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Postdoctoral Fellow, Bioinformatics and Lymphoma Genomics

Job Code: PDFBLG 16-10-24

The British Columbia Cancer Agency is seeking a Postdoctoral Fellow to conduct scientific research in the area of cancer genomics specifically related to an ongoing effort to understand the aetiology of aggressive lymphoid cancers including diffuse large B-cell and mantle cell lymphomas.

                                

The successful applicant will analyze NGS data produced from clinical samples from cancer

patients, namely RNA-seq, whole exome, whole genome, and circulating tumour DNA sequence

data. This position demands a strong bioinformatics and genomics background. Detailed

knowledge of cancer biology (particularly non-Hodgkin lymphomas) would be an asset.

Familiarity with algorithms for inferring clonal structure of tumours from sequence data and

network/pathway analysis methods is also desirable. Characteristics of the ideal candidate

include strong verbal and written communication skills, attention to detail, creativity and the

ability to remain organized in a fast-paced and dynamic environment.

The successful candidate will report to Drs. Ryan Morin(Genome Sciences Centre, BCCA) and David Scott (Centre for Lymphoid Cancer, BCCA) and will interact with a diverse team of clinicians and research scientists at the BC Cancer Agency.

Typical duties will include the following:

● Use alignment and assembly-based methods to detect somatic alterations such as

CNAs, SNVs, indels and structural alterations/fusion transcripts.

● Implement improved algorithms/pipelines for detection of somatic alterations in

heterogeneous tumour samples and damaged DNA (FFPE, ctDNA)

● Infer novel driver genes and pathways using recurrence-based and selective-pressure

based methodologies

● Resolve clonal frequency of mutations and clonal substructure of tumours

● Delineate clonal dynamics from serial tumour biopsies and ctDNA

● Determine significant changes to gene expression and splicing

● Leverage clinical metadata to identify predictive or prognostic signatures

Suitable candidates should possess a PhD degree in molecular biology or bioinformatics.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent

residents will be given priority.

Location:  Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC,

Canada.

Duration: 2 years (possibility of extension).

Salary:  Commensurate with experience (competitive).

 

To Apply

Please send your curriculum vitae with cover letter to: rdmorin@sfu.ca or dscott8@bccancer.bc.ca with subject line “lymphoma bioinformatics PDF application”