Welcome to the Canada's Michael Smith Genome Sciences Centre
Canada's Michael Smith Genome Sciences Centre has a primary mandate to develop and deploy genomics technologies in support of life sciences research, and in particular cancer research.
The Genome Sciences Centre is one of fifteen research programs that operate as part of the BC Cancer Research Centre. The BC Cancer Agency, an agency of the Provincial Health Services Authority, provides a province-wide cancer control program for the residents of British Columbia. Additional support is provided by funds raised by the BC Cancer Foundation for cancer research.
The world-class scientific team at the Genome Sciences Centre has played a major role in advancing the fields of genomics and bioinformatics. Our scientists have been involved in many collaborative sequencing projects within Canada and around the world. A selection of these include:
- The rapid sequencing of the SARS Coronavirus
- Sequencing and genome analysis of the avian flu (H7N3)
- Participation in the Mammalian Gene Collection consortium
- Contributions to sequencing in a variety of organisms including bovine, Atlantic salmon, poplar and spruce, and wine grapes.
The priority of the centre is to develop innovative means to automate the DNA sequencing process, develop cost-effective measures that will make such research financially viable, and utilize state-of-the-art computing facilities to collect, mine, analyze and disperse data collected at this and other genome facilities. To accomplish this, the Genome Sciences Centre fully exploits the most recent technological advances in genome science, and has built a state-of-the-art computing facility. The computing facility is designed to extract information from the large amounts of data generated (DNA sequence) at this and other genome facilities, for the benefit and use of the wider scientific community.
High-throughput DNA sequencing is performed using the latest sequencing equipment, such as the Illumina (Solexa) Genome Analyzer IIx genome analysis system, and the Applied Biosystems ABI 3730 XL DNA Sequencer and SOLid 4.0 Plus. Expansion to include the Illumina HiSeq Genome Analyser will be implemented in the upcoming months. Data analysis is carried out on a dedicated bioinformatics computing network able to process the massively large datasets generated.