Duties/Accountablilties:

1. Assists in the preparation of routine laboratory expenditure reports including monthly and annual reports by performing duties such as compiling information from a variety of sources, entering information into financial spreadsheet software such as Excel and producing reports for forwarding to the supervisor.

2. Updates laboratory inventory database by performing duties such as receiving inventory documents, checking for completeness, contacting vendors and entering data into computerized inventory system.

3. Places specific purchase orders with designated external suppliers by performing duties such as contacting suppliers, completing purchase order and arranging for approvals and forwarding to suppliers.

4. Obtains information such as prices and estimated delivery dates for supplies and/or equipment by performing duties such as using the Internet to identify sources and prices of supplies and/or equipment and forwarding information to supervisor.

5. Contacts external suppliers to investigate a variety of matters such as incorrect invoices, pricing problems, outstanding or backordered items and damaged goods; traces duplicate shipments and organizes invoice adjustments and credit notes with suppliers; returns outdated and/or deleted stock to vendors as directed.

6. Maintains a library of supplies and equipment catalogues by performing duties such as using the Internet to identify sources of catalogues, requesting current catalogues from suppliers, and providing information to staff as requested.

7.Reconciles designated accounts by performing duties such as matching information including payments received, refunds and invoices issued and identifying differences. Balances information with ledger. Refers problems to supervisor.

8. Performs a variety of duties related to the receiving of goods and equipment including unpacking, labeling and recording receipt of goods and equipment.

9. Maintains a variety of laboratory supplies and reagents by performing duties such as by performing duties such as reviewing stock on hand against pre-determined re-order points and completing requisitions for approval and forwarding to purchasing.

10. Maintains information such as MSDS sheets, product information and price lists by performing duties such as receiving and requesting information, advising staff of new and/or changed information and filing for future reference.

11. Performs other related duties as assigned.

Qualifications:

Education, Training and Experience

•Grade 12 and two year’s recent related experience or an equivalent combination of education, training and experience.

Skills and Abilities:

•Ability to keyboard at 45 wpm.
•Ability to communicate effectively both verbally and in writing.
•Ability to deal with others effectively
•Physical ability to carry out the duties of the position.
•Ability to organize work.
• Ability to operate related equipment.

The current estimated queue is ~18-24 weeks. All samples are placed in the queue in the order in which they are received. The queue is dependent on the samples submitted.  This is an estimate only and subject to change without notice.

For more information on our policies, please refer to our Terms of Service.

Typing technical and non-technical materials such as correspondence, grant applications, papers, project outlines, scientific reviews from hand written drafts or dictation. 

1. Composing general routine correspondence such as responses to fundraising requests and covering letters for grant submission information as directed for the signature of scientific and administrative staff.
2.  Arranging meetings as directed; booking meeting rooms; typing and circulates agenda; recording, transcribing and distributing meeting minutes.
3.  Receiving visitors to the GSC, providing information and directing to appropriate persons or areas.
4.  Opening and sorting incoming mail; forwards to appropriate individuals.
5.  Receiving incoming phone calls, answering routine questions and taking messages or forwarding to applicable   party.
6.  Arranging and confirming appointments when requested.
7.  Setting up and maintains filing systems for material such as correspondence, personnel records.
8.  Assisting in the preparation of materials for conferences by formatting abstracts, posters and papers; requesting information as requested and reminding staff of deadlines.
9. Receiving from GSC staff Finance forms such as Petty Cash and Cheque Request forms, reviewing for completeness, verifying the accuracy of totals by tabulating attached receipts.  Reviews General Ledger report details to verify items such as Cheque Requests have been charged to the account code noted.
10.  Performing other related duties.

Qualifications

Education, Training and Experience 

• Completion of Grade 12 plus two years’ recent related experience or an equivalent combination of education, training and experience. 
   

Skills and Abilities 

• Ability to type at 50 wpm.
• Ability to communicate effectively, both verbally and in writing.
• Ability to deal with others effectively.
• Physical ability to carry out the duties of the position.
• Ability to organize work.
• Ability to operate related equipment.

Duties/Accountablilties:

1. Assists the Bioinformatics Coordinator in the day to day activities of the Bioinformatics group by performing duties such as providing input on quantity and quality of work, making recommendations for improvements, workflow and procedures.
   
   2. Coordinates projects of the Bioinformatics group by performing duties such as chairing project-specific meetings and provides project status reports to the Bioinformatics Coordinator, with suggestions towards any required improvement of project management, task allocation and overall process.
   
   3.Develops and implements assays to monitor project progress and measure project accomplishments to ensure that appropriate project focus is maintained and to provide feedback to staff.
   
   4. Provides supervisory support to the Bioinformatics group by performing duties such as:
   
   a. Orientating new staff.
   b. Providing input to the Bioinformatics Coordinator on training requirements.
   c. Providing input to the Production Coordinator on the establishment of clear definitions of responsibility for employees.
   d. Assigning workload assignments and establishing work schedules.
   e. Reviewing and establishing work priorities and adjusting work schedules to ensure priorities are met.
   f. Completing performance reviews and addressing performance issues in conjunction with the Production Coordinator.
   
   5. Participates in the recruitment of staff through methods such as interviewing internal and external applicants and forwards hiring recommendations.
                                                                                                                         6. Participates in the development and implementation of quality improvement programs to ensure services are provided in the most efficient and effective way by performing duties such as:
   
   a. Monitoring quality and quantity of service and information provided by the bioinformatics group and identifying areas for change and/or improvement.
   b. Generating test metrics to evaluate progress of research programs.
   
   7. Assesses practical needs for identified research direction of the GSC in conjunction with the Bioinformatics Coordinator and Analysis Group Leader.
   
   8. Participates in a variety of meetings by performing duties such as providing and/or receiving information and contributing to decision making.
   
   9.Participates, in conjunction with the Bioinformatics Coordinator, in determining the computer infrastructure necessary for successful completion of projects and ensured viability of research programs by performing duties such as providing input and recommendations regarding purchasing decisions related to hardware, software and related items for the Bioinformatics platform.
   
   10. Interprets statistical analyses and makes recommendations for review including preparing reports on statistical findings for publication and presentation in HTML format or as advised.
   
   11.Conducts feasibility studies for computerization by performing duties such as determining user requirements, examining and identifying problems with existing systems and recommending modifications to and/or new systems; provides details of estimated implementation costs including associated staffing requirements.
   
   12. Performs technical functions related to the bioinformatic functions of the GSC.
   
   13. Performs other related duties as required.

Qualifications:

Education, Training and Experience

•Graduation from a recognized Bachelor’s program in a related discipline such as Biochemistry, Genetics, Computer Science, Electrical Engineering or Physics.  A minimum of four (4) years of recent related experience including experience in computer programming and quantitative data analysis, handling biological sequence and/or mapping data, database development and data storage schemas or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and Abilities

•Experience with computer operating systems such as Linux, UNIX.
•Demonstrated ability to work with software such as C, C++, Perl , Matlab, MySQL.
•Demonstrated ability to accept responsibility and work independently.
•Demonstrated ability to work effectively with others in a team environment.
•Demonstrated ability to supervise staff and schedule work.
•Excellent organizational, leadership interpersonal and communication skills.
•Physical ability to perform the duties of the job.

