Summary page for 'UGT1A8' (ENSG00000167165) - Project: LnCAP_AR_KnockIn


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Basic Gene Stats

Species: Human
Gene Name: 'UGT1A8' (HUGO: UGT1A10 UGT1A8 UGT1A7 UGT1A6 UGT1A5 UGT1A9 UGT1A4 UGT1A1 UGT1A3)
ALEXA Gene ID: 12384 (ALEXA_hs_53_36o)
EnsEMBL Gene ID: ENSG00000167165
Entrez Gene Record(s): UGT1A10 UGT1A8 UGT1A7 UGT1A6 UGT1A5 UGT1A9 UGT1A4 UGT1A1 UGT1A3
Ensembl Gene Record: ENSG00000167165
Evidence: Known Gene
Gene Type: protein_coding
Location: chr2 234191093-234346688 (+): 2q37 2q37 2q37 2q37 2q37 2q37 2q37 2q37 2q37
Size (bp): 155596
Description: UDP-glucuronosyltransferase 1-8 Precursor (EC 2.4.1.17)(UDP-glucuronosyltransferase 1A8)(UDPGT)(UGT1*8)(UGT1-08)(UGT1.8)(UGT-1H)(UGT1H) [Source:UniProtKB/Swiss-Prot;Acc:Q9HAW9]



Data links for each library (displays expression data in UCSC Genome Browser)

Comparison: HS1442_vs_HS1441
C42 (HS1441) has 144 total reads for 'UGT1A8'. UCSC data links: (C | P)
AR_KnockIn (HS1442) has 76 total reads for 'UGT1A8'. UCSC data links: (C | P)



Link to other genes in the same chromosome region as 'UGT1A8'

chr2_7



Features defined for this gene: 305

Gene: 1
Transcript: 14
ExonRegion: 25
Junction: 143
    KnownJunction: 15
    NovelJunction: 128
Boundary: 37
    KnownBoundary: 9
    NovelBoundary: 28
Intron: 24
ActiveIntronRegion: 22
SilentIntronRegion: 32
Intergenic: 2
ActiveIntergenicRegion: 2
SilentIntergenicRegion: 4



Summary of transcript specific features for 'UGT1A8' (ENSG00000167165)

ENST00000354728:ER3a, ER3c, E3b_E11a
ENST00000305139:ER6a
ENST00000360418:NA
ENST00000318990:ER8a, E8a_E11a
ENST00000406651:NA
ENST00000373460:E3a_E4b
ENST00000305208:ER10a, E10a_E11a
ENST00000373409:ER9a, E9a_E11a
ENST00000373450:ER2a
ENST00000373445:ER14b
ENST00000373426:ER4a
ENST00000344644:ER1a, E1a_E11a
ENST00000373424:ER5a, E5a_E6c
ENST00000373414:ER7a, E7a_E11a


Summary of known expressed features

Expressed above background

LibraryExon Regions
(Expressed/Total)
Known Junctions
(Expressed/Total)
C42:2/250/15
AR_KnockIn:0/250/15

Detected at any level above 0

LibraryExon Regions
(Detected/Total)
Known Junctions
(Detected/Total)
C42:13/257/15
AR_KnockIn:15/253/15


Normalized expression data for each known or novel expressed feature of 'UGT1A8'

The following table summarizes the expression values of all known features of the gene 'UGT1A8' in each library. Known features (i.e. those that correspond to one or more EnsEMBL transcripts) are included regardless of their expression level. Novel features are only reported in this table if they are expressed above the level of intergenic background noise. The 'FID' column reports the unique Feature ID for the gene, transcript, exon region, exon junction, etc. The 'Name' column reports the Feature Name for the feature (e.g. E5a_E6a is the name of an exon junction corresponding to the connection of exons 5 and 6). The 'Type' column reports the type of the feature and may be one of the following: Gene, Transcript, Exon Region, Known Junction, Novel Junction, Known Boundary, Novel Boundary, Silent or Active Intronic Regions, and Silent or Active Intergenic Regions (see our manuscript for more details). The 'Base Count' column reports the number of nucleotide bases for the feature followed by the percent of these that do NOT correspond to repeats and the percent that are known to be protein coding in one or more EnsEMBL transcripts. The 'Supporting ESTs/mRNAs' column reports the number of ESTs and mRNAs that when aligned to the human genome support the expression of a feature (i.e. the sequence alignment coordinates match an exon junction or boundaries of an exon, retained intron, etc.). The 'Conserved Species' column reports the number of 'other' species for which there was at least 1 supporting EST/mRNA alignment. Finally, the remaining columns report the log2 expression value for each feature in each library. Bold values indicate expression above background. Each expression value is also a hyperlink to a view of the feature's corresponding genomic region in the UCSC genome browser. Expression data will automatically be loaded as custom GFF and wiggle tracks.


