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Projects
Active Projects
- Bovine Genome Sequencing
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This project is part of a large international effort to sequence the bovine genome.
- Canadian Molecular Cytogenetics Platform
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Providing an infrastructure to support Canadian research to develop new molecular cytogenetic technologies, evaluate the clinical utility & cost-effectiveness of these technologies and assess their usefulness as research tools.
- Cancer Genomics
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The goal of this project is to detect cancers at an early stage to increase the chances of long term disease-free survival.
- Colorectal Cancer Screening
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This program's focus is to develop novel easy-to-administer tests that identify individuals at the earliest, most curable stages of the disease
- Development of Technologies for the Derivation, Propagation and Differentiation of hESC
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To lay the groundwork for developing human embryonic stem cell-based therapies and facilitate the broader use of these cells to identify new drugs that stimulate or repress particular regenerative events in vivo.
- Genetics of Non-Hodgkin Lymphoma
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The focus of this research is to discover the inherited genetic factors that influence susceptibility to Non-Hodkin Lymphoma and other related Lymphoid Cancers within families.
- Genomic Tools for the Diagnosis and Evaluation of Mental Retardation
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The identification of pathogenic chromosomal imbalances in children with idiopathic mental retardation using genomic tools.
- Genomics of Berry Quality in Grapevine (GrapeGen)
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Understanding the interaction between the genome and environment in determining berry quality traits in both table and wine grapes.
- Healthy Aging
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The G3 team studies genetic factors that underlie healthy aging and resistance to common age-related diseases such as cancer, cardiovascular and pulmonary disease.
- High Resolution Analysis of Follicular Lymphoma Genomes
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High resolution analysis follicular lymphoma genomes to discover the genomic rearrangements contributing to development of follicular lymphoma and the additional rearrangements contributing to the progression from follicular lymphoma to diffuse large B cell lymphoma.
- Lymphoma Transcriptome Sequencing and Analysis
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This project involves identifying and characterizing the range of mutations found in lymphoma tumours. Once identified, specific mutations may be shown to effect or be associated with response to treatment, patient outcome and survival, or be useful as a target for anti-cancer drug development.
- Mammalian Organogenesis (MORGEN)
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Using the mouse as our model organism, we are identifying transcriptional networks of genes necessary for the development of the heart, lung, and pancreas.
- Molecular Characterization of Autophagic Cell Death
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Exploring the molecular mechanisms essential to autophagy and cell death with genetic, genomic, molecular and proteomic approaches using Drosophila and mammalian cell lines.
- Mutation Specific Inhibitors in Breast Cancer Cell Lines
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To use next generation sequencing technology to derive the complete genomic sequence of breast cancer cell lines.
- Pleiades Promoter Project
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To generate fully characterized, human DNA promoters of less than 4 kb (MiniPromoters) to drive gene expression in defined brain regions of therapeutic interest for diseases such as Alzheimer, Parkinson, Huntington, Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Spinocerebellar Ataxia, Depression, Autism, and Cancer.
- Role of Autophagy in the Therapeutic Response of Breast Cancer Cells
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To evaluate the potential of using autophagy inhibition to sensitize breast cancer cells to endocrine therapy and chemotherapy.
Completed Projects
- Atlantic Salmon
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This project is deciphering the genome of the Atlantic salmon and providing key information to enhance the understanding of fish reproduction, growth and disease resistance.
- Bioinformatics of Mammalian Gene Expression
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This project proposes to find the DNA elements that control gene expression with computational biology and gene expression profiling.
- Follicular Lymphoma as a Model of Cancer Progression
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To examine entirely new aspects of cancer progression with major therapeutic implications for both follicular lymphoma and cancer in general.
- Functional Genomics of C. Neoformans
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An outbreak on Vancouver Island, British Columbia of lung and central nervous system infections caused by Cryptococcus neoformans provided the incentive for this large scale genomics project.
- Microbial Envirogenomics
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The Microbial Envirogenomics project elucidates and exploits the physiology and functioning of environmentally important bacteria through genomic approaches, starting with Rhodococcus RHA1.
- Mouse Atlas
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The primary goal of this project is to create a mouse atlas of genes expressed throughout development in numerous stages and tissues.
- SARS Sequencing
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SARS associated virus genome sequencing project is a collaboration with the British Columbia Centre for Disease Control and the National Microbiology Laboratory, Winnipeg.
- Treenomix: Spruce, Poplar and Arabipdopsis
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This project is utilizing high throughput genomic techniques coupled with proteomic analysis to investigate the regulation of wood formation and pest resistance in forest trees.
