Bioinformatics of Mammalian Gene Expression

This project proposes to find the DNA elements that control gene expression with computational biology and gene expression profiling.

Project Leaders	Steven Jones Marco Marra
Involved Organizations	BC Cancer Agency Canada's Michael Smith Genome Sciences Centre

Overview

Project Resources and Information
Sockeye Coexpression Gene Regulation (Informatics) Lay Summary Chinook The Chinook folder for the chinook webpage ENCODE Target Regions

The various cell types in our bodies are dependent on the correct amount of gene expression in the proper place at the right time. This project proposes to find the DNA elements that control gene expression with computational biology and gene expression profiling. The scientists at the Genome Science Centre will compare genome DNA sequences across species and expression data across different platforms to identify regulatory elements. This project will determine and record the expression of all mouse and many human genes, the most comprehensive effort in mammals to date. This will lead to an understanding of the complex networks of gene regulation that play a role in the normal development of mice and humans. The ability to predict key regulatory events and gene expression controls will facilitate the development of innovative diagnostic tools and gene-based therapies for many disease states.

Contact Information

For all project related inquires please contact us.

Cynthia Ferguson, Project Manager
Genome Sciences Centre, BC Cancer Agency
Email: cferguson@bcgsc.ca
Phone: 604-707-5900 x 6081
Fax: 604-876-3561