FIDNameTypeBase Count
(% unmasked |
% coding)
Supporting
Human
ESTs/mRNAs
Conserved
Species
C42 Log2
Expression
AR_KnockIn Log2
Expression
G12384UGT1A8Gene10451 (97% | 81%)N/AN/A1.46 (C | P)0.85 (C | P)
T30719ENST00000344644Transcript917 (98% | 100%)N/AN/A0.00 (C | P)0.00 (C | P)
T30727ENST00000373450Transcript49 (100% | 0%)N/AN/A0.00 (C | P)0.00 (C | P)
T30726ENST00000373445Transcript578 (63% | 0%)N/AN/A1.72 (C | P)1.41 (C | P)
T30720ENST00000354728Transcript624 (100% | 94%)N/AN/A0.00 (C | P)0.19 (C | P)
T30728ENST00000373460Transcript62 (100% | 100%)N/AN/A0.00 (C | P)0.00 (C | P)
T30725ENST00000373426Transcript329 (100% | 100%)N/AN/A0.00 (C | P)0.74 (C | P)
T30724ENST00000373424Transcript276 (68% | 11%)N/AN/A0.00 (C | P)0.00 (C | P)
T30716ENST00000305139Transcript827 (100% | 83%)N/AN/A0.00 (C | P)0.01 (C | P)
T30729ENST00000406651TranscriptN/A (N/A% | N/A%)N/AN/ANA (C | P)NA (C | P)
T30721ENST00000360418TranscriptN/A (N/A% | N/A%)N/AN/ANA (C | P)NA (C | P)
T30723ENST00000373414Transcript929 (100% | 100%)N/AN/A0.10 (C | P)0.00 (C | P)
T30718ENST00000318990Transcript929 (100% | 100%)N/AN/A0.00 (C | P)0.00 (C | P)
T30722ENST00000373409Transcript929 (99% | 100%)N/AN/A1.12 (C | P)0.99 (C | P)
T30717ENST00000305208Transcript941 (100% | 98%)N/AN/A2.16 (C | P)0.00 (C | P)
ER173032ER1aExonRegion855 (98% | 100%)620.00 (C | P)0.00 (C | P)
EJ1639407E1a_E11aKnownJunction62 (100% | 100%)730.00 (C | P)0.00 (C | P)
ER173033ER2aExonRegion49 (100% | 0%)210.00 (C | P)0.00 (C | P)
EB297719E2_AbKnownBoundary62 (100% | 16%)200.00 (C | P)0.00 (C | P)
ER173034ER2bExonRegion875 (100% | 98%)310.20 (C | P)1.53 (C | P)
EJ1639425E2a_E11aKnownJunction62 (100% | 100%)720.00 (C | P)0.00 (C | P)
ER173035ER3aExonRegion38 (100% | 3%)1030.00 (C | P)0.00 (C | P)
EB297722E3_AbKnownBoundary62 (100% | 50%)1030.00 (C | P)0.00 (C | P)
ER173036ER3bExonRegion330 (100% | 100%)760.00 (C | P)0.00 (C | P)
EB297723E3_DaKnownBoundary62 (100% | 100%)1360.00 (C | P)0.00 (C | P)
EJ1639431E3a_E4bKnownJunction62 (100% | 100%)000.00 (C | P)0.00 (C | P)
ER173037ER3cExonRegion524 (100% | 100%)430.00 (C | P)0.51 (C | P)
EJ1639457E3b_E11aKnownJunction62 (100% | 100%)1450.00 (C | P)0.00 (C | P)
ER173038ER4aExonRegion329 (100% | 100%)410.00 (C | P)0.74 (C | P)
EB297726E4_AbKnownBoundary62 (100% | 100%)920.00 (C | P)0.00 (C | P)
ER173039ER4bExonRegion526 (100% | 100%)510.00 (C | P)0.28 (C | P)
EJ1639471E4a_E11aKnownJunction62 (100% | 100%)511.50 (C | P)0.00 (C | P)
ER173040ER5aExonRegion214 (58% | 0%)100.00 (C | P)0.00 (C | P)
EJ1639478E5a_E6cKnownJunction62 (100% | 50%)300.00 (C | P)0.00 (C | P)
ER173041ER6aExonRegion827 (100% | 83%)000.00 (C | P)0.01 (C | P)
EB297731E6_AbKnownBoundary62 (100% | 100%)6101.54 (C | P)0.00 (C | P)
ER173042ER6bExonRegion107 (100% | 100%)682.20 (C | P)1.58 (C | P)
EB297732E6_AcKnownBoundary62 (100% | 100%)7160.00 (C | P)0.00 (C | P)
EB297733E6_AdKnownBoundary62 (100% | 100%)7160.00 (C | P)0.00 (C | P)
ER173043ER6cExonRegion7 (100% | 100%)10160.00 (C | P)0.00 (C | P)
ER173044ER6dExonRegion59 (100% | 100%)10101.34 (C | P)0.70 (C | P)
EJ1639493E6a_E11aKnownJunction62 (100% | 100%)8101.59 (C | P)1.34 (C | P)
