Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Reference No: PDC_E00375_CCGI_2021_11_15


The role of the CCGI at the GSC is to contribute to patient care by developing, validating, and running clinical bioinformatics pipelines and generating clinical patient reports. Reporting to the Group Leader of the Sequencing Team, the Process Development Coordinator will take the lead role in pipeline validation. 


  • Oversees the validation and implementation of pipelines into the CCGI team.
  • Takes the lead on validation design, content, and quality assurance documentation.
  • Analyze and assess sequencing data including alignments and variant calling.
  • Perform critical concordance, LoD, sensitivity and specificity analysis and data assessment.


  • Graduation from a recognized Bachelor’s program in an appropriate discipline such as Computer Science, Bioinformatics, Genetics, Molecular Biology or Biochemistry (PhD) preferred);
  • Five (5) years of recent related experience in a research and or clinical laboratory including supervisory experience
    An equivalent combination of education, training and experience acceptable to the GSC Group Leaders.


  • Experience analyzing and assessing the quality of NGS data, including:
    • short-read alignment and
    • variant-calling (small variants, copy-number variants, fusions),
  • Strong  skills in statistical analysis and data visualization (e.g. with R),
  • Sufficient molecular biology background to take part in designing validations and drawing conclusions from the results,
  • Ability to work independently with minimal oversight,
  • Ability to collaborate with other CCGI members to complete pipeline validations in a timely manner,
  • Strong analytical and written communication skills,
  • High attention to detail, and
  • Experience in experimental design.


Please submit a detailed cover letter and resume to, using Job Reference No: PDC_E00375_CCGI_2021_11_15 in the subject line of your email.

This posting will remain online until filled.

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans. As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

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