BC scientists play major role in international effort to map the human epigenome
One of the great mysteries in biology is how the many different cell types that make up our bodies are derived from a single cell and from one DNA sequence, or genome. We have learned a lot from studying the human genome, but have only partially unveiled the processes underlying cell determination. The identity of each cell type is largely defined by an instructive layer of molecular annotations on top of the genome – the epigenome – which acts as a blueprint unique to each cell type and developmental stage.
Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor NetworksCell Reports, Vol. 17, Issue 8
Nucleosome Density ChIP-Seq Identifies Distinct Chromatin Modification Signatures Associated with MNase AccessibilityCell Reports, Vol. 17, Issue 8