Postdoctoral Fellow, Bioinformatics and Lymphoma Genomics
Job Code: PDFBLG 16-10-24
The British Columbia Cancer Agency is seeking a Postdoctoral Fellow to conduct scientific research in the area of cancer genomics specifically related to an ongoing effort to understand the aetiology of aggressive lymphoid cancers including diffuse large B-cell and mantle cell lymphomas.
The successful applicant will analyze NGS data produced from clinical samples from cancer
patients, namely RNA-seq, whole exome, whole genome, and circulating tumour DNA sequence
data. This position demands a strong bioinformatics and genomics background. Detailed
knowledge of cancer biology (particularly non-Hodgkin lymphomas) would be an asset.
Familiarity with algorithms for inferring clonal structure of tumours from sequence data and
network/pathway analysis methods is also desirable. Characteristics of the ideal candidate
include strong verbal and written communication skills, attention to detail, creativity and the
ability to remain organized in a fast-paced and dynamic environment.
The successful candidate will report to Drs. Ryan Morin(Genome Sciences Centre, BCCA) and David Scott (Centre for Lymphoid Cancer, BCCA) and will interact with a diverse team of clinicians and research scientists at the BC Cancer Agency.
Typical duties will include the following:
● Use alignment and assembly-based methods to detect somatic alterations such as
CNAs, SNVs, indels and structural alterations/fusion transcripts.
● Implement improved algorithms/pipelines for detection of somatic alterations in
heterogeneous tumour samples and damaged DNA (FFPE, ctDNA)
● Infer novel driver genes and pathways using recurrence-based and selective-pressure
● Resolve clonal frequency of mutations and clonal substructure of tumours
● Delineate clonal dynamics from serial tumour biopsies and ctDNA
● Determine significant changes to gene expression and splicing
● Leverage clinical metadata to identify predictive or prognostic signatures
Suitable candidates should possess a PhD degree in molecular biology or bioinformatics.
All qualified candidates are encouraged to apply; however, Canadian citizens and permanent
residents will be given priority.
Location: Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC,
Duration: 2 years (possibility of extension).
Salary: Commensurate with experience (competitive).