec63p, Brr2p and other proteins
C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins:  P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A)
Immunoglobulin (Ig)-like domain of class III semaphorin
The Sema domain, a protein interacting module, of semaphorin 3B (Sema3B)
The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C)
The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D)
The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E)
The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F)
The Sema domain, a protein interacting module, of semaphorin 3G (Sema3G)
The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A)
The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B)
Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
The Sema domain, a protein interacting module, of semaphorin 4F (Sema4F)
The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A)
The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B)
The Sema domain, a protein interacting module, of semaphorins 6A (Sema6A)
The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B)
The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called semaphorin Y)
The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D)
The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108)
Ulp1 protease family, C-terminal catalytic domain
Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...
Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen)
Ribosome associated membrane protein RAMP4
alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor
Protein Z-dependent protease inhibitor (ZPI) is a member of the serpin superfamily of proteinase inhibitors (clade A10). ZPI inhibits coagulation factor Xa , dependent on protein Z (PZ), a vitamin K-dependent plasma protein. ZPI also inhibits factor XIa...
Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell...
The ovalbumin_like group of serpins contains ovalbumin, the squamous cell carcinoma antigen 1 (SCCA1) and other closely related serpins of clade B of the serpin superfamily. Ovalbumin, the major protein component of avian egg white, is a non-inhibitory...
Maspin (mammary serine proteinase inhibitor), a member of the serpin superfamily, with a multitude of effects on cells and tissues at an assortment of developmental stages. Maspin has tumor suppressing activity against breast and prostate cancer. In...
Antithrombin is a serine proteinase inhibitor (serpin) which controls the process of coagulation. It is the most important anticoagulant molecule in mammalian circulation systems, controlled by its interaction with the co-factor, heparin, which...
Heparin cofactor II (HCII) inhibits thrombin, the final protease of the coagulation cascade. HCII is allosterically activated by binding to cell surface glycosaminoglycans (GAGs). The specificity of HCII for thrombin is conferred by a highly acidic...
Plasminogen activator inhibitor-1_like. Plasminogen activator inhibitor-1 (PAI-1) is the primary, fast-acting inhibitor of plasminogen activators. It is often bound to vitronectin, an abundant component of the extracellular matrix in many tissues
Pigment epithelium-derived factor (PEDF)_like. PEDF is non-inhibitory member of the Serpin superfamily. It exhibits neurotrophic, neuroprotective and antiangiogenic properties and is widely expressed in the developing and adult nervous systems. This...
Alpha2-antiplasmin (alpha2AP) is the primary inhibitor of plasmin, a proteinase that digests fibrin, the main component of blood clots. Alpha2-Antiplasmin forms an inactive 1 : 1 stoichiometric complex with plasmin. It also rapidly crosslinks to fibrin...
C1 inhibitor (C1-Inh) is a protease inhibitor of the serpin family. It plays a pivotal role in regulating the activation of the classical complement pathway and of the contact system, via regulating bradykinin formation, inhibiting factor XII and...
Neuroserpin is a inhibitory member of the SERine Proteinase INhibitor (serpin) family that reacts preferentially with tissue-type plasminogen activator (tPA). It is located in neurons in regions of the brain where tPA is also found, suggesting that...
COMPASS (Complex proteins associated with Set1p) component N
Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins
Splicing factor (branch point binding protein) [RNA processing and modification]
Ubiquitin-like domain of Mammalian splicing factor SF3a_120
Splicing factor 3a, subunit 2 [RNA processing and modification]
Splicing factor 3a, subunit 3 [RNA processing and modification]
Spt5 C-terminal nonapeptide repeat binding Spt4
U2 snRNP spliceosome subunit [RNA processing and modification]
proline-rich domain in spliceosome associated proteins
SAM domain of Scm-like-4MBT1,2 proteins of Polycomb group
14-3-3 sigma, an isoform of 14-3-3 protein
Cysteine-rich domain of the secreted frizzled-related protein 1 (SFRP1), a regulator of Wnt activity
NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily
Cysteine-rich domain of the secreted frizzled-related protein 2 (SFRP2), a regulator of Wnt activity
Cysteine-rich domain of the secreted frizzled-related protein 4 (SFRP4), a Wnt antagonist
Cysteine-rich domain of the secreted frizzled-related protein 5 (SFRP5), a regulator of Wnt activity
Surfactant protein C, N terminal propeptide
Lung surfactant protein D coiled-coil trimerisation
mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second...