1. For best library construction results please submit the recommended amount of starting material or more.
2. The amounts specified work well for mouse or human derived nucleic acids, but other species may require different amounts. Please enquire if you are working with other species.
3. In our experience this is the minimum amount of starting material which will result in adequate sequencing results. Please discuss with our technical staff if your sample size is limited.

Contact Information

For additional information or to arrange for a cost quotation, please contact us.

Diane Miller, Project Manager
Genome Sciences Centre, BC Cancer Agency
Suite 100, 570 West 7th Ave
Vancouver, BC, V5Z 4S6
Email: dmiller@bcgsc.ca
Phone: (604) 707-5808
Fax: (604) 877-6085

1. Sohrab P. Shah, Andrew Roth, Rodrigo Goya, Arusha Oloumi, Gavin Ha, Yongjun Zhao, Gulisa Turashvili, Jiarui Ding, Kane Tse, Gholamreza Haffari, Ali Bashashati, Leah M. Prentice, Jaswinder Khattra, Angela Burleigh, Damian Yap, Virginie Bernard, Andrew McPherson, Karey Shumansky, Anamaria Crisan, Ryan Giuliany, Alireza Heravi-Moussavi, Jamie Rosner, Daniel Lai, Inanc Birol, Richard Varhol, Angela Tam, Noreen Dhalla, Thomas Zeng, Kevin Ma, Simon K. Chan, Malachi Griffith, Annie Moradian, S.-W. Grace Cheng, Gregg B. Morin, Peter Watson, Karen Gelmon, Stephen Chia, Suet-Feung Chin, Christina Curtis, Oscar M. Rueda, Paul D. Pharoah, Sambasivarao Damaraju, John Mackey, Kelly Hoon, Timothy Harkins, Vasisht Tadigotla, Mahvash Sigaroudinia, Philippe Gascard, Thea Tlsty, Joseph F. Costello, Irmtraud M. Meyer, Connie J. Eaves, Wyeth W. Wasserman, Steven Jones, David Huntsman, Martin Hirst, Carlos Caldas, Marco A. Marra & Samuel Aparicio The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature 2012 (doi:10.1038/nature10933) Published online 04 April 2012.
2. Astanehe A, Finkbeiner MR, Krzywinski M, Fotovati A, Dhillon J, Berquin IM, Mills GB, Marra MA, Dunn SE. MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition. Oncogene. 2012 Jan 16.
3. Baradaran-Heravi A, Cho KS, Tolhuis B, Sanyal M, Morozova O, Morimoto M, Elizondo LI, Bridgewater D, Lubieniecka J, Beirnes K, Myung C, Leung D, Fam HK, Choi K, Huang Y, Dionis KY, Zonana J, Keller K, Stenzel P, Mayfield C, Lücke T, Bokenkamp A, Marra MA, van Lohuizen M, Lewis DB, Shaw C, Boerkoel CF. Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression. Hum Mol Genet. 2012 Mar 13.
4. Chu JS-C, Johnsen RC, Chua S-Y, Tu D, Dennison M, Marra M, Jones SJM, Baillie DL, Rose AM. Allelic Ratios and the Mutational Landscape Reveal Biologically Significant Heterozygous SNVs. Genetics. 2012 Apr;190(4):1225-33. Epub 2012 Jan 20.
5. Collins CC, Volik SV, Lapuk A, Wang Y, Gout PW, Wu C, Xue H, Cheng H, Haegert A, Bell RH, Brahmbhatt S, Anderson S, Fazli L, Hurtado-Coll A, Rubin MA, Demichelis F, Beltran H, Hirst M, Marra MA, Maher CA, Chinnaiyan AM, Gleave ME, Bertino JR, Lubin M, Wang Y. Next Generation Sequencing of Prostate Cancer from a Patient Identifies a Deficiency of Methylthioadenine Phosphorylase (MTAP), an Exploitable Tumor Target. Molecular cancer therapeutics. 2012 Mar;11(3):775-83. Epub 2012 Jan 17.
6. Dubuc AM, Morrissy AS, Kloosterhof NK, Northcott PA, Yu EPY, Shih D, Peacock J, Grajkowska W, van Meter T, Eberhart CG, Pfister S, Marra MA, Weiss WA, Scherer SW, Rutka JT, French PJ, Taylor MD. Subgroup-specific alternative splicing in medulloblastoma. Acta Neuropathol. 2012 Apr 1;123(4):485-99.
7. Gibson WT, Hood RL, Zhan SH, Bulman DE, Fejes AP, Moore R, Mungall AJ, Eydoux P, Babul-Hirji R, An J, Marra MA, Consortium FC, Chitayat D, Boycott KM, Weaver DD, Jones SJM. Mutations in EZH2 Cause Weaver Syndrome. Am J Hum Genet. 2012 Jan 13;90(1):110-8.
8. Greenman CD, Pleasance ED, Newman S, Yang F, Fu B, Nik-Zainal S, Jones D, Lau KW, Carter N, Edwards PAW, Futreal PA, Stratton MR, Campbell PJ. Estimation of rearrangement phylogeny for cancer genomes. Genome Res. 2012 Feb 1;22(2):346-61.
9. Griffith M, Mwenifumbo JC, Cheung PY, Paul JE, Pugh TJ, Tang MJ, Chittaranjan S, Morin RD, Asano JK, Ally AA, Miao L, Lee A, Chan SY, Taylor G, Severson T, Hou Y-C, Griffith OL, Cheng GSW, Novik K, Moore R, Luk M, Owen D, Brown CJ, Morin GB, Gill S, Tai IT, Marra MA. Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer. The Pharmacogenomics journal. 2012 Jan 17.
10. Heravi-Moussavi A, Anglesio MS, Cheng S-WG, Senz J, Yang W, Prentice L, Fejes AP, Chow C, Tone A, Kalloger SE, Hamel N, Roth A, Ha G, Wan ANC, Maines-Bandiera S, Salamanca C, Pasini B, Clarke BA, Lee AF, Lee C-H, Zhao C, Young RH, Aparicio SA, Sorensen PHB, Woo MMM, Boyd N, Jones SJM, Hirst M, Marra MA, Gilks B, Shah SP, Foulkes WD, Morin GB, Huntsman DG. Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers. N Engl J Med. 2012 Jan 19;366(3):234-42.
11. Kridel R, Meissner B, Rogic S, Boyle M, Telenius A, Woolcock B, Gunawardana J, Jenkins C, Cochrane C, Ben-Neriah S, Tan K, Morin RD, Opat S, Sehn LH, Connors JM, Marra MA, Weng AP, Steidl C, Gascoyne RD. Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma. Blood. 2012 Jan 18.
12. Lebovitz CB, Bortnik SB, Gorski SM. Here, There Be Dragons: Charting Autophagy-Related Alterations in Human Tumors. Clinical Cancer Research. 2012 Mar 1;18(5):1214-26.
13. Lee C-H, Ou W-B, Mariño-Enriquez A, Zhu M, Mayeda M, Wang Y, Guo X, Brunner AL, Amant F, French CA, West RB, McAlpine JN, Gilks CB, Yaffe MB, Prentice LM, McPherson A, Jones SJM, Marra MA, Shah SP, van de Rijn M, Huntsman DG, Dal Cin P, Debiec-Rychter M, Nucci MR, Fletcher JA. 14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma. Proc Natl Acad Sci USA. 2012 Jan 5.
14. Najafzadeh M, Lynd LD, Davis JC, Bryan S, Anis A, Marra M, Marra CA. Barriers to integrating personalized medicine into clinical practice: a best-worst scaling choice experiment. Genetics in medicine : official journal of the American College of Medical Genetics. 2012 Jan 19.
15. Roth A, Ding J, Morin R, Crisan A, Ha G, Giuliany R, Bashashati A, Hirst M, Turashvili G, Oloumi A, Marra MA, Aparicio S, Shah SP. JointSNVMix: a probabilistic model for accurate detection of somatic mutations in normal/tumour paired next-generation sequencing data. Bioinformatics (Oxford, England). 2012 Apr 1;28(7):907-13.
16. Schmouth J-F, Banks KG, Mathelier A, Gregory-Evans CY, Castellarin M, Holt RA, Gregory-Evans K, Wasserman WW, Simpson EM. Retina Restored and Brain Abnormalities Ameliorated by Single-Copy Knock-In of Human NR2E1 in Null Mice. Mol Cell Biol. 2012 Apr 1;32(7):1296-311.
17. Schuetz JM, Daley D, Graham J, Berry BR, Gallagher RP, Connors JM, Gascoyne RD, Spinelli JJ, Brooks-Wilson AR. Genetic variation in cell death genes and risk of non-Hodgkin lymphoma. PLoS ONE. 2012 Jan 1;7(2):e31560.
18. Wu C, Wyatt AW, Lapuk AV, McPherson A, McConeghy BJ, Bell RH, Anderson S, Haegert A, Brahmbhatt S, Shukin R, Mo F, Li E, Fazli L, Hurtado-Coll A, Jones EC, Butterfield YS, Hach F, Hormozdiari F, Hajirasouliha I, Boutros PC, Bristow RG, Jones SJ, Hirst M, Marra MA, Maher CA, Chinnaiyan AM, Sahinalp SC, Gleave ME, Volik SV, Collins CC. Integrated genome and transcriptome sequencing identifies a novel form of hybrid and aggressive prostate cancer. J Pathol. 2012 May 1;227(1):53-61.

