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Image DSC_0062.JPG
by smcinnis last modified Oct 07, 2011 02:52 PM
Located in About / News Releases
Image PNG image copy_of_header.png
by smcinnis last modified Dec 06, 2011 09:30 PM
Located in About / News Releases
Image JPEG image CryoPort.jpg
by smcinnis last modified Dec 10, 2012 05:57 PM
Photo by Jared Slobodan
Located in About / News Releases
Image shell script
by smcinnis last modified Apr 21, 2015 05:53 PM
Getty Images / Photographer: Marcy Maloy / RF
Located in Projects / Healthy Aging (The Super-Seniors Study)
Image GIF image CAP_Cert_Large_WEB_Color.gif
by smcinnis last modified May 02, 2017 04:06 PM
Located in About / News Releases
"Cracking Cancer" on The Nature of Things with David Suzuki, CBC
by smcinnis published Feb 21, 2017 last modified Feb 23, 2017 04:41 PM
"Cracking Cancer" will debut on February 23rd at 8 PM. With exclusive and rare access, Cracking Cancer follows a group of patients, all with incurable cancer, through the highly experimental clinical trial at the BC Cancer Agency, a trial that holds the promise of personalized cancer diagnosis and treatment.
Located in About / News Releases
Image (Richard) Altman's Army
by smcinnis last modified Jan 17, 2011 01:09 PM
Altman's Army Team photo.
Located in Training / Genome Sciences Centre Retreat 2010
Image (Richard) Altman's Army
by smcinnis last modified Jan 17, 2011 01:09 PM
Altman's Army Team photo.
Located in Training / Genome Sciences Centre Retreat 2010
4th Canadian Conference on Epigenetics: Mechanisms of Disease - Whistler, British Columbia from November 26-29, 2017
by smcinnis published Aug 16, 2017 last modified Aug 16, 2017 01:43 PM
Registration is open. Travel award application deadline: Friday, September 1, 2017 Abstract submission deadline: Thursday, October 26, 2017
Located in About / News Releases
Publication Mathematica Notebook 14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma.
by smcinnis published Nov 26, 2012
14-3-3 proteins are ubiquitously expressed regulators of various cellular functions, including proliferation, metabolism, and differentiation, and altered 14-3-3 expression is associated with development and progression of cancer. We report a transforming 14-3-3 oncoprotein, which we identified through conventional cytogenetics and whole-transcriptome sequencing analysis as a highly recurrent genetic mechanism in a clinically aggressive form of uterine sarcoma: high-grade endometrial stromal sarcoma (ESS). The 14-3-3 oncoprotein results from a t(10;17) genomic rearrangement, leading to fusion between 14-3-3ε (YWHAE) and either of two nearly identical FAM22 family members (FAM22A or FAM22B). Expression of YWHAE-FAM22 fusion oncoproteins was demonstrated by immunoblot in t(10;17)-bearing frozen tumor and cell line samples. YWHAE-FAM22 fusion gene knockdowns were performed with shRNAs and siRNAs targeting various FAM22A exons in an t(10;17)-bearing ESS cell line (ESS1): Fusion protein expression was inhibited, with corresponding reduction in cell growth and migration. YWHAE-FAM22 maintains a structurally and functionally intact 14-3-3ε (YWHAE) protein-binding domain, which is directed to the nucleus by a FAM22 nuclear localization sequence. In contrast to classic ESS, harboring JAZF1 genetic fusions, YWHAE-FAM22 ESS display high-grade histologic features, a distinct gene-expression profile, and a more aggressive clinical course. Fluorescence in situ hybridization analysis demonstrated absolute specificity of YWHAE-FAM22A/B genetic rearrangement for high-grade ESS, with no fusions detected in other uterine and nonuterine mesenchymal tumors (55 tumor types, n = 827). These discoveries reveal diagnostically and therapeutically relevant models for characterizing aberrant 14-3-3 oncogenic functions.
Located in Platforms / Scientific Publications