Src Homology 3 domain of Small G protein Signaling Modulator 3
Src homology 2 (SH2) domain found in SH2B adapter protein family
Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
LNK-family Pleckstrin homology (PH) domain
Src homology 2 (SH2) domain found in SLAM-associated protein (SAP) 1a
Src homology 2 (SH2) domain found in SLAM-associated protein (SAP)1
Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)
Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A)
Src homology 2 domain found in the SH2 domain containing protein 7 (SH2D7)
Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily
The Bin/Amphiphysin/Rvs (BAR) domain of SH3-domain Binding Protein 1
Src homology 2 domain found in c-Abl SH3 domain-binding protein-2 (SH3BP2)
Src Homology 3 domain of SH3 domain-binding protein 4
First Src homology 3 domain of ADAM-binding protein Eve-1
Second Src homology 3 domain of ADAM-binding protein Eve-1
Third Src homology 3 domain of ADAM-binding protein Eve-1
Fourth Src homology 3 domain of ADAM-binding protein Eve-1
Fifth Src homology 3 domain of ADAM-binding protein Eve-1
Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A2
The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A1
The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A3
The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B1
The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
The phosphoinositide binding Phox Homology domain of Five SH protein
First Src homology 3 domain of Tyrosine kinase substrate (Tks) proteins
Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
Third Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
First Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
Second Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
Third Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
Fourth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
First Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
Third Src Homology 3 domain of SH3 domain containing ring finger 1, an E3 ubiquitin-protein ligase
C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
First Src Homology 3 domain of SH3 domain containing ring finger 2
Second Src Homology 3 domain of SH3 domain containing ring finger 2
Third Src Homology 3 domain of SH3 domain containing ring finger 2
First Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
Second Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
Third Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains
The SYLF domain (also called DUF500), a novel lipid-binding module, of SH3 domain containing Ysc84-like 1 (SH3YL1) and similar proteins
Src homology 3 domain of SH3 domain containing Ysc84-like 1 (SH3YL1) protein
Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 1
SAM domain of Shank1,2,3 family proteins
Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 3
Src homology 2 domain found in SH2 domain-containing adapter protein B (SHB)
Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
Src homology 2 domain found in SH2 domain-containing adapter proteins D (SHD)
Src homology 2 domain found in SH2 domain-containing adapter protein E (SHE)
Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)
Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine
Seven in absentia (Sina) protein family, C-terminal substrate binding domain
Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
Histone deacetylase complex, SIN3 component [Chromatin structure and dynamics]
Signal-regulatory protein (SIRP) immunoglobulin-like domain
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs
Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 1
Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 2
SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones]
Src homology 3 domain of Src-Like Adaptor Protein
Src homology 2 domain found in Src-like adaptor proteins
Src homology 3 domain of Src-Like Adaptor Protein 2
Signaling lymphocytic activation molecule (SLAM) protein
SBF-like CPA transporter family (DUF4137)
NRAMP (natural resistance-associated macrophage protein) metal ion transporters
Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]
Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...
Na+/H+-dicarboxylate symporters [Energy production and conversion]
Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]
Xanthine/uracil permeases [Nucleotide transport and metabolism]
ADP/ATP transporter on adenylate translocase
Sulfate transporter N-terminal domain with GLY motif
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors
Na+ dependent nucleoside transporter N-terminus
Na+ dependent nucleoside transporter C-terminus
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
cation diffusion facilitator family transporter
Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]
Transmembrane amino acid transporter protein
Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
Eukaryotic protein of unknown function (DUF914)
Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]
Amino acid permeases [Amino acid transport and metabolism]
Sugar phosphate permease [Carbohydrate transport and metabolism]
Alpha amylase catalytic domain found in Solute Carrier family 3 member 1 proteins
Alpha amylase catalytic domain found in solute carrier family 3 member 2 proteins
Na+-driven multidrug efflux pump [Defense mechanisms]
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...
Sugar efflux transporter for intercellular exchange
Na(+)/glucose cotransporter SGLT5 and related proteins
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins
Na(+)/monocarboxylate cotransporter SMCT2 and related proteins
Na(+)/glucose cotransporter SGLT2 and related proteins
Na(+)/myo-inositol cotransporter SMIT and related proteins
Na(+)/iodide cotransporter NIS and related proteins
Na(+)/multivitamin cotransporter SMVT and related proteins
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins
Na(+)/monocarboxylate cotransporter SMCT1 and related proteins
Na(+)/glucose cotransporter SGLT4 and related proteins
Na(+)- and Cl(-)-dependent GABA transporter 1
Na(+)- and Cl(-)-dependent GABA transporter 3
Na(+)- and Cl(-)-dependent betaine/GABA transporter-1, and related proteins
Na(+)- and Cl(-)-dependent GABA transporter 2
Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+
Sodium-coupled branched-chain amino-acid transporter 1
Na(+)-dependent neutral amino acids transporter, B0AT1
Na(+)- and Cl(-)-dependent norepinephrine transporter NET
Na(+)- and Cl(-)-dependent imino acid transporter SIT1
Na(+)- and Cl(-)-dependent dopamine transporter 1
Serotonin (5-HT) neurotransmitter transporter, N-terminus
Na(+)- and Cl(-)-dependent serotonin transporter SERT
Na(+)- and Cl(-)-dependent glycine transporter GlyT2
Na(+)- and Cl(-)-dependent taurine transporter
Na(+)- and Cl(-)-dependent L-proline transporter PROT
Na(+)- and Cl(-)-dependent creatine transporter 1
Na(+)- and Cl(-)-dependent glycine transporter GlyT1
Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]
NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a...
