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How is gene science applied to cancer?
by Stephanie McInnis published Feb 23, 2017 last modified Feb 23, 2017 06:10 PM
Located in About
History of Canada's Michael Smith Genome Sciences Centre (GSC)
by Stephanie McInnis published Feb 23, 2017 last modified Feb 23, 2017 06:08 PM
Located in About
Image GSC Timeline
by Stephanie McInnis last modified Feb 23, 2017 06:03 PM
Located in About
Image chemical/x-cerius Progression of Cancer
by Stephanie McInnis last modified Feb 23, 2017 05:54 PM
Located in About
Image shell script Mutation specific icon
by Stephanie McInnis last modified Feb 23, 2017 03:25 PM
Located in Projects / Mutation Specific Inhibitors in Breast Cancer Cell Lines
Image shell script Potential Therapies
by Stephanie McInnis last modified Feb 23, 2017 03:15 PM
Located in Projects / Potential Therapy for Prostate Cancer
Image shell script Massively Parallel Sequencing
by Stephanie McInnis last modified Feb 23, 2017 03:10 PM
Located in Projects / Massively Parallel Sequencing of the human T-cell Receptor Repertoire
Publication Genome-wide chemical mapping of O-GlcNAcylated proteins in Drosophila melanogaster.
by Stephanie McInnis published Feb 21, 2017
N-Acetylglucosamine β-O-linked to nucleocytoplasmic proteins (O-GlcNAc) is implicated in the regulation of gene expression in organisms, from humans to Drosophila melanogaster. Within Drosophila, O-GlcNAc transferase (OGT) is one of the Polycomb group proteins (PcGs) that act through Polycomb group response elements (PREs) to silence homeotic (HOX) and other PcG target genes. Using Drosophila, we identify new O-GlcNAcylated PcG proteins and develop an antibody-free metabolic feeding approach to chemoselectively map genomic loci enriched in O-GlcNAc using next-generation sequencing. We find that O-GlcNAc is distributed to specific genomic loci both in cells and in vivo. Many of these loci overlap with PREs, but O-GlcNAc is also present at other loci lacking PREs. Loss of OGT leads to altered gene expression not only at loci containing PREs but also at loci lacking PREs, including several heterochromatic genes. These data suggest that O-GlcNAc acts through multiple mechanisms to regulate gene expression in Drosophila.
Located in Platforms / Scientific Publications
Publication chemical/x-pdb Sequencing Strategies to Guide Decision Making in Cancer Treatment.
by Stephanie McInnis published Feb 21, 2017
In a Perspective, James Topham and Marco Marra discuss progress in the use of genomic information to guide cancer treatment.
Located in Platforms / Scientific Publications
Publication Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study.
by Stephanie McInnis published Feb 21, 2017
Follicular lymphoma (FL) is an indolent, yet incurable B cell malignancy. A subset of patients experience an increased mortality rate driven by two distinct clinical end points: histological transformation and early progression after immunochemotherapy. The nature of tumor clonal dynamics leading to these clinical end points is poorly understood, and previously determined genetic alterations do not explain the majority of transformed cases or accurately predict early progressive disease. We contend that detailed knowledge of the expansion patterns of specific cell populations plus their associated mutations would provide insight into therapeutic strategies and disease biology over the time course of FL clinical histories.
Located in Platforms / Scientific Publications