Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Reference No: RP_R00008_Karsan Lab_2023_05_03


The Karsan lab at Canada’s Michael Smith Genome Sciences Centre (GSC) are seeking a Research Programmer to join a Marathon of Hope Cancer Centre research project. The team will be working with other research programmers at the Karsan lab to perform data analysis on next-generation sequencing (NGS) data including but not limited to WGS, RNA-seq, targeted sequencing, scRNA-seq, scATAC-seq, and Bisulfite-Seq, to study of clonal evolution of blood cancers and resistance to therapy. We seek candidates with strong analytical and programming skills to research, develop, and improve existing research pipelines.

The role is ideally suited for detail-oriented individuals with a strong interest in data analysis, research, and scientific programming within a high throughput academic setting.  The Karsan lab has a history of strong publications and can offer great experience in research with full access to the GSC’s world-class compute cluster.  Additionally, the Karsan Lab has a diverse computational biology core for knowledge sharing, collaboration, and support. 


  • Design and implement bioinformatic data analysis to meet objectives of the project
  • Work with other project team members to develop and test code, and implement analysis
  • Collects, records, analyzes, validates, interprets and organizes experimental and research data and communicates scientific findings to the Principal Investigator.
  • Evaluate and incorporate third-party software into pipelines
  • Produce thorough but concise written documentation of experiments, algorithms, validations, and other procedures as required.


  • Graduation from a recognized Bachelor of Science Program in Computer Science or relevant program. A Master’s degree in a relevant field would be a strong asset. 
  • Two (2) years of recent related experience or an equivalent combination of education, training, and experience.

Core Skills and Abilities: 

  • Expertise with scientific programming and able to provide links to code samples via GitHub
  • Familiarity with cancer biology
  • Excellent verbal and written communication skills
  • Demonstrated ability to interpret results
  • Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools
  • Established ability to efficiently organize work assignments and establish priorities
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.

Additional Assets:

  • Familiarity in statistical analysis using modern computational tools (experience with any relevant tools will be considered, but R and Python are preferred)
  • Familiarity in next-generation sequencing datasets


Please submit a detailed cover letter and resume to, using RP_R00008_Karsan Lab_2023_05_03 in the subject line of your email.

This posting will remain online until filled.


As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

PHSA and BC Cancer are committed to employment equity, encouraging all qualified individuals to apply. We recognize that our ability to provide the best care for our diverse patient populations relies on a rich diversity of skills, knowledge, background and experience, and value a safe, inclusive and welcoming environment.

Back to top