Organic Anion Transporter Polypeptide (OATP) family
Catalytic domain of the Protein Serine/Threonine Kinase, Ste20-like kinase
WAP-type (Whey Acidic Protein) 'four-disulfide core'
Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its eukaryotic homologs
N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
N-terminal Mad Homology 1 (MH1) domain in SMAD4
C-terminal Mad Homology 2 (MH2) domain in SMAD4
C-terminal Mad Homology 2 (MH2) domain in SMAD6
N-terminal Mad Homology 1 (MH1) domain in SMAD6
N-terminal Mad Homology 1 (MH1) domain in SMAD7
C-terminal Mad Homology 2 (MH2) domain in SMAD7
domain in helicases and associated with SANT domains
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone...
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
Suppressor of morphogenetic effect on genitalia-1 (SMG-1), catalytic domain
PIN domain of human telomerase-binding protein EST1, Smg5, and other similar eukaryotic homologs
PIN domain of human telomerase-binding protein EST1, Smg6, and other similar eukaryotic homologs
Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
Secreted protein acidic and rich in cysteine Ca binding region
acid sphingomyelinase and related proteins, metallophosphatase domain
Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine
SMUG: single-strand-selective monofunctional uracil-DNA glycosylase
C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
Small nuclear RNA activating complex (SNAPc), subunit SNAP43
Small nuclear RNA activating complex subunit 2-like
snRNA-activating protein of 50kDa MW C terminal
Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds
U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
Syntrophin pleckstrin homology (PH) domain
C-terminal m3G cap-binding domain of nuclear import adaptor snurportin-1
The phosphoinositide binding Phox Homology domain of Sorting Nexin 1
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 1
The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
The phosphoinositide binding Phox Homology domain of Sorting Nexin 12
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
The phosphoinositide binding Phox Homology domain of Sorting Nexin 15
The phosphoinositide binding Phox Homology domain of Sorting Nexin 16
The phosphoinositide binding Phox Homology domain of Sorting Nexins 17 and 31
Src Homology 3 domain of Sorting nexin 18
The phosphoinositide binding Phox Homology domain of Sorting Nexin 18
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 18
The phosphoinositide binding Phox Homology domain of Sorting Nexin 19
The phosphoinositide binding Phox Homology domain of Sorting Nexin 2
The phosphoinositide binding Phox Homology domain of Sorting Nexin 20
The phosphoinositide binding Phox Homology domain of Sorting Nexin 21
The phosphoinositide binding Phox Homology domain of Sorting Nexin 22
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
The phosphoinositide binding Phox Homology domain of Sorting Nexin 27
Ubiquitin domain of SNX27 (sorting nexin protein 27)
The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
The phosphoinositide binding Phox Homology domain of Sorting Nexin 3 and related proteins
The phosphoinositide binding Phox Homology domain of Sorting Nexin 30
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 30
The phosphoinositide binding Phox Homology domain of Sorting Nexins 5 and 6
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
Src Homology 3 domain of Sorting Nexin 33
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 33
The phosphoinositide binding Phox Homology domain of Sorting Nexin 4
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 4
The phosphoinositide binding Phox Homology domain of Sorting Nexin 5
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 5
The phosphoinositide binding Phox Homology domain of Sorting Nexin 6
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 6
The phosphoinositide binding Phox Homology domain of Sorting Nexin 7
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 7
The phosphoinositide binding Phox Homology domain of Sorting Nexins 7 and 30
The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8
Src Homology 3 domain of Sorting nexin 9
The phosphoinositide binding Phox Homology domain of Sorting Nexin 9
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 9
Src homology 2 (SH2) domain found in  suppressor of cytokine signaling (SOCS) proteins
SOCS (suppressors of cytokine signaling) box of SOCS1-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS1, like CIS1 and SOCS3, is involved in the...
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate...
SOCS (suppressors of cytokine signaling) box of SOCS3-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS3, like CIS1 and SOCS1, is involved in the...
Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the...
SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting...
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the...
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal...
Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]
Iron/manganese superoxide dismutases, alpha-hairpin domain
Iron/manganese superoxide dismutases, C-terminal domain
Superoxide dismutase [Inorganic ion transport and metabolism]
First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
First Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)
Second Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)
Third (or C-terminal) Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)
Son of Sevenless (SOS) Pleckstrin homology (PH) domain
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin...