ER173045ER7aExonRegion867 (100% | 100%)210.20 (C | P)0.00 (C | P)
EJ1639501E7a_E11aKnownJunction62 (100% | 100%)310.00 (C | P)0.00 (C | P)
ER173046ER8aExonRegion867 (100% | 100%)520.00 (C | P)0.00 (C | P)
EJ1639508E8a_E11aKnownJunction62 (100% | 100%)650.00 (C | P)0.00 (C | P)
ER173047ER9aExonRegion867 (99% | 100%)201.74 (C | P)0.26 (C | P)
EJ1639514E9a_E11aKnownJunction62 (100% | 100%)360.00 (C | P)1.47 (C | P)
ER173048ER10aExonRegion879 (100% | 98%)321.11 (C | P)0.00 (C | P)
EJ1639519E10a_E11aKnownJunction62 (100% | 100%)7112.76 (C | P)0.00 (C | P)
ER173049ER11aExonRegion132 (100% | 100%)52233.46 (C | P)2.14 (C | P)
EJ1639524E11a_E12aKnownJunction62 (100% | 100%)55253.32 (C | P)0.00 (C | P)
ER173050ER12aExonRegion88 (100% | 100%)55284.07 (C | P)1.67 (C | P)
EJ1639528E12a_E13aKnownJunction62 (100% | 100%)56242.32 (C | P)1.34 (C | P)
ER173051ER13aExonRegion220 (100% | 100%)54243.86 (C | P)2.38 (C | P)
EJ1639531E13a_E14aKnownJunction62 (100% | 100%)1201.98 (C | P)0.00 (C | P)
EJ1639532E13a_E15aKnownJunction62 (100% | 100%)47222.95 (C | P)0.00 (C | P)
ER173052ER14aExonRegion171 (100% | 18%)101.61 (C | P)0.71 (C | P)
EB297749E14_DaKnownBoundary62 (61% | 0%)402.16 (C | P)0.00 (C | P)
ER173053ER14bExonRegion578 (63% | 0%)001.72 (C | P)1.41 (C | P)
ER173054ER15aExonRegion407 (100% | 73%)202.83 (C | P)2.23 (C | P)
EB297752E15_DaKnownBoundary62 (100% | 0%)2802.21 (C | P)2.49 (C | P)
ER173055ER15bExonRegion631 (100% | 0%)003.09 (C | P)1.79 (C | P)
ER173056ER15cExonRegion4 (100% | 0%)000.00 (C | P)0.00 (C | P)


Figures displaying gene and feature expression levels in each library

The following figures illustrate the expression of the gene 'UGT1A8' and its component features for each library. First, a simple gene model is depicted. In this model, features that are alternatively expressed in at least one comparison are marked red (see below for the actual expression levels of each feature). Next, the expression values are displayed for only the exons and known (or expressed novel) exon junctions. This first display consists of a single plot with one colored line per library (as indicated in the legend). Next, the expression of the gene relative to the distribution of all gene expression values is displayed as a histogram. In these figures (one for each library) the expression of the current gene is indicated by a dotted red line. Estimated cutoffs for background expression level corresponding to intergenic and intragenic noise are indicated by dotted black lines. The bar plots following these histograms display the expression level of all individual features. The color of the bars correspond to different feature types (enumerated as colored boxes in the legend). As in the histograms, the estimated cutoffs level for intergenic and intragenic noise are indicated as dotted lines. For genes with low expression values, these cutoffs converge to a single value. Features with significant alternative expression values are highlighted yellow in the line plot, and marked with a pink asterix below. *If you can not see the figure below, click here