2011

1. Yip S, Butterfield Y, Morozova O, Chittaranjan S, Blough MD, An J, Birol I, Chesnelong C, Chiu R, Chuah E, Corbett R, Docking R, Firme M, Hirst M, Jackman S, Karsan A, Li H, Louis DN, Maslova A, Moore R, Moradian A, Mungall KL, Perizzolo M, Qian J, Roldan G, Smith EE, Tamura-Wells J, Thiessen N, Varhol R, Weiss S, Wu W, Young S, Zhao Y, Mungall AJ, Jones SJ, Morin GB, Chan JA, Cairncross JG, Marra MA. Concurrent CIC Mutations, IDH Mutations and 1P/19Q Loss Distinguish Oligodendrogliomas from Other Cancers J Pathol. 2011 Sep 7. [Epub ahead of print]
2. Castellarin M*, Warren RL*, Freeman JD, Dreolini L, Krzywinski M, Strauss J, Barnes R, Watson P, Allen-Vercoe E, Moore RA, Holt RA. Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res. 2011 Oct 18. [Epub ahead of print] *Authors contributed equally to this work. Castellarin M*, Warren RL*
3. Brooks-Wilson A and Marra F. Response to Leiro-Fernandez et al. Pharmacogenomics. Brooks-Wilson A et al. In press.
4. Rebollo R, Karimi MM, Bilenky M, Gagnier L, Miceli-Royer K, Zhang Y, Goyal P, Keane TM, Jones S, Hirst M, Lorincz MC, Mager DL.  Retrotransposon-induced heterochromatin spreading in the mouse revealed by insertional polymorphisms. PLoS Genetics. 2011 Sep;7(9):e1002301. Epub 2011 Sep 29.
5. Rahman M, Chan APK, Tai IT. A peptide of SPARC interferes with the interaction between caspase8 and Bcl2 to resensitize chemoresistant tumors and enhance their regression in vivo. PLoS One. 2011;6(11):e26390. Epub 2011 Nov 1.
6. Chiu CG, Yao R, Chan SK, Strugnell SS, Bugis S, Irvine R, Anderson D, Walker B, Jones SJ, and Wiseman SM. Hemithyroidectomy is the preferred initial operative approach for an indeterminant fine needle aspiration biopsy diagnosis. Can J Surg. In press.
7. Johner A, Griffith OL, Walker B, Wood L, Piper H, Wilkins G, Baliski C, Jones SJ, Wiseman SM. Detection and management of hypothyroidism following thyroid lobectomy: evaluation of a clinical algorithm. Ann Surg Oncol. 2011 Sep;18(9):2548-2554.
8. Earl DA, Bradnam K, St. John J, Darling A, Lin D, Faas J, Yu HOK, Vince B, Zerbino DR, Diekhans M, Nguyen N, Nuwantha P, Wing-Kin Sung A, Ning Z, Haimel M, Simpson JT, Fronseca NA, Birol I, Docking TR, Ho IY, Rokhsar DS, Chikhi R, Lavenier D, Chapuis G, Naquin D, Maillet N, Schatz MC, Kelly DR, Phillippy AM, Koren S, Yang SP, Wu W, Chou WC, Srivastava A, Shaw TI, Ruby JG, Skewes-Cox P, Betegon M, Dimon MT, Solovyev V, Kosarev P, Vorobyev D, Ramirez-Gonzalez R, Leggett R, MacLean D, Xia F, Luo R, Zhenyu L, Xie Y, Liu B, Gnerre S, MacCallum I, Przybylski D, Ribeiro FJ, Yin S, Sharpe T, Hall G, Kersey PJ, Durbin R, Jackman SD, Chapman JA, Huang X, DeRisi JL, Caccamo M, Li Y, Jaffe DB, Green R, Haussler D, Korf I, Paten B. Assemblathon 1: A competitive assessment of de novo short read assembly methods. Genome Res. 2011 Sep 16.
9. Linger BR, Morin GB, and Price CM. The Pot1a-Associated Proteins Tpt1 And Pat1 Coordinate Telomere Protection And Length Regulation In Tetrahymena. Mol Biol Cell. Nov;22(21):4161-70. Epub 2011 Sep 7.
10. Starczynowski DT, Lockwood WW, Delehouzee S, Chari R, Wegrzyn J, Tsao M-S, Lam S, Gazdar AF, Lam WL, Karsan A. TRAF6 is an amplified oncogene bridging the Ras and nuclear factor-?B cascade in human lung cancer. J Clin Invest. 2011 Sep 12. pii: 58818. doi: 10.1172/JCI58818
11. Haile S, Lal A, Myung J-K. Sadar MD. FUS/TLS is a co-activator of the androgen receptor in prostate cancer cells. PLoS One. 2011;6(9):324197.
12. Tognon CE, Martin MJ, Moradian A, Trigo G, Rotblat B, Cheng SW, Pollard M, Uy E, Chow C, Carboni JM, Gottardis MM, Pollak M, Morin GB, Sorensen PH. A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation. Oncogene. 2011 Aug 1. doi: 10.1038/onc.2011.323.
13. Chan QWT, Cornman RS, Birol I, Liao NY, Chan SK, Docking TR, Jackman SD, Taylor GA, Jones SJM, de Graaf DC, Evans JD, Foster LJ. Updated genome assembly and annotation of Paenibacillus larvae, the agent of American foulbrood disease of honey bees. BMC Genomics. 2011, 12:450doi:10.1186/1471-2164-12-450.
14. Sadar MD. Advances in Small Molecule Inhibitors of Androgen Receptor for the Treatment of Advanced Prostate Cancer. World J Urol. 2011 Aug 11.
15. Haile S, Sadar MD. Androgen receptor and its splice variants in prostate cancer. Cell Mol Life Sci. 2011 Dec;68(24):3971-81. Epub 2011 Jul 12.
16. Li YY, An J, Jones SJM. A Computational Approach to Finding Novel Targets for Existing Drugs. PLoS Comput Biol 7(9): e1002139. doi:10.1371/journal.pcbi.1002139.
17. Kasaian K, Jones SJ. A new frontier in personalized cancer therapy: mapping molecular changes. Future Oncol. 2011 Jul;7(7):873-894.