R3H domain of a group of metazoan proteins that is related to the sperm-associated antigen 7. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted...
Sperm protein associated with nucleus, mapped to X chromosome
Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes
Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) [Translation, ribosomal structure and biogenesis]
Microsomal signal peptidase 12 kDa subunit (SPC12)
Microsomal signal peptidase 25 kDa subunit (SPC25)
Sterile alpha motif (SAM)/Pointed domain of prostate-derived ETS factor
Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the...
TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI)...
Transcription factor S-II (TFIIS), central domain
Speckle-type POZ protein (SPOP) family, MATH domain
PA_hSPPL_like: Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the...
Presenilin, signal peptide peptidase, family
sepiapterin reductase (SPR)-like, classical (c) SDRs
EVH1 (Enabled, Vasp-Homology) or WASP Homology (WH1) domain
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for...
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for...
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to...
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for...
Beta-spectrin pleckstrin homology (PH) domain
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]
The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which...
S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression
Src homology 3 domain of Src Protein Tyrosine Kinase
Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in...
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 1
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs...
Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 2
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
Src homology 3 domain of Srms Protein Tyrosine Kinase
Src homology 2 (SH2) domain found in Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristoylation sites (srm)
Signal recognition particle 14kD protein
The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...
signal recognition particle protein SRP54
SRP54-type protein, helical bundle domain
Signal recognition particle 9 kDa protein (SRP9)
Signal recognition particle receptor, beta subunit (SR-beta), together with SR-alpha, forms the heterodimeric signal recognition particle (SRP)
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...
U2 snRNP auxilliary factor, large subunit, splicing factor
La RNA-binding domain of La-related protein 3
Single-stranded DNA-binding protein [DNA replication, recombination, and repair]
SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...
Single-stranded DNA binding protein, SSDP
N-terminal domain conserved in slingshot (SSH) phosphatases
Translocon-associated protein (TRAP), alpha subunit
Translocon-associated protein, gamma subunit (TRAP-gamma)
Translocon-associated protein, delta subunit precursor (TRAP-delta)
Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)
This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the...
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing (Stac) proteins
Second C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing proteins 1 and 3
C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 2 (Stac2)
First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 3 (Stac3)
Src homology 3 domain of Signal Transducing Adaptor Molecules
Src homology 3 domain of Signal Transducing Adaptor Molecule 2
Src homology 2 domain found in Signal-transducing adaptor protein 1 (STAP1)
Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
Cholesterol-binding START domain of mammalian STARD1 and related proteins
Lipid-binding START domain of mammalian STARD10 and related proteins
C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
Cholesterol-binding START domain of mammalian STARD3 and related proteins
Lipid-binding START domain of mammalian STARD5 and related proteins
Lipid-binding START domain of mammalian STARD6 and related proteins
Lipid-binding START domain of mammalian STARD7 and related proteins
C-terminal lipid-binding START domain of mammalian STARD8 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
C-terminal START domain of mammalian STARD9, and related domains
STAT protein, protein interaction domain
Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
Signal transducer and activator of transcription 2 C terminal
Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins
Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
Genethonin-1, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. Genethonin-1 is a human skeletal muscle protein with no known function. It contains a C-terminal CBM20 domain. The CBM20 domain is found in a large number of starch...
Catalytic domain of the Protein Serine/Threonine Kinase, STK25 or Yeast Sps1/Ste20-related kinase 1
Catalytic domain of the Protein Serine/Threonine Kinases, Mammalian Ste20-like protein kinase 1 and 2
Catalytic domain of the Protein Serine/Threonine Kinase, Yank1
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase
Catalytic domain of the Protein Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1
Catalytic domain of the Protein Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2
Mu homology domain (MHD) of adaptor-like protein (AP-like), stonin-1 (also called Stoned B-like factor)
Mu homology domain (MHD) of adaptor-like protein (AP-like), stonin-2
Pseudokinase domain of STE20-related kinase adapter protein alpha
Pseudokinase domain of STE20-related kinase adapter protein beta
Suppressor of Fused Gli/Ci N terminal binding domain
p23_like domain similar to the C-terminal CS (CHORD-SGT1) domain of human (h) Sgt1 and related proteins. hSgt1 is a co-chaperone which has been shown to be elevated in HEp-2 cells as a result of stress conditions such as heat shock. It interacts with the...
molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of...
Related to aminopeptidase P and aminopeptidase M, a member of this domain family is present in cell division control protein 68, a transcription factor
The TATA Binding Protein (TBP) Associated Factor 13 (TAF13) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
Spt5 transcription elongation factor, acidic N-terminal
Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
N-terminal Src homology 2 (SH2) domain found in Spt6
C-terminal Src homology 2 (SH2) domain found in Spt6
Bromodomain transcription factors and PHD domain containing proteins
Mitochondrial degradasome RNA helicase subunit C terminal
SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...
Adhesion-associated domain present in MUC4 and other proteins
Actin depolymerization factor/cofilin- and gelsolin-like domains
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying...
N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
Symplekin tight junction protein C terminal
Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]
Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 2
Integral membrane protein S linking to the trans Golgi network
C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
C2 domain second repeat present in Synaptotagmin 1
C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
C2A domain first repeat present in Synaptotagmins 4 and 11
C2 domain second repeat present in Synaptotagmin 4
C2 domain second repeat present in Synaptotagmin 12
C2 domain second repeat present in Synaptotagmin 13
C2A domain first repeat present in Synaptotagmins 14 and 16
C2 domain second repeat present in Synaptotagmins 14 and 16
C2A domain first repeat present in Synaptotagmins 15 and 17
C2 domain second repeat present in Synaptotagmin 15
C2 domain second repeat present in Synaptotagmin 17
C2A domain first repeat present in Synaptotagmin 7
C2 domain second repeat present in Synaptotagmin 7
C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
C2 domain second repeat present in Synaptotagmin-like proteins 1-4
C2 domain first repeat present in Synaptotagmin-like protein 3
C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
Transcriptional regulator of RNA polII, SAGA, subunit
Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to...
The TATA Binding Protein (TBP) Associated Factor 10
TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
RNA polymerase I-specific transcription initiation factor Rrn7
TATA binding protein (TBP) associated factor 2
TAF5_NTD2 is the second conserved N-terminal region of TATA Binding Protein (TBP) Associated Factor 5 (TAF5), involved in forming Transcription Factor IID (TFIID)
TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
TATA Binding Protein (TBP) Associated Factor 8
TATA Binding Protein (TBP) Associated Factor 9 (TAF9) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
Transaldolases including both TalA and TalB
Catalytic domain of the Protein Serine/Threonine Kinase, Thousand-and-one amino acids proteins
Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...
ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...
Ligand-binding domain of the T1R taste receptor
Mammalian taste receptor protein (TAS2R)
Pollux (PLX) Phosphotyrosine-binding (PTB) domain
Ubiquitin-like domain of Alp11 tubulin-folding cofactor B
Member of the Rhodanese Homology Domain superfamily. Included in this CD are the rhodanese-like domains found C-terminal of the serine/threonine protein kinases catalytic (S_TKc) domain and the Tre-2, BUB2p, Cdc16p (TBC) domain. The putative active site...
eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation...
C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
RNA polymerase II transcription factor SIII (Elongin) subunit A
type VI secretion system FHA domain protein
Treacher Collins syndrome protein Treacle
TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins
G:T/U mismatch specific DNA glcosylase (MUG)
Catalytic domain, repeat 1, of metazoan tyrosyl-DNA phosphodiesterase
Catalytic domain, repeat 2, of metazoan tyrosyl-DNA phosphodiesterase
Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains
The first LOTUS domain on Tudor-containing protein 5 (TDRD5)
The second LOTUS domain on Tudor-containing protein 5 (TDRD5)
The third LOTUS domain on Tudor-containing protein 5 (TDRD5)
The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
Catalytic domain of the Protein Tyrosine Kinase, Tie2
Src homology 2 domain found in Tensin-like proteins
Rhs family protein [Cell envelope biogenesis, outer membrane]
Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
RAP1 binding motif of telomere repeat binding factor
DNA-binding modules of yeast Rap1 and related proteins
C-terminal domain of RAP1 recruits proteins to telomeres
Telomerase ribonucleoprotein complex - RNA binding domain
TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as...
Oxygenase domain of the 2OGFeDO superfamily
Rix1 complex component involved in 60S ribosome maturation
Putative integral membrane protein conserved region (DUF2404)
Predicted transmembrane and coiled-coil 2 protein
SAM domain of TFCP2 transcription factors
SAM domain of LBP9 transcriptional factors
The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in...
Kunitz/Bovine pancreatic trypsin inhibitor domain
PA_TfR: Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28...
M28 Zn-peptidase Transferrin Receptor family
dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]
dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs
The second LIM domain of the paxillin like protein family
Transforming growth factor beta receptor 2 ectodomain
ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tyrosine hydroxylases (TH)
Putative death-receptor fusion protein (DUF2428)
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
Thrombomodulin like fifth domain, EGF-like
4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...
Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria
Threonine synthase [Amino acid transport and metabolism]
Tryptophan synthase beta superfamily (fold type II)
THO complex subunit 1 transcription elongation factor
Death domain of Nuclear Matrix Protein P84
Transcription- and export-related complex subunit
Transcription factor/nuclear export subunit protein 2
DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases
THUMP domain associated with S-adenosylmethionine-dependent methyltransferases
Catalytic domain of the Protein Tyrosine Kinase, Tie1
mitochondrial import inner membrane translocase subunit tim17
mitochondrial import inner membrane translocase subunit tim23
mitochondrial import inner membrane, translocase subunit
Replication Fork Protection Component Swi3
Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
Src homology 3 domain of the Tight junction protein, Zonula occludens protein 3
Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module
Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
Eukaryotic integral membrane protein (DUF1751)
Eukaryotic protein of unknown function (DUF872)
Wnt-binding factor required for Wnt secretion
Kua-ubiquitin conjugating enzyme hybrid localisation domain
Endoplasmic reticulum-based factor for assembly of V-ATPase
Protein of unknown function C-terminus (DUF2448)
Predicted permease, member of the PurR regulon [General function prediction only]
LEM3 (ligand-effect modulator 3) family / CDC50 family
Eukaryotic protein of unknown function (DUF829)
Brain specific membrane anchored protein
Homo sapiens TMEM62, N-terminal metallophosphatase domain
Late exocytosis, associated with Golgi transport
Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain
FOG: TPR repeat [General function prediction only]
Death domain of Tumor necrosis factor-Related Apoptosis-Inducing Ligand Receptors
Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain
Death domain of Tumor Necrosis Factor Receptor 1
Death domain of tumor necrosis factor receptor superfamily member 21
Death domain of Tumor Necrosis Factor Receptor superfamily 25
Catalytic domain of the Protein Serine/Threonine Kinase, Traf2- and Nck-interacting kinase
SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin...
C2 domain present in Toll-interacting protein (Tollip)
mitochondrial import receptor subunit translocase of outer membrane 20 kDa subunit
Translocase of outer mitochondrial membrane 40 (Tom40)
Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I.  Topo I enzymes are divided into:  topo type IA (bacterial) and type IB (eukaryotic)
DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...
Eukaryotic DNA topoisomerase I, DNA binding fragment
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA.  S. cerevisiae Topo IIA is a homodimer encoded...
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of...
Topoisomerase IA [DNA replication, recombination, and repair]
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...
Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]
Topoisomerase DNA binding C4 zinc finger
ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]
Src Homology 3 (SH3) domain of Apoptosis Stimulating of p53 protein 2
ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...
Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
Cell cycle regulated microtubule associated protein
Death Domain of Tumor Necrosis Factor Receptor 1-Associated Death Domain protein
Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain
Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain
Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain
Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF4 subfamily, TRAF domain, C-terminal MATH subdomain
Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF5 subfamily, TRAF domain, C-terminal MATH subdomain
Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF6 subfamily, TRAF domain, C-terminal MATH subdomain
Trafficking protein particle complex subunit 10, TRAPPC10
Gryzun, putative trafficking through Golgi
ER-Golgi trafficking TRAPP I complex 85 kDa subunit
Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
Neutral trehalase [Carbohydrate transport and metabolism]
DEDDh 3'-5' exonuclease domain of three prime repair exonuclease (TREX)1, TREX2, and similar proteins
(ADP-ribosylation factor domain protein 1 (ARD1)
Tripartite motif containing protein 37 (TRIM37) family, MATH domain
Bluetongue virus non-structural protein NS2
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...
tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]
SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]
tRNA methyltransferase complex GCD14 subunit
tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]
tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes
Probable RNA and SrmB- binding site of polymerase A
RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]
RNA 2'-phosphotransferase, Tpt1 / KptA family
TRansformation/tRanscription domain-Associated Protein (TRRAP), pseudokinase domain
tRNA intron endonuclease, N-terminal domain
tRNA splicing endonuclease [Translation, ribosomal structure and biogenesis]
tRNA intron endonuclease, catalytic C-terminal domain
tRNA-splicing endonuclease subunit sen54 N-term
Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model...
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model...
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
Thiosulfate sulfurtransferases (TST) contain 2 copies of the Rhodanese Homology Domain. Only the second repeat contains the catalytically active Cys residue. The role of the 1st repeat is uncertain, but believed to be involved in protein interaction
GDP-fucose synthetase, extended (e) SDRs
Member of the Rhodanese Homology Domain superfamily. This CD includes the heat shock protein 67B2 of Drosophila melanogaster and other similar proteins, many of which are uncharacterized
Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins
putative PEP-CTERM system TPR-repeat lipoprotein
M5, fifth immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins
Transthyretin (TTR) is a 55 kDa protein responsible for the transport of thyroid hormones and retinol in vertebrates.  TTR distributes the two thyroid hormones T3 (3,5,3'-triiodo-L-thyronine) and T4 (Thyroxin, or 3,5,3',5'-tetraiodo-L-thyronine), as well...