18. Qu C, Schuetz JM, Min JE, Leach S, Daley D, Spinelli JJ, Brooks-Wilson A and J Graham. Cost-effective prediction of gender-labeling errors and estimation of gender-labeling error rates in candidate-gene association studies. Front. Gene. 2011 June 15. doi: 10.3389/fgene.2011.00031.
19. Pharoah PDP, Palmieri RT, Ramus SJ, Gayther SA, Andrulis IL, Anton-Culver HA, Antonenkova N, Antoniou AC, Study Group of BCFR Investigators, Beattie MS, Beckman M, Birrer MJ, Bogdanova N, Bolton KL, Brewster W, Brooks-Wilson A, Brown R, Butzow R, Caldes T, Caligo MA, Campbell IG, Chang-Claude J, Chen A, Chenevix-Trench G, Cook LS, Couch FJ, Cramer DW, Cunningham JM, Despierre E, Doherty JA, Dörk T, Dürst M, Eccles D, Ekici AB, Study Group of EMBRACE Investigators, Fasching PA, de Fazio A, Fenstermacher DA, Flanagan JM, Fridley BL, Friedman E, Gao B, Study Group of GEMO Study Collaborators, Gentry-Maharaj A, Godwin AK, Goode E, Goodman MT, Gross J, Hansen TVO, Harnett PR, Study Group of HEBON Investigators, Heikkinen T, Hein R, Høgdall CK, Høgdall EV, Iversen E, Jakubowska A, Johnatty SE, Karlan BY, Kauff ND, Kaye SB, Study Group of kConFab Investigators, Kelemen LE, Kiemeney LA, Kjaer SK, Lambrechts D, LaPolla JP, Lázaro C, Le ND, Leminen A, Leunen K, Levine DA, Lu Y, Lundvall L, Macgregor S, Marees T, Massuger L, McLaughlin JR, Menon U, Montagna M, Moysich KB, Narod S, Nathanson KL, Nedergaard L, Ness RB, Nevanlinna HA, Nickels S, Osorio A, Paul J, Pearce CL, Phelan CM, Pike MC, Radice P, Rossing MA, Schildkraut J, Sellers TA, Singer CF, Song H, Stram DO, Sutphen R, Study Group of SWE-BRCA Investigators, Terry KL, Tsai Y-Y, van Altena AM, Vergote I, Vierkant RA, Vitonis AF, Walsh C, Wang-Gohrke S, Wappenschmidt B, Wu AH, Ziogas A, Berchuck A and HA Risch. The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing. Clin Cancer Res. 2011 Jun 1;17(11):3742-3750.
20. Wong JCT*, Chan SK*, Schaeffer DF, Sagaert X, Lim H, Kennecke H, Owen D, Suh KW, Kim YB, Tai IT. Absence of MMP2 expression correlates with poor clinical outcomes in rectal cancer, and is distinct from MMP1-related outcomes in colon cancer. Clin Cancer Res. 2011 Jun 15;17(12):4167-4176.
21. Hasan MR, Ho SHY, Owen D, Tai IT. Inhibition of VEGF induces cellular senescence in colorectal cancer cells. Int J Cancer. 2011 May 26:10.1002/ijc.26179.
22. Schrader KA, Heravi-Moussavi A, Waters PJ, Senz J, Whelan J, Ha G, Eydoux P, Nielsen T, Gallagher B, Oloumi A, Boyd N, Fernandez BA, Young TL, Jones SJ, Hirst M, Shah SP, Marra MA, Green J, Huntsman DG. Using next-generation sequencing for the diagnosis of rare disorders: a family with retinitis pigmentosa and skeletal abnormalities. J Pathol. 2011 Sep;225(1):12-8. doi: 10.1002/path.2941.
23. Chang ACY, Fu Y, Garside VC, Niessen K, Chang L, Fuller M, Setiadi A, Smrz J, Kyle A, Minchinton A, Marra M, Hoodless PA, Karsan A. Notch initiates endothelial-to-mesenchymal transition in the atrioventricular canal through autocrine activation of soluble guanylyl cyclase. Dev Cell. 2011 Aug 16;21(2):288-300.
24. Morrissy AS, Griffith M, Marra MA. Extensive relationship between antisense transcription and alternative splicing in the human genome. Genome Res. 2011 Aug;21(8):1203-1212.
25. O'Connor MD, Wederell E, Robertson G, Delaney A, Morozova O, Poon SS, Yap D, Fee J, Zhao Y, McDonald H, Zeng T, Hirst M, Marra MA, Aparicio SA, Eaves CJ. Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance. Exp Hematol. 2011 Aug;39(8):866-879.e1
26. White AK, Vaninsberghe M, Petriv OI, Hamidi M, Sikorski D, Marra MA, Piret J, Aparicio S, Hansen CL. High-Throughput Microfluidic RT-qPCR of Single Cells. Proc Natl Acad Sci U SA. 2011 Aug 1.
27. Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJ, Connors JM, Hirst M, Gascoyne RD, Marra MA. Frequent mutation of histone- modifying genes in non-Hodgkin lymphoma. Nature. 2011 Jul 27. doi: 10.1038/nature10351.
28. Heuser M, Yun H, Berg T, Yung E, Argiropoulos B, Kuchenbauer F, Park G, Hamwi I, Palmqvist L, Lai CK, Leung M, Lin G, Chaturvedi A, Thakur BK, Iwasaki M, Bilenky M, Thiessen N, Robertson G, Hirst M, Kent D, Wilson NK, Göttgens B, Eaves C, Cleary ML, Marra M, Ganser A, Humphries RK. Cell of Origin in AML: Susceptibility to MN1-Induced Transformation Is Regulated by the MEIS1/AbdB-like HOX Protein Complex. Cancer Cell. 2011 Jul 12;20(1):39-52.
29. Karimi MM, Goyal P, Maksakova IA, Bilenky M, Leung D, Tang JX, Shinkai Y, Mager DL, Jones S, Hirst M, Lorincz MC. DNA Methylation and SETDB1/H3K9me3 Regulate Predominantly Distinct Sets of Genes, Retroelements, and Chimeric Transcripts in mESCs. Cell Stem Cell. 2011 Jun 3;8(6):676-87.
30. McPherson AW, Hormozdiari F, Zayed A, Giuliany R, Ha G, Sun MG, Griffith M, Heravi Moussavi A, Senz J, Melnyk N, Pacheco M, Marra MA, Hirst M, Nielsen TO, Sahinalp SC, Huntsman D, Shah S. deFuse: an algorithm for gene fusion discovery in tumor RNA-Seq data. deFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data. PLoS Comput Biol. 2011 May;7(5):e1001138.
31. Kuchenbauer F, Mah SM, Heuser M, McPherson A, Ruschmann J, Rouhi A, Berg T, Bullinger L, Argiropoulos B, Morin RD, Lai D, Starczynowski DT, Karsan A, Eaves CJ, Watahiki A, Wang Y, Aparicio SA, Ganser A, Krauter J, Döhner H, Döhner K, Marra MA, Camargo FD, Palmqvist L, Buske C, Humphries RK. Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells. Blood. 2011 May 31.
32. Moore RA, Warren RL, Freeman JD, Gustavsen JA, Chénard C, Friedman JM, Suttle CA, Zhao Y, Holt RA. The sensitivity of massively parallel sequencing for detecting candidate infectious agents associated with human tissue. PLoS One. 2011;6(5):e19838. Epub 2011 May 13.
33. Warren RL, Holt RA. Targeted assembly of short sequence reads. PLoS One. 2011 May 11;6(5):e19816.
34. Bashash M, Hislop TG, Shah AM, Le N, Brooks-Wilson A, Bajdik CD. The prognostic effect of ethnicity for gastric and esophageal cancer: the population-based experience in British Columbia, Canada. BMC Cancer. 2011 May 9;11(1):164.
35. Warren RL,Freeman JD, Zeng T, Choe G, Munro S, Moore R, Webb JR, Holt RA. Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes. Genome Res. 2011 May;21(5):790-797.
36. Wiseman SM, Griffith OL, Gown A, Walker B, Jones SJ. Immunophenotyping of thyroid tumors identifies molecular markers altered during transformation of differentiated into anaplastic carcinoma. Am J Surg. 2011 May;201(5):578-584.
37. Fejes AP, Khodabakhshi AH, Birol I, Jones SJ. Human variation database: an open-source database template for genomic discovery. Bioinformatics. 2011 Apr 15;27(8):1155-1156.
38. Wong JC, Chan SK, Schaeffer DF, Sagaert X, Lim H, Kennecke H, Owen D, Suh KW, Kim YB, Tai IT. Absence of MMP2 expression correlates with poor clinical outcomes in rectal cancer, and is distinct from MMP1-related outcomes in colon cancer. Clin Cancer Res. 2011 Apr 29. (Epub ahead of print)
39. Wegrzyn J, Lam JC, Karsan A. Mouse models of myelodysplastic syndromes. Leuk Res. 2011 Jul;35(7):853-62. Epub 2011 Apr 3
40. Bhat RK, Ellestad KK, Wheatley BM, Warren R, Holt RA, Power C. Age- and Disease-Dependent HERV-W Envelope Allelic Variation in Brain: Association with Neuroimmune Gene Expression. PLoS One. 2011 Apr 29;6(4):e19176.
41. Smedby KE, Foo JN, Skibola CF, Darabi H, Conde L, Hjalgrim H, Kumar V, Chang ET, Rothman N, Cerhan JR, Brooks-Wilson AR, Rehnberg E, Irwan ID, Ryder LP, Brown PN, Bracci PM, Agana L, Riby J, Cozen W, Davis S, Hartge P, Morton LM, Severson RK, Wang SS, Slager SL, Fredericksen ZS, Novak AJ, Kay NE, Habermann TM, Armstrong B, Kricker A, Milliken S, Purdue MP, Vajdic CM, Boyle P, Lan Q, Zahm SH, Zhang Y, Zheng T, Leach S, Spinelli JJ, Smith MT, Chanock SJ, Padyukov L, Alfredsson L, Klareskog L, Glimelius B, Melbye M, Liu ET, Adami HO, Humphreys K, Liu J. GWAS of Follicular Lymphoma Reveals Allelic Heterogeneity at 6p21.32 and Suggests Shared Genetic Susceptibility with Diffuse Large B-cell Lymphoma. PLoS Genet. 2011 Apr;7(4):e1001378.
42. Starczynowski DT, Vercauteren S, Sung S, Brooks-Wilson A, Lam WL, Karsan A. Copy number alterations at polymorphic loci may be acquired somatically in patients with myelodysplastic syndromes. Leuk Res. 2011 Apr;35(4):444-447.
43. Fu Y, Chang AC, Fournier M, Chang L, Niessen K, Karsan A. RUNX3 maintains the mesenchymal phenotype after termination of the notch signal. J Biol Chem. 2011 Apr 1;286(13):11803-11813.
44. McConechy MK, Anglesio MS, Kalloger SE, Yang W, Senz J, Chow C, Heravi-Moussavi A, Morin GB, Mes-Masson AM; Australian Ovarian Cancer Study Group, Carey MS, McAlpine JN, Kwon JS, Prentice LM, Boyd N, Shah SP, Gilks CB, Huntsman DG. Subtype-specific mutation of PPP2R1A in endometrial and ovarian carcinomas. J Pathol. 2011 Apr;223(5):567-73. doi: 10.1002/path.2848.
45. Bashash M, Yavari P, Hislop TG, Shah A, Sadjadi A, Babaei M, Le N, Brooks-Wilson A, Malekzadeh R, Bajdik C. Comparison of two diverse populations, British Columbia, Canada, and Ardabil, Iran, indicates several variables associated with gastric and esophageal cancer survival. J Gastrointest Cancer. 2011 Mar;42(1):40-45.
46. Zhang X, Robertson G, Krzywinski M, Ning K, Droit A, Jones S, Gottardo R. PICS: Probabilistic Inference for ChIP-seq . Biometrics. 2011 Mar;67(1):151-63. doi: 10.1111/j.1541-0420.2010.01441.x.
47. Tucker T, Montpetit A, Chai D, Chan S, Chénier S, Coe BP, Delaney A, Eydoux P, Lam WL Langlois S, Lemyre E, Marra M, Qian H, Rouleau GA, Vincent D, Michaud JL, Friedman JM. Comparison of genome-wide array genomic hybridization platforms for the detection of copy number variants in idiopathic mental retardation. BMC Med Genomics. 2011 Mar 25;4(1):25.
48. Slobodan J, Corbett R, Wye N, Schein JE, Marra MA, Coope RJN. High performance gel imaging with a commercial single lens reflex camera. Rev Sci Instrum. 2011 Mar;82(3):034301.
49. Steidl C, Shah SP, Woolcock BW, Rui L, Kawahara M, Farinha P, Johnson NA, Zhao Y, Telenius A, Ben-Neriah S, McPherson A, Meissner B, Okoye UC, Diepstra A, van den Berg A, Sun M, Leung G, Jones SJ, Connors JM, Huntsman DG, Savage KJ, Rimsza LM, Horsman DE, Staudt LM, Steidl U, Marra MA, Gascoyne RD. MHC Class II Transactivator CIITA is a Recurrent Gene Fusion Partner in Lymphoid Cancers. Nature. 2011 Mar 17;471(7338):377-381
50. Yap DB, Chu J, Berg T, Schapira M, Cheng SW, Moradian A, Morin RD, Mungall AJ, Meissner B, Boyle M, Marquez VE, Marra MA, Gascoyne RD, Humphries RK, Arrowsmith CH, Morin GB, Aparicio SA. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood. 2011 Feb 24;117(8):2451-2459.
51. Gardy JL, Johnston JC, Ho Sui SJ, Cook VJ, Shah L, Brodkin E, Rempel S, Moore R, Zhao Y, Holt R, Varhol R, Birol I, Lem M, Sharma MK, Elwood K, Jones SJ, Brinkman FS, Brunham RC, Tang P. Whole-genome sequencing and social-network analysis of a tuberculosis outbreak. N Engl J Med. 2011 Feb 24;364(8):730-739.
52. Sadar MD. Small molecule inhibitors targeting the "achilles' heel" of androgen receptor activity. Cancer Res. 2011 Feb 15;71(4):1208-1213.
53. Blahnik KR, Dou L, Echipare L, Iyengar S, O'Geen H, Sanchez E, Zhao YJ, Marra MA, Hirst M, Costello JF, Korf I, Farnham PJ. Characterization of the contradictory chromatin signatures at the 3' exons of zinc finger genes.PLoS One. 2011 Feb 15;6(2):e17121.
54. D'Souza C, Kronstad J, Taylor G, Warren R, Yuen M, Hu G, Jung WH, Sham A, Kidd S, Tangen K, Lee N, Zeilmaker T, Sawkins J, McVicker G, Shah S, Gnerre S, Griggs A, Zeng Q, Bartlett K, Li W, Wang X, Heitman J, Stajich J, Fraser J, Meyer W, Carter D, Schein J, Krzywinski M, Kwon-Chung KJ, Varma A, Wang J, Brunham R, Fyfe M, Ouellette BFF, Siddiqui A, Marra M, Jones S, Holt R, Birren B, Galagan J, Cuomo C. Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts. MBio. 2011 Feb 8;2(1). pii: e00342-10. doi: 10.1128/mBio.00342-10.
55. DiGuistini S, Wang Y, Liao NY, Taylor G, Tanguay P, Feau N, Henrissat B, Chan SK, Hesse-Orce U, Alamouti SM, Tsui CK, Docking R, Levasseur A, Haridas S, Robertson G, Birol I, Holt R, Marra M, Hamelin RC, Hirst M, Jones SJM, Bohlmann J, Breuil C. Genome and transcriptome analyses of the mountain pine beetle-fungal symbiont Grosmannia clavigera, a lodgepole pine pathogen. Proc Natl Acad Sci U SA. 2011 Feb 8;108(6):2504-2509.
56. Shin H, Lee H, Fejes AP, Baillie DL, Koo HS, Jones SJ. Gene expression profiling of oxidative stress response of C. elegans aging defective AMPK mutants using massively parallel transcriptome sequencing. BMC Res Notes. 2011 Feb 8;4:34.
57. Berezikov E, Robine N, Samsonova A, Westholm JO, Naqvi A, Hung JH, Okamura K, Dai Q, Bortolamiol-Becet D, Martin R, Zhao YJ, Zamore PD, Hannon GJ, Marra MA, Weng Z, Perrimon N, Lai EC. Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome Res. 2011 Feb;21(2):203-215.
58. Jädersten M, Karsan A. Clonal evolution in myelodysplastic syndromes with isolated del(5q): the importance of genetic monitoring. Haematologica. 2011 Feb;96(2):177-180.
59. Starczynowski DT, Kuchenbauer F, Wegrzyn J, Rouhi A, Petriv O, Hansen CL, Humphries RK, Karsan A. MicroRNA-146a disrupts hematopoietic differentiation and survival. Exp Hematol. 2011 Feb;39(2):167-178.e4.
60. Starczynowski D, Morin RD, McPherson A, Kuchenbauer F, Tohyama K, Hirst M, Humphries K, Marra M, Lam W, Karsan A. Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations. Blood. 2011 Jan 13;117(2):595-607.
61. Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW, Beare D, Stebbings LA, McLaren S, Lin ML, McBride DJ, Varela I, Nik-Zainal S, Leroy C, Jia M, Menzies A, Butler AP, Teague JW, Quail MA, Burton J, Swerdlow H, Carter NP, Morsberger LA, Iacobuzio-Donahue C, Follows GA, Green AR, Flanagan AM, Stratton MR, Futreal PA, Campbell PJ. Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell. 2011 Jan 7;144(1):27-40.
62. Schrader K, Masciari S, Boyd N, Salamanca C, Senz J, Saunders DN, Yorida E, Maines-Bandiera S, Kaurah P, Tung N, Robson M, Ryan PD, Olopade OI, Domchek SM, Ford J, Isaacs C, Brown P, Balmana J, Miron P, Coffey K, Terry MB, John EM, Andrulis IL, Knight JA, O’Malley FP, Daly M, Bender P, ConFab K, Moore R, Southey MC, Hopper JL, Garber J, Huntsman D. Germline mutations in CDH1 are infrequent in in women with early-onset or familial lobular breast cancers. Journal of Medical Genetics. 2011 Jan;48(1):64-8. Epub 2010 Oct 4.
63. Yakovenko OY, Li YY, Oliferenko AA, Vashchenko GM, Bdzhola VG, Jones SJM. Ab initio parameterization of YFF1, a universal force field for drug-design applications. Journal of molecular modeling. 2011 May 12.
64. Laing R, Hunt M, Protasio AV, Saunders G, Mungall K, Laing S, Jackson F, Quail M, Beech R, Berriman M, Gilleard JS. Annotation of two large contiguous regions from the Haemonchus contortus genome using RNA-seq and comparative analysis with Caenorhabditis elegans. PLoS ONE. 2011 Jan 1;6(8):e23216.
65. Earp MA, Rahmani M, Chew K, Brooks-Wilson A. Estimates of array and pool-construction variance for planning efficient DNA-pooling genome wide association studies. BMC medical genomics. 2011 Nov 28;4(1):81.
66. Ding J, Bashashati A, Roth A, Oloumi A, Tse K, Zeng T, Haffari G, Hirst M, Marra MA, Condon A, Aparicio S, Shah SP. Feature based classifiers for somatic mutation detection in tumour-normal paired sequencing data. Bioinformatics (Oxford, England). 2011 Nov 13.
67. Beesley J, Pickett HA, Johnatty SE, Dunning AM, Chen X, Li J, Michailidou K, Lu Y, Rider DN, Palmieri RT, Stutz MD, Lambrechts D, Despierre E, Lambrechts S, Vergote I, Chang-Claude J, Nickels S, Vrieling A, Flesch-Janys D, Wang-Gohrke S, Eilber U, Bogdanova N, Antonenkova N, Runnebaum IB, Dörk T, Goodman MT, Lurie G, Wilkens LR, Matsuno RK, Kiemeney LA, Aben KKH, Marees T, Massuger LFAG, Fridley BL, Vierkant RA, Bandera EV, Olson SH, Orlow I, Rodriguez-Rodriguez L, Cook LS, Le ND, Brooks-Wilson A, Kelemen LE, Campbell I, Gayther SA, Ramus SJ, Gentry-Maharaj A, Menon U, Ahmed S, Baynes C, Pharoah PD, Investigators K, Group AOCS, Investigators A, Muir K, Lophatananon A, Chaiwerawattana A, Wiangnon S, Macgregor S, Easton DF, Reddel RR, Goode EL, Chenevix-Trench G, Consortium obotOCA. Functional Polymorphisms in the TERT Promoter Are Associated with Risk of Serous Epithelial Ovarian and Breast Cancers. PLoS ONE. 2011 Jan 1;6(9):e24987.
68. Chu Y, Gao P, Zhao P, He Y, Liao N, Jackman S, Zhao Y, Birol I, Duan X, Lu Z. Genome sequence of Mycoplasma capricolum subsp. capripneumoniae strain M1601. J Bacteriol. 2011 Nov 1;193(21):6098-9.
69. Dauphinee SM, Voelcker V, Tebaykina Z, Wong F, Karsan A. Heterotrimeric Gi/Go proteins modulate endothelial TLR signaling independent of the MyD88-dependent pathway. Am J Physiol Heart Circ Physiol. 2011 Sep 23.
70. Krzywinski M, Birol I, Jones SJ, Marra MA. Hive plots--rational approach to visualizing networks. Briefings in bioinformatics. 2011 Dec 9.
71. Zhou X, Maricque B, Xie M, Li D, Sundaram V, Martin EA, Koebbe BC, Nielsen C, Hirst M, Farnham P, Kuhn RM, Zhu J, Smirnov I, Kent WJ, Haussler D, Madden PAF, Costello JF, Wang T. The human epigenome browser at washington university. Nat Methods. 2011 Jan 1;8(12):989-90.
72. Huang Y, Sitwala K, Bronstein J, Sanders D, Dandekar M, Collins C, Robertson G, Macdonald J, Cezard T, Bilenky M, Thiessen N, Zhao Y, Zeng T, Hirst M, Hero A, Jones S, Hess JL. Identification and characterization of Hoxa9 binding sites in hematopoietic cells. Blood. 2011 Nov 9.
73. Mo F, Wyatt AW, Wu C, Lapuk AV, Marra MA, Gleave ME, Volik SV, Collins CC. Next generation sequencing of prostate tumours provides independent evidence of XMRV contamination. Journal of clinical microbiology. 2011 Dec 7.
74. Andersen R, Sadar M, Williams D, Meimetis L, Mawji N, Banuelos C, Lal A, Park J, de Voogd NJ, Tien A, Fernandez J. Niphatenones, Glycerol Ethers from the Sponge Niphates digitalis Block Androgen Receptor Transcriptional Activity in Prostate Cancer Cells: Structure Elucidation, Synthesis, and Biological Activity. Journal of medicinal chemistry. 2011 Dec 8.
75. Amankwah EK, Wang Q, Schildkraut JM, Tsai Y-Y, Ramus SJ, Fridley BL, Beesley J, Johnatty SE, Webb PM, Chenevix-Trench G, Group AOCS, Dale LC, Lambrechts D, Amant F, Despierre E, Vergote I, Gayther SA, Gentry-Maharaj A, Menon U, Chang-Claude J, Wang-Gohrke S, Anton-Culver H, Ziogas A, Dörk T, Dürst M, Antonenkova N, Bogdanova N, Brown R, Flanagan JM, Kaye SB, Paul J, Bützow R, Nevanlinna H, Campbell I, Eccles DM, Karlan BY, Gross J, Walsh C, Pharoah PDP, Song H, Krüger Kjær S, Høgdall E, Høgdall C, Lundvall L, Nedergaard L, Kiemeney LALM, Massuger LFAG, van Altena AM, Vermeulen SHHM, Le ND, Brooks-Wilson A, Cook LS, Phelan CM, Cunningham JM, Vachon CM, Vierkant RA, Iversen ES, Berchuck A, Goode EL, Sellers TA, Kelemen LE. Polymorphisms in stromal genes and susceptibility to serous epithelial ovarian cancer: a report from the Ovarian Cancer Association Consortium. PLoS ONE. 2011 Jan 1;6(5):e19642.
76. Geraldes A, Pang J, Thiessen N, Cezard T, Moore R, Zhao Y, Tam A, Wang S, Friedmann M, Birol I, Jones SJM, Cronk QCB, Douglas CJ. SNP discovery in black cottonwood (Populus trichocarpa) by population transcriptome resequencing. Mol Ecol Resour. 2011 Mar 1;11 Suppl 1:81-92.

2010 Publications

Duties/Accountablilties:

1.Performs biological sequence searches by:

a.Inputting  laboratory data into GSC analysis programs.
b.Running data through public data bases and according to established protocol determines whether noted probability constitutes an acceptable match.
c.Running biological sequence data through search tools available on-line via world-wide web (WWW) interfaces and according to established protocol determines whether noted probability constitutes an acceptable match.
d.Documenting any matches located.

2.Maintains GSC biological databases.

3.Responds to data requests from the scientific community by searching for biological sequence information currently available on public databases and prepares summaries of the relevant information located.

4.Tests and validates new data analysis software.

5.Performs data manipulation and transformation by creating programming scripts using tools such as PERL, AWK, SED and UNIX shells.

6.Performs other related duties as required.

Qualifications:

Education, Training and Experience

• Graduation from a recognized Bachelor of Science Program in either Biological Sciences or Computer Science.
• Two (2) year’s of recent related experience or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and Abilities

• Experience with relevant operating systems.
• Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
• Demonstrated ability to efficiently organize work assignments and establish priorities.
• Ability to use related equipment.

• establish budgets for research projects, grants, collaborations and core activities and assist with preparing progress reports
• monitor expenditures
• establish, monitor and coordinate milestones, deadlines and objectives
• recommend strategies for improving projects management methods liaise with grant/core funding agencies

Specifications:

While equivalencies will be considered, ideally you bring a degree in Science (preferably Engineering, Computer Science, Physics, Mathematics, Genetics, Biochemistry or Microbiology) plus 5 years' recent related experience in project management and/or research development management.

Certification as a Project Management professional will help you make the short list, as will experience in academic scientific research or the biotech or software industry. Proficiency with MS Word, Excel and Project is essential and you should have excellent organizational, analytical and verbal and written communication skills.

• Working with the Projects Team and the laboratory groups, establish and maintain accurate information on project and research costs, schedule and progress.
• Develop strategies to monitor progress on projects and collaborations to ensure that the project objectives are met.
• Coordinate and contribute to the production of written proposals, project progress reports, and project budgets and cost estimates.
• Liaise with collaborators and project leaders on project objectives and scientific issues, referring significant issues to the Production Coordinator and the Project Leader.
• Evaluate project progress versus milestones and work with the Lab Production Coordinators to address issues. Recommend strategies to resolve project efficiency issues.
• Document, disseminate and archive research results include quality and quantity information.
• Work with other groups at the GSC to establish other supporting and service tools for collaborators and other GSC users.

Excellent written and verbal communication skills and proactive interactions with collaborators are a must to perform successfully in this position. Active participation in laboratory meetings and seminars relevant to the group’s activities is highly encouraged.

Specifications

While equivalencies will be considered, ideally you will bring a Bachelor’s degree from a recognized University in Science or Business Administration, plus 3 years of recent related

The technology and clinical platforms at Canada's Michael Smith Genome Sciences Centre are staffed by teams of professional scientists with expertise in several areas of genomics research. These teams support researchers and collaborators in BC and around the world in work addressing topical questions in the life sciences.

Technology Platforms Bioinformatics Platform The bioinformatics group at the GSC participates in a diverse number of areas on computational genomic analysis such as expression profiling, gene regulation, comparative genomics analysis, genome assembly, and laboratory information management. The platform has nearly 60 computational biologists, software programmers, and informatics specialists working with all GSC activity areas to provide data analysis and management solutions. The development of data analysis tools for high-throughput sequencing is a major focus of the bioinformatics group, with key projects and publications already in place. Sequencing Platform High-throughput large-scale DNA analysis facility designed to maximize capacity while maintaining efficiency, scalability and flexibility. The platform is the largest platform of its type in Canada and is well recognized internationally. The Ion Torrent PGM platform is currently in development. Illumina HiSeq 2000 The GSC currently has 12 Illumina HiSeq 2000 systems. Sequencing capabilities include both single-end sequencing (50 and 75bp read lengths) and pair-end sequencing (50, 75 and 100bp read lengths). Library construction for Illumina sequencing is available for whole genome, transcriptome (RNA-seq), epigenome, exome, and microRNA, as well as for “bar coding” of samples for multiplex sequencing. The GSC has constructed more than 2,000 libraries and generated over 75 x 10 12 base pairs of data on the Illumina Genome Analyzer, contributing to many projects and publications. Proteomics Platform The Proteomics group at the GSC performs protein and post-translational modification identification on protein samples using high pressure liquid chromatography coupled to nano-electrospray mass spectrometry. Current applications include protein-protein interaction mapping, and protein phosphorylation site detection and quantitation. Drug Discovery Platform The drug discovery platform performs high-throughput virtual screening using leading molecular docking software and high performance computing resources to find novel therapeutics for human diseases.

Clinical Platforms Centre for Clinical Diagnostic Genomics Providing sustainable and scalable clinical diagnostic genomic testing for the population of British Columbia. Centre for Translational and Applied Genomics (CTAG) A translational research facility, CTAG provides clinical grade services to the academic and private sector clients.

Major funding for the Genomics Platform is provided by the Government of Canada through Genome Canada. Funding from Genome Canada flows through Genome BC, which also provides support to the Platform.

Duties/Accountablilties:

1. Following established laboratory procedures, performs tasks such as colony purification of plasmid/BAC clones, RNA and DNA purification, DNA sequencing, analysis of DNA fingerprints for physical map construction, Polymerase Chain Reaction (PCR) experiments, DNA restriction analysis, agarose gel electrophoresis, southern blot analysis and library construction.

2. Prepares solutions following standard operating procedures.

3. Maintains general lab and equipment cleanliness.  Recognizes and reports malfunctions in equipment.

4. Processes patient samples according to established procedures for clinical sequencing diagnostic tests. 

5. Performs other related duties as required

Qualifications:

Education, Training and Experience

• Graduation from a recognized diploma program in Biotechnology, Microbiology or Biochemistry and two (2) years’ of recent related experience in a research laboratory or an equivalent combination of education, training and experience acceptable to the Genome Sciences Centre Group Leaders and Production Coordinators.


Skills and Abilities

• Knowledge of molecular biology techniques particularly DNA and RNA preparation and manipulation.
• Demonstrated ability to perform detailed procedures reproducibly and accurately.
• Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
• Demonstrated ability to efficiently organize work assignments and establish priorities.
• Basic knowledge of and ability to operate personal computers.

• establish budgets for research projects, grants, collaborations and core activities and assist with preparing progress reports
• monitor expenditures
• establish, monitor and coordinate milestones, deadlines and objectives
• recommend strategies for improving projects management methods liaise with grant/core funding agencies

Specifications:

While equivalencies will be considered, ideally you bring a degree in Science (preferably Engineering, Computer Science, Physics, Mathematics, Genetics, Biochemistry or Microbiology) plus 5 years' recent related experience in project management and/or research development management.

Certification as a Project Management professional will help you make the short list, as will experience in academic scientific research or the biotech or software industry. Proficiency with MS Word, Excel and Project is essential and you should have excellent organizational, analytical and verbal and written communication skills.

Duties/Accountablilties:

1.Performs biological sequence searches by:

a.Inputting  laboratory data into GSC analysis programs.
b.Running data through public data bases and according to established protocol determines whether noted probability constitutes an acceptable match.
c.Running biological sequence data through search tools available on-line via world-wide web (WWW) interfaces and according to established protocol determines whether noted probability constitutes an acceptable match.
d.Documenting any matches located.

2.Maintains GSC biological databases.

3.Responds to data requests from the scientific community by searching for biological sequence information currently available on public databases and prepares summaries of the relevant information located.

4.Tests and validates new data analysis software.

5.Performs data manipulation and transformation by creating programming scripts using tools such as PERL, AWK, SED and UNIX shells.

6.Performs other related duties as required.

Qualifications:

Education, Training and Experience

• Graduation from a recognized Bachelor of Science Program in either Biological Sciences or Computer Science.
• Two (2) year’s of recent related experience or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and Abilities

• Experience with relevant operating systems.
• Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
• Demonstrated ability to efficiently organize work assignments and establish priorities.
• Ability to use related equipment.