N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of...
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The epsilon-tubulins which are widespread but not...
Gamma-tubulin is a ubiquitous phylogenetically conserved member of tubulin superfamily.  Gamma is a low abundance protein present within the cells in both various types of microtubule-organizing centers and cytoplasmic protein complexes.  Gamma-tubulin...
Elongation Factor Tu (EF-Tu) GTP-binding proteins
EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...
Domain III of mitochondrial EF-TU (mtEF-TU). mtEF-TU is highly conserved and is 55-60% identical to bacterial EF-TU. The overall structure is similar to that observed in the Escherichia coli and Thermus aquaticus EF-TU. However, compared with that...
N-terminal ADF domain of twinfilin and related proteins
C-terminal ADF domain of twinfilin and related proteins
RNAP_I_Rpa43_N: Rpa43, N-terminal ribonucleoprotein (RNP) domain. Rpa43 is a subunit of eukaryotic RNA polymerase (RNAP) I that is homologous to Rpb7 of eukaryotic RNAP II, Rpc25 of eukaryotic RNP III, and RpoE of archaeal RNAP. Rpa43 has two domains, an...
Twisted gastrulation (Tsg) protein conserved region
Src Homology 3 domain of TXK, also called Resting lymphocyte kinase (Rlk)
Src homology 2 (SH2) domain found  in Tec protein, Txk
Endoplasmic reticulum protein 19 (ERp19) family
PDIa family, endoplasmic reticulum protein 44 (ERp44)-like subfamily
Human TRX-related protein 14 (TRP14)-like family
PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily
Phosducin (Phd)-like family, Thioredoxin (TRX) domain containing protein 9 (TxnDC9) subfamily
Dim1 family, Dim1-like protein (DLP) subfamily
thioredoxin and glutathione reductase selenoprotein
Carboxy-terminal domain of Formyltransferase and similar domains
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
Glycosyl transferase family, helical bundle domain
Pyrimidine nucleoside phosphorylase C-terminal domain
Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...
Catalytic domain of the Protein Tyrosine Kinase, Tyro3
domain present in proteins, which are involved in regulation of nuclear pre-mRNA
UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating
Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating
Repeat in ubiquitin-activating (UBA) protein
Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to...
Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to...
thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily
Ubiquitin-activating enzyme e1 C-terminal domain
Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein A
Histidine phosphatase superfamily (branch 1)
Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
Ubiquitin fusion degradation protein 2 [Posttranslational modification, protein turnover, chaperones]
type II restriction endonuclease, Alw26I/Eco31I/Esp3I family
SAM domain of LBP1 (UBP1) transcription factors
Ubiquitin-like domain of hPLIC-1 and hPLIC2
Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
ATP-dependent Clp protease adaptor protein ClpS
C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
dendritic cell derived ubiquitin-like protein
Domain present in ubiquitin-regulatory proteins
Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3
Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
Uridine kinase [Nucleotide transport and metabolism]
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway
Agonist of corticotropin releasing factor R2, Urocortin-2
Ubiquitin fusion-degradation protein [Posttranslational modification, protein turnover, chaperones]
Ubiquitin fusion degradation protein UFD1
Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis
UDP-glucose/GDP-mannose dehydrogenase family, central domain
UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
Eukaryotic UGPase catalyses the synthesis of UDP-Glucose
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...
amino-terminal ubiquitin-like domain of  Np95 and NIRF
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear
MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar...
Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...
C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
Myosin-binding striated muscle assembly central
Family 1 of Uracil-DNA glycosylase (UDG) enzymes
mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases)
Uridine phosphorylase [Nucleotide transport and metabolism]
Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like
Ubiquinol-cytochrome C reductase complex, 6.4kD protein
Ubiquinol-cytochrome C reductase complex 14kD subunit
Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
Ubiquinol cytochrome reductase transmembrane region
ubiquinol-cytochrome c reductase, iron-sulfur subunit
Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain
Ubiquinol-cytochrome C reductase hinge protein
Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...
Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...
N-terminal protein-binding module of harmonin
Uso1 / p115 like vesicle tethering protein, head region
Uso1 / p115 like vesicle tethering protein, C terminal region
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...
Isopeptidase T [Posttranslational modification, protein turnover, chaperones]
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl...
Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90.  p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including...
p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has...
Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain
Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain
PIN domain of rRNA-processing protein Fcf1- and Utp23-like homologs found in eukaryotes except fungi
U3 small nucleolar RNA-associated protein 6
UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
Vacuolar protein 14 C-terminal Fig4p binding
Glutathione S-transferase C-terminal-like, alpha helical domain of vertebrate Valyl-tRNA synthetase
catalytic core domain of valyl-tRNA synthetases
Anticodon-binding domain of valyl tRNA synthetases
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family
First Src homology 3 domain of VAV1 protein
Src homology 2 (SH2) domain found in the Vav1 proteins
C-terminal (or second) Src homology 3 domain of VAV1 protein
First Src homology 3 domain of VAV2 protein
Src homology 2 (SH2) domain found in the Vav2 proteins
C-terminal (or second) Src homology 3 domain of VAV2 protein
Src homology 2 (SH2) domain found in the Vav3 proteins
C-terminal (or second) Src homology 3 domain of VAV3 protein
First Src homology 3 domain of VAV3 protein
Second immunoglobulin (Ig)-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1, CD106) and intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican
Cell division protein 48 (CDC48) domain 2
Voltage-dependent anion channel of the outer mitochondrial membrane
DNA-binding domain of vitamin D receptors (VDR) is composed of two C4-type zinc fingers
The ligand binding domain of vitamin D receptors, a member of the nuclear receptor superfamily
Short repeats in human TONDU, fly vestigial and other proteins
von Hippel-Landau (pVHL) tumor suppressor protein
Family of likely enzymes that includes the catalytic subunit of vitamin K epoxide reductase
Vitelline membrane outer layer protein I (VOMI)
Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs
Vacuolar protein sorting protein 11 C terminal
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion]
Homo sapiens Vps29 and related proteins, metallophosphatase domain
Vacuolar protein sorting-associated protein 35
Vacuolar protein sorting protein 36 Vps36
Modifier of rudimentary (Mod(r)) protein
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in intracellular protein transport proteins of the AAA-ATPase family. The molecular function of the MIT domain is unclear
Golgi CORVET complex core vacuolar protein 8
Vesicle transport v-SNARE protein N-terminus
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal
Wings apart-like protein regulation of heterochromatin
catalytic core domain of tryptophanyl-tRNA synthetase
Wiskott Aldrich syndrome homology region 2
Methyltransferase involved in Williams-Beuren syndrome
Utp21 specific WD40 associated putative domain
DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1...
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but...
human WWOX (WW domain-containing oxidoreductase)-like, classical (c)-like SDRs
type IV pilus biogenesis/stability protein PilW
Chemokine_C, C or lymphotactin subgroup, 1 of 4 subgroup designations of chemokines based on the arrangement of two N-terminal, conserved cysteine residues. Most of the known chemokines (cd00169) belong to either the CC (cd00272) or CXC (cd00273)...
The Lim domain of Epithelial Protein Lost in Neoplasm (Eplin) like proteins
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline
RecA/RadA recombinase [DNA replication, recombination, and repair]
DNA double-strand break repair and V(D)J recombination protein XRCC4
Ku70/Ku80 N-terminal domain. The Ku78 heterodimer (composed of Ku70 and Ku80) contributes to genomic integrity through its ability to bind DNA double-strand breaks (DSB) in a preferred orientation. DSB's are repaired by either homologues recombination or...
ATP-dependent DNA helicase II, 70 kDa subunit (ku70)
catalytic core domain of tyrosinyl-tRNA synthetase
uncharacterized YdjC-like family proteins from eukaryotes
Transcription initiation factor IIF, auxiliary subunit [Transcription]
Src homology 3 domain of Yes Protein Tyrosine Kinase
Src homology 2 (SH2) domain found in Yes
Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]
R3H domain of a group of proteins which also contain a DEXH-box helicase domain, and may function as ATP-dependent DNA or RNA helicases. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine...
14-3-3 beta and zeta isoforms of 14-3-3 protein
14-3-3 epsilon, an isoform of 14-3-3 protein
14-3-3 gamma, an isoform of 14-3-3 protein
14-3-3 eta, an isoform of 14-3-3 protein
14-3-3 theta/tau (theta in mice, tau in human), an isoform of 14-3-3 protein
Mgc45594 gene product and other MDR family members
C-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70)
Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa
zinc finger in transposases and transcription factors
S1_pNO40: pNO40 , S1-like RNA-binding domain. pNO40 is a nucleolar protein of unknown function with an N-terminal S1 RNA binding domain, a CCHC type zinc finger, and clusters of basic amino acids representing a potential nucleolar targeting signal
Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
Zfx / Zfy transcription activation region
Fungal specific transcription factor domain
Smad anchor for receptor activation (SARA)
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins
The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions.  BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND...
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11
C4-type Zn-finger protein [General function prediction only]
APC10/DOC1-like domain of uncharacterized Zinc finger ZZ-type and EF-hand domain-containing protein 1 (ZZEF1) and homologs
Zinc finger, ZZ type. Zinc finger present in proteins with an EF_hand motif. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding
Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have...
Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding